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Stiffness-tuned and ROS-sensitive hydrogel incorporating complement C5a receptor antagonist modulates antibacterial activity of macrophages for periodontitis treatment

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Bioactive Materials 2023年第7期25卷 347-359页

作者： Ziqi Gan Zecong Xiao Zhen Zhang Yang Li Chao liu Xin Chen yuanbo liu Dongle Wu Chufeng liu Xintao Shuai Yang Cao Hospital of Stomatology Guangdong Provincial Key Laboratory of StomatologyGuanghua School of StomatologySun Yat-sen UniversityGuangzhou510055China Nanomedicine Research Center The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou510630China Stomatological Hospital Southern Medical UniversityGuangzhou510260China

Periodontitis is admittedly a microbe-driven intractable infectious disease,in which Porphyromonas gingivalis(Pg)plays a keystone role.Pg can selectively impair the antimicrobial responses of periodontal resident macrophages including their phagocytic and bactericidal activity without interfering their proinflammatory activity,which leads to microflora disturbance,destructive periodontal inflammation and alveolar bone loss eventually.Here,an injectable ROS-sensitive hydrogel is developed for releasing active bone marrow-derived macrophages(named ex-situ macrophages hereafter)and a complement C5a receptor antagonist(C5A)to the gingival crevice.Through appropriately tuning the hydrogel stiffness,the phagocytic activity of these macrophages is greatly enhanced,reaching an optimal performance at the elastic modulus of 106 kPa.Meanwhile,C5A avoids undesired C5a receptor activation by Pg to ensure the bacterial killing activity of both the ex-situ and in-situ macrophages.Besides,the ROS-sensitive hydrogels show another distinct feature of decreasing the ROS level in periodontal niche,which contributes to the alleviated periodontal inflammation and attenuated bone loss as well.This study highlights the potential of utilizing hydrogels with tailored biomechanical properties to remodel the functions of therapeutic cells,which is expected to find wide applications even beyond periodontitis treatment.

关键词： Periodontitis treatment Cell therapy ROS-Responsive hydrogels C5a receptor blockade Mechanostimulation

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数字素养与农户收入差距:加剧还是缓解?——基于中西部地区的微观证据

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西北农林科技大学学报（社会科学版） 2024年第4期24卷 91-101页

作者：刘渊博温涛西南大学经济管理学院西南大学“一带一路”研究院重庆400715

数字经济时代,数字贫困问题对农户收入差距的影响引发新的关注。基于2021年中国农村经济与农村金融数据,采用再中心化响应函数(RIF)回归方法探究数字素养对农户收入差距的影响。研究发现:(1)数字素养显著扩大了农户收入差距,并具备明显... 详细信息

数字经济时代,数字贫困问题对农户收入差距的影响引发新的关注。基于2021年中国农村经济与农村金融数据,采用再中心化响应函数(RIF)回归方法探究数字素养对农户收入差距的影响。研究发现:(1)数字素养显著扩大了农户收入差距,并具备明显的马太效应,高数字素养能够攫取更多数字红利,而低数字素养更容易陷入“数字贫困”状态,无法发挥出数字经济的增收效应。(2)应用数字素养会显著加剧农户收入差距,而通用数字素养对农户收入差距的影响并不显著。这种情况也得以印证,现阶段数字“接入鸿沟”已经得以解决,数字“应用鸿沟”差距逐渐凸显。(3)数字素养能够缩小农户财产性收入差距,但会显著扩大工资性收入差距与非农经营性收入差距。脱贫地区受到数字素养的马太效应更强,农户收入差距明显加剧。研究结论证实了我国农村内部存在明显的数字鸿沟,同时数字贫困问题加剧了农户收入差距。新发展阶段我国数字乡村战略的推进不仅要注重农村低收入群体以及弱势群体数字素养的培育,更要加快构建农村数字经济的包容性发展路径,助力农民农村共同富裕的实现。

关键词：数字素养数字贫困收入差距 RIF回归异质性分析

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Shifting from homogeneous to heterogeneous surfaces in estimating terrestrial evapotranspiration: Review and perspectives

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Science China Earth Sciences 2022年第2期65卷 197-214页

作者： yuanbo liu Guoyu QIU Hongsheng ZHANG Yonghui YANG Yinsheng ZHANG Quan WANG Wenzhi ZHAO Li JIA Xibin JI Yujiu XIONG Chunhua YAN Ning MA Shumin HAN Yifan CUI Nanjing Institute of Geography and Limnology Chinese Academy of SciencesNanjing 210008China School of Environment and Energy Peking University Shenzhen Graduate SchoolShenzhen 518055China Laboratory for Climate and Ocean-Atmosphere Studies Department of Atmospheric and Oceanic SciencesSchool of PhysicsPeking UniversityBeijing 100081China Key Laboratory for Agricultural Water Resources Center for Agricultural Resources ResearchInstitute of Genetics and Developmental BiologyChinese Academy of SciencesShijiazhuang 050022China Key Laboratory of Tibetan Environment Changes and Land Surface Processes Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China Center for Excellence in Tibetan Plateau Earth Sciences Chinese Academy of SciencesBeijing 100101China Faculty of Agriculture Shizuoka UniversityShizuoka 422-8529Japan Northwest Institute of Eco-Environment and Resources Chinese Academy of SciencesLanzhou 730000China Key Laboratory of Ecohydrology of Inland River Basin Chinese Academy of SciencesLanzhou 730000China Aerospace Information Research Institute Chinese Academy of SciencesBeijing 100094China School of Civil Engineering Sun Yat-Sen UniversityGuangzhou 510275China Key Laboratory of Water Cycle and Related Land Surface Processes Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China

Terrestrial evapotranspiration(ET)is a crucial link between Earth’s water cycle and the surface energy budget.Accurate measurement and estimation remain a major challenge in geophysical,biological,and environmental studies.Pioneering work,represented by Dalton and Penman,and the development of theories and experiments on turbulent exchange in the atmospheric boundary layer(ABL),laid the foundation for mainstream methodologies in ET estimation.Since the 1990s,eddy covariance(EC)systems and satellite remote sensing have been widely applied from cold to tropical and from arid to humid regions.They cover water surfaces,wetlands,forests,croplands,grasslands,barelands,and urban areas,offering an exceptional number of reports on diverse ET processes.Surface nocturnal ET,hysteresis between ET and environmental forces,turbulence intermittency,island effects on heterogeneous surfaces,and phase transition between underlying surfaces are examples of reported new phenomena,posing theoretical and practical challenges to mainstream ET methodologies.Additionally,based on non-conventional theories,new methods have emerged,such as maximum entropy production and nonparametric approaches.Furthermore,high-frequency on-site observation and aerospace remote sensing technology in combination form multi-scale observations across plant stomata,leaves,plants,canopies,landscapes,and basins.This promotes an insightful understanding of diverse ET processes and synthesizes the common mechanisms of the processes between and across spatial and temporal scales.All the recent achievements in conception,model,and technology serve as the basis for breaking through the known difficulties in ET estimation.We expect that they will provide a rigorous,reliable scientific basis and experimental support to address theoretical arguments of global significance,such as the water-heat-carbon cycle,and solve practical needs of national importance,including agricultural irrigation and food security,precise management of water resources and eco-environmental prot

关键词： Evapotranspiration Atmospheric boundary layer Heterogeneous surface Uncertainty

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基于EnKF方法和SWAT模型的土壤湿度数据同化试验

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武汉大学学报（工学版） 2024年第1期57卷 17-27页

作者：刘永伟王文刘元波崔巍中国科学院南京地理与湖泊研究所流域地理学重点实验室江苏南京210008 河海大学水文水资源与水利工程科学国家重点实验室江苏南京210098 南京水利科学研究院江苏南京210017

基于集合卡尔曼滤波(ensemble Kalman filter,EnKF)方法和分布式水文模型SWAT(soil and water assessment tool),构建了一个土壤水分状态与参数同时更新的土壤湿度数据同化方案,通过遥感观测土壤湿度数据同化的仿真试验,研究土壤湿度数... 详细信息

基于集合卡尔曼滤波(ensemble Kalman filter,EnKF)方法和分布式水文模型SWAT(soil and water assessment tool),构建了一个土壤水分状态与参数同时更新的土壤湿度数据同化方案,通过遥感观测土壤湿度数据同化的仿真试验,研究土壤湿度数据同化在优化土壤水分参数、改进模型产汇流过程模拟方面的效果及潜力。结果表明:通过表层(0~5 cm)土壤湿度数据同化可实现土壤持水能力参数的准确估计;当给定的参数更新平滑因子在合理范围时,基于EnKF方法的参数优化效果具有较好的稳定性;表层土壤湿度数据同化对SWAT模型产汇流过程模拟有一定改进,但受降雨误差的影响,其对流域出口径流过程改进效果有限,表明基于遥感土壤湿度数据同化改进流域水文过程模拟还有赖于降雨输入精度及可靠性的提高。

关键词： EnKF SWAT 土壤湿度数据同化参数优化

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Deep Learning Applications Based on WISE Infrared Data:Classification of Stars,Galaxies and Quasars

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Research in Astronomy and Astrophysics 2023年第8期23卷 164-177页

作者： Guiyu Zhao Bo Qiu A-Li Luo Xiaoyu Guo Lin Yao Kun Wang yuanbo liu School of Electronic and Information Engineering Hebei University of TechnologyTianjin 300401China CAS Key Laboratory of Optical Astronomy National Astronomical ObservatoriesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China

The Wide-field Infrared Survey Explorer(WISE)has detected hundreds of millions of sources over the entire sky.However,classifying them reliably is a great challenge due to degeneracies in WISE multicolor space and low detection levels in its two longest-wavelength bandpasses.In this paper,the deep learning classification network,IICnet(Infrared Image Classification network),is designed to classify sources from WISE images to achieve a more accurate classification *** shows good ability on the feature extraction of the WISE sources.Experiments demonstrate that the classification results of IICnet are superior to some other methods;it has obtained 96.2%accuracy for galaxies,97.9%accuracy for quasars,and 96.4%accuracy for stars,and the Area Under Curve of the IICnet classifier can reach more than 99%.In addition,the superiority of IICnet in processing infrared images has been demonstrated in the comparisons with VGG16,GoogleNet,ResNet34,Mobile Net,EfficientNetV2,and RepVGG-fewer parameters and faster inference.The above proves that IICnet is an effective method to classify infrared sources.

关键词： methods data analysis-techniques image processing-infrared general

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Interstitial pneumonitis during rituximab-containing chemotherapy for primary central nervous system lymphomas: a case report and review of literature

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Chinese Neurosurgical Journal 2018年第2期4卷 108-112页

作者： Yuchen Wu Xuefei Sun Jing liu Jun Qian Xueyan Bai Yuedan Chen yuanbo liu Department of Hematology Beijing Tiantan Hospital Capital Medical University Beijing 100050 China

Background: Primary central nervous system lymphoma(PCNSL) is a rare kind of non-Hodgkin lymphoma. Rituximab combined with high-dose methotrexate, cytarabine and dexamethasone (R-MAD regimen) were reported effective for PCNSL patients. Rituximab can cause several side effects, including fever, chills and rigors. Case presentation: In this case report, we demonstrate rituximab-induced interstitial pneumonitis in a PCNSL patient who has been treated with R-MAD regimen. The patient recovered after treatment and she remains complete remission after following consolidation chemotherapy. Conclusions: Here is no report of potential fatal complications of Rituximab like interstitial pneumonitis nowadays in PCNSL patients. As Rituximab is widely used, physicians should raise their awareness of this rare complication and detect RTX-ILD in early stage.

关键词： Central nervous system neoplasm Lymphoma Interstitial pneumonitis Rituximab R-MAD regimen Rituximab induced lung disease Chemotherapy Immunotherapy

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初诊多发性骨髓瘤合并骨髓纤维化患者临床特征及预后分析

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中华医学杂志 2024年第1期104卷 57-62页

作者：张磊李玉龙刘益民刘渊博商保军程薇董晓燕朱尊民河南省人民医院血液病研究所河南省血液病理重点实验室河南省CAR‑T细胞治疗与转化工程研究中心郑州大学人民医院血液病研究所郑州450003

目的探讨初诊多发性骨髓瘤(NDMM)合并骨髓纤维化(MF)患者的临床特征及预后。方法回顾性分析2012年1月至2022年7月河南省人民医院收治的160例NDMM患者临床资料,根据是否合并MF分为MF组(n=74)及非MF组(n=86)。MF组进一步分为MF-1级组(n=47... 详细信息

目的探讨初诊多发性骨髓瘤(NDMM)合并骨髓纤维化(MF)患者的临床特征及预后。方法回顾性分析2012年1月至2022年7月河南省人民医院收治的160例NDMM患者临床资料,根据是否合并MF分为MF组(n=74)及非MF组(n=86)。MF组进一步分为MF-1级组(n=47)和MF-2/3级组(n=27)。所有患者均采用以硼替佐米和免疫调节剂为基础的联合治疗方案,4个疗程后进行疗效评估,比较两组间的临床特征及预后。随访日期截至2022年12月30日,随访时间[M(Q_(1),Q_(3))]为23.5(14.4,40.5)个月。采用Kaplan-Meier法进行生存分析,生存率影响因素分析采用Cox风险回归模型。结果160例NDMM患者中,男91例,女69例,年龄[M(Q_(1),Q_(3))]为59(54,69)岁。MF组骨髓原/幼浆细胞、总浆细胞比例分别为9.6%(3.2%,28.5%)、36.4%(18.5%,51.1%),均高于非MF组的6.0%(1.2%,17.2%)、24.0%(12.0%,46.0%)(均P0.05)。两组间治疗客观缓解率(ORR)、总生存期(OS)及无进展生存期(PFS)差异均无统计学意义(均P>0.05)。MF-2/3级组患者17p-阳性率为25.9%(7/27),高于非MF组的8.1%(7/86)(P=0.049)。MF-2/3级组中位OS为25.0(95%CI:23.6~26.4)个月,短于非MF组的54.0个月(P=0.031)。多因素Cox回归分析显示,MF-2/3级不是影响NDMM患者OS的危险因素(HR=1.507,95%CI:0.624~3.993,P=0.425)。结论合并MF的NDMM患者骨髓原/幼浆细胞、总浆细胞比例高于未合并MF患者,Hb、PLT低于未合并MF患者。合并2/3级MF的NDMM患者较未合并MF患者生存期短。

关键词：多发性骨髓瘤骨髓纤维化生物学特征预后荧光原位杂交

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疏水水平管滴状冷凝研究:液滴脱落分区特征

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工程热物理学报 2024年第4期45卷 1169-1178页

作者：刘渊博李世成李启迅张帅帅兰忠温荣福马学虎辽宁省化工资源清洁利用重点实验室大连理工大学化学工程研究所大连116024

在电力系统中,滴状冷凝能够有效提升凝汽器传热性能,其中液滴动态行为与其传热过程息息相关,明确液滴动态行为对凝汽器的设计具有指导意义。本文利用PFA疏水涂层改性紫铜圆管,在空气中的接触角为142.6°能实现稳定的滴状冷凝。与竖壁冷... 详细信息

在电力系统中,滴状冷凝能够有效提升凝汽器传热性能,其中液滴动态行为与其传热过程息息相关,明确液滴动态行为对凝汽器的设计具有指导意义。本文利用PFA疏水涂层改性紫铜圆管,在空气中的接触角为142.6°能实现稳定的滴状冷凝。与竖壁冷凝中液滴脱落过程不同,水平管上液滴受到的重力分量与水平管周向角有关,造成液滴延水平管周向的脱落尺寸的差异,以此为基础将水平管表面进行分区,并提出“局部冲刷”和“完整冲刷”两种液滴冲刷模式;脱离液滴的位置和时序性差异形成下部较高的表面更新率,在液滴尺寸r<400μm的范围内,下部分的液滴数密度高于上部分;局部冲刷可限制下部分区域液滴尺寸,降低液滴覆盖面积。

关键词：滴状冷凝水平管液滴脱落行为尺寸分布低压蒸汽

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深井超深井钻井装备技术现状与发展趋势探讨

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钻采工艺 2024年第2期47卷 141-151页

作者：张斌曹晓宇周天明刘远波夏辉中国石油宝鸡石油钢管有限责任公司中国石油宝鸡石油机械有限责任公司国家油气钻井装备工程技术研究中心

为助力我国深层超深层油气资源高效勘探开发,文章分析了深井超深井对钻井装备提出的挑战,论述了美国Nabors、斯伦贝谢和NOV等公司的自动化钻机、管柱自动化装备、储能节能与能源管理系统、司钻集成控制系统、智能决策与支持平台等7类产... 详细信息

为助力我国深层超深层油气资源高效勘探开发,文章分析了深井超深井对钻井装备提出的挑战,论述了美国Nabors、斯伦贝谢和NOV等公司的自动化钻机、管柱自动化装备、储能节能与能源管理系统、司钻集成控制系统、智能决策与支持平台等7类产品的功能、特性;并对国内管柱自动化钻机、一键式人机交互7 000 m自动化钻机、12 000 m特深井自动化钻机、管柱自动化装备、储能节能与能源管理系统、司钻集成控制系统、钻井辅助决策与支持系统等产品发展和应用现状进行了阐述。通过技术对标分析得出:我国石油钻井装备取得了长足的进步,但从工程需求和应用上看还存在许多不足,与国外先进技术相比还有不小差距。建议国内各装备制造厂家顺应国家“碳达峰、碳中和”目标和数字化转型、智能化发展趋势,从参数强化、钻机全面自动化、装备运维数智化、司钻操控值守化和钻井作业绿色化等方面开展关键技术攻关。

关键词：深井超深井钻井装备挑战技术现状对标分析发展趋势

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Treatment of secondary central nervous system involvement in systemic aggressive B cell lymphoma using R-MIADD chemotherapy:a single-center study

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Chinese Neurosurgical Journal 2021年第2期7卷 143-150页

作者： Yuchen Wu Xuefei Sun Xueyan Bai Jun Qian Hong Zhu Qu Cui Ruixian Xing Yuedan Chen Qing liu Wenyuan Lai Junhong Li Yaming Wang Shengjun Sun Nan Ji yuanbo liu Department of Hematology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Neurosurgery Beijing Xuanwu HospitalCapital Medical UniversityBeijingChina Neuroimaging Center Beijing Tiantan HospitalCapital Medical UniversityBeijingChina

Background:Secondary central nervous system lymphoma(SCNSL)is defined as lymphoma involvement within the central nervous system(CNS)that originated elsewhere,or a CNS relapse of systemic lymphoma.Prognosis of SCNSL is poor and the most appropriate treatment is still undetermined.Methods:We conducted a retrospective study to assess the feasibility of an R-MIADD(rituximab,high-dose methotrexate,ifosfamide,cytarabine,liposomal formulation of doxorubicin,and dexamethasone)regimen for SCNSL patients.Results:Nineteen patients with newly diagnosed CNS lesions were selected,with a median age of 58(range 20 to 72)years.Out of 19 patients,11(57.9%)achieved complete remission(CR)and 2(10.5%)achieved partial remission(PR);the overall response rate was 68.4%.The median progression-free survival after CNS involvement was 28.0 months(95%confidence interval 11.0–44.9),and the median overall survival after CNS involvement was 34.5 months.Treatment-related death occurred in one patient(5.3%).Conclusions:These single-centered data underscore the feasibility of an R-MIADD regimen as the induction therapy of SCNSL,further investigation is warranted.

关键词： Central nervous system B cell lymphoma SCNSL R-MIADD Chemotherapy

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