检索结果-南通市图书馆

在线全文

学校读者我要写书评

暂无评论

自身免疫相关性癫痫临床研究进展

中国现代神经疾病杂志 2023年第2期23卷 94-99页

作者：任瑞青沈恺源丁晶汪昕复旦大学附属中山医院神经内科上海200032

癫痫病因复杂,免疫因素已成为癫痫的独立病因。随着对“自身免疫性癫痫”概念和发病机制的深入研究,提出“继发于自身免疫性脑炎的急性症状性发作”和“自身免疫相关性癫痫”两个概念。本文介绍“自身免疫相关性癫痫”概念进展,阐述抗... 详细信息

癫痫病因复杂,免疫因素已成为癫痫的独立病因。随着对“自身免疫性癫痫”概念和发病机制的深入研究,提出“继发于自身免疫性脑炎的急性症状性发作”和“自身免疫相关性癫痫”两个概念。本文介绍“自身免疫相关性癫痫”概念进展,阐述抗神经元细胞内或细胞表面抗原抗体通过不同途径介导癫痫发作的作用机制,总结常见的以癫痫发作为主要表现的自身免疫性脑炎,以提高临床对自身免疫相关性癫痫的认识及诊断术语的规范。

关键词：脑炎自身免疫疾病癫痫自身抗体神经元综述

The Identification of the Cryptosporidium ubiquitum in Pre-weaned Ovines from Aba Tibetan and Qiang Autonomous Prefecture in China

在线全文

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2011年第3期24卷 315-320页

作者： shen YuJuan YIN JianHai yuan ZhongYing LU Weiyuan XU YuXin XIAO LiHua CAO JianPing National Institute of Parasitic Diseases Chinese Center for Disease Control and Prevention Laboratory of Parasite and Vector Biology MOH China WHO Collaborating Centre for Malaria Schistosomiasis and Filariasis Shanghai 200025 China Centers for Disease Control and Prevention Atlanta Georgia USA

Objective Cryptosporidium spp. are prevalent globally and sheep are an important zoonotic reservoir. Little data regarding the rates of Cryptosporidium infections in ovines in China are available. This study assessed the prevalence of Cryptosporidium spp. in pre-weaned ovines from Aba Tibetan and Qiang Autonomous Prefecture in the Sichuan province of China. Methods A total of 213 fecal samples were collected from pre-weaned ovines and were examined microscopically （following modified acid fast staining）. In addition, 18S rRNA genetic sequences were amplified from fecal samples by nested PCR and phylogenetically analyzed. Results The prevalence of Cryptosporidium in the collected samples was at 14.6% （31/213） and four isolates identified by PCR belonged to the Cryptosporidium cervine genotype （Cryptosporidium ubiquiturn） demonstrating that this species was the primary sheep species found in sheep in China. Conclusion The present study suggested that the high incidence of Cryptosporidium in sheep poses a significant public health threat and that surveillance practices must be established to prevent zoonotic disease of humans.

关键词： Cryptosporidium ubiquitum Ovines Aba China Cryptosporidium cervine genotype

血清miR-203a、miR-31-5p、miR-19b-1-5p水平与股骨颈骨折患者骨折延迟愈合的关系及其预测价值分析

在线全文

学校读者我要写书评

暂无评论

现代生物医学进展 2024年第5期24卷 949-954页

作者：周屾裴方彭大霖闫梓文金王亦王国梁王远郭开今徐州医科大学研究生院江苏徐州221006 徐州医科大学附属医院骨科江苏徐州221004

目的:探讨血清微小核糖核酸(miR)-203a、miR-31-5p、miR-19b-1-5p水平与股骨颈骨折患者术后骨折延迟愈合的关系及对术后骨折延迟愈合的预测价值。方法:选择2020年1月~2022年10月在徐州医科大学附属医院行内固定治疗的292例新鲜股骨颈骨... 详细信息

目的:探讨血清微小核糖核酸(miR)-203a、miR-31-5p、miR-19b-1-5p水平与股骨颈骨折患者术后骨折延迟愈合的关系及对术后骨折延迟愈合的预测价值。方法:选择2020年1月~2022年10月在徐州医科大学附属医院行内固定治疗的292例新鲜股骨颈骨折患者为研究对象。于术后4周复查时,检测患者血清miR-203a、miR-31-5p、miR-19b-1-5p水平;并根据其骨折愈合情况分为延迟组(n=36)和愈合组(n=256)。采用多因素Logistic回归分析股骨颈骨折患者术后骨折延迟愈合的影响因素。采用受试者工作特征(ROC)曲线分析血清miR-203a、miR-31-5p、miR-19b-1-5p对股骨颈骨折患者术后骨折延迟愈合的预测价值。结果:术后4个月复查时,骨折延迟愈合发生率为12.33%。两组年龄、吸烟史、合并糖尿病组间比较,差异有统计学意义(P<0.05)。愈合组血清miR-203a、miR-31-5p、miR-19b-1-5p水平均高于延迟组(P<0.05)。多因素Logistic回归分析结果显示,年龄≥60岁、合并糖尿病、血清miR-203a、miR-31-5p、miR-19b-1-5p水平降低是股骨颈骨折患者术后骨折延迟愈合的独立危险因素(P<0.05)。ROC曲线结果显示,三者联合检测的曲线下面积(AUC)(0.95CI)为0.841(0.738~0.936),高于各指标单独应用时的AUC,三者联合检测的灵敏度和特异度亦高于单一指标检测。结论:血清miR-203a、miR-31-5p、miR-19b-1-5p在股骨颈骨折术后骨折延迟愈合患者中呈低表达,是骨折延迟愈合的独立危险因素,三者联合检测对股骨颈骨折患者骨折延迟愈合具有较高的预测价值。

关键词：股骨颈骨折延迟愈合 miR-203a miR-31-5p miR-19b-1-5p 预测价值

Search for variable stars in the open cluster NGC 1245

在线全文

学校读者我要写书评

暂无评论

Research in Astronomy and Astrophysics 2021年第5期21卷 223-234页

作者： Dong-Xiang shen Yu Zhang Chun-Yan Li Xiang-Yun Zeng Guo-Liang Lv Chun-Hua Zhu qing-Shun Hu Jin-Zhong Liu School of Physical Science and Technology Xinjiang UniversityUrumqi 830046China Xinjiang Astronomical Observatory National Astronomical ObservatoriesChinese Academy of SciencesUrumqi 830000China University of Chinese Academy of Sciences Beijing 100049China

We used the Nanshan 1 m telescope of Xinjiang Astronomical Observatory to investigate variable stars in the region of NGC 1245. We detected 55 variable stars in the field of view, 42 of them are newly discovered: six binaries, 22 pulsating stars, 14 unclassified variables. We discussed the physical properties and classifications of the variable stars through their light curves. The cross-matching with the members catalog of NGC 1245 suggests that 10 variable stars are identified as probable cluster members, which including one EW type binary, eight δ Scuti stars, and an unknown type variable star. Since the difference of the members catalog of the cluster and the limitations of the instrument, there are some huge differences in the variable list of NGC 1245 compared with the previous work.

关键词： open clusters and associations:individual(NGC 1245) stars:variables:general stars:variables:delta Scuti binaries:eclipsing

Science Letters:Assignment of CCR7 gene to chicken chromosome 27 by radiation hybrid panel mapping

在线全文

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2007年第5期8卷 314-317页

作者： TIAN Yong LU Li-zhi FU Yan TAO Zheng-rong shen Jun-da WANG De-qian yuan Ai-ping YIN Zhao-zheng Laboratory of Animal Genetics College of Animal Sciences Zhejiang University Hangzhou 310029 China Institute of Animal Husbandry and Veterinary Science Zhejiang Academy of Agricultural Sciences Hangzhou 310021 China

The protein encoded by CC chemokine receptor 7 (CCR7) is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. To map the CCR7 gene in chicken chromosome, a 6 000 rads chicken-hamster radiation hybrid panel (ChickRH6) was used. PCR of samples from ChickRH6 revealed that the location of CCR7 gene is linked to the maker SEQ0347 (6 cR away) with LOD score of 16.6 and that the marker SEQ0347 is located on chromosome 27 at 27 cR of RH (radiation hydrid) map. We compared the corresponding human mRNA sequence with the predicted coding sequence of chicken CCR7 gene, and found that the assembled contig shared a high percentage of similarity with that of the human gene.

关键词： Radiation hybrid panel Mapping CCR7 gene Chicken

The Progress of PD-1 Inhibitors in Small-Cell Lung Cancer

在线全文

学校读者我要写书评

暂无评论

The Progress of PD-1 Inhibitors in Small-Cell Lung Cancer

连云港市2018—2022年度流感暴发疫情流行病学特征及相关影响因素

浙江省免疫学会第六次会员代表大会暨第十一次学术大会

作者： Mengyuan Yang Ying yuan Hong shen DepartmentofMedicalOncology theSecondAffiliatedHospitalZhejiangUniversitySchoolofMedicine

Recently,the immune checkpoint inhibitors have shown significant clinical responses in a variety of malignancies,including melanoma,non-small-cell lung cancer(NSCLC)and renal carcinoma *** num

关键词： small-cell lung cancer PD-1 inhibitors animal experiments clinical trials

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

江苏预防医学 2024年第2期35卷 191-194页

作者：沈飞虎程晓庆赵兴杨皓舒徐梦蝶穆星宇李海朋连云港市疾病预防控制中心江苏连云港222003 江苏省现场流行病学培训项目江苏省疾病预防控制中心

目的了解连云港市流感暴发疫情的流行病学特征,为防控流感暴发提供依据。方法收集连云港市2018—2022年度流感暴发疫情资料,对其流行病学特征进行描述性分析,并分析流行强度和疫情持续时间的影响因素。结果2018—2022年度连云港市共报告... 详细信息

目的了解连云港市流感暴发疫情的流行病学特征,为防控流感暴发提供依据。方法收集连云港市2018—2022年度流感暴发疫情资料,对其流行病学特征进行描述性分析,并分析流行强度和疫情持续时间的影响因素。结果2018—2022年度连云港市共报告160起流感暴发疫情,累计发病4701例,平均罹患率为1.22%,主要发生在小学,114起,占71.25%;地区分布主要在海州区,112起,占70.00%。流感暴发高峰期在每年3月(54.38%)及12月(22.50%),总体以A型流感为主,但优势型别每年呈交替流行。不同学校类型中,幼儿园罹患率>3%的疫情数占比最大,为75.00%(9/12);学校规模越小,罹患率>3%的疫情数占比越大。规模≤1000人的学校疫情持续时间≤7 d占比最高,为79.41%(27/34)。结论流感暴发疫情多发生于冬春季,小学是高发场所,幼儿园、小规模学校的流感罹患率相对较高,需要重点关注。

关键词：流感暴发疫情小学流行病学特征

Intestinal Mucosal-Associated Lymphoid Tissue Lymphoma Mimicked Cryptogenic Multifocal Ulcerous Stenosing Enteritis

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2018年第9期131卷 1126-1127页

作者： Kai-Ni shen Yan Zhang Jiao-Lin Zhou Xuan Wang Xiao-qing Li Department of Internal Medicine Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China Department of Hematology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China Department of General Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China Department of Radiology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China Department of Gastroenterology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China

To the Editor：A 50-year-old man was admitted to Peking Union Medical College Hospital with recurrent abdominal pain,vomiting,and *** the past 2 years,he had visited several hospitals for abdominal discomfort and was ... 详细信息

关键词： POSITRON-EMISSION-TOMOGRAPHY

在线全文

学校读者我要写书评

暂无评论

基于蚁群算法的定向扩散算法研究

传感技术学报 2008年第7期21卷 1226-1231页

作者：张小庆李腊元武汉理工大学计算机科学与技术学院武汉430063

无线传感器网络中定向扩散算法周期性地进行探测分组扩散时采用的是洪泛方式,这样会给网络带来巨大负载,严重影响网络的传输性能。提出一种改进的蚁群算法并将其应用于定向扩散协议中,算法中将定向扩散中的梯度建立在蚁群的信息素与网... 详细信息

无线传感器网络中定向扩散算法周期性地进行探测分组扩散时采用的是洪泛方式,这样会给网络带来巨大负载,严重影响网络的传输性能。提出一种改进的蚁群算法并将其应用于定向扩散协议中,算法中将定向扩散中的梯度建立在蚁群的信息素与网络节点剩余能量基础上,在寻找优化路径的同时,使网络节点能量得到均衡消耗。通过仿真实验验证了新方法的可行性,仿真结果表明新方法有效地控制了网络节点能量的均衡消耗,延长了整个网络的生存周期。

关键词：无线传感器网络定向扩散梯度蚁群算法洪泛路由