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Evaluation of potential hazards from teletsunami in China:Tidal observations of a teletsunami generated by the Chile 8.8 M_w earthquake

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Chinese Science Bulletin 2011年第11期56卷 1108-1116页

作者： YU FuJiang yuan ye ZHAO LianDa wang PeiTao National Marine Environmental Forecasting Center Beijing 100081 China

At 14:34 Beijing time on February 27,2010,an earthquake of M w 8.8 rocked the central coast of Chile.A teletsunami was triggered by the huge earthquake and then propagated across the entire Pacific in less than 24 *** initial tsunami wave arrived at the southeast coast of China at 16:20 on February 28 and was recorded in real time by a number of tidal gauges off China's Mainland and Taiwan *** teletsunami waves have never been recorded with such a broad geographical scope in China before this *** aim of the present work is to report the first description of sea-level oscillations generated by the Chile tsunami,and evaluate the potential hazards that teletsunami poses to the coast of *** results reveal that the east coast of Taiwan Province,Zhejiang Province and the north coast of Fujian Province are vulnerable to transoceanic *** addition,spectral and wavelet analysis of the recorded sea-level oscillations shows that "seiches" are easily excited by the resonance resulting from the interaction between the initial tsunami waves and local geometry (such as semi-enclosed bays and ports).The superimposition of the two oscillations would amplify the wave height further.

关键词：中国大陆 8级地震潮汐观测智利评估危险东南沿海实时记录

Change of MicroRNA-134,CREB and p-CREB expression in epileptic rat

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Asian Pacific Journal of Tropical Medicine 2015年第4期8卷 292-298页

作者： Yan Zhu Cheng-Shan Li yuan-ye wang Sheng-Nian Zhou Department of ICU(Jining medical college affiliated hospital) Department of Neurology Qilu Hospital of Shandong University Brain Science Research Institute Shandong University

Objective:To To investigate the changes of MicroRNA-134,CREB and p-CREB expression in epileptic rat brains in order to elucidate the molecular mechanisms of epilepsy,providing new ideas for clinical ***:Sixty-four Spraque-Dawley(SD)rats were divided into groups randomly,including control group,six hours after seizure group,24-hour group,threeday group,one-week group,two-week group,four-week group,and eight-week *** groups were placed under a pilocarpine-induced epilepsy model except the control group,and all rats were decapitated in different points of *** specimens were taken for quantitative PCR experiments,immunohistochemistry and Western blot *** results of the epilepsy model groups and the control group were ***:There were no significant differences between the six hours after seizure group,the 24-hour group and the control group about the MicroRNA-134 ***-134 in the hippocampus tissue of the three-day group significantly reduced compared with the control group;same result was observed with the one-week,two-week,four-week and eight-week *** CREB and p-CREB levels in the three-day group's rat hippocampus significantly increased compared with the control group;and the high levels of CREB and p-CREB were constantly maintained in the one-week,two-week,four-week and eight-week ***:The MicroRNA-134 level of the epileptic rat hippocampus is significantly lower than normal after three days,and continues to maintain a low level:while CREB and p-CREB levels are rsignificantly increased after three days,and continue to remain at a high ***-134 plays a role in inhibiting synaptic plasticity by inhibiting CREB and p-CREB expressions.

关键词： MicroRNA-134 CREB p-CREB Quantitative PCR Western blot Immunohistochemistry

Insight Into the Separation-of-Variable Methods for the Closed-Form Solutions of Free Vibration of Rectangular Thin Plates

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 329-355页

作者： Yufeng Xing ye yuan Gen Li Institute of Solid Mechanics Beihang University(BUAA)Beijing100191China

The separation-of-variable(SOV)methods,such as the improved SOV method,the variational SOV method,and the extended SOV method,have been proposed by the present authors and coworkers to obtain the closed-form analytical solutions for free vibration and eigenbuckling of rectangular plates and circular cylindrical *** taking the free vibration of rectangular thin plates as an example,this work presents the theoretical framework of the SOV methods in an instructive way,and the bisection–based solution procedures for a group of nonlinear eigenvalue ***,the explicit equations of nodal lines of the SOV methods are presented,and the relations of nodal line patterns and frequency orders are *** is concluded that the highly accurate SOV methods have the same accuracy for all frequencies,the mode shapes about repeated frequencies can also be precisely captured,and the SOV methods do not have the problem of missing roots as well.

关键词： Separation-of-variable method Rayleigh quotient nodal line eigenvalue equation bisection method

Effect of brain-derived neurotrophic factor on the change of glial fibrillary acidic protein in rat hippocampus after chronic unpredictable mild stress

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Effect of brain-derived neurotrophic factor on the change of...

Peripheral mitochondrial DNA as a neuroinflammatory biomarker for major depressive disorder

中华医学会精神病学分会第九次全国学术会议

作者： ye yuan-yuan,wang Gao-hua,wang Hui-ling and wang Xiao-ping Renmin Hospital of Wuhan University

Background To investigate the effect of brain-derived neurotrophic factor(BDNF)on the change of glial fibrillary acidic protein(GFAP)in the hippocampus of a rat model of depression.

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Neural Regeneration Research 2025年第6期20卷 1541-1554页

作者： Jinmei ye Cong Duan Jiaxin Han Jinrong Chen Ning Sun yuan Li Tifei yuan Daihui Peng Division of Mood Disorder Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Department of Psychiatry First Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Shanghai Key Laboratory of Psychotic Disorders Brain Health InstituteNational Center for Mental DisordersShanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Co-Innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina

In the pathogenesis of major depressive disorder, chronic stress-related neuroinflammation hinders favorable prognosis and antidepressant response. Mitochondrial DNA may be an inflammatory trigger, after its release from stress-induced dysfunctional central nervous system mitochondria into peripheral circulation. This evidence supports the potential use of peripheral mitochondrial DNA as a neuroinflammatory biomarker for the diagnosis and treatment of major depressive disorder. Herein, we critically review the neuroinflammation theory in major depressive disorder, providing compelling evidence that mitochondrial DNA release acts as a critical biological substrate, and that it constitutes the neuroinflammatory disease pathway. After its release, mitochondrial DNA can be carried in the exosomes and transported to extracellular spaces in the central nervous system and peripheral circulation. Detectable exosomes render encaged mitochondrial DNA relatively stable. This mitochondrial DNA in peripheral circulation can thus be directly detected in clinical practice. These characteristics illustrate the potential for mitochondrial DNA to serve as an innovative clinical biomarker and molecular treatment target for major depressive disorder. This review also highlights the future potential value of clinical applications combining mitochondrial DNA with a panel of other biomarkers, to improve diagnostic precision in major depressive disorder.

关键词： biomarker cytokine exosomes inflammasome major depressive disorder microglia mitochondrial DNA mitochondrial dysfunction neuroinflammation Toll-like receptor

The compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one alleviates neuroinflammation and cognitive impairment in a mouse model of Alzheimer's disease

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Neural Regeneration Research 2025年第11期20卷 3330-3344页

作者： Xueyan Liu Wei Wu Xuejuan Li Chengyan wang Ke Chai Fanru yuan Huijuan Zheng Yuxing Yao Chenlu Li Zu-Cheng ye Daijun Zha Department of Medicinal Chemistry School of PharmacyFujian Medical UniversityFuzhouFujian ProvinceChina Fujian Provincial Key Laboratory of Brain Aging and Neurodegenerative Diseases School of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina Institute of Laboratory Animal Center Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurosurgery Neurosurgery Research InstituteThe First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina Department of Hyperbaric Oxygen National Regional Medical CenterBinhai Campus of the First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina

Previous studies have shown that the compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one(D30),a pyromeconic acid derivative,possesses antioxidant and anti-inflammatory properties,inhibits amyloid-β aggregation,and alleviates scopolamine-induced cognitive impairment,similar to the phase Ⅲ clinical drug *** this study,we established a mouse model of Alzheimer's disease via intracerebroventricular injection of fibrillar amyloid-β to investigate the effect of D30 on fibrillar amyloid-β-induced *** results showed that D30 alleviated fibrillar amyloid-β-induced cognitive impairment,promoted fibrillar amyloid-β clearance from the hippocampus and cortex,suppressed oxidative stress,and inhibited activation of microglia and astrocytes.D30 also reversed the fibrillar amyloid-β-induced loss of dendritic spines and synaptic protein ***,we demonstrated that exogenous fibrillar amyloid-βintroduced by intracerebroventricular injection greatly increased galectin-3 expression levels in the brain,and this increase was blocked by *** the role of D30 in clearing amyloid-β,inhibiting neuroinflammation,protecting synapses,and improving cognition,this study highlights the potential of galectin-3 as a promising treatment target for patients with Alzheimer's disease.

关键词： Alzheimer's disease amyloid-β astrocyte cognitive impairment D30 dendritic spines galectin-3 microglia neuroinflammation neuron

基于数字几何信息增益的服装3D人体特征识别

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北京服装学院学报（自然科学版） 2016年第2期36卷 58-63页

作者：李丹华袁晔王帅军北京服装学院信息工程学院北京100029

提出了一种基于数字几何信息增益的服装3D人体特征识别算法.首先,给出3D扫描人体的数字几何信息增益的定义,计算3D扫描人体模型上各点的数字几何增益信息并将统计结果由大到小进行标记,由人体比例学将3D扫描人体模型区域分割为颈部、肩... 详细信息

提出了一种基于数字几何信息增益的服装3D人体特征识别算法.首先,给出3D扫描人体的数字几何信息增益的定义,计算3D扫描人体模型上各点的数字几何增益信息并将统计结果由大到小进行标记,由人体比例学将3D扫描人体模型区域分割为颈部、肩部、腋下、胸部、腰部、臀部,并选取数字几何信息增益值变化显著的点作为特征点.然后对特征点进行3次B样条拟合得到3D扫描人体轮廓线,并测定指导服装设计的人体尺寸数据.最后将人体尺寸测量结果与标记测试数据进行比较,计算误差值.仿真结果表明本文算法对不同的3D人体扫描模型具有准确的识别效果.

关键词：数字几何信息增益 3次B-样条插值 3D扫描人体特征识别

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基于SWOT视角下的深圳经济发展研究

企业技术开发 2010年第3期29卷 118-119,123页

作者：叶远望中南财经政法大学湖北武汉430074

文章以SWOT分析理论为基础,通过对深圳的经济发展优劣和机遇与威胁的具体分析,浅述了深圳经济发展的可行性建议。

关键词： SWOT 深圳经济发展产业转型产业升级

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外阴阴道假丝酵母菌病的菌种与耐药性研究

实用妇产科杂志 2010年第10期26卷 756-758页

作者：阳华叶元王玉春曾永群桂林医学院附属医院广西桂林541001

目的:对复发性外阴阴道假丝酵母菌病(RVVC)、外阴阴道假丝酵母菌病(VVC)患者阴道分泌物进行培养、菌种分型及药物敏感试验,探讨其治疗策略。方法:用沙氏培养基35℃培养194例患者阴道分泌物,其中RVVC97例,VVC97例。用API32℃假丝酵母菌... 详细信息

目的:对复发性外阴阴道假丝酵母菌病(RVVC)、外阴阴道假丝酵母菌病(VVC)患者阴道分泌物进行培养、菌种分型及药物敏感试验,探讨其治疗策略。方法:用沙氏培养基35℃培养194例患者阴道分泌物,其中RVVC97例,VVC97例。用API32℃假丝酵母菌鉴定板及ATBTMFUNGUS3药敏板接种,在ATBExpression全自动微生物鉴定仪判读结果。结果:在培养检测的194例阴道分泌物中白假丝酵母菌156例,占80.41%(156/194);RVVC组中73例为白假丝酵母菌,占75.26%(73/97),VVC组中83例为白假丝酵母菌,占85.57%(83/97)。RVVC组非白假丝酵母菌比例高,与VVC组比较差异有统计学意义(P<0.05)。RVVC组假丝酵母菌对氟康唑药物敏感率(68.04%)低于VVC组(86.60%)(P<0.05)。结论:VVC、RVVC的主要致病菌仍是白假丝酵母菌,RVVC组非白假丝酵母菌比例高于VVC组。RVVC组假丝酵母菌对氟康唑的敏感性明显低于VVC组。

关键词：外阴阴道假丝酵母菌病复发菌种分型药物敏感性试验