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Nano Research 2024年第6期17卷 5409-5423页

作者： Ding Wang Qi Jiang Ruoyu shen Lijun Peng Wentao Zhou Tingting Meng Fuqiang Hu Jianwei Wang Hong yuan College of Pharmaceutical Science Zhejiang UniversityHangzhou 310058China Jinhua Institute of Zhejiang University Jinhua 321299China The Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310009China

The destruction of the intestinal barrier is likely to cause an increase in intestinal permeability and cause pathological *** studies have demonstrated that intestinal barrier function plays an important role in the occurrence and development of inflammatory bowel disease(IBD).Oral administration is the most common route for intestinal *** this study,a synergistic strategy is proposed for IBD management through active barrier repair combined with anti-inflammatory treatment,which can interrupt the pathological process of IBD,resulting in the significantly improved efficacy of existing *** on the specific pH values and high reactive oxygen species(ROS)levels in inflammatory sites of IBD,an orally administrated ROS-responsive drug delivery system targeting inflamed colon has been designed,and confirmed in vitro and in *** anti-inflammatory drug dexamethasone acetate(Dex)and the barrier function regulator LY294002 are delivered by the synthesized nanocarrier to treat IBD synergistically by inhibiting inflammation and actively repairing the intestinal barrier through tight junctions(TJs).The accumulation of nanocarriers in the inflamed colon and synergistic efficacy has been validated in mice with *** brief,a drug delivery system and a therapeutic strategy for IBD are successfully developed.

关键词： nanotechnology reactive oxygen species(ROS)-responsive targeted delivery inflammatory bowel disease(IBD) intestinal barrier combination treatment

microRNA-2184 orchestrates Mauthner-cell axon regeneration in zebrafish via syt3 modulation

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Journal of Genetics and Genomics 2024年第9期51卷 911-921页

作者： Xinghan Chen Yueru shen Zheng Song Xinliang Wang Huaitong Yao yuan Cai Zi-Ang Zhao Bing Hu Hefei National Research Center for Physical Sciences at the Microscale University of Science and Technology of ChinaHefeiAnhui 230026China The First Affiliated Hospital of USTC Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui 230026China Center for Advanced Interdisciplinary Science and Biomedicine of IHM Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui 230026China

MicroRNAs(miRNAs)play a significant role in axon regeneration following spinal cord ***,the functions of numerous miRNAs in axon regeneration within the central nervous system(CNS)remain largely ***,we elucidate the positive role of microRNA-2184(miR-2184)in axon regeneration within zebrafish Mauthner cells(M-cells).The upregulation of miR-2184 in a single M-cell can facilitate axon regeneration,while the specific sponge-induced silencing of miR-2184 leads to impeded *** show that syt3,a downstream target of miR-2184,negatively regulates axon regeneration,and the regeneration suppression modulated by syt3 depends on its binding to Ca2+.Furthermore,pharmacological stimulation of the cAMP/PKA pathway suggests that changes in the readily releasable pool may affect axon *** data indicate that miR-2184 promotes axon regeneration of M-cells within the CNS by modulating the downstream target syt3,providing valuable insights into potential therapeutic strategies.

关键词： Axon regeneration Axon ablation miR-2184 syt3 Readily releasable pool

Microwave-Assisted Confining Growth and Liquid Exfoliation of sp^(3)-Hybrid Carbon Nitride Nano/Micro-Crystals

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Energy & Environmental Materials 2024年第6期7卷 399-408页

作者： Chenglong shen qing Lou Kaikai Liu Guangsong Zheng Runwei Song Jinhao Zang Xigui Yang Xing Li Lin Dong Chongxin Shan Henan Key Laboratory of Diamond Optoelectronic Materials and Devices Key Laboratory of Material PhysicsMinistry of EducationSchool of Physics and Laboratory of Zhongyuan LightZhengzhou UniversityZhengzhou 450052China

As one promising carbon-based material,sp^(3)-hybrid carbon nitride has been predicted with various novel physicochemical ***,the synthesis of sp^(3)-hybrid carbon nitride is still limited by the nanaoscale,low crystallinity,complex source,and expensive ***,we have presented a facile approach to the sp^(3)-hybrid carbon nitride nano/micro-crystals with microwave-assisted confining growth and liquid ***,the carbon nitride nano/micro-crystals can spontaneously emerge and grow in the microwave-assisted polymerization of citric acid and urea,and the liquid exfoliation can break the bulk disorder polymer to retrieve the highly crystalline carbon nitride nano/*** obtained carbon nitride nano/micro-crystals present superior blue light absorption strength and surprising photoluminescence quantum yields of 57.96%in ethanol and 18.05%in solid *** experimental characterizations and density functional theory calculations reveal that the interface-trapped localized exciton may contribute to the excellent intrinsic light emission capability of carbon nitride nano/micro-crystals and the interparticle staggered stacking will prevent the aggregation-caused-quenching ***,the carbon nitride nano/micro-crystals are demonstrated to be potentially useful as the phosphor medium in light-emitting-diode for interrupting blue light-induced eye *** work paves new light on the synthesis strategy of sp^(3)-hybrid carbon nitride materials and thus may push forward the development of multiple carbon nitride research.

关键词： confining growth density functional theory liquid exfoliation luminescence sp^(3)-hybrid carbon nitride

Ketogenic diet therapy in children with epilepsy caused by SLC2A1 mutations:a single-center single-arm retrospective study

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World Journal of Pediatrics 2024年第5期20卷 517-524页

作者： Ying-Yan Wang Yun-qing Zhou Li-Juan Luo Cui-Jin Wang Nan shen Hao Li Ji-Wen Wang Department of Neurology Shanghai Children’s Medical CenterSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Infectious Diseases Shanghai Children’s Medical CenterSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Clinical Research Ward Clinical Research CenterShanghai Children’s Medical CenterSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina

Background This retrospective study assessed the efficacy and safety of ketogenic diet therapies in children with epilepsy caused by SLC2A1 genetic mutations and glucose transporter type 1 deficiency *** Pediatric patients with epilepsy symptoms admitted to our medical center between January 2017 and October 2021 were included if they presented with an SLC2A1 genetic mutation on whole-exome *** analyzed the patients’convulsions and treatment with antiepileptic *** patients were followed up at different time periods after ketogenic diet *** Six patients with SLC2A1 mutations were included in this *** patients had seizures of different types and frequencies,and they took antiepileptic drugs to relieve their *** were then treated with a ketogenic diet for at least four *** analyzed epilepsy control rates at 1,2,3,6,and 12 months after ketogenic diet *** patients were seizure-free within a month of receiving the diet *** patients were followed up for six months,three were followed up for 12 months after the treatment,and there was no recurrence of epilepsy during this *** antiepileptic drug withdrawal,none of the patients experienced seizure relapse when receiving ketogenic diet treatment *** severe adverse events occurred during the *** Ketogenic diet therapy is very effective and safe for the treatment of epilepsy caused by SLC2A1 ***,patients with glucose transporter type 1 deficiency syndrome caused by SLC2A1 mutations should begin ketogenic diet treatment as soon as possible.

关键词： Epilepsy Glucose transporter type 1 Ketogenic diet SLC2A1

GAN-DIRNet:A Novel Deformable Image Registration Approach for Multimodal Histological Images

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Computers, Materials & Continua 2024年第7期80卷 487-506页

作者： Haiyue Li Jing Xie Jing Ke Ye yuan Xiaoyong Pan Hongyi Xin Hongbin shen Institute of Image Processing and Pattern Recognition Shanghai Jiao Tong Universityand Key Laboratory of System Control and Information ProcessingMinistry of Education of ChinaShanghai200240China Department of Pathology Ruijin HospitalShanghai Jiao Tong UniversitySchool of MedicineShanghai200025China Department of Computer Science and Engineering Shanghai Jiao Tong UniversityShanghai200240China Global Institute of Future Technology Shanghai Jiao Tong UniversityShanghai200240China

Multi-modal histological image registration tasks pose significant challenges due to tissue staining operations causing partial loss and folding of *** neural network(CNN)and generative adversarial network(GAN)are pivotal inmedical image ***,existing methods often struggle with severe interference and deformation,as seen in histological images of conditions like Cushing’s *** argue that the failure of current approaches lies in underutilizing the feature extraction capability of the discriminator *** this study,we propose a novel multi-modal registration approach GAN-DIRNet based on GAN for deformable histological image *** begin with,the discriminators of two GANs are embedded as a new dual parallel feature extraction module into the unsupervised registration networks,characterized by implicitly extracting feature descriptors of specific ***,modal feature description layers and registration layers collaborate in unsupervised optimization,facilitating faster convergence and more precise ***,experiments and evaluations were conducted on the registration of the Mixed National Institute of Standards and Technology database(MNIST),eight publicly available datasets of histological sections and the Clustering-Registration-Classification-Segmentation(CRCS)dataset on the Cushing’s *** results demonstrate that our proposed GAN-DIRNet method surpasses existing approaches like DIRNet in terms of both registration accuracy and time efficiency,while also exhibiting robustness across different image types.

关键词： Histological images registration deformable registration generative adversarial network cushing’s disease machine learning computer vision

Characterization of local chemical ordering and deformation behavior in high entropy alloys by transmission electron microscopy

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International Journal of Minerals,Metallurgy and Materials 2024年第5期31卷 877-886页

作者： Qiuhong Liu qing Du Xiaobin Zhang yuan Wu Andrey A.Rempel Xiangyang Peng Xiongjun Liu Hui Wang Wenli Song Zhaoping Lü Beijing Advanced Innovation Center for Materials Genome Engineering State Key Laboratory for Advanced Metals and MaterialsUniversity of Science and Technology BeijingBeijing 100083China School of Materials Science and Engineering Ocean University of ChinaQingdao 266100China Institute of Metallurgy of the Ural Branch of the Russian Academy of Sciences Ekaterinburg 620016Russia China Nuclear Power Technology Research Institute Co.Ltd. Shenzhen 518000China Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China

Short-range ordering(SRO)is one of the most important structural features of high entropy alloys(HEAs).However,the chemical and structural analyses of SROs are very difficult due to their small size,complexed compositions,and varied *** electron microscopy(TEM)as well as its aberration correction techniques are powerful for characterizing SROs in these compositionally complex *** this short communication,we summarized recent progresses regarding characterization of SROs using TEM in the field of *** using advanced TEM techniques,not only the existence of SROs was confirmed,but also the effect of SROs on the deformation mechanism was ***,the perspective related to application of TEM techniques in HEAs are also discussed.

关键词： high entropy alloys transmission electron microscopy short-range ordering deformation mechanisms

Microstructure and properties of coarse-grained WC-10Co cemented carbides with different carbon contents during heat treatments

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Rare Metals 2024年第4期43卷 1786-1792页

作者： yuan-Feng Xie Xing-Cheng Xie Zhong-Wu Li Rui-Jun Cao Zhong-Kun Lin qing Li Chen-Guang Lin Powder Metallurgy and Special Materials Research Department General Research Institute for Nonferrous MetalsBeijing100088China

The effects of cryogenic treatment(CT)and tempering-cryogenic treatment(TCT)on the microstructure and properties of coarse-grained WC-10Co cemented carbides with different carbon contents were *** binder phase,WC mean grain sizes,W solubility in the binder,relative magnetic s aturation,densities,hardness,wear resistance and second phase precipitation of cemented carbides with different heat treatments were *** results show that there are significant changes of microstructure and properties in the samples with CT and TCT,especially due to the precipitation of metastable nanoparticles W_(x)Co_(y)C_(z) in the binder during the heat treatments of CT and *** the simultaneous combination of microstructure and nanoparticle-reinforced binder,a dramatically improved combination of hardness and wear resistance of the samples after TCT has been achieved.

关键词： Cryogenic treatment Tempering Coarsegrained cemented carbide Carbon content Nanoparticlereinforced binder

Characteristics of life-cycle carbon dioxide emissions of arterial highway maintenance and the influencing factors

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Advances in Climate Change Research 2024年第4期15卷 751-765页

作者： Yao WANG yuan-qing WANG Shu-Juan JI Si-Jia SUN Shu-Hong MA Ya-Nan GAO Key Laboratory of Transport Industry of Management Control and Cycle Repair Technology for Traffic Network Facilities in Ecological Security Barrier Area Chang'an UniversityXi'an 710064China Guangzhou Aids to Navigation Office Southem Navigation Service CenterMaritime Safety AdministrationGuangzhou 51000China

With the focus of highway development transitioning from construction to maintenance,a comprehensive understanding of the characteristics and influencing factors of carbon dioxide(CO_(2))emissions from highway maintenance activities is crucial for formulating effective strategies to promote the low-carbon development of road ***,the quantitative relationships between CO_(2) emissions from highway maintenance schemes and factors such as pavement deterioration,traffic volume,and road grade remain unclear owing to a lack of compre-hensive,multi-category,and real *** real maintenance data from 340 arterial highway segments in China,this study conducts the life cycle assessment(LCA)to estimate CO_(2) emissions from maintenance activities and examines the primary emission sources among various structural layers and ***,multiple linear regression(MLR)analysis is conducted to investigate the impact of traffic volume,road grade,and pavement deterioration on CO_(2) emissions from maintenance projects,and factors influencing the early-stage degradation of pavement *** results demonstrate that average CO_(2) emissions from heavy rehabilitation projects are 6.97 times higher than those from medium rehabilitation *** from heavy rehabilitation projects exhibit a significantly negative linear relationship with the riding quality index(RQI)before maintenance(p<0.05),and emissions from medium rehabilitation projects show a significant negative linear relationship with the pavement condition index(PCI)before maintenance(p<0.05).Emissions from heavy and medium rehabilitation projects are significantly positively correlated with heavy vehicle traffic volume before maintenance(p<0.05).Moreover,the early-stage degradation of PCI after heavy rehabilitation and RQI after medium rehabilitation exhibit significantly negative linear relationships with their respective in-dicators before maintenance(p<0.05).The early-stage d

关键词： Life cycle assessment(LCA) Arterial highway Maintenance Emission factor Pavement performance Traffic volume

Exfoliation Corrosion of As‑Extruded Mg–1Li–1Ca:the Influence of the Superficial Layer

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Acta Metallurgica Sinica(English Letters) 2024年第8期37卷 1339-1353页

作者： Ze‑Song Wei Zi‑You Ding Lei Cai Shao‑Xia Ma Dong‑qing Zhao Lan‑Yue Cui Cheng‑Bao Liu yuan‑sheng Yang yuan‑Ding Huang Rong‑Chang Zeng Corrosion Laboratory for Light Metals College of Materials Science and EngineeringShandong University of Science and TechnologyQingdao 266590China Engineering Research Center for Magnesium‑Based New Materials Center for Advancing Materials Performance from the Nanoscale(CAMP‑Nano)State Key Laboratory for Mechanical Behavior of MaterialsXi’an Jiaotong UniversityXi’an 710049China Shandong Provincial Key Laboratory of High Strength Lightweight Metallic Materials Advanced Materials InstituteQilu University of Technology(Shandong Academy of Sciences)Jinan 250014China Institute of Metals Research Chinese Academy of SciencesShenyang 110016China Institute of Metallic Biomaterials Helmholtz-Zentrum HereonMax‑Planck‑Str.121502 GeesthachtGermany

Exfoliation corrosion(EFC)has rarely been reported for wrought magnesium *** EFC of the as-extruded Mg–1Li–1Ca alloy was observed after the removal of outermost fine-grained *** microstructure and corrosion products were investigated using optical microscopy,scanning electron microscopy,electron backscattered diffraction,X-ray diffraction,and Fourier transform infrared *** corrosion behavior was analyzed using electrochemical polarization,electrochemical impedance spectroscopy,and scanning Kelvin probe *** results indicated that the surface of Mg–1Li–1Ca,with the superficial layer removed,was more susceptible to EFC.A linear correlation between grain boundary density and corrosion resistance was ***,the influence of factors such as grain size,intermetallic compounds,different alloy surfaces,and corrosion products on EFC were discussed,and the corresponding EFC mechanism was clarified.

关键词： Magnesium alloys Exfoliation corrosion Microstructure Intermetallic compound Metamorphic skin

Long-term thinning decreases the contribution of heterotrophic respiration to soil respiration in subalpine plantations

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Journal of Forestry Research 2024年第3期35卷 189-204页

作者： Longfei Chen Zhibin He Wenzhi Zhao Xi Zhu Qin shen Mingdan Song Zhengpeng Li Junqia Kong Shuping Yang yuan Gao Northwest Institute of Eco-Environment and Resources Chinese Academy of SciencesLanzhou 730000People's Republic of China State Forestry Administration Key Laboratory of Forest Resources and Environmental Management Beijing Forestry UniversityBeijing 100083People's Republic of China Academy of Agriculture and Forestry Sciences Qinghai UniversityXining 810000People's Republic of China College of Landscape Architecture Zhejiang A&F UniversityHangzhou 310000People's Republic of China

Interest in the dynamics of soil respiration(R_(S))in subalpine forest ecosystems is increasing due to their high soil carbon density and potential sensitivity to environmental ***,as a principal silvicultural practice,the long-term impacts of thinning on R_(S) and its heterotrophic and autotrophic respiration components(R_(h) and Ra,respectively)in subalpine plantations are poorly understood,espe-cially in winter.A 3-year field observation was carried out with consideration of winter CO_(2) efflux in middle-aged sub-alpine spruce plantations in northwestern China.A trench-ing method was used to explore the long-term impacts of thinning on Rs,Rn and R_(a).Seventeen years after thinning,mean annual Rs,Rn and R_(a) increased,while the contribu-tion of R_(h) to R_(s) decreased with thinning *** significantly decreased winter R,because of the reduction in R_(n) but had no significant effect on *** temperature sensitivity(Q_(10))of R_(h) and R_(a) also increased with thinning intensity,with lower Q_(10) values for R_(h)(2.1-2.6)than for Ra(2.4-2.8).The results revealed the explanatory variables and pathways related to R_(n) and R_(a) *** increased soil moisture and nitrate nitrogen(NO_(3)^(-)-N),and the enhanced nitrogen and water availability promoted R_(h) and R_(a) by improving fine root biomass and microbial *** results highlight the positive roles of NO_(3)^(-)-N in stimulating R_(s) components following long-term ***,applications of nitrogen fertilizer are not recommended while thinning subalpine spruce plantations from the perspective of reducing soil CO_(2) *** increased Q_(10) values of R_(s) components indicate that a large increase in soil CO_(2) emissions would be expected following thinning because of more pronounced climate warming in alpineregions.

关键词： Heterotrophic respiration Autotrophic respiration Long-term thinning impacts Cold seasons Subalpine plantations Temperature sensitivity