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Occupational Carbon Monoxide Poisoning Associated with Diesel Motor Operation in an Air-raid Shelter in June 2015, jinan City, China-An Epidemiological Investigation

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Biomedical and Environmental Sciences 2017年第10期30卷 777-781页

作者： CUI Liang Liang ZHOU jing Wen GENG Xing Yi LI Xin wei LIU Zhong George A.Conway ZHANG ji jinan Municipal Center for Disease Control and Prevention Jinan 250021ShandongChina Deschutes County Health Services Department Bend OR 97703USA

Carbon monoxide （CO） is an odorless, colorless gas produced by incomplete combustion of carbonbased compounds. Exposure to CO can cause various adverse health effects ranging from headache and fatigue to coma and death. Thousands of illnesses and deaths have been documented through CO poisoning surveillance systems and accident investigations each year.

关键词： CO ARS Occupational Carbon Monoxide Poisoning Associated with Diesel Motor Operation in an Air-raid Shelter in June 2015,jinan City,China An Epidemiological Investigation

_(a_1)_(d_1)-A_(a_2)D_(d_2)型氢键体系的网络结构参数

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高等学校化学学报 2007年第3期28卷 506-509页

作者：及媛媛王海军李元峰河北大学化学与环境科学学院保定071002 廊坊师范学院物理与电子信息学院廊坊102800

利用溶胶-凝胶分配理论对氢键溶液的模型体系进行研究,给出了体系的凝胶化条件以及凝胶点后氢键网络中各类结构参数的计算方案,并进行了相应的数值计算.结果表明,当两类质子受体基团的活性不同时,质子受体基团的竞争作用对网络结构有一... 详细信息

利用溶胶-凝胶分配理论对氢键溶液的模型体系进行研究,给出了体系的凝胶化条件以及凝胶点后氢键网络中各类结构参数的计算方案,并进行了相应的数值计算.结果表明,当两类质子受体基团的活性不同时,质子受体基团的竞争作用对网络结构有一定影响.这为控制氢键网络结构特征提供了可能的理论线索.

关键词：氢键网络结构参数溶胶-凝胶相变

Vacuolar H^(+)-ATPase and BZR1 form a feedback loop to regulate the homeostasis of BR signaling inArabidopsis

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Molecular Plant 2023年第12期16卷 1976-1989页

作者： Yu-Tong jiang Lu-Han Yang ji-Xuan Zheng Xian-Chen Geng Yu-Xuan Bai Yu-Chen Wang Hong-wei Xue Wen-Hui Lin School of Life Sciences and Biotechnology The Joint International Research Laboratory of Metabolic&Developmental SciencesShanghai Jiao Tong UniversityShanghai 200240China Shanghai Collaborative Innovation Center of Agri-Seeds Joint Center for Single Cell BiologyShanghai 200240China School of Agricuture and Biology Shanghai Jiao Tong UniversityShanghai 200240China Zhiyuan College Shanghai Jiao Tong UniversityShanghai 200240China

Brassinosteroid(BR)is a vital plant hormone that regulates plant growth *** RESISTANT1(BZR1)is a key transcription factor in BR signaling,and its nucleocytoplasmic localization is crucial for BR ***,the mechanisms that regulate BzR1 nucleocytoplasmic distribution and thus the homeostasis of BR signaling remain largely *** vacuole is the largest organelle in mature plantcells and plays a key role in maintenance of cell ular pH,storage of intracellular substances,and transport *** this study,weuncovered anovel mechanismof BR signaling homeostasis regulatedbythe vacuolar H+-ATPase(V-ATPase)and BZR1 feedback *** results revealed that the vha-a2 vha-a3 mutant(vha2,lacking V-ATPase activity)exhibits enhanced BR signaling with increased total amount of BZR1,nuclearlocalized BZR1,and the ratio of BZR1/phosphorylated BZR1 in the *** biochemical assays revealed that VHA-a2 and VHA-a3 of V-ATPase interact with the BZR1 protein through a domain that is conserved across multiple ***-a2 and VHA-a3 negatively regulate BR signaling by interacting with BzR1 and promoting its retention in the ***,a series of molecular analyses demonstrated that nuclear-localized BZR1 could bind directlyto specific motifs in the promoters of VHA-a2 andVHAa3topromote their *** together,these results suggest that V-ATPase and BzR1 mayforma feedback regulatory loop to maintain thehomeostasis of BR signaling in Arabidopsis,providing new insights into vacuole-mediated regulation of hormone signaling.

关键词： BR BZR1 vacuole V-ATPase tonoplast

MAPK9 as a therapeutic target:unveiling ferroptosis in localized prostate cancer progression

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BIOCELL 2024年第5期48卷 771-792页

作者： CHENG-GONG LUO jiAO ZHANG YUN-ZHAO AN XUAN LIU SHUAI-jiE LI wei ZHANG KAI LI XU ZHAO DONG-BO yuan LING-YUE AN wei CHEN YE TIAN BIN XU Department of Urology Guizhou Provincial People’s HospitalGuiyangChina Department of Urology First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina

Background:Ferroptosis,a lipid peroxidation-mediated programmed cell death,is closely linked to tumor development,including prostate cancer(PCa).Despite established connections between ferroptosis and PCa,a comprehensive investigation is essential for understanding its impact on patient ***:A risk model incorporating four ferroptosis-related genes was developed and *** risk scores correlated with an increased likelihood of biochemical recurrence(BCR),diminished immune infiltration,and adverse clinicopathological *** corroborate these results,we performed validation analyses utilizing datasets from both the Cancer Genome Atlas Cohort(TCGA)and the Gene Expression Synthesis Cohort(GEO).Moreover,we conducted further investigations into the pivotal gene identified in our model to explore its impact on tumor characteristics through cell proliferation and invasion assays,as well as animal studies conducted in ***,we conducted further experiments involving ferroptosis-related analysis to validate its association with ***:The risk model demonstrated exceptional predictive capabilities for prognosis and therapeutic outcomes in PCa ***-activated protein kinase 9(MAPK9)emerged as a crucial gene within the *** vivo and in vitro experiments explored MAPK9’s role in ferroptosis and its influence on tumor migration and ***:The findings provide a novel perspective for advancing ferroptosis exploration in PCa,bridging basic research and clinical applications.

关键词： Ferroptosis Biochemical recurrence Prostate cancer TCGA GEO MAPK9

New isoflavonoids from Erythrina arborescens and structure revision of anagyroidisoflavone A

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Natural Products and Bioprospecting 2013年第5期3卷 238-242页

作者： Fei WANG Xu-Long LI Guo-Zhu wei Fu-Cai REN ji-Kai LIU BioBioPha Co. Ltd.Kunming 650201China State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China

Five hitherto unknown isoflavonoids,namely erythrinins D-H(1-5),were isolated from the ethanol extract of Erythrina *** structures were elucidated on the basis of extensive spectroscopic *** addition,the structure of anagyroidisoflavone A(6a)has been revised as 1″-O-methylerythrinin F(6)by re-analysis of the original spectroscopic data.

关键词： Erythrina arborescens isoflavonoid erythrinin structure revision

Glycyrrhetinic acid-modified nanoparticles for drug delivery: Preparation and characterization

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Chinese Science Bulletin 2009年第10期54卷 3121-3126页

作者： TIAN Qin WANG wei HE XiaoTing ZHU XiaoCui HUANG wei ZHANG ChuangNian yuan Zhi CHEN XueSi Key Laboratory of Functional Polymer Materials Ministry of Education Institute of Polymer Chemistry Nankai University Tianjin 300071 China State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied Chemistry Chinese Academy of SciencesChangchun 130022 China

In this work, glycyrrhetinic acid-modified chitosan (mGA-suc-CTS) used as liver targeted carrier for drug delivery, was prepared via hemisuccinate as a bridged group. The structure of the product was confirmed by IR and NMR methods and the degree of substitution (DS) of glycyrrhetinic acid groups was estimated via elemental analysis. Nanoparticles were formed by ionic gelation methold. The drug-loading and release behavior of the nanoparticles were investigated using BSA as the model drug. The results indicated that the carrier with a highest DS of 5.19% could be got and the DS was controlled by changing reaction temperature or feed ratio. BSA could be entrapped into the nanoparticles with the drug-loading ratio of 26.3% and the encapsulation efficiency of 81.5%. A sustained release over an 11-day period was observed in pH 7.4 in vitro.

关键词：药物输送纳米粒子甘草次酸酸改性表征制备核磁共振方法牛血清白蛋白

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采用矩形到同轴扇形渐变TE10^□→TE01^⊙模式变换器带宽特性的研究

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电子与信息学报 2007年第6期29卷 1508-1510页

作者：朱敏罗积润栾远涛郭炜袁广江中国科学院电子学研究所

该文对一种矩形到同轴扇形渐变TE10^□→TE01^⊙模式变换器的带宽特性进行了研究。分析了工作频带内竞争模式对工作模式的影响，探讨了滤模加载对改善模式转换性能的作用。模拟结果表明，滤模加载可以削弱竞争模式对工作模式的影响。加... 详细信息

该文对一种矩形到同轴扇形渐变TE10^□→TE01^⊙模式变换器的带宽特性进行了研究。分析了工作频带内竞争模式对工作模式的影响，探讨了滤模加载对改善模式转换性能的作用。模拟结果表明，滤模加载可以削弱竞争模式对工作模式的影响。加滤模结构后，模式变换器工作在Ku波段时，在模式转换效率大于70％的情况下，带宽可以大于700MHz。

关键词：回旋管放大器模式转换输入耦合转换效率工作频带

Dose-dependent Cardiac Dysfunction and Structural Damage in Rats after Shortwave Radiation

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Biomedical and Environmental Sciences 2020年第8期33卷 603-613页

作者： ZHANG jing YU Chao YAO Bin wei WANG Hui ZHAO Li XU Xin Ping DONG ji WANG Hao Yu HAO Yan Hui PENG Rui Yun Department of Experimental Pathology Institute of Radiation MedicineAcademy of Military Medical SciencesBeijing 100850China

Objective To detect the effects of shortwave radiation on dose-dependent cardiac structure and function in rats after radiation and to elucidate the mechanism of shortwave radiation induced cardiac injury to identify sensitive indicators and prophylactic *** One hundred Wistar rats were either exposed to 27 MHz continuous shortwave at a power density of 5,10,and 30 mW/cm^2 for 6 min or undergone sham exposure for the control(the rats had to be placed in the exposure system with the same schedules as the exposed animals,but with an inactive antenna).The Ca^2+,glutamic oxaloacetic transaminase(AST),creatine kinase(CK)and lactate dehydrogenase(LDH)content in the peripheral serum of the rats were detected by an automatic blood biochemical *** electrocardiogram(ECG)of standard lead II was recorded by a multi-channel physiological recording and analysis *** cardiac structure of rats was observed by light and electron *** The results showed that the 5,10,and 30 mW/cm^2 shortwave radiation caused a significant increased in the levels of Ca2+,AST,CK,and LDH in the peripheral serum of *** cardiac structure was damaged by radiation and showed a disordered arrangement of myocardial fibres,the cavitation and swelling of myocardial *** injuries were most significant 7 d after radiation and were not restored until 28 d after *** Shortwave radiation of 5,10,and 30 mW/cm^2 can damage rat cardiac function,including damage to the tissue structure and ultrastructure,especially at the level of the myocardial fibres and *** radiation at 5,10,and 30 mW/cm^2 induced damage to rat heart function and structure with a dose-effect relationship,i.e.,the greater the radiation dose was,the more significant the damage was.

关键词： Shortwave Rat heart Function Structure Damage effect Dose dependence

Reconstruction of complex chest wall defects:A case report

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World Journal of Clinical Cases 2022年第11期10卷 3505-3510页

作者： Sheng-Chao Huang Chun-Yan Chen Pu Qiu Ze-Ming Yan wei-Zhang Chen Zhong-Zheng Liang Kang-wei Luo jian-Wen Li yuan-Qi Zhang Bao-Yi Huang Department of Vascular Thyroidand Breast SurgeryAffiliated Hospital of Guangdong Medical UniversityZhanjiang 524000Guangdong ProvinceChina

BACKGROUND Chronic radiative chest wall ulcers are common in patients undergoing radiation *** not treated early,then symptoms such as erosion,bleeding and infection will appear on the *** severe cases,ulcers invade the ribs and pleura,presenting a mortality *** ulcers can be repaired with pedicle *** radioactive ulcers often invade the thorax,surgeons need to remove large areas of skin and muscle,and sometimes *** large chest wall defects are a challenge for *** SUMMARY A 74-year-old female patient was admitted to our department with chest wall skin ulceration after radiation therapy for left breast *** patient was diagnosed with chronic radioactive *** multidisciplinary discussion,the authors performed expansive resection of the chest wall ulcers and repaired large chest wall defects using a deep inferior epigastric perforator(DIEP)flap combined with a high-density polyethylene(HDPE)*** patient was followed-up 6 mo after the *** pigmentation or edema was found in the *** DIEP flap plus HDPE patch is one of the better treatments for radiation-induced chest wall ulcers.

关键词： Deep inferior epigastric perforator flap High-density polyethylene patch Breast cancer Chest wall Chronic radiation-induced ulcer Case report