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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2015年第3期16卷 217-228页

作者： yuan-qing wang xiao-wei liao yuan-yuan zhang yong-jiu shi Key laboratory of Civil Engineering Safety and Durability of China Education Ministry Department of Civil Engineering Tsinghua University Beijing 100084 China

Lamellar tearing and crack-induced brittle failures along steel plates in the through-thickness direction seriously threaten the safety and reliability of steel thick plate structures in construction and service, especially at low ambient temperatures. Three kinds of tests, including uniaxial tensile tests, Charpy V-Notch impact tests, and three-point bending （TPB） tests were performed at normal and low temperatures to investigate the through-thickness mechanical properties, impact and fraclure toughness of Q345B structural steel plates with thicknesses from 60 to 165 mm. The test specimens were mainly sampled along the through-thickness direction of the plate, but transverse specimens along the rolling direction were also involved. The ductility index （percentage reduction of area）, impact toughness index （Charpy impact energy）, and fracture toughness index （critical crack tip opening displacement （CTOD） values） all decrease as the temperature declines. All the mechanical properties and the impact and fracture toughness along the through-thickness direction are worse than those along the rolling direction. The results also offer experimental support for the determination of an evaluation indicator for structural steel thick plates with through-thickness characteristics.

关键词： Structural steel thick plate Through-thickness properties Mechanical properties Impact toughness Fracturetoughness Low temperature

Stratigraphic framework and sedimentary evolution during the Cryogenian-Ediacaran transition in northeastern Sichuan Basin,South China

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Petroleum Science 2024年第2期21卷 823-835页

作者： Yi zhang Hong-wei Kuang yong-qing Liu Qiang shi Dong-Ge wang Ke-Ning Qi Yu-Chong wang Da-wei Qiao xiao-Shuai Chen Li-Zhi Wu Meng Tian Long Chen Yi wei liao-yuan Song Jian Li Zi-Gang Wu Yun-Qian Liu Xuan-Chun Liu An-qing Chen Zhi-wei liao Institute of Geology Chinese Academy of Geological SciencesBeijing100037China State Key Laboratory of Coal Mine Disaster Dynamics and Control School of Resources and Safety EngineeringChongqing UniversityChongqing400044China No.205 Geological Team Chongqing Bureau of Geology and Minerals ExplorationChongqing401121China Chongqing Institute of Geological Survey Chongqing401122China Key Laboratory of Deep-time Geography and Environment Reconstruction and Applications of Ministry of Natural Resources Chengdu University of TechnologyChengdu610059SichuanChina

The northeastern Sichuan area in the northern Yangtze margin has unique Ediacaran geological records,especially the Doushantuo Formation(DST),and become a hot research area in recent ***,the Cryogenian-Ediacaran(C-E)boundary has not been precisely identified,which restricts the in-depth study of geological information during this crucial transitional period and is unfavorable for a systematic and complete understanding of the Yangtze Block and even the global paleogeographic *** study conducted stratigraphy,sedimentology,and chronostratigraphy to establish the stratigraphic framework and sedimentary evolution of the C-E transition strata in northeastern *** results showed that the Ediacaran sediments,without the cap dolomite,unconformably overlaid the Cryogenian sediments in the studied *** Member II of the DST,characterized by 50-160 m of red-green sandstone(approximately equivalent to the original Chengkou“Guanyinya Formation”),directly overlaid the Cryogenian sediments and displayed a 623±2.3 Ma maximum depositional age from the detrital zircon U-Pb *** stratigraphic correlations indicate that the C-E transition strata in northeastern Sichuan had a consistent lithological association and sedimentary sequence characteristics but differed from the Three ***,the upper Nantuo massive glacial diamictites transition to the icebergs rafted lonestone-bearing mudstones at the top,then change upward to DST barrier coast *** proposed DST of the northeastern Sichuan Basin was divided into three lithostratigraphic members without the regional Member I cap dolomite:(i)Member II purple-red,gray-green sandstone strata,(ii)MemberⅢblack mudstone strata,and(iii)Member IV P-Mn bearing *** the C-E transition,the study area experienced(i)the global deglaciation stage in the terminal Marinoan glaciation and(ii)the filling-leveling up stage with clastic rocks in the early ***,the early Ediacaran

关键词： Marinoan glaciation Doushantuo formation Cap dolomite Deglacial and coastal deposits Detrital zircon U-Pb dating

Soluble CD4 effectively prevents excessive TLR activation of resident macrophages in the onset of sepsis

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Signal Transduction and Targeted Therapy 2023年第7期8卷 3498-3511页

作者： Sheng-yuan zhang Qiu-ping Xu Li-na shi shih-wen Li wei-hong wang qing-qing wang liao-xun Lu Hui xiao Jun-hong wang Feng-ying Li Yin-ming Liang Si-tang Gong Hao-ran Peng Zheng zhang Hong Tang CAS Key Laboratory of Molecular Virology and Immunology Institut Pasteur of ShanghaiChinese Academy of SciencesShanghai 210031China The Third People’s Hospital of Shenzhen Shenzhen 518112China University of Chinese Academy of Sciences Beijing 100101China The Laboratory of Genetic Regulators in The Immune System Xin-xiang Medical UniversityXin-xiangHenan Province 453003China The Joint Center of Translational Medicine Guangzhou Women and Children’s Medical Center and Institut Pasteur of ShanghaiGuangzhou 510623China Department of Microbiology Naval Medical UniversityShanghai 200433China State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Centre for Infectious DiseasesCollaborative Innovation Centre for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

T lymphopenia,occurring in the early phase of sepsis in response to systemic inflammation,is commonly associated with morbidity and mortality of septic *** have previously shown that a sufficient number of T cells is required to constrain Toll-like receptors(TLRs)mediated ***,the underlying mechanisms remains ***,we unveil that CD4^(+)T cells engage with MHC II of macrophages to downregulate TLR pro-inflammatory signaling.

关键词： CD4 TLR infections

CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci xiao-Jun Bi yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen shiqiang Chen Tianlu Chen wei Chen Xiang Chen xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

低温环境下桥梁钢Q345qD疲劳裂纹扩展行为研究

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工程力学 2018年第10期35卷 85-91页

作者：廖小伟王元清石永久陈宏土木工程安全与耐久教育部重点实验室清华大学土木工程系北京100084 清华大学建筑设计研究院有限公司北京100084

为了明确在寒冷地区服役桥梁钢的疲劳裂纹扩展行为,以16 mm厚桥梁钢Q345qD为研究对象,完成了室温和低温下的夏比冲击韧性试验、疲劳裂纹扩展速率试验和疲劳裂纹扩展门槛值试验。结果表明,夏比冲击功和试样断口剪切断面率随温度的降低而... 详细信息

为了明确在寒冷地区服役桥梁钢的疲劳裂纹扩展行为,以16 mm厚桥梁钢Q345qD为研究对象,完成了室温和低温下的夏比冲击韧性试验、疲劳裂纹扩展速率试验和疲劳裂纹扩展门槛值试验。结果表明,夏比冲击功和试样断口剪切断面率随温度的降低而减少;在应力比0.1、0.2和0.5条件下,疲劳裂纹扩展速率均随温度降低而变缓,该桥梁钢的疲劳韧-脆转变温度点在-60℃以下;在室温^-60℃,其裂纹扩展速率均对应力比的变化不敏感;应力比0.1条件下的疲劳裂纹扩展门槛值随温度的降低有略微增大的趋势。该批次桥梁钢表现出了良好的抵抗低温疲劳裂纹扩展性能,防止低温脆性破坏成为疲劳设计的重点;试验数据能为钢结构桥梁的进一步抗低温疲劳和防低温冷脆断裂设计提供参考。

关键词： Q345qD桥梁钢疲劳裂纹扩展低温门槛值韧-脆转变温度

低温环境下十字形非传力角焊缝接头的疲劳性能

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浙江大学学报（工学版） 2020年第10期54卷 2018-2026页

作者：廖小伟王元清吴剑国石永久浙江工业大学建筑工程学院浙江杭州310023 清华大学土木工程安全与耐久教育部重点实验室北京100084

为了研究低温环境下钢桥焊接细节的疲劳行为和性能,以典型的十字形非传力角焊缝接头为对象,开展室温和-60℃下的高周常幅疲劳试验;基于三维裂纹扩展数值模拟,分析低温对该焊接细节疲劳裂纹扩展寿命的影响机理.结果表明,该焊接细节的室温... 详细信息

为了研究低温环境下钢桥焊接细节的疲劳行为和性能,以典型的十字形非传力角焊缝接头为对象,开展室温和-60℃下的高周常幅疲劳试验;基于三维裂纹扩展数值模拟,分析低温对该焊接细节疲劳裂纹扩展寿命的影响机理.结果表明,该焊接细节的室温和-60℃条件下试验S-N疲劳寿命未表现出显著区别,初始焊接缺陷裂纹会在细节焊趾处的多个位置同时扩展;由低温环境导致的钢材断裂韧性的降低不会对该焊接细节的疲劳寿命产生明显影响.虽然低温会增强钢材抵抗疲劳裂纹扩展的能力,但是该焊接细节的疲劳寿命主要受焊接过程产生的多样化初始裂纹缺陷因素控制;建议采用考虑多裂纹耦合扩展的三维裂纹扩展数值模拟来更加精确地预测疲劳裂纹扩展寿命.

关键词：桥梁钢材十字形焊接接头低温疲劳裂纹扩展断裂力学

Timing analysis of the black hole candidate EXO 1846–031 with Insight-HXMT monitoring

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Research in Astronomy and Astrophysics 2021年第3期21卷 193-204页

作者： He-Xin Liu Yue Huang Guang-Cheng xiao qing-Cui Bu Jin-Lu Qu Shu zhang Shuang-Nan zhang Shu-Mei Jia Fang-Jun Lu Xiang Ma Lian Tao wei zhang Li Chen Li-Ming Song Ti-Pei Li Yu-Peng Xu Xue-Lei Cao yong Chen Cong-Zhan Liu Ce Cai Zhi Chang Gang Chen Tian-Xiang Chen Yi-Bao Chen Yu-Peng Chen wei Cui wei-wei Cui Jing-Kang Deng yong-wei Dong yuan-yuan Du Min-Xue Fu Guan-Hua Gao He Gao Min Gao Ming-Yu Ge Yu-Dong Gu Ju Guan Cheng-Cheng Guo Da-wei Han Jia Huo Lu-Hua Jiang wei-Chun Jiang Jing Jin yong-Jie Jin Ling-Da Kong Bing Li Cheng-Kui Li Gang Li Mao-Shun Li wei Li Xian Li xiao-Bo Li Xu-Fang Li Yang-Guo Li Zheng-wei Li xiao-Hua Liang Jing-yuan liao Bai-Sheng Liu Guo-qing Liu Hong-wei Liu xiao-Jing Liu Yi-Nong Liu Bo Lu Xue-Feng Lu Qi Luo Tao Luo Bin Meng Yi Nang Jian-Yin Nie Ge Ou Na Sai Ren-Cheng Shang Xin-Ying Song Liang Sun Ying Tan You-Li Tuo Chen wang Guo-Feng wang Juan wang Ling-Jun wang Weng-Shuai wang Yu-Sa wang Xiang-Yang Wen Bai-Yang Wu Bo-Bing Wu Mei Wu Shuo xiao Shao-Lin Xiong He Xu Jia-wei Yang Sheng Yang Yan-Ji Yang Yi-Jung Yang Qi-Bin Yi Qian-qing Yin yuan You Ai-Mei zhang Cheng-Mo zhang Fan zhang Hong-Mei zhang Juan zhang Tong zhang Wan-Chang zhang Wen-Zhao zhang Yi zhang Yi-Fei zhang yong-Jie zhang yuan-Hang zhang Yue zhang Zhao zhang Zhi zhang Zi-Liang zhang Hai-Sheng Zhao xiao-Fan Zhao shi-Jie Zheng Yao-Guang Zheng Deng-Ke Zhou Jian-Feng Zhou Yu-Xuan Zhu Ren-Lin Zhuang Yue Zhu Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China Institut fur Astronomie und Astrophysik Kepler Center for Astro and Particle PhysicsEberhard Karls Universität72076 TubingenGermany Department of Astronomy Beijing Normal UniversityBeijing 100088China Department of Astronomy Tsinghua UniversityBeijing 100084China Department of Physics Tsinghua UniversityBeijing 100084China Department of Engineering Physics Tsinghua UniversityBeijing 100084China Key Laboratory of Space Astronomy and Technology National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China College of Physics Sciences&Technology Hebei UniversityBaoding 071002Hebei ProvinceChina

We present the observational results from a detailed timing analysis of the black hole candidate EXO 1846-031 during its outburst in 2019 with the observations of Insight-HXMT,NICER and *** outburst can be classified roughly into four different ***-C quasi-periodic oscillations(QPOs)observed by NICER(about 0.1-6 Hz)and Insight-HXMT(about 0.7-8 Hz)are also reported in this ***,we study various physical quantities related to QPO *** QPO rms-frequency relationship in the energy band 1-10 keV indicates that there is a turning pointing in frequency around2 Hz,which is similar to that of GRS 1915+105.A possible hypothesis for the relationship above may be related to the inclination of the source,which may require a high inclination to explain *** relationships between QPO frequency and QPO rms,hardness,total fractional rms and count rate have also been found in other transient sources,which can indicate that the origin of type-C QPOs is non-thermal.

关键词： X-ray binaries black hole candidate QPO EXO 1846–031

Original article Efficacy and safety of Changfu peritoneal dialysis solution： a multi-center prospective randomized controlled trial

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Chinese Medical Journal 2013年第22期126卷 4204-4209页

作者： ZHOU Jian-hui NI Zhao-hui MEI Chang-lin YU Xue-qing LIU Fu-you MIAO Li-ning LIU Zhi-hong yuan wei-jie zhang Ai-ping LIN Hong-li CHEN Meng-hua CHEN Jiang-hua zhang Jin-yuan HE Ya-ni CHEN Jian ZHAO jiu-yang DING xiao-qiang LI Ying LI Rong-shan XIE Ru-juan LIU Wen-hu XING Chang-ying wang Rong DENG Yue-yi CAO Xue-ying CAI Guang-yan MOU Shan MAO Zhi-guo YANG xiao LIU Hong SUN Jing YU Yu-sheng LIU Jun shi Shu-mei LI Long-kai TIAN Na zhang xiao-hui ZHOU wei YANG Jie zhang yong SUN Jing-di JI Jun zhang Tao YAN Yan LIU xiao-gang wang Gang zhang Li zhang Hong LUO Jian-hua CHEN Xiang-mei Department of Nephrology State Key Laboratory of Kidney Disease Chinese People's Liberation Army General Hospital Beijing 100853 China Renal Division Renji Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200127 China

Background A multi-center large scale study is needed to confirm the efficacy and safety of domestic peritoneal dialysis （PD） solutions. Some researchers believe that 6 Lid is enough for adequate dialysis, but there is no multi-center prospective study on Chinese population to confirm this. In this study, we evaluated the efficacy and safety of domestic PD solution （Changfu） and its difference between 6 L and 8 L dosage. Methods Adult PD patients who had taken PD therapy for at least one month were selected and divided into four groups according to two dialysis solution brands and two dialysis dosages, i.e., 6 L dose with Changfu dialysis solution, 6 L dose with Baxter dialysis solution, 8 L dose with Changfu dialysis solution, and 8 L dose with Baxter dialysis solution. After 48 weeks, the changes of primary and secondary efficacy indices were compared between different types and different dosages. We also analyzed the changes of safety indices. Results Changes of Kt/V from baseline to 48 weeks between Changfu and Baxter showed no statistical differences; so did those of creatinine clearance rate （Ccr）. Normalized protein catabolic rate （nPCR） from baseline to 48 weeks between Changfu and Baxter showed no statistical differences; so did those of net ultrafiltration volume （nUF） and estimated glomerular filtration rate （eGFR）. Changes of nPCR from baseline to 48 weeks between 6 L and 8 L showed no statistical differences; so did those of nUF and eGFR. The decline of Kt/V from baseline to 48 weeks in 6 L group was more than that in 8 L group. Change of Ccr was similar. During the 48-week period, the mean Kt/V was above 1.7/w, and mean Ccr was above 50 L.1.73 m-2.w1. More adverse events were found in Changfu group before Changfu Corporation commenced technology optimization, and the statistical differences disappeared after that. Conclusions The domestic PD solution （Changfu） was proven to be as effective as Baxter dialysis solution. During 48- week period, a dosage o

关键词： Changfu peritoneal dialysis solution efficacy safety

基于SINTAP-FAD方法的含裂纹缺陷钢结构构件安全性评定研究

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工程力学 2017年第5期34卷 42-51页

作者：王元清廖小伟周晖石永久陈健陵叶国平清华大学土木工程系土木工程安全与耐久教育部重点实验室北京100084 北京工业大学城市与工程安全减灾教育部重点实验室北京100124 东方电气集团东方锅炉股份有限公司四川自贡643001 成都益国工程设计顾问有限公司四川成都610036

在施工和运营过程中,钢结构构件上出现的裂纹缺陷可能会扩展而导致其发生断裂破坏,因此对含裂纹缺陷钢结构构件的安全性进行评估具有重要意义。首先,引入断裂力学K_(IC)断裂判据和失效评定图(FAD)概念,并介绍了结构整体性评估程序(SINT... 详细信息

在施工和运营过程中,钢结构构件上出现的裂纹缺陷可能会扩展而导致其发生断裂破坏,因此对含裂纹缺陷钢结构构件的安全性进行评估具有重要意义。首先,引入断裂力学K_(IC)断裂判据和失效评定图(FAD)概念,并介绍了结构整体性评估程序(SINTAP)的原理;给出了裂纹缺陷评定所需材料参数的确定方法,以及含裂纹缺陷构件的断裂力学参数和塑性屈服荷载的计算方法;然后,提出了基于SINTAP-FAD的含裂纹缺陷钢结构构件的安全性评估流程。最后,以华南和华东两个电厂锅炉钢结构大板梁的焊接缺陷为例,进行了基于K_(IC)断裂判据和SINTAP-FAD的裂纹缺陷安全性评定研究。结果表明,基于SINTAP-FAD的方法为含裂纹缺陷工作的钢结构构件的安全性评估提供了一种行之有效的方法,考虑多裂纹耦合作用的安全性评定方法有待进一步研究。

关键词：钢结构构件裂纹缺陷断裂力学结构整体性评估程序安全性评定

The DIRECT consortium and the REST-meta-MDD project:towards neuroimaging biomarkers of major depressive disorder

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Psychoradiology 2022年第1期2卷 32-42页

作者： xiao Chen Bin Lu Hui-Xian Li Xue-Ying Li Yu-wei wang Francisco Xavier Castellanos Li-Ping Cao Ning-Xuan Chen wei Chen Yu-Qi Cheng shi-Xian Cui Zhao-Yu Deng Yi-Ru Fang Qi-yong Gong Wen-Bin Guo Zheng-Jia-Yi Hu Li Kuang Bao-Juan Li Le Li Tao Li Tao Lian Yi-Fan liao Yan-Song Liu Zhe-Ning Liu Jian-Ping Lu qing-Hua Luo Hua-qing Meng Dai-Hui Peng Jiang Qiu Yue-Di Shen Tian-Mei Si Yan-qing Tang Chuan-Yue wang Fei wang Hua-Ning wang Kai wang Xiang wang Ying wang Zi-Han wang xiao-Ping Wu Chun-Ming Xie Guang-Rong Xie Peng Xie Xiu-Feng Xu Hong Yang Jian Yang Shu-Qiao Yao yong-Qiang Yu yong-Gui yuan Ke-Rang zhang wei zhang Zhi-Jun zhang Jun-Juan Zhu Xi-Nian Zuo Jing-Ping Zhao Yu-Feng Zang the DIRECT consortium Chao-Gan Yan CAS Key Laboratory of Behavioral Science Institute of PsychologyChinese Academy of SciencesBeijing 100101China International Big-Data Center for Depression Research Chinese Academy of SciencesBeijing 100101China Magnetic Resonance Imaging Research Center Institute of PsychologyChinese Academy of SciencesBeijing 100101China Department of Psychology University of Chinese Academy of SciencesBeijing 100049China Sino-Danish College University of Chinese Academy of SciencesBeijing 101408China Sino-Danish Center for Education and Research Graduate University of Chinese Academy of SciencesBeijing 101408China Department of Child and Adolescent Psychiatry NYU Grossman School of MedicineNew YorkNY 10016USA Nathan Kline Institute for Psychiatric Research OrangeburgNew YorkNY 10962USA 9Affiliated Brain Hospital of Guangzhou Medical UniversityGuangzhou 510370China Capital Normal University Beijing 100089China Department of Psychiatry Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310020ZhejiangChina Department of Psychiatry First Affiliated Hospital of Kunming Medical UniversityKunmingYunnan 650032China Shanghai Mental Health Center Shanghai Jiao Tong University School of MedicineShanghai 200030China Huaxi MR Research Center(HMRRC) Department of RadiologyWest China Hospital of Sichuan UniversityChengduSichuan 610044China Research Unit of Psychoradiology Chinese Academy of Medical SciencesChengduSichuan 610052China Department of Psychiatry and National Clinical Research Center for Mental DisordersThe Second Xiangya Hospital of Central South UniversityChangsha 410011HunanChina Department of Psychiatry The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400042China Xijing Hospital of Air Force Military Medical University Xi’anShaanxi 710032China Center for Cognitive Science of Language Beijing Language and Culture UniversityBeijing 100083China Affiliated Mental Health Center&Hangzhou Seventh People’s Hospital Zhejiang University School of

Despite a growing neuroimaging literature on the pathophysiology of major depressive disorder(MDD),repro-ducible findings are lacking,probably reflecting mostly small sample sizes and heterogeneity in analytic *** address these issues,the Depression Imaging REsearch ConsorTium(DIRECT)was *** REST-meta-MDD project,pooling 2428 functional brain images processed with a standardized pipeline across all participating sites,has been the first effort from *** this review,we present an overview of the moti-vations,rationale,and principal findings of the studies so far from the REST-meta-MDD *** from the first round of analyses of the pooled repository have included alterations in functional connectivity within the default mode network,in whole-brain topological properties,in dynamic features,and in functional *** well-powered exploratory observations have also provided the basis for future longitudinal hypothesis-driven *** these fruitful explorations,DIRECT has proceeded to its second stage of data sharing that seeks to examine ethnicity in brain alterations in MDD by extending the exclusive Chinese original sample to other ethnic groups through international collaborations.A state-of-the-art,surface-based preprocessing pipeline has also been introduced to improve *** images from patients with bipolar disorder and schizophrenia will be included to identify shared and unique abnormalities across diag-nosis *** addition,large-scale longitudinal studies targeting brain network alterations following antidepressant treatment,aggregation of diffusion tensor images,and the development of functional magnetic resonance imaging-guided neuromodulation approaches are *** these endeavours,we hope to accelerate the translation of functional neuroimaging findings to clinical use,such as evaluating longitudinal effects of antidepressant medications and developing individualized

关键词： major depressive disorder DIRECT R-fMRI database neuroimaging