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Biomimetic natural biomaterials for tissue engineering and regenerative medicine:new biosynthesis methods,recent advances,and emerging applications

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Military Medical Research 2024年第1期11卷 50-79页

作者： Shuai Liu Jiang-Ming Yu Yan-chang Gan Xiao-Zhong Qiu Zhe-Chen Gao Huan Wang Shi-Xuan Chen yuan Xiong Guo-Hui Liu Si-En Lin Alec McCarthy Johnson V.John Dai-Xu Wei Hong-Hao Hou Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering the Fifth Affiliated HospitalSchool of Basic Medical ScienceSouthern Medical UniversityGuangzhou 510900China Department of Orthopedics Tongren HospitalShanghai Jiao Tong UniversityShanghai 200336China The Eighth Affiliated Hospital Sun Yat-Sen UniversityShenzhen 518033GuangdongChina Engineering Research Center of Clinical Functional Materials and Diagnosis&Treatment Devices of Zhejiang Province Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhou 325011ZhejiangChina Department of Orthopedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Orthopaedics and Traumatology Faculty of Medicinethe Chinese University of Hong KongHong Kong SAR 999077China Department of Functional Materials Terasaki Institute for Biomedical InnovationLos AngelesCA 90064USA Mary&Dick Holland Regenerative Medicine Program College of MedicineUniversity of Nebraska Medical CenterOmahaNE 68130USA Zigong Affiliated Hospital of Southwest Medical University Zigong Psychiatric Research CenterZigong Institute of Brain ScienceZigong 643002SichuanChina Key Laboratory of Resource Biology and Biotechnology in Western China Ministry of EducationSchool of MedicineDepartment of Life Sciences and MedicineNorthwest UniversityXi’an 710127China

Biomimetic materials have emerged as attractive and competitive alternatives for tissue engineering(TE)and regenerative *** contrast to conventional biomaterials or synthetic materials,biomimetic scaffolds based on natural biomaterial can offer cells a broad spectrum of biochemical and biophysical cues that mimic the in vivo extracellular matrix(ECM).Additionally,such materials have mechanical adaptability,micro-structure interconnectivity,and inherent bioactivity,making them ideal for the design of living implants for specific applications in TE and regenerative *** paper provides an overview for recent progress of biomimetic natural biomaterials(BNBMs),including advances in their preparation,functionality,potential applications and future *** highlight recent advances in the fabrication of BNBMs and outline general strategies for functionalizing and tailoring the BNBMs with various biological and physicochemical characteristics of native ***,we offer an overview of recent key advances in the functionalization and applications of versatile BNBMs for TE ***,we conclude by offering our perspective on open challenges and future developments in this rapidly-evolving field.

关键词： Biomimic Scaffold Biosynthesis Natural biomaterial Tissue engineering

含偶氮苯侧链不对称分子刷聚合物的合成及其自组装研究

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高分子学报 2024年第4期55卷 407-418页

作者：姚远何品陶鑫峰徐彬彬林绍梁上海市先进聚合物材料重点实验室、华东理工大学材料科学与工程学院上海200237

设计合成了含有2-羰基溴和烷基氯基团的功能性丙烯酸酯单体(Br-acrylate-Cl),利用可逆加成断裂链转移(RAFT)聚合得到大分子试剂poly(Br-acrylate-Cl).首先通过poly(Br-acrylate-Cl)引发偶氮苯丙烯酸酯单体(Azo)的原子转移自由基聚合(ATR... 详细信息

设计合成了含有2-羰基溴和烷基氯基团的功能性丙烯酸酯单体(Br-acrylate-Cl),利用可逆加成断裂链转移(RAFT)聚合得到大分子试剂poly(Br-acrylate-Cl).首先通过poly(Br-acrylate-Cl)引发偶氮苯丙烯酸酯单体(Azo)的原子转移自由基聚合(ATRP),然后用取代反应接入六甘醇修饰的四苯乙烯(OH-TPE-HEG),合成了同时含有偶氮苯侧链、四苯乙烯侧基和六甘醇侧链的不对称分子刷聚合物PA-g-PAzo/(TPE-HEG).偶氮苯侧链和四苯乙烯侧基的π-π相互作用和有序堆积,赋予了PA-g-PAzo/(TPE-HEG)组装体规整的分子排布.系统研究了PA-g-PAzo/(TPE-HEG)在甲醇/四氢呋喃混合溶剂中的自组装行为,得到了束状、捆状和片状等形貌组装体,并探究了捆状组装体的形成过程以及组装体的光响应形貌调控.本文的研究不仅提供了构建不对称分子刷聚合物的新合成方法,还丰富了分子刷组装体的种类.

关键词：分子刷偶氮苯捆状组装体光响应性自组装

C+L波段低弯曲损耗非耦合三模组渐变折射率光纤设计

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电子学报 2024年第8期52卷 2659-2667页

作者：王卓崔明杰余长源香港理工大学电机及电子工程学系中国香港999077 香港理工大学光子研究院中国香港999077 香港理工大学深圳研究院广东深圳518057

光纤是现代通信网络中最为稳定的信号传输媒介,提升光纤模式的数量是满足通信容量日益增加的有效方法.本文设计了低弯曲损耗的非耦合三模组(LP_(01),LP_(11),LP_(21))渐变折射率光纤,运用分层分析法给出了渐变折射率光纤中模组的严格截... 详细信息

光纤是现代通信网络中最为稳定的信号传输媒介,提升光纤模式的数量是满足通信容量日益增加的有效方法.本文设计了低弯曲损耗的非耦合三模组(LP_(01),LP_(11),LP_(21))渐变折射率光纤,运用分层分析法给出了渐变折射率光纤中模组的严格截止条件.此外,利用有限元仿真软件求解光纤模式的有效模场面积和弯曲损耗,得到低弯曲损耗条件下在C+L波段(1530~1625 nm)传输三模组的设计区间.揭示了纤芯中心折射率凹陷和沟槽层共同作用可促进光纤径向高阶模式的截止.模拟结果表明,所设计光纤的模组间有效折射率差大于等于3×10^(-3),弯曲半径为30 mm时的最大弯曲损耗为1.3 d B/km,符合ITU-T推荐的低弯曲损耗条件.而且,在1550 nm波长下,模组内简并模有较小的差分模式群时延(≈176 ps/km),可通过4×4多输入多输出技术补偿简并模之间的串扰.该光纤可适用于C+L波段上实现模组间非耦合的空分复用信号传输.

关键词：少模光纤渐变折射率低弯曲损耗空分复用光纤通信

散粒体压制成型过程非线性负载力补偿算法研究

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华中科技大学学报（自然科学版） 2024年第6期52卷 63-70页

作者：武哲袁畅李宝仁杨钢华中科技大学机械科学与工程学院湖北武汉430074

针对特殊散粒体压制成型过程发生弹塑性变形时,负载刚度呈现复杂的非线性时变特性,散粒体压制成型装置容易产生抖动现象,进而影响产品的密度均匀性和一致性问题,建立了散粒体压制成型装置电-液伺服系统的数学模型,提出了一种基于压制成... 详细信息

针对特殊散粒体压制成型过程发生弹塑性变形时,负载刚度呈现复杂的非线性时变特性,散粒体压制成型装置容易产生抖动现象,进而影响产品的密度均匀性和一致性问题,建立了散粒体压制成型装置电-液伺服系统的数学模型,提出了一种基于压制成型过程的非线性负载力补偿算法,通过对消补偿机制将非线性负载力对系统的影响进行抑制,使系统成为解耦线性系统.试验结果表明:当采用PID+LOC非线性负载力补偿算法时,散粒体压制成型过程中非线性负载力对控制系统性能的影响显著降低,运动控制曲线基本上呈线性变化;由于散粒体的蠕变特性,当采用比例-积分-微分(PID)控制算法时,在保压阶段容易诱发压制力的衰落振荡现象,而采用PID+LOC非线性负载力补偿算法则彻底消除了压制力的衰落振荡现象,并且提高了系统的控制精度,扩展了系统的频宽.

关键词：散粒体压制成型非线性负载对消补偿机制解耦线性系统

Structural features in the mid-southern section of the Kyushu–Palau Ridge based on satellite altimetry gravity anomaly

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Acta Oceanologica Sinica 2024年第4期43卷 50-60页

作者： Feifei Zhang Dingding Wang Xiaolin Ji Fanghui Hou yuan Yang Wanyin Wang School of Geological Engineering and Geomatics Chang’an UniversityXi’an 710054China Qingdao Institute of Marine Geology China Geological SurveyQingdao 266071China Information and Navigation College Air Force Engineering UniversityXi’an 710077China National Engineering Research Center of Offshore Oil and Gas Exploration Beijing 100028China Key Laboratory of Marine Geology and Environment Institute of OceanologyChinese Academy of SciencesQingdao 266071China

The Kyushu–Palau Ridge(KPR),an anti-S-shaped submarine highland at the center of the Philippine Sea Plate(PSP),is considered the residual arc of the Izu–Bonin–Mariana Island Arc,which retains key information about the cessation of the Western Philippine Basin(WPB)expansion and the Parece Vela Basin(PVB)***,using the new generation of satellite altimetry gravity data,high-precision seafloor topography data,and newly acquired ship-borne gravity data,the topographic and gravity characteristics of the KPR mid-southern section and adjacent region are *** distribution characteristics of the faults were delineated using the normalized vertical derivative–total horizontal derivative method(NVDR-THDR)and the minimum curvature potential field separation *** Moho depth and crustal thickness were inverted using the rapid inversion method for a double-interface model with depth *** on these results,the crust structure features in the KPR mid-southern section,and the“triangular”structure geological significance where the KPR and Central Basin Rift(CBR)of the WPB intersect are *** KPR crustal thickness is approximately 6–16 km,with a distinct discontinuity that is slightly thicker than the normal oceanic *** KPR mid-southern section crust structure was divided into four segments(S1–S4)from north to south,formed by the CBR eastward extension joint action and clockwise rotation of the PVB expansion axis and the Mindanao fault zone blocking effect.

关键词： structural features satellite altimetry gravity data Kyushu-Palau Ridge Central Basin Rift faults Moho depth

Relationship between Phenotypic changes of Dendritic Cell Subsets and the Onset of Plateau Phase during Intermittent Interferon Therapy in Patients with CHB

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Biomedical and Environmental Sciences 2024年第3期37卷 303-314页

作者： YANG Liu WANG Shi Yu JIANG Ting Ting DENG Wen chang Min WU Shu Ling CAO Wei Hua LU Yao SHEN Ge LIU Ru Yu GAO yuan Jiao XU Meng Jiao HU Lei ping ZHANG Lu XIE Yao LI Ming Hui Department of Hepatology Division 2 Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Center for Infectious Diseases Second Affiliated Hospital of Air Force Medical UniversityXi'an 710038ShaanxiChina Department of Hepatology Division 2 Peking University Ditan Teaching HospitalBeijing 100015China

Objective This study aimed to evaluate whether the onset of the plateau phase of slow hepatitis B surface antigen decline in patients with chronic hepatitis B treated with intermittent interferon therapy is related to the frequency of dendritic cell subsets and expression of the costimulatory molecules CD40,CD80,CD83,and *** This was a cross-sectional study in which patients were divided into a natural history group(namely NH group),a long-term oral nucleoside analogs treatment group(namely NA group),and a plateau-arriving group(namely P group).The percentage of plasmacytoid dendritic cell and myeloid dendritic cell subsets in peripheral blood lymphocytes and monocytes and the mean fluorescence intensity of their surface costimulatory molecules were detected using a flow *** In total,143 patients were enrolled(NH group,n=49;NA group,n=47;P group,n=47).The results demonstrated that CD141/CD1c double negative myeloid dendritic cell(DNmDC)/lymphocytes and monocytes(%)in P group(0.041[0.024,0.069])was significantly lower than that in NH group(0.270[0.135,0.407])and NA group(0.273[0.150,0.443]),and CD86 mean fluorescence intensity of DNmDCs in P group(1832.0[1484.0,2793.0])was significantly lower than that in NH group(4316.0[2958.0,5169.0])and NA group(3299.0[2534.0,4371.0]),Adjusted P all<*** Reduced DNmDCs and impaired maturation may be associated with the onset of the plateau phase during intermittent interferon therapy in patients with chronic hepatitis B.

关键词： CHB Dendritic Cells Intermittent Interferon Therapy Plateau Phase

基于实测数据的高海拔大日温差地区拱上组合梁桥-无砟轨道体系温度场研究

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铁道学报 2024年第2期46卷 159-170页

作者：勾红叶陈子豪刘畅肖畅袁蔚苏延文西南交通大学土木工程学院四川成都610031 中铁第四勘察设计院集团有限公司湖北武汉430061 中铁二院工程集团有限责任公司四川成都610031 中国铁道学会标准与认证部北京100844 兰州交通大学土木工程学院甘肃兰州730070

温度作用是影响桥梁-轨道结构服役性能的重要因素之一。为探究高海拔大日温差地区拱上组合梁桥-无砟轨道体系的温度场变化规律,基于某拟建铁路上承式大跨拱桥桥址处的环境温度持续监测数据与卫星反演得到的太阳辐射数据,建立了考虑太阳... 详细信息

温度作用是影响桥梁-轨道结构服役性能的重要因素之一。为探究高海拔大日温差地区拱上组合梁桥-无砟轨道体系的温度场变化规律,基于某拟建铁路上承式大跨拱桥桥址处的环境温度持续监测数据与卫星反演得到的太阳辐射数据,建立了考虑太阳辐射阴影遮挡效应的拱上组合梁桥-无砟轨道体系温度场模型,重点分析日温度变化规律和竖向温差分布规律,获得了考虑实测气温和太阳辐射逐时变化的全年日温度场;采用广义帕累托分布对竖向温差样本进行了极值分布估计,确定不同超越概率的竖向温差代表值,提出多折线形式的竖向温度梯度模式。研究结果表明,梯度相较于平原地区更为显著,无砟轨道的遮挡效应使得温度梯度分布上移,钢梁外侧腹板在冬季产生局部梯度作用;基于实测数据的温差极值估计方法考虑了环境温度和太阳辐射对结构温度场的随机影响,可为特殊地区桥梁设计阶段温度作用的计算提供参考。

关键词：组合梁桥-无砟轨道体系温度场阴影遮挡效应竖向温度梯度广义帕累托分布

从物性关系看主宾易位句的合格性条件和构式意义

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汉语学习 2024年第5期 45-54页

作者：尹常乐袁毓林北京语言大学教师教育学院北京100083 澳门大学中国语言文学系中国澳门519000

本文主要考察“工具+动词+受事”“材料+动词+结果”和“处所+动词+受事”三类主宾易位句。文章以生成过程为切入点,从物性关系的角度分析三种主宾易位句的合格性条件。文章将三种主宾易位句的构式义总结为“功用—处置”“功用—行为... 详细信息

本文主要考察“工具+动词+受事”“材料+动词+结果”和“处所+动词+受事”三类主宾易位句。文章以生成过程为切入点,从物性关系的角度分析三种主宾易位句的合格性条件。文章将三种主宾易位句的构式义总结为“功用—处置”“功用—行为”和“处置—行为”,并说明了功用、行为和处置三者之间联系的普遍性。最后,文章把上述结论推广到其他主宾易位句中,进一步证明了结论的可靠性。

关键词：物性关系主宾易位句合格性条件构式意义

维普期刊数据库博看期刊

球扁钢肋钢纤维混凝土组合桥面板正弯矩受力性能试验

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吉林大学学报（工学版） 2024年第6期54卷 1634-1642页

作者：张春雷邵长宇苏庆田戴昌源同济大学土木工程学院上海200092 上海市政工程设计研究总院(集团)有限公司上海200092 上海高性能组合结构桥梁工程技术研究中心上海200092

针对一种采用80 mm厚钢纤维混凝土(SFRC)和球扁钢纵肋的新型组合桥面板,设计制作了两个组合桥面板足尺模型,进行了正弯矩加载试验,测试得到加载全过程结构变形和应变变化情况。采用截面弹塑性截面分析方法、线弹性分析方法和刚塑性分析... 详细信息

针对一种采用80 mm厚钢纤维混凝土(SFRC)和球扁钢纵肋的新型组合桥面板,设计制作了两个组合桥面板足尺模型,进行了正弯矩加载试验,测试得到加载全过程结构变形和应变变化情况。采用截面弹塑性截面分析方法、线弹性分析方法和刚塑性分析方法计算了正弯矩承载力,并与试验结果进行对比。研究结果表明:组合桥面板在承受正弯矩荷载时位移延性系数为4.90~5.77,具有较好的延性;在承载能力极限状态下,组合桥面板正弯矩承载力由球扁钢受力控制,SFRC具有充足的抗压强度,提高混凝土强度对正弯矩承载力影响很小;截面弹塑性分析能较为准确地计算正弯矩承载力,适合用于组合桥面板设计计算。

关键词：桥梁工程组合桥面板正交异性钢桥面板钢纤维混凝土球扁钢加劲肋弯矩承载力