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Spheroid construction strategies and application in 3D bioprinting

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Bio-Design and Manufacturing 2024年第5期7卷 800-818页

作者： Chunxiang Lu Chuang Gao Hao Qiao Yi Zhang Huazhen liu Aoxiang Jin yuanyuan liu School of Mechatronic Engineering and Automation Shanghai UniversityShanghai 200444China School of Medicine Shanghai UniversityShanghai 200444China

Tissue engineering has been striving toward designing and producing natural and functional human *** are the fundamental building blocks of *** with traditional two-dimensional cultured cells,cell spheres are threedimensional(3D)structures that can naturally form complex cell–cell and cell–matrix *** structure is close to the natural environment of cells in living *** addition to being used in disease modeling and drug screening,spheroids have significant potential in tissue *** 3D bioprinting is an advanced biofabrication *** accurately deposits bioinks into predesigned 3D shapes to create complex tissue *** 3D bioprinting is efficient,the time required for cells to develop into complex tissue structures can be *** 3D bioprinting of spheroids significantly reduces the time required for their development into large tissues/organs during later cultivation stages by printing them with high cell *** spheroid fabrication and bioprinting technology should provide a new solution to many problems in regenerative *** paper systematically elaborates and analyzes the spheroid fabrication methods and 3D bioprinting strategies by introducing spheroids as building ***,we present the primary challenges faced by spheroid fabrication and 3D bioprinting with future requirements and some recommendations.

关键词： Spheroids Strategies 3D bioprinting Biofabrication

Tuning the crystalline and electronic structure of ZrO_(2)via oxygen vacancies and nano-structuring for polysulfides conversion in lithium-sulfur batteries

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Journal of Energy Chemistry 2024年第1期88卷 82-93,I0003页

作者： Shengnan Fu Chaowei Hu Jing Li Hongtao Cui yuanyuan liu Kaihua liu Yanzhao Yang Meiri Wang Shandong Key Laboratory for Chemical Engineering and Processing School of Chemistry&Chemical EngineeringYantai UniversityYantai 264000ShandongChina Key Laboratory for Special Functional Aggregate Materials of Education Ministry School of Chemistry and Chemical EngineeringShandong UniversityJinan 250100ShandongChina

The recent emergence of tetragonal phases zirconium dioxide(ZrO_(2))with vacancies has generated significant interest as a highly efficient and stable electrocatalyst with potential applications in trapping polysulfides and facilitating rapid conversion in lithium-sulfur batteries(LSBs).However,the reduction of ZrO_(2)is challenging,even under strong reducing atmospheres at high temperatures and ***,the limited presence of oxygen vacancies results in insufficient active sites and reaction interfaces,thereby hindering practical ***,we successfully introduced abundant oxygen vacancies into ZrO_(2)at the nanoscale with the help of carbon nanotubes(CNTs-OH)through hydrogen-etching at lower temperatures and *** introduced oxygen vacancies on ZrO_(2-x)/CNTs-OH can effectively rearrange charge distribution,enhance sulfiphilicity and increase active sites,contributing to high ionic and electronic transfer kinetics,strong binding energy and low redox barriers between polysulfides and ZrO_(2-x).These findings have been experimentally validated and supported by theory *** a result,LSBs assembled with the ZrO_(2-x)/CNTs-OH modified separators demonstrate excellent rate performance,superior cycling stability,and ultra-high sulfur ***,at high sulfur loading of 6 mg cm^(-2),the area capacity is still up to 6.3 mA h cm^(-2).This work provides valuable insights into the structural and functional optimization of electrocatalysts for batteries.

关键词： Lithium-sulfur batteries Oxygen vacancies Zirconium dioxide/carbon nanotubes with–OH Improved redox kinetics Superior cycling stability

Current Immunotherapy Strategies for Rheumatoid Arthritis:The Immunoengineering and Delivery Systems

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Research 2024年第3期2023卷 169-189页

作者： Chenyu Zhang Peixiang Ma An Qin Liao Wang Kerong Dai yuanyuan liu Jie Zhao Zuyan Lu School of Medicine Shanghai UniversityShanghaiChina Clinical and Translational Research Center for 3D Printing Technology Shanghai Ninth People's HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Shanghai Key Laboratory of Orthopedic Implants Department of Orthopedic SurgeryShanghai Ninth People's HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Shanghai Frontiers Science Center of Degeneration and Regeneration in Skeletal System ShanghaiChina.

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease accompanied by persistent multiarticular synovitis and cartilage degradation. The present clinical treatments are limited to disease-modifying anti-rheumatic drugs (DMARDs) and aims to relieve pain and control the inflammation of RA. Despite considerable advances in the research of RA, the employment of current clinical procedure is enormous, hindered by systemic side effect, frequent administration, tolerance from long-lasting administration, and high costs. Emerging immunoengineering-based strategies, such as multiple immune-active nanotechnologies via mechanism-based immunology approaches, have been developed to improve specific targeting and to reduce adverse reactions for RA treatments. Here, we review recent studies in immunoengineering for the treatment of RA. The prospect of future immunoengineering treatment for RA has also been discussed.

关键词： drugs Rheumatoid treatment

Intense and Superflat White Laser with 700-nm 3-dB Bandwidth and 1-mJ Pulse Energy Enabling Single-Shot Subpicosecond Pulse Laser Spectroscopy

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Research 2024年第2期6卷 319-327页

作者： Lihong Hong Haiyao Yang Liqiang liu Mingzhou Li yuanyuan liu Baoqin Chen Huakang Yu Wenbo Ju Zhi-Yuan Li School of Physics and Optoelectronics South China University of TechnologyGuangzhou 510641China State Key Laboratory of Luminescent Materials and Devices South China University of TechnologyGuangzhou 510640China

An optical spectrometer is a basic spectral instrument that probes microscopic physical and chemical properties of macroscopic objects but generally suffers from difficulty in broadband time-resolved *** this work,we report the creation of ultrabroadband white-light laser with a 3-dB bandwidth covering 385 to 1,080 nm,pulse energy of 1.07 mJ,and pulse duration of several hundred femtoseconds by passing 3-mJ pulse energy,50-fs pulse duration Ti:Sapphire pulse laser through a cascaded fused silica plate and chirped periodically poled lithium niobate *** utilize this unprecedented superflat,ultrabroadband,and intense femtosecond laser light source to build a single-shot(i.e.,single-pulse)subpicosecond pulse laser ultraviolet-visible-near-infrared spectrometer and successfully measure various atomic and molecular absorption *** single-shot ultrafast spectrometer may open up a frontier to monitor simultaneously the ultrafast dynamics of multiple physical and chemical processes in various microscopic systems.

关键词： Pulse utilize frontier

Performance Analysis of an Efficient Integration System of Coal-Fired Power Plant,Solar Thermal Energy and CO_(2)Capture

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Journal of Thermal Science 2024年第4期33卷 1509-1522页

作者： WANG Yuhao WANG Ruilin liu Lanhua XING Chenjian GUO Yafei YANG Qingshan YING Jiaheng SUN Jian LI Wenjia liu yuanyuan ZHAO Chuanwen School of Energy and Mechanical Engineering Nanjing Normal UniversityNanjing210023China China Huadian Group Co.LTD.Shanghai Branch Shanghai200120China Key Laboratory of Efficient Utilization of Low and Medium Grade Energy(Tianjin University) Ministry of Education of ChinaTianjin300350China Huadian Zhengzhou Mechanical Design Institute Company Limited Zhengzhou450046China

Coal-fired power plant is a major contributor to greenhouse gas *** post-combustion capture is a promising method for CO_(2)emission reduction but the high thermal demand is *** address this issue,solar thermal energy and CO_(2)capture are jointly integrated into the coal-fired power plant in this *** solar thermal energy is employed to meet the heat requirement of the CO_(2)capture process,thereby avoiding the electricity loss caused by self-driven CO_(2)***,the heat released from the carbonation reaction of MgO adsorbent is integrated into the steam Rankine *** partially substituting the extracted steam for feedwater heating,the electricity output of the power plant is further *** to the results from the developed model,the system could achieve a CO_(2)capture rate of 86.5%and an electricity output enhancement of 9.8%compared to the reference system,which consists of a self-driven CO_(2)capture coal-fired power plant and PV generation *** operational strategy is also optimized and the amount of CO_(2)emission reduction on a typical day is increased by 11.06%.This work shows a way to combine fossil fuels and renewable energy for low carbon emissions and efficient power generation.

关键词： CO_(2)capture parabolic trough collector solar aided coal-fired electricity generation

Synergic action of linear dispersion, second-order nonlinearity, and third-order nonlinearity in shaping the spectral profile of a femtosecond pulse transporting in a lithium niobate crystal

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Photonics Research 2024年第4期12卷 774-783页

作者： LIHONG HONG yuanyuan liu ZHI-YUAN LI State Key Laboratory of High Field Laser Physics Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghai 201800China School of Physics and Optoelectronics South China University of TechnologyGuangzhou 510640China

We present a detailed theoretical and numerical analysis on the temporal-spectral-spatial evolution of a highpeak-power femtosecond laser pulse in two sets of systems:a pure lithium niobate(LN)plate and a periodically poled lithium niobate(PPLN)*** develop a modified unidimensional pulse propagation model that considers all the prominent linear and nonlinear processes and carried out the simulation process based on an improved split-step Fourier transformation *** theoretically analyze the synergic action of the linear dispersion effect,the second-order nonlinearity(2nd-NL)second-harmonic generation(SHG)effect,and the third-order nonlinearity(3rd-NL)self-phase modulation(SPM)effect,and clarify the physical mechanism underlying the peculiar and diverse spectral broadening patterns previously reported in LN and PPLN thin plate *** analysis and discussion provides a deeper insight into the synergetic contribution of these linear and nonlinear effects brought about by the interaction of a femtosecond laser pulse with the LN nonlinear crystal and helps to draw a picture to fully understand these fruitful optical physical processes,phenomena,and laws.

关键词： pulse nonlinearity lithium

Using Intelligent Screening Service Platform(ISSP)to Improve the Screening Process of Clinical Trial Subjects during COVID-19 Pandemic:An Experimental Study

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Data Intelligence 2024年第3期6卷 666-691页

作者： Bin Li Runfang Guo Huan Zhou yuanyuan liu Xiaolei Zhang Qian Zhang Drug Clinical Trial Institution The First Affiliated Hospital of Bengbu Medical CollegeBengbu233004China School of Public Health Bengbu Medical CollegeBengbu233030China

Background:During the COVID-19 pandemic,clinical trial recruitment could not be carried out due to travel restrictions,transmission risks and other factors,resulting in the stagnation of many ongoing or upcoming clinical ***:An intelligent screening tool was developed using artificial intelligence technology to rapidly prescreen potential patients for phase I solid tumor drug clinical ***:A total of 429 screening process records were collected from 27 phase I solid tumor drug clinical trials at the First Affiliated Hospital of Bengbu Medical College from April 2018 to May *** of the experimental data were analyzed,and the collinearity(principal component analysis)and strong correlation(χ^(2)test)among features were ***,random forest,and naive Bayes were used to determine the weight importance of the ***,prescreening models were constructed using a classification machine learning algorithm,and the optimal model was ***:Among the 429 screening records,33 were generated by repeated subject participation in different clinical trials,and of the remaining 396 screening records,246(62.12%)were screened *** gold standard for subject screening success was the final judgment made by the principal investigator(PI)based on the clinical trial protocol.A Venn diagram was used to identify the important feature intersections of the machine learning *** intersecting the top 15 characteristic variables of the different feature screening models,9 common variables were obtained:age,sex,distance from residence to the central institution,tumor histology,tumor stage,tumorectomy,interval from diagnosis/postoperative to screening,chemotherapy,and Eastern Cooperative Oncology Group(ECOG)*** select the optimal subset,the 9 important feature variables were expanded to 12 and 15 feature subsets,and the performance of different feature subsets under different machine learning models was vali

关键词： Phase I clinical trials Solid tumors Patient screening COVID-19 Artificial intelligence Machine learning APP

Acute Effects of Exposure to Fine Particulate Matter and Its Constituents on Sex Hormone Among Postmenopausal Women — Beijing, Tianjin, and Hebei PLADs, China, 2018–2019

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China CDC weekly 2024年第13期6卷 249-253,I0001-I0004页

作者： Yanlin Tian Jiaonan Wang Jianlong Fang Chen Chen Feng Zhao Yi Zhang Peng Du Yawei Li Wanying Shi yuanyuan liu Enmin Ding Song Tang Xu Yue Xiaoming Shi Chinese Research Academy of Environmental Sciences BeijingChina Collaborative Innovation Center of Atmospheric Environment and Equipment Technology Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control(AEMPC)Nanjing University of Information Science&TechnologyNanjing CityJiangsu ProvinceChina China CDC Key Laboratory of Environment and Population Health National Institute of Environmental HealthChinese Center for Disease Control and PreventionBeijingChina Department of Epidemiology and Health Statistics School of Public HealthCapital Medical Universityand Beijing Municipal Key Laboratory of Clinical EpidemiologyBeijingChina National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases National Institute of Environmental HealthChinese Center for Disease Control and PreventionBeijingChina

What is already known on this topic?Exposure to fine particulate matter(PM_(2.5))was linked to endocrine hormone disruption in the reproductive ***,it was unclear which specific components of PM_(2.5) were primarily responsible for these *** is added by this report?The study presented the initial epidemiological evidence that brief exposure to PM_(2.5) can elevate estradiol levels in postmenopausal *** particle components had unique effects,with watersoluble ions and specific inorganic elements like Ag,As,Cd,Hg,Ni,Sb,Se,Sn,and Tl potentially playing significant roles in increasing estradiol *** are the implications for public health practice?The study established that the prevalence of air pollution,along with its specific components,has been recognized as a novel risk factor affecting the balance of sex hormones.

关键词： pollution Particulate primarily

Statement on Establishment of Public Health Protection Guideline for Cold Spells—China

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China CDC weekly 2024年第5期6卷 92-94页

作者： Tiantian Li Qinghua Sun Chen Chen Qing Wang Jie Ban Runmei Ma Yi Zhang Lijun Pan yuanyuan liu Qiutong Li Leyao Chang Hanshuo Zhang Yirong liu Miaoyou Niu Xiangxiang Wei Lin Wang China CDC Key Laboratory of Environment and Population Health National Institute of Environmental HealthChinese Center for Disease Control and PreventionBeijingChina

Cold spells are extreme weather events characterized by the invasion of cold air from high latitudes into the middle and low latitudes,resulting in significant *** spells have various adverse health effects,including epidermal damage,respiratory tract spasms,respiratory immune abnormalities,acute cardiopulmonary diseases,and exacerbation of urinary and endocrine *** response to the frequent cold spells in recent years.

关键词： respiratory invasion acute