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早发性白内障与年龄相关性白内障患者房水代谢组学的差异研究

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中华眼科杂志 2024年第6期60卷 518-527页

作者：陈曦腾高楠寇振宇吴桂佳蒋元丰杨军白小妹东莉洁田芳天津医科大学眼科医院、天津医科大学眼视光学院、天津医科大学眼科研究所、国家眼耳鼻喉疾病临床医学研究中心天津市分中心、天津市视网膜功能与疾病重点实验室天津300384

目的:探讨早发性白内障与年龄相关性白内障患者房水中代谢物及代谢通路的差异。方法:代谢组学研究。收集2020年8月至2022年9月就诊于天津医科大学眼科医院的16例(17只眼)白内障患者。其中早发性白内障8例(8只眼),年龄相关性白内障8例(9... 详细信息

目的:探讨早发性白内障与年龄相关性白内障患者房水中代谢物及代谢通路的差异。方法:代谢组学研究。收集2020年8月至2022年9月就诊于天津医科大学眼科医院的16例(17只眼)白内障患者。其中早发性白内障8例(8只眼),年龄相关性白内障8例(9只眼)。收集患者年龄、性别、术前裸眼视力、眼压、晶状体功能失调指数和眼轴长度等一般临床资料,并于白内障摘除术中留取房水和前囊膜组织标本,采用液相色谱-串联质谱法非靶向检测房水中的代谢物,进一步使用主成分分析、差异分析、聚类分析、相关性分析筛选差异代谢物,并根据代谢物的变化倍数(FC)对差异代谢物进行排名。使用受试者工作特征(ROC)曲线分析和代谢富集分析来筛选两组间的差异通路,并鉴定早发性白内障的生物标志物。前囊膜组织行免疫组织化学染色。采用比色法检测丙酮酸含量验证代谢组学分析结果。结果:8例早发性白内障患者中男性7例,女性1例,年龄(37.50±4.90)岁;8例年龄相关性白内障患者中男性7例,女性1例,年龄(73.44±5.22)岁;基线资料除年龄外差异均无统计学意义(P>0.05)。差异分析共鉴别出347种差异代谢物,其中10种经ROC曲线分析确定为潜在的早发性白内障生物标志物(均P<0.05),其中阳离子(POS)模式5种,分别是丙氧卡因(log 2FC=7.26)、2-甲基-2,3,4,5-四氢-1,5-苯并氧氮杂卓-4-酮(log 2FC=6.35)、l-焦谷氨酸(log 2FC=-1.72)、亮氨酰脯氨酸(log 2FC=-0.77)和胆碱(log 2FC=-0.56),阴离子(NEG)模式5种,分别是N-苯乙酰谷氨酰胺(log 2FC=-1.84)、丙酮酸(log 2FC=1.07)、抗坏血酸(log 2FC=0.92)、假尿嘧啶核苷(log 2FC=-0.68)和棕榈酸(log 2FC=-0.51)。代谢富集分析共富集到72条差异通路(POS模式32条,NEG模式40条),其中谷胱甘肽代谢及半胱氨酸和蛋氨酸代谢、糖酵解或糖异生、丙酮酸代谢、三羧酸循环两组间的差异有统计学意义(P<0.05)。验证结果显示早发性白内障患者房水中乳酸脱氢酶减少,丙酮酸升高(P<0.05)。结论:丙酮酸等10种代谢物可能是潜在的早发性白内障生物标志物;谷胱甘肽代谢、半胱氨酸和蛋氨酸代谢、糖酵解或糖异生、丙酮酸代谢和三羧酸循环代谢通路在早发性白内障患者中明显失调。

关键词：白内障眼房水代谢组学生物标记计算生物学

The impact of posterior corneal astigmatism on the surgical planning of toric multifocal intraocular lens implantation

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Advances in Ophthalmology Practice and Research 2023年第1期3卷 39-46页

作者： Shaochong Bu yuanfeng jiang Yichen Gao Xiaomei Bai Xiteng Chen Hong Zhang Fang Tian Tianjin Key Laboratory of Retinal Functions and Diseases Tianjin Branch of National Clinical Research Center for Ocular DiseaseEye Institute and School of OptometryTianjin Medical University Eye Hospital300384TianjinChina

Purpose:To investigate the influence of posterior corneal astigmatism on the prediction accuracy of toric multifocal intraocular lens(IOL)***:The keratometric astigmatism measured by Lenstar LS 900(KCA_(L)),keratometric astigmatism(KCAp)and total corneal astigmatism(TCA)measured by Scheimpflug camera(Pentacam HR)were documented and analyzed *** deduction models using different parameters were *** 1:KCA_(L)+keratometric comeal surgically induced astigmatism(KCSIA,0.30 D@50°);Model 2:KCA_(P)+KCSIA);Model 3:TCA 4-total CSIA(TCSIA,0.23 D@50°).The prediction errors of each model as the difference vector between the actual and the intended residual astigmatism were ***:Seventy-six eyes implanted with toric multifocal IOLs were included in this *** vector differences of the actual KCSIA and TCSIA were statistically significant in the total sample and against-the-rule(ATR)subgroup(both P<0.05).Model 1 deduced the smallest mean values of prediction error,while that of Model 3 were smaller than that of Model 2,both in the total sample and the ATR subgroups(all P<0.05).Meanwhile,in the total sample and ATR subgroups,the centroid vector magnitudes of Model 3 were smaller than that of Model 1(0.31±0.76 D and 0.39±0.76 D).Conclusions:The calculation of toric multifocal IOL should be individualized especially in the ATR eyes for the impact of PCA on the estimation of the preoperative comeal astigmatism and the CSIA.

关键词： Posterior corneal astigmatism Toric multifocal intraocular lens Corneal surgically induced astigmatism

散光矫正型与非散光矫正型多焦点人工晶状体植入术后视觉质量比较

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中华实验眼科杂志 2022年第5期40卷 431-439页

作者：蒋元丰田芳步绍翀张红天津医科大学眼科医院天津医科大学眼视光学院天津医科大学眼科研究所国家眼耳鼻喉疾病临床医学研究中心天津市分中心天津市视网膜功能与疾病重点实验室天津300384

目的评价超声乳化白内障摘出联合散光矫正型多焦点人工晶状体(ART IOL)植入术后的视觉质量,并与非散光矫正型多焦点IOL(ReSTOR IOL)进行比较。方法采用队列研究方法,纳入2017年1月至2018年1月于天津医科大学眼科医院行超声乳化白内障摘... 详细信息

目的评价超声乳化白内障摘出联合散光矫正型多焦点人工晶状体(ART IOL)植入术后的视觉质量,并与非散光矫正型多焦点IOL(ReSTOR IOL)进行比较。方法采用队列研究方法,纳入2017年1月至2018年1月于天津医科大学眼科医院行超声乳化白内障摘出联合ART IOL植入术的患者39例50眼和联合ReSTOR IOL植入术的患者32例41眼,分别作为ART组和ReSTOR组。对比2个组患眼术后3个月时的裸眼远视力(UDVA)、裸眼中视力(UIVA)、裸眼近视力(UNVA)、最佳矫正远视力(CDVA)、显然验光、离焦曲线、对比敏感度(CS)、调制传递函数截止频率、二维斯特列尔比(SR)、客观散射指数、不同对比度下OQAS值(OV 100%、OV 20%、OV 9%)、总像差、总低阶像差、总高阶像差、球差、彗差和三叶草像差。结果术后3个月,ART组和ReSTOR组的UDVA分别为(0.07±0.09)LogMAR和(0.09±0.12)LogMAR,CDVA分别为(-0.01±0.07)LogMAR和(-0.01±0.07)LogMAR,UIVA分别为(0.23±0.11)LogMAR和(0.22±0.13)LogMAR,UNVA分别为(0.11±0.15)LogMAR和(0.06±0.11)LogMAR。ReSTOR组的UNVA略优于ART组,差异有统计学意义(t=2.085,P=0.040)。ART组和ReSTOR组的平均焦点深度分别为(4.12±0.79)D和(4.24±0.95)D。ART组术后残余散光为(0.32±0.31)D,较术前角膜散光的(1.27±0.40)D显著降低,差异有统计学意义(t=13.209,P<0.001)。ART组在明视6、12和18 c/d,明视眩光12和18 c/d,以及暗视3、6和12 c/d空间频率时的CS值略低于ReSTOR组,差异均有统计学意义(均P<0.05),但不具有临床意义。ART组的SR和OV 20%值分别为0.14±0.05和0.55±0.24,略低于ReSTOR组的0.17±0.06和0.66±0.29,差异均有统计学意义(t=-2.012,P=0.048;t=-2.557,P=0.043)。ART组在5 mm瞳孔直径下的总像差和彗差分别为0.88(0.59,1.13)μm和0.21(0.13,0.30)μm,高于ReSTOR组的0.58(0.47,0.74)μm和0.10(0.08,0.21)μm,差异均有统计学意义(Z=-2.073,P=0.038;Z=-2.101,P=0.036)。结论超声乳化白内障摘出联合ART IOL植入可以在矫正术前角膜散光的同时为患者提供良好的全程视力和主客观视觉质量,但暗光下或中低空间频率的解析能力略弱于ReSTOR IOL植入眼。

关键词：白内障超声乳化白内障摘出术多焦点人工晶状体 Toric 视觉质量

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An improved initial rotor position estimation method using high-frequency pulsating voltage injection for PMSM

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Defence Technology（防务技术） 2024年第3期33卷 19-29页

作者： Yang jiang Ming Cheng School of Electrical Engineering Southeast UniversityNanjing 210096China

High frequency pulsating voltage injection method is a good candidate for detecting the initial rotor position of permanent magnet synchronous ***,traditional methods require a large number of filters,which leads to the deterioration of system stability and dynamic *** order to solve these problems,a new signal demodulation method is proposed in this *** proposed new method can directly obtain the amplitude of high-frequency current,thus eliminating the use of filters,improving system stability and dynamic performance and saving the work of adjusting filter *** addition,a new magnetic polarity detection method is proposed,which is robust to current measurement ***,experiments verify the effectiveness of the method.

关键词： Initial position detection Signal demodulation algorithm Magnetic polarity detection Filter elimination

冲击载荷作用下黑砂岩动态断裂参数的分形修正

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爆炸与冲击 2022年第7期42卷 14-27页

作者：张人凡朱哲明王飞周磊王蒙江源峰四川大学建筑与环境学院灾变力学与工程防灾四川省重点实验室四川成都610065

基于分形理论研究了偏折裂纹扩展路径对动载荷作用下黑砂岩的动态断裂力学参数的测试误差影响作用,采用传统的分离式霍普金森压杆(split Hopkinson pressure bar,SHPB)实验装置对修正侧开单裂纹半孔板(improved single cleavage semi-ci... 详细信息

基于分形理论研究了偏折裂纹扩展路径对动载荷作用下黑砂岩的动态断裂力学参数的测试误差影响作用,采用传统的分离式霍普金森压杆(split Hopkinson pressure bar,SHPB)实验装置对修正侧开单裂纹半孔板(improved single cleavage semi-circle specimen,ISCSC)试样进行动态冲击实验,随后采用裂纹扩展计进行裂纹起裂时间与裂纹扩展速度等动态断裂力学参数测试,采用分形理论对测试的裂纹扩展速度与动态应力强度因子进行修正,利用实验-数值法对黑砂岩的动态断裂韧度进行计算。研究结果表明,ISCSC构型构件能够有效应用于岩石材料动态裂纹扩展行为的研究,并发生了止裂现象,经分形修正的裂纹扩展速度与动态断裂韧度更接近实际裂纹动态扩展情况,修正前后得到黑砂岩材料的裂纹扩展速度误差为33.51%,动态断裂韧度最大误差为7.68%,说明利用分形理论对动态断裂韧度等动态断裂参数计算更合理。

关键词：冲击荷载霍普金森压杆分形理论裂纹扩展动态应力强度因子

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Capturing Plateau-Rayleigh instability in silver nanowires via ultrafast electron microscopy

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Nano Research 2024年第9期17卷 8402-8407页

作者： Shuai jiang Volkan Ortalan Department of Materials Science and Engineering University of ConnecticutStorrsCT 06269USA

Understanding the structural stability of nanomaterials such as nanowires is imperative for their practical ***,using single-shot ultrafast transmission electron microscopy,we captured the Plateau-Rayleigh instability behavior of silver nanowires decomposing into silver nanoparticles upon laser irradiation on nanosecond time *** found that this dynamic process can be accelerated by a factor of 10 through increasing the peak laser fluence from 6.03 to 14.60 mJ/cm^(2).Moreover,by comparing the laser fluence required to initiate the Plateau-Rayleigh instability in silver nanowires on carbon and Formvar membranes,it was found that the main driving force for the Plateau-Rayleigh instability in this study was substrate *** element analysis and molecular dynamics simulations are also applied to estimate the temperature jump of the nanowires and atomistic behavior,*** addition,the complex motions of silver nanowires under laser irradiation were systematically investigated by combining the results of ultrafast transmission electron microscopy with scanning electron microscopy characterizations and were determined to be related to nanowire-membrane interactions or pre-existing stresses on the nanowires,which in turn demonstrated the potential of ultrafast transmission electron microscopy for the characterization of nanomaterials and devices under extreme conditions.

关键词： silver nanowire Plateau-Rayleigh instability ultrafast transmission electron microscopy molecular dynamics simulation

Drug-Target Interactions Prediction Based on Signed Heterogeneous Graph Neural Networks

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Chinese Journal of Electronics 2024年第1期33卷 231-244页

作者： Ming CHEN Yajian jiang Xiujuan LEI Yi PAN Chunyan JI Wei jiang College of Information Science and Engineering Hunan Normal University School of Computer Science Shaanxi Normal University Faculty of Computer Science and Control Engineering Shenzhen Institute of Advanced TechnologyChinese Academy of Sciences Computer Science Department BNU-HKBU United International College

Drug-target interactions(DTIs) prediction plays an important role in the process of drug *** computational methods treat it as a binary prediction problem, determining whether there are connections between drugs and targets while ignoring relational types information. Considering the positive or negative effects of DTIs will facilitate the study on comprehensive mechanisms of multiple drugs on a common target, in this work, we model DTIs on signed heterogeneous networks, through categorizing interaction patterns of DTIs and additionally extracting interactions within drug pairs and target protein pairs. We propose signed heterogeneous graph neural networks(SHGNNs), further put forward an end-to-end framework for signed DTIs prediction, called SHGNN-DTI,which not only adapts to signed bipartite networks, but also could naturally incorporate auxiliary information from drug-drug interactions(DDIs) and protein-protein interactions(PPIs). For the framework, we solve the message passing and aggregation problem on signed DTI networks, and consider different training modes on the whole networks consisting of DTIs, DDIs and PPIs. Experiments are conducted on two datasets extracted from Drug Bank and related databases, under different settings of initial inputs, embedding dimensions and training modes. The prediction results show excellent performance in terms of metric indicators, and the feasibility is further verified by the case study with two drugs on breast cancer.

关键词： Drugs Training Proteins Measurement Message passing Prediction methods Graph neural networks

Advances in Triboelectric Nanogenerators for Blue Energy Harvesting and Marine Environmental Monitoring

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Engineering 2024年第2期33卷 204-224页

作者： Yang jiang Xi Liang Tao jiang Zhong Lin Wang CAS Center for Excellence in Nanoscience Beijing Key Laboratory of Micro–Nano Energy and SensorsBeijing Institute of Nanoenergy and NanosystemsChinese Academy of SciencesBeijing 101400China School of Nanoscience and Technology University of Chinese Academy of SciencesBeijing 100049China Georgia Institute of Technology AtlantaGA 30332USA

Blue energy,which includes rainfall,tidal current,wave,and water-flow energy,is a promising renewable resource,although its exploitation is limited by current technologies and thus remains *** form of energy is mainly harvested by electromagnetic generators(EMGs),which generate electricity via Lorenz force-driven electron *** nano genera tors(TENGs)and TENG networks exhibit superiority over EMGs in low-frequency and high-entropy energy harvesting as a new approach for blue energy harvesting.A TENG produces electrical outputs by adopting the mechanism of Maxwell’s displacement *** date,a series of research efforts have been made to optimize the structure and performance of TENGs for effective blue energy harvesting and marine environmental *** the great progress that has been achieved in the use of TENGs in this context so far,continuous exploration is required in energy conversion,device durability,power management,and environmental *** review reports on advances in TENGs for blue energy harvesting and marine environmental *** introduces the theoretical foundations of TENGs and discusses advanced TENG prototypes for blue energy harvesting,including TENG structures that function in freestanding and contact-separation *** enhancement strategies for TENGs intended for blue energy harvesting are also ***,marine environmental applications of TENGs based on blue energy harvesting are discussed.

关键词： Triboelectric nanogenerator TENG networks Blue energy Energy harvesting Ocean sensors

Highly homogeneous zero-index metamaterials make devices more compact and perform better

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Light(Science & Applications) 2024年第5期13卷 806-807页

作者： Wei-Xiang jiang State Key Laboratory of Millimeter Waves School of Information Science and EngineeringSoutheast University210096 NanjingChina

A highly homogeneous microwave zero-index metamaterial based on high-permittivity SrTiO3 ceramics is demonstrated to realize the small-aperture high-directivity *** a novel technique is a remarkable step forward to de... 详细信息

关键词： ceramics SrTiO3 Highly