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High-throughput first-principle prediction of collinear magnetic topological materials

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npj Computational Materials 2022年第1期8卷 2490-2497页

作者： Yunlong Su Jiayu Hu Xiaochan Cai Wujun Shi Yunyouyou Xia yuanfeng xu xuguang xu Yulin Chen Gang Li School of Physical Science and Technology ShanghaiTech University201210ShanghaiChina Center for Transformative Science ShanghaiTech University201210ShanghaiChina Shanghai High Repetition Rate XFEL and Extreme Light Facility(SHINE) ShanghaiTech University201210ShanghaiChina ShanghaiTech Laboratory for Topological Physics ShanghaiTech University201210ShanghaiChina Center for Correlated Matter and School of Physics Zhejiang University310058HangzhouChina Department of Physics Princeton UniversityPrincetonNJUSA Department of Physics Clarendon LaboratoryUniversity of OxfordParks RoadOxfordOX13PUUK

The success of topological band theory and symmetry-based topological classification significantly advances our understanding of the Berry *** on the critical concept of topological obstruction,efficient theoretical frameworks,including topological quantum chemistry and symmetry indicator theory,were developed,making a massive characterization of real materials ***,the classification of magnetic materials often involves the complexity of their unknown magnetic structures,which are often hard to know from experiments,thus,hindering the topological *** this paper,we design a high-throughput workflow to classify magnetic topological materials by automating the search for collinear magnetic structures and the characterization of their topological *** computed 1049 chosen transition-metal compounds(TMCs)without oxygen and identified 64 topological insulators and 53 semimetals,which become 73 and 26 when U correction is further *** to the lack of magnetic structure information from experiments,our high-throughput predictions provide insightful reference results and make the step toward a complete diagnosis of magnetic topological materials.

关键词： materials topological symmetry

52例症状性颅内动脉粥样硬化性狭窄患者个体化血管内治疗的回顾性分析

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海军军医大学学报 2024年第4期45卷 520-526页

作者：华敏王佳佳陈文亚刘志清马爱金张金许元丰毛伦林江苏大学附属武进医院神经内科徐州医科大学武进临床学院常州213017

目的评估症状性颅内动脉粥样硬化性狭窄(sICAS)患者个体化血管内治疗的安全性和有效性。方法回顾性收集2019年1月至2022年12月在我院接受个体化血管内治疗的sICAS患者的临床资料,分析血管重建成功率、围手术期并发症发生率和死亡情况,... 详细信息

目的评估症状性颅内动脉粥样硬化性狭窄(sICAS)患者个体化血管内治疗的安全性和有效性。方法回顾性收集2019年1月至2022年12月在我院接受个体化血管内治疗的sICAS患者的临床资料,分析血管重建成功率、围手术期并发症发生率和死亡情况,以及随访期间复发性缺血性脑卒中(IS)、短暂性脑缺血发作、死亡和血管再狭窄的发生率。结果52例sICAS患者共有55处病变,均接受血管内治疗。患者平均年龄为(62.94±9.04)岁。术前病变血管狭窄程度为90%(80%,99%),狭窄长度为8(5,11)mm。采用的手术方式分别为球囊扩张式支架植入术(25例,27个病变)、自膨式支架植入术(19例,20个病变)、单纯球囊扩张血管成形术(8例,8个病变)。术后残余狭窄程度为10%(0,20%),较术前降低且差异有统计学意义(P<0.001)。血管重建成功率为94.23%(49/52),围手术期并发症发生率为3.85%(2/52)。临床随访12(12,18)个月,影像学随访10(6,12)个月,血管再狭窄发生率为7.69%(4/52),复发性IS发生率为1.92%(1/52),无患者死亡。结论个体化血管内治疗对sICAS安全、有效,其可提高血管重建成功率,降低围手术期并发症、远期IS复发和再狭窄风险。

关键词：颅内动脉粥样硬化性狭窄缺血性脑卒中血管内治疗球囊扩张血管成形术支架植入

Repurposing disulfiram with CuET nanocrystals:Enhancing anti-pyroptotic effect through NLRP3 inflammasome inhibition for treating inflammatory bowel diseases

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2698-2715页

作者： xueming xu yuanfeng Han Jiali Deng Shengfeng Wang Shijie Zhuo Kai Zhao Wenhu Zhou Hematology and Department of Critical Care Medicine The Third Xiangya HospitalCentral South UniversityChangsha 410013China Xiangya School of Pharmaceutical Sciences Central South UniversityChangsha 410013China Hunan Chidren's Hospital Changsha 410007China Department of Pharmacy The Third Xiangya HospitalCentral South UniversityChangsha 410013China Key Laboratory of Biological Nanotechnology of National Health Commission Changsha 410008China

Drug repurposing offers a valuable strategy for identifying new therapeutic applications for existing ***,disulfiram(DSF),a drug primarily used for alcohol addiction treatment,has emerged as a potential treatment for inflammatory diseases by inhibiting pyroptosis,a form of programmed cell *** therapeutic activity of DSF can be further enhanced by the presence of Cu^(2+),although the underlying mechanism of this enhancement remains *** this study,we investigated the mechanistic basis of Cu^(2+)-induced enhancement and discovered that it is attributed to the formation of a novel copper ethylthiocarbamate(CuET)*** exhibited significantly stronger anti-pyroptotic activity compared to DSF and employed a distinct mechanism of ***,despite its potent activity,CuET suffered from poor solubility and limited permeability,as revealed by our druggability *** overcome these intrinsic limitations,we developed a scalable method to prepare CuET nanocrystals(CuET NCs)using a metal coordination-driven self-assembly *** studies demonstrated that CuET NCs exhibited a 6-fold improvement in ***,CuET NCs exhibited high biodistribution in the intestine,suggesting their potential application for the treatment of inflammatory bowel diseases(IBDs).To evaluate their therapeutic efficacy in vivo,we employed a murine model of DSS-induced colitis and observed that CuET NCs effectively attenuated inflammation and ameliorated colitis *** findings highlight the discovery of CuET as a potent anti-pyroptotic agent,and the development of CuET NCs represents a novel approach to enhance the druggability of CuET.

关键词： Drug repurposing Pyroptosis Nanoparticles Bioavailability Disulfiram DSS-induced colitis NLRP3 inflammasome CuET

Multi-omics analysis reveals the pivotal role of phytohormone homeostasis in regulating maize grain water content

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The Crop Journal 2024年第4期12卷 1081-1092页

作者： Yuanliang Liu Manman Li Jianju Liu Suining Deng Yan Zhang yuanfeng Xia Baoshen Liu Mingliang xu State Key Laboratory of Plant Environmental Resilience/College of Agronomy and Biotechnology/National Maize Improvement Center/Center for Crop Functional Genomics and Molecular Breeding China Agricultural UniversityBeijing 100193China College of Agronomy/State Key Laboratory of Crop Biology Shandong Agricultural UniversityTai’an 271018ShandongChina Institute of Agricultural Biotechnology Jilin Academy of Agricultural SciencesGongzhuling 136100JilinChina Maize Research Institute Jilin Academy of Agricultural SciencesGongzhuling 136100JilinChina

Grain water content(GWC)is a key determinant for mechanical harvesting of maize(Zea mays).In our previous research,we identified a quantitative trait locus,qGWC1,associated with GWC in ***,we examined near-isogenic lines(NILs)NILL and NILH that differed at the qGWC1 *** GWC in NILL was primarily attributed to reduced grain water weight(GWW)and smaller fresh grain size,rather than the accumulation of dry *** difference in GWC between the NILs became more pronounced approximately 35 d after pollination(DAP),arising from a faster dehydration rate in *** an integrated analysis of the transcriptome,proteome,and metabolome,coupled with an examination of hormones and their derivatives,we detected a marked decrease in JA,along with an increase in cytokinin,storage forms of IAA(IAA-Glu,IAA-ASP),and IAA precursor IPA in immature NILL *** kernel development,genes associated with sucrose synthases,starch biosynthesis,and zein production in NILL,exhibited an initial up-regulation followed by a gradual down-regulation,compared to those in *** discovery highlights the crucial role of phytohormone homeostasis and genes related to kernel development in balancing GWC and dry matter accumulation in maize kernels.

关键词： Grain water content Maize kernel Phytohormone homeostasis

Characterization of a 4.1 Mb inversion harboring the stripe rust resistance gene YR86 on wheat chromosome 2AL

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The Crop Journal 2024年第4期12卷 1168-1175页

作者： Qiang Cao Zhanwang Zhu Dengan xu Jianhui Wu Xiaowan xu Yan Dong Yingjie Bian Fugong Ding Dehui Zhao Yang Tu Ling Wu Dejun Han Caixia Lan Xianchun Xia Zhonghu He yuanfeng Hao College of Agronomy Northwest A&F UniversityYangling 712100ShaanxiChina State Key Laboratory of Crop Gene Resources and Breeding Institute of Crop SciencesChinese Academy of Agricultural Sciences(CAAS)Beijing 100081China Food Crops Institute Hubei Academy of Agricultural Sciences/Wheat Disease Biology Research Station for Central ChinaWuhan 430064HubeiChina Crop Research Institute Sichuan Academy of Agricultural SciencesChengdu 610066SichuanChina Hubei Hongshan Laboratory College of Plant Science and TechnologyHuazhong Agricultural UniversityWuhan 430070HubeiChina CIMMYT-China Office C/O CAASBeijing 100081China

Wheat cultivar Zhongmai 895 was earlier found to carry YR86 in an 11.6 Mb recombination-suppressed region on chromosome 2AL when crossed with Yangmai *** fine-map the YR86 locus,we developed two large F2 populations from crosses Emai 580/Zhongmai 895 and Avocet S/Zhongmai ***,both populations exhibited suppressed recombination in the same 2AL *** analysis across Chinese Spring,Aikang 58,and 10+wheat genomes revealed a 4.1 Mb chromosomal inversion spanning 708.5-712.6 Mb in the Chinese Spring reference *** markers were developed in the breakpoint and were used to assess a wheat cultivar panel,revealing that Chinese Spring,Zhongmai 895,and Jimai 22 shared a common sequence named InvCS,whereas Aikang 58,Yangmai 16,Emai 580,and Avocet S shared the sequence named *** inverted configuration explained the suppressed recombination observed in all three bi-parental *** recombination was observed in a Jimai 22/Zhongmai 895 F2 population,facilitating mapping of YR86 to a genetic interval of 0.15 cM corresponding to 710.27-712.56 Mb falling within the inverted ***-three high-confidence genes were annotated in the interval using the Chinese Spring reference genome,with six identified as potential candidates for YR86 based on genome and transcriptome *** results will accelerate map-based cloning of YR86 and its deployment in wheat breeding.

关键词： Adult-plant resistance Chromosomal inversion Puccinia striiformis Triticum aestivum

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俄罗斯国家治理模式的演进及其对中国的启示

俄罗斯东欧中亚研究 2009年第1期 49-53页

作者：景维民许源丰南开大学经济学系系天津300071

俄罗斯于20世纪90年代初启动的制度转型,彻底改变了原苏联高度集权的全能主义国家治理模式,并促使政府、市场与社会各自内部的制度结构以及三者之间的耦合关系发生了剧烈重构。全能主义国家治理模式虽然一度对其社会经济发展有过积极作... 详细信息

俄罗斯于20世纪90年代初启动的制度转型,彻底改变了原苏联高度集权的全能主义国家治理模式,并促使政府、市场与社会各自内部的制度结构以及三者之间的耦合关系发生了剧烈重构。全能主义国家治理模式虽然一度对其社会经济发展有过积极作用,但随着社会经济发展的深入推进其固有的弊端凸现出来。当全能主义国家治理模式解体之后,现代国家治理模式的构建就提上议事日程。虽然俄罗斯的国家治理模式进行了长时间的边际性调整,但只有到普京执政以后,俄罗斯的国家治理模式的重大调整才取得显著成效。

关键词：俄罗斯转型国家治理全能主义

中国转型期农村宅基地使用权的流转及其突破点

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东岳论丛 2010年第3期31卷 16-19页

作者：许源丰王敏南开大学经济学系天津300071

客观存在的土地市场供求关系使农村宅基地的转让有着极大的内在动力,但现行法律法规又不允许农村宅基地自由流转,导致农村宅基地的转让多为私下进行。这种"暗箱操作"一方面使得农用土地无法得到有效保护,另一方面又使得本属于农民的土... 详细信息

客观存在的土地市场供求关系使农村宅基地的转让有着极大的内在动力,但现行法律法规又不允许农村宅基地自由流转,导致农村宅基地的转让多为私下进行。这种"暗箱操作"一方面使得农用土地无法得到有效保护,另一方面又使得本属于农民的土地权益被第三方侵占。最近施行的《物权法》在某些方面放松了对农村宅基地流转的管制但依然难以流转,农村宅基地的流转是未来经济发展的必然选择。

关键词：农村宅基地使用权流转突破点

Genetic basis of geographical differentiation,breeding selection,domestication effects,and breeding application for TaJAZ1 in wheat

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Journal of Genetics and Genomics 2024年第6期51卷 665-668页

作者： Botao Ye Yangyang Liu Ziying Wang Liping Shen Changbin Yin Kuocheng Shen Jiaqiang Sun Xiaowan xu Mengjing Sun Jianhui Wu Zhonghu He xuchang Yu Fei Lu yuanfeng Hao Zifeng Guo Key Laboratory of Plant Molecular Physiology Institute of BotanyChinese Academy of SciencesBeijing 100093China University of Chinese Academy of Sciences Beijing 100049China China National Botanical Garden Beijing 100093China State Key Laboratory of Plant Cell and Chromosome Engineering Institute of Genetics and Developmental BiologyInnovative Academy of Seed DesignChinese Academy of SciencesBeijing 100101China Institute of Crop Sciences Chinese Academy of Agricultural SciencesBeijing 100081China State Key Laboratory of Crop Stress Biology for Arid Areas Northwest A&F UniversityYanglingShaanxi 712100China International Maize and Wheat Improvement Center China Office c/o CAASBeijing 100081China CAS-JIC Centre of Excellence for Plant and Microbial Science Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China

Common wheat(Triticum aestivum L.,2n=6x=42,AABBDD)is one of the most widely grown crops worldwide,providing about 20%of the daily calories and protein consumed by humans(Shiferaw et al.,2013).The world population is projected to reach 9.8 billion in 2050(https://***/en/desa/world-population-projectedreach-98-billion-2050-and-112-billion-2100);thus,to meet the challenges of global food and nutritional security,wheat yields must continue to be increased through breeding programs and improved agricultural techniques(Hunter et al.,2017).

关键词： breeding crops wheat

The wheat sucrose synthase gene TaSus1 is a determinant of grain number per spike

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The Crop Journal 2024年第1期12卷 295-300页

作者： Liping Shen Lili Zhang Changbin Yin Xiaowan xu Yangyang Liu Kuocheng Shen He Wu Zhiwen Sun Ke Wang Zhonghu He xueyong Zhang Chenyang Hao Jian Hou Aoyue Bi xuebo Zhao Daxing xu Botao Ye xuchang Yu Ziying Wang Danni Liu yuanfeng Hao Fei Lu Zifeng Guo Key Laboratory of Plant Molecular Physiology Institute of BotanyChinese Academy of SciencesBeijing 100093China China National Botanical Garden Beijing 100093China State Key Laboratory of Plant Cell and Chromosome Engineering Institute of Genetics and Developmental BiologyInnovative Academy of Seed DesignChinese Academy of SciencesBeijing 100101China Institute of Crop Sciences Chinese Academy of Agricultural Sciences(CAAS)Beijing 100081China University of Chinese Academy of Sciences Beijing 100049China International Maize and Wheat Improvement Center(CIMMYT)China Office c/o CAASBeijing 100081China CAS-JIC Centre of Excellence for Plant and Microbial Science(CEPAMS) Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China

Some haplotypes of the sucrose synthase gene TaSus1 are associated with thousand-grain weight(TGW)in wheat(Triticum aestivum L.).However,no mutations have been identified within the gene to test this *** effects of TaSus1 on grain number per spike(GNS)also are largely *** previous genome-wide association study identified TaSus-A1 as a candidate gene controlling fertile spikelet number per spike(FSN).In the present study,we generated two independent mutants for the three TaSus1 homoeologs by CRISPR/Cas9-mediated genome *** triple mutants displayed lower FSN,GNS,grain number per spikelet(GNST),and TGW than wild-type *** 306 hexaploid wheat accessions,two single-nucleotide polymorphisms in TaSus-A1 contributed differently to *** of the two alleles into a wheat genetic background confirmed their *** alleles differed in geographical distribution among the accessions.

关键词： Domestication selection Fertile spikelet number per spike(FSN) Geographical differentiation Grain number per spike(GNS) TaSus1