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A nanoplatform with oxygen self-supplying and heat-sensitizing capabilities enhances the efficacy of photodynamic therapy in eradicating multidrug-resistant biofilms

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Journal of Materials Science & Technology 2024年第2期169卷 209-219页

作者： Haixin Zhang Yi Zou Kunyan Lu Yan Wu yuancheng lin Jingjing Cheng Chunxia Liu Hong Chen Yanxia Zhang Qian Yu State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials College of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123China Department of Cardiovascular Surgery of the First Affiliated Hospital and Institute for Cardiovascular Science Suzhou Medical College of Soochow UniversitySoochow UniversitySuzhou 215007China

Bacterial biofilms,especially those caused by multidrug-resistant bacteria,have emerged as one of the greatest dangers to global public health.The acceleration of antimicrobial resistance to conventional an-tibiotics and the severe lack of new drugs necessitates the development of novel agents for biofilm eradication.Photodynamic therapy(PDT)is a promising non-antibiotic method for treating bacterial infections.However,its application in biofilm eradication is hampered by the hypoxic microenvironment of biofilms and the physical protection of extracellular polymeric substances.In this study,we develop a composite nanoplatform with oxygen(O_(2))self-supplying and heat-sensitizing capabilities to improve the PDT efficacy against biofilms.CaO_(2)/ICG@PDA nanoparticles(CIP NPs)are fabricated by combining calcium peroxide(CaO_(2))with the photosensitizer indocyanine green(ICG)via electrostatic interactions,followed by coating with polydopamine(PDA).The CIP NPs can gradually generate O_(2)in response to the acidic microenvironment of the biofilm,thereby alleviating its hypoxic state.Under near-infrared(NIR)irradiation,the nanoplatform converts O_(2)into a significant amount of singlet oxygen(^(1)O_(2))and heat to eradicate biofilm.The generated heat enhances the release of O_(2),accelerates the generation of^(1)O_(2)in PDT,increases cell membrane permeability,and increases bacterial sensitivity to^(1)O_(2).This nanoplatform significantly improves the efficacy of PDT in eradicating biofilm-dwelling bacteria without fostering drug resistance.Experiments on biofilm eradication demonstrate that this nanoplatform can eradicate over 99.9999%of methicillin-resistant Staphylococcus aureus(MRSA)biofilms under 5-min NIR irradiation.Notably,these integrated advantages enable the system to promote the healing of MRSA biofilm-infected wounds with negligible toxicity in vivo,indicating great promise for overcoming the obstacles associated with bacterial biofilm eradication.

关键词： Bacterial biofilm Multidrug-resistant bacteria Photodynamic therapy Oxygen supplying Photothermal therapy

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基于超图Transformer的APT攻击威胁狩猎网络模型

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通信学报 2024年第2期45卷 106-114页

作者：李元诚林玉坤华北电力大学控制与计算机工程学院北京102206

针对物联网环境中高级持续性威胁(APT)具有隐蔽性强、持续时间长、更新迭代快等特点,传统被动检测模型难以对其进行有效搜寻的问题,提出了一种基于超图Transformer的APT攻击威胁狩猎(HTTN)模型,能够在时间跨度长、信息隐蔽复杂的物联网... 详细信息

针对物联网环境中高级持续性威胁(APT)具有隐蔽性强、持续时间长、更新迭代快等特点,传统被动检测模型难以对其进行有效搜寻的问题,提出了一种基于超图Transformer的APT攻击威胁狩猎(HTTN)模型,能够在时间跨度长、信息隐蔽复杂的物联网系统中快速定位和发现APT攻击痕迹。该模型首先将输入的网络威胁情报(CTI)日志图和物联网系统内核审计日志图编码为超图,经超图神经网络(HGNN)层计算日志图的全局信息和节点特征;然后由Transformer编码器提取超边位置特征;最后对超边进行匹配计算相似度分数,从而实现物联网系统网络环境下APT攻击的威胁狩猎。在物联网仿真环境下的实验结果表明,提出的HTTN模型与目前主流的图匹配神经网络相比均方误差降低约20%,Spearman等级相关系数提升约0.8%,匹配精度提升约1.2%。

关键词：高级持续性威胁威胁狩猎图匹配超图

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面向城乡融合的都市农业功能转型研究进展及其关键科学问题

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热带地理 2024年第1期44卷 42-55页

作者：杨忍林元城中山大学地理科学与规划学院广州510006 中山大学乡村振兴联合研究院广州510275 中山大学土地研究中心广州510275

面向城乡融合和乡村振兴等国家重大战略,聚焦于都市农业发展的功能演化与空间重组机制具有重要的理论和现实意义。文章系统梳理了都市农业功能转型的研究进展,提出了未来亟需关注的关键科学问题。研究发现:1)都市农业功能转型研究的主... 详细信息

面向城乡融合和乡村振兴等国家重大战略,聚焦于都市农业发展的功能演化与空间重组机制具有重要的理论和现实意义。文章系统梳理了都市农业功能转型的研究进展,提出了未来亟需关注的关键科学问题。研究发现:1)都市农业功能转型研究的主要议题包括都市农业发展转型评价及类型划分、都市农业多功能转型及可持续发展、都市农业空间组织与生产组织方式、都市农业发展中土地利用及竞租机制、都市农业发展问题及其多维效应等5个方面。2)都市农业地域系统与城乡地域系统间的要素流动、物质循环,以及两者间的内在作用逻辑是都市农业发展的理论基石。都市农业地域系统功能演化和空间重组的动力机制有待深入探索,亟待强化基于地域系统视角的都市农业发展中的土地竞租、土地权属和相关利益主体等研究。3)聚焦于都市农业地域系统功能演变的关键科学问题,未来亟待开展的研究包括3个方面:其一,基于城乡连续体的视角,厘清都市农业系统地域功能演化的内源性和外部性驱动力间的交互联动和耦合作用机制;其二,揭示都市农业地域系统空间重组的核心机理,以及利益主体的作用关系与土地竞租的内在逻辑;其三,探索都市农业地域系统功能演化带来的生态环境效应,以及对生态环境的影响机制。

关键词：都市农业农业功能转型城乡融合生态环境效应农业生态系统

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Superhydrophobic photothermal coatings based on candle soot for prevention of bioﬁlm formation

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Journal of Materials Science & Technology 2023年第1期132卷 18-26页

作者： yuancheng lin Haixin Zhang Yi Zou Kunyan Lu Luohuizi Li Yan Wu Jingjing Cheng Yanxia Zhang Hong Chen Qian Yu State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials College of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123China Institute for Cardiovascular Science and Department of Cardiovascular Surgery of the First Affiliated Hospital Soochow UniversitySuzhou 215007China Key Laboratory of Polymeric Materials Design and Synthesis for Biomedical Function Soochow UniversitySuzhou 215123China

Bacterial biofilms formed on the material surfaces have posed a series of serious problems for human health and industries.The treatment of mature biofilms is particularly difficult because they are inher-ently highly resistant against antibiotics and other adverse factors.The prevention is strategically advan-tageous over the treatment,and thus the development of innovative surfaces with capability to inhibit biofilm formation is highly demanded.In this work,we developed a superhydrophobic photothermal coating for prevention of biofilm formation,which was based on candle soot with hierarchical structure and excellent light-to-heat conversion ability.This coating was fabricated by deposition of a candle soot layer on the substrate,followed by sequential chemical vapor deposition of tetraethoxysilane and immo-bilization of fluorinated silane to make the coating robust and superhydrophobic.The resulted coating could repel a majority of bacteria from the surface at the early stage,and then eradicate a small number of bacteria remained on the surface under a short-term irradiation of near-infrared laser.The combi-nation of anti-adhesive property and photothermal bactericidal property endowed the coating with good antibiofilm property to prevent biofilm formation for at least 2 weeks.This coating is facile for deposition on various substrates with good storage stability,showing great potential for diverse practical applications to solve the biofilm-associated problems of materials and devices.

关键词： Antibiofilm Candle soot Superhydrophobic surface Anti-adhesive Photothermal surface

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Dual-functional bacterial cellulose modified with phase-transitioned proteins and gold nanorods combining antifouling and photothermal bactericidal properties

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Journal of Materials Science & Technology 2022年第15期110卷 14-23页

作者： Luohuizi Li Guize Li Yong Wu yuancheng lin Yangcui Qu Yan Wu Kunyan Lu Yi Zou Hong Chen Qian Yu Yanxia Zhang State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials College of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123China Institute for Cardiovascular Science and Department of Cardiovascular Surgery of the First Affiliated Hospital Soochow UniversitySuzhou 215007China College of Biomedical Engineering&the Key Laboratory for Medical Functional Nanomaterials Jining Medical UniversityJining 272067China

Bacterial cellulose(BC)is one of the most versatile natural biopolymers with unique physical,chemical,and biological features.However,the lack of intrinsic antibacterial property of native BC limits its broad biomedical applications where such property is highly required to prevent contamination or infection caused by attached bacteria.In this work,we developed a simple and facile method to fabricate a dualfunctional BC membrane by physical incorporation of gold nanorods(GNRs)followed by deposition of a phase-transitioned bovine serum albumin(PTB)film.Due to the broad-spectrum antifouling property of the PTB film,the resulting membrane could prevent the adhesion and accumulation of bacteria.A few bacteria that broke through the protection of the PTB film could be eradicated under short-term irradiation of a near-infrared laser due to the excellent photothermal property of incorporated GNRs.The whole fabrication was conducted in a simple and environmentally friendly manner,avoiding complicated processes and toxic organic solvents.Moreover,because all the components were biocompatible,the resulting membrane showed negligible cytotoxicity in vitro and good histocompatibility in vivo.This work thus provided a reliable way to endow BC with antibacterial property,being beneficial for diverse biomedical applications.

关键词： Bacterial cellulose Gold nanorods Phase-transitioned proteins Antifouling Antibacterial Photothermal therapy

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Bacterial cellulose-based dressings with photothermal bactericidal activity and pro-angiogenic ability for infected wound healing

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Journal of Materials Science & Technology 2023年第29期160卷 76-85页

作者： Yan Wu Dongxu Jia Kunyan Lu Haixin Zhang Chunxia Liu yuancheng lin Jingjing Cheng Yi Zou Hu Xu Hong Chen Yanxia Zhang Qian Yu State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials College of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123China Department of Cardiovascular Surgery of the First Affiliated Hospital and Institute for Cardiovascular Science Suzhou Medical College of Soochow UniversitySoochow UniversitySuzhou 215000China

For most traditional wound dressings,it is challenging to simultaneously eliminate bacteria and promote angiogenesis to accelerate the healing process of bacteria-infected wounds.In this work,we develop a multifunctional dressing based on bacterial cellulose(BC)deposited with a tannic acid/Cu^(2+)ion/Mg^(2+)ion(TCM)complex film.Overall,the TCM complex exhibits robust interfacial adhesion to modify BC and good photothermal properties to effectively eradicate bacteria in the wound area under near-infrared(NIR)irradiation.The individual components of the TCM complex have several advantageous features for wound healing,such as antibacterial ability and negligible cytotoxicity;in particular,the released Cu^(2+)and Mg^(2+)ions are favorable for the proliferation,migration,and tube formation of endothelial cells in vitro.The results of in vivo experiments demonstrated that with the assistance of NIR irradiation,this composite dressing is more effective than traditional gauze or pristine BC dressing in promotion of angiogenesis and collagen deposition without causing remarkable inflammation,thereby accelerating the healing process of bacteria-infected full-thickness skin wounds.This work thus provides a simple and facile way to fabricate multifunctional BC-based dressings that could be potentially used for treating infected wounds.

关键词： Bacterial cellulose Metal-phenolic network Photothermal therapy Antibacterial Angiogenesis Wound dressing

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城乡互动视角下都市边缘区乡村空间转型的资本介入机制——以广州港头村为例

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地理科学进展 2024年第3期43卷 458-473页

作者：葛语思杨忍战歌林元城中山大学地理科学与规划学院广州510006 中山大学乡村振兴联合研究院广州510275 中山大学土地研究中心广州510275

伴随中国城乡关系的急速转型,资本成为重组城乡要素的重要因素,推动都市边缘区的乡村空间转型和重构,厘清其介入机制对补充完善乡村空间重构的动力释义具有重要意义。论文构建了城乡互动视角下资本循环和乡村空间转型间交互作用的分析框... 详细信息

伴随中国城乡关系的急速转型,资本成为重组城乡要素的重要因素,推动都市边缘区的乡村空间转型和重构,厘清其介入机制对补充完善乡村空间重构的动力释义具有重要意义。论文构建了城乡互动视角下资本循环和乡村空间转型间交互作用的分析框架,以都市边缘区典型村广州港头村为例,深度解析珠三角都市边缘区典型乡村空间转型的阶段特征及其资本介入机制。结果表明:(1)20世纪80年代以来,港头村的空间转型重构经历了代际交替的村民资本城乡市场循环下的初步空心化、工商资本介入与剩余价值有限城乡市场流通下的城镇化与深度空心化和国有资本带动的“不征地”乡村闲置空间改造下的初步实心化三个阶段。(2)资本通过投资统筹乡村权益关系网络直接改造空间、投资基建改善发展环境等手段促进乡村空间转型,并全面渗透第一到第三产业;乡村可通过提升可达性、加快自然历史文化资源整合修缮等诱发资本持续注入。(3)资本介入通过活化闲置空间、激发乡村土地等剩余价值实现“城—乡”资本转移进而推动城乡互动;现有资本介入带有极强的政策福利属性,并不完全能表征剩余价值“乡—城”流动特征已经转变,村民主体地位弱化、城乡互动主体融入度低、资本“脱实向虚”等风险依然潜存。

关键词：乡村空间转型资本下乡城乡融合发展资本三循环都市边缘区

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数字化转型下的乡村国土空间数字治理技术体系构建

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规划师 2024年第3期40卷 22-27页

作者：周素红吴帅霖林元城杨忍中山大学地理科学与规划学院中山大学广东省公共安全与灾害工程技术研究中心中山大学乡村振兴联合研究院中山大学土地研究中心

数字技术向乡村地域延伸与渗透,深刻影响着乡村社会、经济和政治的组织方式及结构。乡村国土空间治理的对象、主体、技术都在数字技术的介入下发生了转变。在梳理数字技术介入下乡村发展转型的物质空间特征及作用机制的基础上,剖析了数... 详细信息

数字技术向乡村地域延伸与渗透,深刻影响着乡村社会、经济和政治的组织方式及结构。乡村国土空间治理的对象、主体、技术都在数字技术的介入下发生了转变。在梳理数字技术介入下乡村发展转型的物质空间特征及作用机制的基础上,剖析了数字化转型下的乡村国土空间治理主体关系,从乡村数字治理的空间底座框架及其关键技术体系两个方面构建了基于乡村多主体协同治理的国土空间数字治理技术体系。

关键词：数字化转型乡村国土空间数字治理

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基于可重构阵列的CNN数据量化方法

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计算机应用研究 2024年第4期41卷 1070-1076页

作者：朱家扬蒋林李远成宋佳刘帅西安科技大学通信与信息工程学院西安710600 西安科技大学计算机科学与技术学院西安710600 西安科技大学电气与控制工程学院西安710600

针对卷积神经网络(CNN)模型中大量卷积操作,导致网络规模大幅增加,从而无法部署到嵌入式硬件平台,以及不同粒度数据与底层硬件结构不协调导致计算效率低的问题,基于项目组开发的可重构阵列处理器,面向支持多种位宽的运算单元,通过软硬... 详细信息

针对卷积神经网络(CNN)模型中大量卷积操作,导致网络规模大幅增加,从而无法部署到嵌入式硬件平台,以及不同粒度数据与底层硬件结构不协调导致计算效率低的问题,基于项目组开发的可重构阵列处理器,面向支持多种位宽的运算单元,通过软硬件协同和可重构计算方法,采用KL(Kullback-Leibler)散度自定义量化阈值和随机取整进行截断处理的方式,寻找参数定长的最佳基点位置,设计支持多种计算粒度并行操作的指令及其卷积映射方案,并以此实现三种不同位宽的动态数据量化。实验结果表明,将权值与特征图分别量化到8 bit可以在准确率损失2%的情况下将模型压缩为原来的50%左右;将测试图像量化到三种位宽下进行硬件测试的加速比分别达到1.012、1.273和1.556,最高可缩短35.7%的执行时间和降低56.2%的访存次数,同时仅带来不足1%的相对误差,说明该方法可以在三种量化位宽下实现高效率的神经网络计算,进而达到硬件加速和模型压缩的目的。

关键词：卷积神经网络数据量化可重构结构并行映射加速比

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Rural Development Transformation and Social Governance from the Perspective of Specialization:A Case Study of Ruiling Village in Guangzhou City,China

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中国地理科学:英文版 2023年第5期33卷 796-812页

作者： lin yuancheng YANG Ren LI Simeng School of Geography and Planning Sun Yat-sen UniversityGuangzhou 510006China Land Research Center Sun Yat-sen UniversityGuangzhou 510275China

The reorganization of the global production network and the increased mobility of urban-rural elements have accelerated the differentiation of rural spaces,resulting in a trend towards specialization in rural areas.This paper focuses on the concept of specialization,and takes a renowned bonsai specialized village in Guangzhou City,China as a typical case to explore its transformation and development process,action logic and coupling mechanism with the social governance.The results show that:1)the development of rural specialization in Ruiling Village is shaped by several key actors,such as local governments,grassroots organizations,villagers,social organizations,policies,markets and infrastructure.The transfer of these key actors and the reconstruction of actor-networks in different stages have an important influence on the transformation and realization of rural development goals.2)Through subjects-driven,organization management and resource connection,social governance supports the specialization of rural industrial organization,operation,technology and mode.The governance structure shifts from decentralization to networking,refinement and integration.A coupling community of social governance and specialization is created by the social governance system of‘local government-grassroots organizationseconomic cooperatives-villagers’,which links industries,industrial chains and cooperatives.3)Social governance integrates into the value chain extension process of rural specialized development with a central,multi-level organizational structure.It promotes the construction of the whole value chain through organizational planning,resource integration and image shaping,thus realizing the value,branding and organization of the industry,as well as the integration of rural sustainable development and governance mechanism.Social governance has a profound impact on the development of rural specialization in terms of subject,structure and mode,and participates in the construction of the whole value chain of rural areas.This p

关键词： rural specialization rural development transformation social governance rural differentiation actor-network theory(ANT) Ruiling Village

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