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A Ruin Model with Random Income and Dependence between Claim Sizes and Claim Intervals

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Acta Mathematicae Applicatae Sinica 2010年第4期26卷 625-632页

作者： Hu Yang yuan-yuan hao College of Mathematics and Statistics Chongqing UniversityChongqing400030China

In this paper,we consider a generalization of the classical ruin model,where the income is random and the distribution of the time between two claim occurrences depends on the previous claim *** model is more appropriate than the classical ruin *** expression for the generating function of the Gerber-Shiu expected discounted penalty function are derived.A similar model is ***,the result are showed by two examples.

关键词： Ruin model expected discounted penalty function dependence ruin probability

Portal vein gas combined with pneumatosis intestinalis and emphysematous cystitis:A case report and literature review

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World Journal of Clinical Cases 2022年第25期10卷 8945-8953页

作者： Shi-Fu Hu Han-Bo Liu yuan-yuan hao Department of General Surgery Tianjin Xiqing HospitalTianjin 300100China Department of Geriatrics Tianjin Xiqing HospitalTianjin 300100China

BACKGROUND Portal venous gas(PVG)is a rare clinical condition usually indicative of severe disorders,including necrotizing enterocolitis,bowel ischemia,or bowel wall rupture/*** intestinalis(PI)is a rare illness characterized by an infiltration of gas into the intestinal *** cystitis(EC)is relatively rare and characterized by intramural and/or intraluminal bladder gas best depicted by cross-sectional *** study reports a rare case coexistence of PVG presenting with PI and *** SUMMARY An 86-year-old woman was admitted to the emergency room due to the progressive aggravation of pain because of abdominal fullness and distention,complicated with vomiting and stopping defecation for 4 *** abdominal computed tomography(CT)plain scan indicated intestinal obstruction with ischemia changes,gas in the portal vein,left renal artery,superior mesenteric artery,superior mesenteric vein,some branch vessels,and bladder pneumatosis with air-fluid *** surgery was conducted on the *** necrosis was found in the small intestine approximately 110 cm below the Treitz ligament and in the ileocecal junction and ascending colon *** included excision of the necrotic small intestine and right colon,fistulation of the proximal small intestine,and distal closure of the transverse ***,the patient displayed postoperative short bowel syndrome but had a good *** received intravenous fluid infusion and enteral nutrition maintenance every other day after discharge from the community *** Emergency surgery should be performed when CT shows signs of PVG with PI and EC along with a clinical situation strongly suggestive of bowel ischemia.

关键词： Portal vein gas Mesenteric ischemia Pneumatosis intestinalis Emphysematous cystitis Bowel necrosis Case report

Chidamide and sintilimab combination in diffuse large B-cell lymphoma progressing after chimeric antigen receptor T therapy

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World Journal of Clinical Cases 2022年第19期10卷 6555-6562页

作者： yuan-yuan hao Pan-Pan Chen Xiang-Gui yuan Ai-Qi Zhao Yun Liang Hui Liu Wen-Bin Qian Department of Hematology The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310009Zhejiang ProvinceChina

BACKGROUND Diffuse large B-cell lymphoma(DLBCL)is curable with first-line chemoimmunotherapy but patients with relapsed/refractory(R/R)DLBCL still face a poor *** patients with R/R DLBCL,the complete response rate to traditional next-line therapy is only 7%and the median overall survival is 6.3 ***,CD19-targeting chimeric antigen receptor T cells(CAR-T)have shown promise in clinical ***,approximately 50%of patients treated with CAR-T cells ultimately progress and few salvage therapies are *** SUMMARY Here,we report on 7 patients with R/R DLBCL whose disease progressed after CAR-T *** received a PD-1 inhibitor(sintilimab)and a histone deacetylase inhibitor(chidamide).Five of the 7 patients tolerated the treatment without any serious adverse *** patients discontinued the treatment due to lung infection and *** the 20-mo follow-up,the median overall survival of these 7 patients was 6 *** note,there were 2 complete response rates(CRs)and 2 partial response rates(PRs)during this novel therapy,with an overall response rate(ORR)of 57.1%,and one patient had a durable CR that lasted at least 20 *** In conclusion,chidamide combined with sintilimab may be a choice for DLBCL patients progressing after CD19-targeting CAR-T therapy.

关键词： Chimeric antigen receptor T cell therapy Diffuse large B-cell lymphoma Immunotherapy PD-1 inhibitor Histone deacetylase inhibitor Case report

An extensive DeBakey type IIIb aortic dissection with massive right pleural effusion presenting as abdominal pain and acute anemia： particular case report

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Journal of Geriatric Cardiology 2015年第3期12卷 319-322页

作者： Hui-Chun YU Zhen-Qing WANG yuan-yuan hao Feng-Ping AN Yu-Chuan HU Rui-Bing DENG Peng YU Guang-Bin CUI He LI Department of Gerontology Xiqing Hospital Tianjin China Department of Radiology Tangdu Hospital Fourth Military Medical University Xi 'an Shaanxi Province China Cardiovascular Dtvtszon of Gerontology Pingjin Hospital Logistic University of CAPF Tianjin China

We describe the case of a 79-year-old male presented with sudden onset of abdominal pain and mild breathlessness, and complicated acute progressive anemia with haemoglobin which declined from 120 g/L to 70 g/L within five days. An urgent computed tomography an- giography showed acute thoracic aortic dissection, DeBakey type IIIb, a dissecting aneurysm in the proximal descending thoracic aorta start- ing immediately after the origin of the left subclavian artery and extending distally below the renal arteries with evidence of rupture into the right pleural cavity for massive pleural effusion. Plasma D-dimer, brain natriuretic peptide and C reactive protein level were elevated. Our case showed that D-dimer can be used as a ＇rule-out＇ test in patients with suspected aortic dissection. A raised BNP may exert a protective role through anti-inflammatory endothelial actions in the systemic circulation.

关键词： Acute aortic dissection Anemia D-dimer The elderly

Quick System-Level DDR3 Signal Integrity Simulation Research

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Journal of Electronic Science and Technology 2013年第3期11卷 286-290页

作者： Run-Jing Zhou yuan-yuan hao Jin-Song Hu the College of Electronic Information Engineering Inner Mongolia University the PC Client Group Intel Asia-Pacific R&D Ltd.

---Double data rate synchronous dynamic random access memory （DDR3） has become one of the most mainstream applications in current server and computer systems. In order to quickly set up a system-level signal integrity （SI） simulation flow for the DDR3 interface, two system-level SI simulation methodologies, which are board-level S-parameter extraction in the frequency-domain and system-level simulation assumptions in the time domain, are introduced in this paper. By comparing the flow of Speed2000 and PowerSI/Hspice, PowerSI is chosen for the printed circuit board （PCB） board-level S-parameter extraction, while Tektronix oscilloscope （TDS7404） is used for the DDR3 waveform measurement. The lab measurement shows good agreement between simulation and measurement. The study shows that the combination of PowerSI and Hspice is recommended for quick system-level DDR3 SI simulation.

关键词： Index Terms--Double data rate synchronousdynamic random access memory Hspice PowerSI,signal integrity system-level signal integrity simulation.

Unexpected right-sided sigmoid colon in laparoscopy: A case report and review of literature

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World Journal of Gastrointestinal Surgery 2024年第11期16卷 3606-3613页

作者： Shi-Fu Hu Xiang-Yu Liu Han-Bo Liu yuan-yuan hao Department of General Surgery Tianjin Xiqing HospitalTianjin 300100China Department of Geriatrics Tianjin Xiqing HospitalTianjin 300100China

BACKGROUND The presence of a right-sided sigmoid colon is a rare anatomical variation usually discovered incidentally during surgical *** case report details an unexpected right-sided sigmoid colon identified during a laparoscopic appendectomy and examines the pertinent literature to explore its clinical *** SUMMARY A 71-year-old woman presented with acute appendicitis.A preoperative computed tomography(CT)scan showed peri-appendiceal inflammation but no significant anatomical *** laparoscopic surgery,an unexpected finding was encountered:The sigmoid colon was situated on the right side and exhibited an abnormal relationship with the cecum and ascending *** pathological examination confirmed appendicitis with no additional pathological *** right-sided sigmoid colon anomaly was verified through intraoperative assessment and later re-evaluation with CT and colonographic *** patient underwent a laparoscopic appendectomy and experienced a smooth postoperative *** This case highlights the necessity of being attentive to anatomical variations during laparoscopic surgery,particularly when managing appendicitis.A review of the literature indicated that the occurrence of a right-sided sigmoid colon is infrequent and may be associated with anomalies in midgut rotation during embryonic *** of this variation can help prevent surgical complications and inform future clinical practice.

关键词： Right-sided sigmoid colon Laparoscopy Anatomical variation Literature review Surgical implications Case report

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复合动作电位与迷走神经刺激个性化参数调控

清华大学学报（自然科学版） 2017年第2期57卷 134-140页

作者：袁媛郝红伟李路明清华大学航天航空学院北京100084 北京脑重大疾病研究院癫痫研究所北京100093 清华-伯克利深圳学院深圳518055

迷走神经刺激(VNS)广泛应用于癫痫和抑郁等多种药物难治性疾病的治疗,实现VNS个性化调控对疗法的临床推广具有重要意义。该文提出了以术中复合动作电位(CAP)为评估依据的VNS疗法个性化参数选择方法。搭建了CAP信号采集平台,开展了中华... 详细信息

迷走神经刺激(VNS)广泛应用于癫痫和抑郁等多种药物难治性疾病的治疗,实现VNS个性化调控对疗法的临床推广具有重要意义。该文提出了以术中复合动作电位(CAP)为评估依据的VNS疗法个性化参数选择方法。搭建了CAP信号采集平台,开展了中华小型猪的活体实验,在恒流刺激模式下分析了电流幅度、脉宽和频率等VNS刺激参数与迷走神经CAP信号的量化关系,明确了VNS疗法临床常用刺激参数的选择依据,进而提出了个性化治疗参数的选择标准及选择范围。实验结果表明:应以CAP信号中A类纤维和B类纤维的不同响应特性为依据,开展VNS治疗癫痫和抑郁的个性化参数调控。该方法为VNS疗效的提高以及闭环VNS疗法的发展奠定了基础。

关键词：迷走神经刺激参数调控复合动作电位个性化治疗活体实验

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电液伺服系统的故障自愈设计与仿真

计算机工程与设计 2018年第6期39卷 1716-1720页

作者：孙文理袁宇浩袁野南京工业大学电气工程与控制科学学院江苏南京211816

为提高电液伺服控制系统的稳定性并降低维修成本,根据人工免疫原理,从电液伺服系统内部出发,设计完成对其自身故障的识别与诊断,通过调用自愈策略实现其故障的自愈。利用基于模块化的仿真软件AMESim,构建电液伺服系统的仿真模型,通过HC... 详细信息

为提高电液伺服控制系统的稳定性并降低维修成本,根据人工免疫原理,从电液伺服系统内部出发,设计完成对其自身故障的识别与诊断,通过调用自愈策略实现其故障的自愈。利用基于模块化的仿真软件AMESim,构建电液伺服系统的仿真模型,通过HCD库对其中的液压缸仿真模型进行优化设计。在分析其放大器故障的基础上,设计电液伺服系统故障自愈模型。仿真分析结果表明,该模型的可行性和有效性。

关键词：免疫原理故障自愈故障分析 AMESim仿真软件电液伺服系统

降钙素基因相关肽对肺纤维化大鼠肺组织eIF3a、p27表达的影响

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中国应用生理学杂志 2017年第1期33卷 16-21页

作者：李先伟左东泽沈媛媛郝伟皖南医学院药理学教研室安徽芜湖241002

目的:观察降钙素基因相关肽(CGRP)对肺纤维化大鼠肺组织真核翻译起始因子3a(e IF3a)、p27表达的影响,探讨CGRP在肺纤维化中的作用及机制。方法:雄性SD大鼠,体重180~220 g,随机分为3组(n=8):对照组、博莱霉素组、博莱霉素+辣椒素组。采... 详细信息

目的:观察降钙素基因相关肽(CGRP)对肺纤维化大鼠肺组织真核翻译起始因子3a(e IF3a)、p27表达的影响,探讨CGRP在肺纤维化中的作用及机制。方法:雄性SD大鼠,体重180~220 g,随机分为3组(n=8):对照组、博莱霉素组、博莱霉素+辣椒素组。采用气管内注射博莱霉素(5 mg/kg)诱导肺纤维化大鼠模型。造模前4 d大鼠皮下注射辣椒素(Capsaicin)(50 mg/kg·d),造模后第28天处死动物,颈动脉采血ELISA法测定血浆CGRP含量。细胞实验分6组(n=9):Control组,转化生长因子-β1(TGF-β1)组,CGRP(1、10、100 nmol/L)组,CGRP8-37 1μmol/L和CGRP 100 nmol/L组。细胞用CGRP和(或)CGRP8-37预处理1 h,再用TGF-β1(5 ng/ml)处理48 h。5-溴脱氧尿嘧啶核苷(Brd U)法检测细胞增殖。免疫组化、real-time PCR和(或)Western blot检测e IF3a、p27、α-平滑肌肌动蛋白(α-SMA)、collagenⅠm RNA及蛋白表达。结果:博莱霉素诱发肺纤维化动物肺组织e IF3a、α-SMA及Ⅰ胶原表达增高,CGRP及p27的表达明显降低。外源性CGRP可剂量依赖性的抑制TGF-β1诱导的肺成纤维细胞增殖,明显抑制e IF3a、α-SMA、Ⅰ胶原的表达,上调p27的表达,这些作用可以被CGRP阻断剂CGRP8-37所取消。结论:CGRP在博莱霉素诱导的肺纤维化中起着重要作用,可能通过抑制e IF3a、上调p27的表达而抑制肺成纤维细胞的增殖,进而抑制肺纤维化的形成与发展。

关键词：降钙素基因相关肽肺纤维化肺成纤维细胞 eIF3a p27 大鼠