检索结果-南通市图书馆

人外周血树突状细胞诱导Th1/Th2细胞分化的研究

在线全文

学校读者我要写书评

暂无评论

医学研究生学报 2004年第1期17卷 9-11页

作者：袁国林邹萍陈智超武汉协和医院血液病研究所湖北武汉430030

目的 :研究人外周血树突状细胞 (DC)与Th0细胞在不同比例条件下 ,诱导Th0向Th1/Th2分化的关系。方法 :健康人外周血单个核细胞经传统的方法诱导得到DC ,将DC与自体的Th0细胞以 1∶4和 1∶30 0的比例混合培养 4天 ,收集Th细胞 ,经CD3和CD... 详细信息

目的 :研究人外周血树突状细胞 (DC)与Th0细胞在不同比例条件下 ,诱导Th0向Th1/Th2分化的关系。方法 :健康人外周血单个核细胞经传统的方法诱导得到DC ,将DC与自体的Th0细胞以 1∶4和 1∶30 0的比例混合培养 4天 ,收集Th细胞 ,经CD3和CD2 8抗体扩增 4 8h ,ELISA法测上清中IFN γ和IL 4的浓度。　结果 :从外周血中诱导出DC高表达CD83(73.4 % )、CD86 (90 .3% )、HLA DR(6 8.5 % )和CD4 0 (73.7% ) ,DC与Th0以 1∶4混合 ,产生的IFN γ与 1∶30 0混合组比有显著差异〔(34± 4 .3) μg/Lvs(3.5± 1.2 ) μg/L〕 ,产生的IL 4亦有显著差异〔(2 5 ± 4 .3)ng/Lvs (35 0± 12 0 )ng/L〕。　结论 :人外周血DC与Th0高比例混合时 ,诱导Th0向Th1分化 ;低比例混合时 ,诱导Th0向Th2分化。显示人外周血DC在调控T淋巴细胞免疫应答类型上具有可塑性 ,为临床移植物抗宿主病 (GVHD)免疫干预治疗奠定基础。

关键词：树突状细胞 T细胞外周血抗原呈递细胞免疫应答细胞因于

Enhanced carbon solubility in solvent for SiC rapid solution growth:Thermodynamic evaluation of Cr-Ce-Si-C system

在线全文

学校读者我要写书评

暂无评论

Journal of Rare Earths 2023年第8期41卷 1272-1278,I0006页

作者： lingling guo guobin Wang Jiawei lin Zhongnan guo Zesheng Zhang Hui Li Zhanmin Cao Wenxia yuan Department of Chemistry School of Chemistry and Biological EngineeringUniversity of Science and Technology BeijingBeijing 100083China Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China

The carbon dissolution in solvent plays a key role in the process of solution growth route for SiC single crystal,which could determine the growth rate and quality of the ***,the carbon dissolving ability of binary alloy solvent still needs to be ***,we demonstrate the improved carbon dissolution and enlarged carbon supersaturation in Cr-Ce-Si ternary solvent,showing great potential for SiC solution *** phase relations of Cr-Ce-Si-C system were determined by using CALPHAD method based on thermodynamic parameters of CeCr_(2)Si_(2)*** is indicated that the Cr-Ce-Si ternary solvent shows much larger carbon solubility in temperature range from 1700 to 2000℃compared to Cr-Si binary one,Furthermore,the carbon supersaturation in solvent is also significantly increased in low temperature range after the addition of Ce,leading to a rapid growth *** work not only demonstrates the feasibility of adding Ce in the alloy solvent for rapid growth of SiC crystal,but also provides an example for investigating the C solubility in ternary solvent.

关键词： Sic solution growth Thermodynamic evaluation Cr-Ce-Si-C system Carbon solubility CeCr_(2)Si_(2)C quaternary compound

Synthesis and Ferrimagnetic Behaviour of Mn Doped Rare Earth Iron Garnets

在线全文

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 2012年第3期28卷 391-394页

作者： guo Li yuan lin PENG Wen yuan Hong-ming FENG Shou-hua State Key Laboratory of Inorganic Synthesis and Preparative Chemistry College of ChemistryJilin UniversityChangchun 130012R R.China

Rare earth iron garnets R3Fe5-xMnxO12（R=Pr, Nd, Sm, Eu） were prepared through mild hydrothermal me- thod. The initial alkalinity of solutions was thought to play an important role in governing the content of Mn. The effect of substitution Fe^3＋ ions by Mn^3＋ ions on magnetic properties was investigated. The saturation magnetizations of Mn-doped samples are larger than that of corresponding parent compounds due to the moment of Mn^3＋ ion being smaller than that of Fe^3＋. It is clearly shown that incorporation of Mn^3＋ gives rise to significant variations in the Curie temperature. With increasing of Mn content x, Curie temperatures reduced sharply for the garnets, which could be explained by the exchange interaction between a-d Fe^3＋ being reduced in these compounds.

关键词： Hydrothermal synthesis Garnet Substitution Ferrimagnetism

Middle Jurassic climate oscillations from paleosol records of the Sichuan Basin,SW China

在线全文

学校读者我要写书评

暂无评论

Journal of Palaeogeography 2022年第1期11卷 97-122页

作者： Jun Li Cheng-Min Huang guo-lin Yang yuan-yuan Pan Xing-Yue Wen College of Urban Environment Lanzhou City UniversityLanzhou 730070Gansu ProvinceChina Department of Environmental Science and Engineering Sichuan UniversityChengdu 610065Sichuan ProvinceChina BaiLie School of Petroleum Engineering Lanzhou City UniversityLanzhou 730070Gansu ProvinceChina School of Environmental Science and Engineering China West Normal UniversityNanchong 637002Sichuan ProvinceChina

The Middle Jurassic is characterized by major plate tectonic changes,variable atmospheric CO_(2)concentrations(pCO_(2)),and climate oscillations in both marine and terrestrial ***,the limited evidence from the terrestrial sedimentary records hampers a comprehensive understanding of global climate state in this ***-exposed strata of the Shaximiao Formation in the Sichuan Basin,Southwest China,preserve successions of paleosols that offer the possibility of evaluating the terrestrial paleoclimatic changes during the Middle Jurassic(Bajocian to Callovian).A total of 151 paleosol profiles belonging to four paleosol types(Entisol-like,Inceptisol-like,Aridisol-like and argillic Inceptisol-like paleosols)were identified and *** quantitative paleoclimate reconstructions based on the bulk geochemistry of paleosol horizons and depths of carbonate nodules indicate a generally semiarid-subhumid climate alternating with arid-humid and cool/warm-temperate climates during this time *** dynamic climate terminated in a dry,subhumid,humid/perhumid and superhumid moisture regime characterized by steppe/wet or rain forest floral *** suggest that these climatic fluctuations may have been related to global geodynamic(e.g.,the fragmentation of Pangea,“megamonsoonal”circulation,and bolide impacts)and regional tectonic uplift(e.g.,the uplift of the Longmenshan Mountains in the South China Block)during the Middle *** pCO_(2)estimates suggest relatively low pCO_(2)levels within the range of~100 ppm-~890 ppm during the Bajocian to *** results coincide with the threshold for the initiation of glaciation and may help to explain the occurrence of cool intervals in the generally warm *** pCO_(2)fluctuations,which coincide with paleotemperature variations in the low paleolatitudes of the Northern Hemisphere,are possibly attributable to global geological events(e.g.,wildfire events,eustatic sea-level oscillations,and th

关键词： Paleosols Paleoprecipitation Paleotemperature Paleoatmospheric CO_(2) Shaximiao Formation Bajocian-Callovian

Federated Learning on Multimodal Data:A Comprehensive Survey

在线全文

学校读者我要写书评

暂无评论

Machine Intelligence Research 2023年第4期20卷 539-553页

作者： Yi-Ming lin yuan Gao Mao-guo Gong Si-Jia Zhang yuan-Qiao Zhang Zhi-yuan Li School of Electronic Engineering Xidian UniversityXi’an710071China

With the growing awareness of data privacy,federated learning(FL)has gained increasing attention in recent years as a major paradigm for training models with privacy protection in mind,which allows building models in a collaborative but private way without exchanging ***,most FL clients are currently *** the rise of edge computing,various types of sensors and wearable devices generate a large amount of data from different modalities,which has inspired research efforts in multimodal federated learning(MMFL).In this survey,we explore the area of MMFL to address the fundamental challenges of FL on multimodal ***,we analyse the key motivations for ***,the currently proposed MMFL methods are technically classified according to the modality distributions and modality annotations in ***,we discuss the datasets and application scenarios of ***,we highlight the limitations and challenges of MMFL and provide insights and methods for future research.

关键词： Federated learning multimodal learning heterogeneous data edge computing collaborative learning

Correlation Study on Grain Size Characteristics and Geotechnical Properties of Surface Sediments in Qingdao Offshore Area

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Ocean University of China 2024年第3期23卷 721-730页

作者： LI Anlong WANG Panpan guo Xijun JI Xiangkun SHEN Kunming lin lin YAN Zhichao yuan lin Key Laboratory of Submarine Geosciences and Prospecting Techniques Ministry of Education and College of Marine GeosciencesOcean University of ChinaQingdao 266100China College of Marine Geoscience Ocean University of ChinaQingdao 266100China China Construction Second Engineering Bureau Co. LTDYueyang 414000China Tianjin Research Institute for Water Transport Engineering M.O.T.Tianjin 3000456China Lianyungang Xuwei Port Holding Group Co. Ltd.Lianyungang 222042China

The comprehension of sediment grain size parameters and the corresponding sedimentary environment holds paramount importance in elucidating the engineering geological attributes of the subaqueous *** study delineated the sedimentary environment zoning in the northern sea area of Qingdao through cluster analysis of grain size parameters derived from 123 surface sediment *** study analyzed the correlation between sediment geotechnical indices and grain size parameters across diverse sedimentary environments.A correlation equation was established for samples exhibiting a strong *** study found four distinct sedimentary environments in the study area:coastal,transitional,shallow sea,and *** the same sedimentary environment,the average grain size and sorting coefficient exhibit significant correlations with geotechnical indices such as water content,density,shear strength,plastic limit,liquid limit,and plastic ***,notable disparities in the correlation between grain size parameters and geotechnical indices emerge across different sedimentary environments.

关键词： grain size parameters cluster analysis sedimentary environment correlations geotechnical indexes

An integrated method of selecting environmental covariates for predictive soil depth mapping

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Agriculture 2019年第2期18卷 301-315页

作者： LU yuan-yuan LIU Feng ZHAO Yu-guo SONG Xiao-dong ZHANG Gan-lin State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of SciencesNanjing 210008P.R.China University of Chinese Academy of Sciences Beijing 100049P.R.China

Environmental covariates are the basis of predictive soil *** selection determines the performance of soil mapping to a great extent,especially in cases where the number of soil samples is limited but soil spatial heterogeneity is *** this study,we proposed an integrated method to select environmental covariates for predictive soil depth ***,candidate variables that may influence the development of soil depth were selected based on pedogenetic ***,three conventional methods(Pearson correlation analysis(PsCA),generalized additive models(GAMs),and Random Forest(RF))were used to generate optimal combinations of environmental ***,three optimal combinations were integrated to produce a final combination based on the importance and occurrence frequency of each environmental *** tested this method for soil depth mapping in the upper reaches of the Heihe River Basin in Northwest China.A total of 129 soil sampling sites were collected using a representative sampling strategy,and RF and support vector machine(SVM)models were used to map soil *** results showed that compared to the set of environmental covariates selected by the three conventional selection methods,the set of environmental covariates selected by the proposed method achieved higher mapping *** combination from the proposed method obtained a root mean square error(RMSE)of 11.88 cm,which was 2.25–7.64 cm lower than the other methods,and an R^2 value of 0.76,which was 0.08–0.26 higher than the other *** results suggest that our method can be used as an alternative to the conventional methods for soil depth mapping and may also be effective for mapping other soil properties.

关键词： environmental covariate selection integrated method predictive soil mapping soil depth

Two new lncRNAs regulate the key immune factor NOD1 and TRAF5 in chicken lymphocyte

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Agriculture 2019年第11期18卷 2589-2597页

作者： BI Yu-lin yuan Xiao-ya CHEN Ying CHANG guo-bin CHEN guo-hong College of Animal Science and Technology Yangzhou University

Reticuloendotheliosis virus(REV)causes the atrophy of immune organs and immuno-suppression in chickens,but the underlying molecular mechanism of the immune response after infection by REV is not well ***,the RNA-seq was used to analyze the regulation of immune response to REV in chicken lymphocytes from peripheral ***,134 differentially expressed long non-coding RNAs(lncRNAs)between cells with REV infection or without in vitro were *** on the differentially expressed protein-coding genes,the nucleotide-binding oligomerization domain(NOD)-like receptor pathway related to immune regulation was *** lncRNAs(L11530 and L09863)were predicted to target the NOD1 and tumor necrosis factor receptor-associated factor 5(TRAF5)gene,respectively,which are involved in the NOD-like receptor pathway with cis-regulation *** in vitro results revealed the significantly up-regulated(P<0.01)levels of lncRNA-L11530 and its target gene,NOD1,and the significantly down-regulated(P<0.05)levels of lncRNA-L09863 and its target gene,TRAF5,in lymphocytes after REV *** changes also occurred in vivo in blood lymphocytes of chickens infected with ***,L09863 and L11530 were respectively interfered,the expression levels of their target genes NOD1 or TRAF5 were significantly down-regulated,accompanied by the change of IL-8 and IL-18 secretions in *** NOD-like receptor pathway appears to be important in the immune response to REV,LncRNA-11530 and lncRNA-09863 might involve in the immune regulation on REV infection by targeting NOD1 or TRAF5 in blood lymphocytes of *** findings reveal a new regulation of lncRNAs(L11530 and L09863)on immunity in chicken peripheral blood lymphocytes for REV infection by changing the expression of the target genes via the NOD-like receptor pathway.

关键词： lncRNA NOD-like receptor pathway chicken lymphocyte REV immune regulation

Does cranial-medial mixed dominant approach have a unique advantage for laparoscopic right hemicolectomy with complete mesocolic excision?

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Surgery 2022年第3期14卷 221-235页

作者： Li lin Si-Bo yuan Huan guo Department of Gastrointestinal Surgery and Xiamen City Key Laboratory of Gastrointestinal Cancer Zhongshan HospitalXiamen UniversityXiamen 361000Fujian ProvinceChina

BACKGROUND Complete mesocolic excision(CME)with central vascular ligation(CVL)was proposed by Hohenberger in *** CME principle has gradually become the technical standard for colon cancer *** to achieve CME with CVL in laparoscopic right hemicolectomy(LRH)is controversial,and a unified standard approach is not yet *** recent years,the authors’team has integrated the theory of membrane anatomy,tried to combine the cephalic approach with the classic medial approach(MA)for technical optimization,and proposed a cranialmedial mixed dominant approach(CMA).AIM To explore the feasibility of operational approaches for LRH with *** In this retrospective cohort study,the clinical data of 57 patients with right-sided colon cancer(TNM stage I,II,or III)who underwent LRH with CME from January 2016 to June 2020 were collected and *** were 31 patients in the traditional MA group and 26 in the CMA *** There were no significant differences in baseline data between the two *** operation was shorter and the number of lymph nodes dissected was higher in the CMA group than in the MA group,but there was no significant difference in the number of positive lymph nodes,intraoperative blood loss,postoperative exhaust time,feeding time,postoperative hospital stay or postoperative complication *** Our study shows that the CMA is a safe and feasible procedure for LRH with CME and has a unique advantage.

关键词： Right hemicolectomy Laparoscopic surgery Complete mesocolic excision Mesocolon Embryology Colon cancer