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生命早期肠道菌群异常参与发育源性骨质疏松症发生的研究进展

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中华骨质疏松和骨矿盐疾病杂志 2024年第1期17卷 75-80页

作者：马翅何航元肖浩李斌汪晖陈廖斌武汉大学中南医院骨科武汉430071 武汉大学基础医学院药理学系武汉430071 发育源性疾病湖北省重点实验室武汉430071

骨质疏松症(osteoporosis,OP)的发生与生命早期骨发育密切相关,是一种发育起源疾病。本文总结了OP发育起源相关的文献报道,提出其发生机制可能与生命早期肠道菌群异常有关。同时,简要阐明了生命早期肠道菌群的组成特征及其影响因素,并... 详细信息

骨质疏松症(osteoporosis,OP)的发生与生命早期骨发育密切相关,是一种发育起源疾病。本文总结了OP发育起源相关的文献报道,提出其发生机制可能与生命早期肠道菌群异常有关。同时,简要阐明了生命早期肠道菌群的组成特征及其影响因素,并系统阐述了生命早期肠道菌群异常参与发育源性OP相关的临床与实验室研究。最后,鉴于生命早期肠道菌群在骨骼发育中的重要作用,从益生菌/益生元两方面总结生命早期干预肠道菌群策略对宿主生长发育及骨量的影响,为防治发育源性OP提供新思路与新策略。

关键词：骨质疏松症肠道菌群生命早期发育源性疾病

Jianpi Gushen Huayu decoction ameliorated diabetic nephropathy through modulating metabolites in kidney,and inhibiting TLR4/NF-κB/NLRP3 and JNK/P38 pathways

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World Journal of Diabetes 2024年第3期15卷 502-518页

作者： Zi-Ang ma Li-Xin Wang Hui Zhang Han-Zhou Li Li Dong Qing-Hai Wang yuan-Song Wang Bao-ChaoPan Shu-Fang Zhang Huan-Tian Cui Shu-Quan Lv Graduate School Hebei University of Chinese MedicineShijiazhuang 050000Hebei ProvinceChina Department of Endocrinology Cangzhou Hospital of Integrated Traditional Chinese Medicine and Western Medicine of Hebei Province Affiliated to Hebei University of Chinese MedicineCangzhou 061000Hebei ProvinceChina School of Integrative Medicine Tianjin University of Traditional Chinese MedicineTianjin 300000China The First School of Clinical Medicine Yunnan University of Traditional Chinese MedicineKunming 065000Yunnan ProvinceChina Department of Endocrinology Hebei Cangzhou Hospital of Integrative MedicineCangzhou 061000Hebei ProvinceChina

BACKGROUND Jianpi Gushen Huayu Decoction(JPGS)has been used to clinically treat diabetic nephropathy(DN)for many ***,the protective mechanism of JPGS in treating DN remains *** To evaluate the therapeutic effects and the possible mechanism of JPGS on *** We first evaluated the therapeutic potential of JPGS on a DN mouse *** then investigated the effect of JPGS on the renal metabolite levels of DN mice using non-targeted ***,we examined the effects of JPGS on c-Jun N-terminal kinase(JNK)/P38-mediated apoptosis and the inflammatory responses mediated by toll-like receptor 4(TLR4)/nuclear factor-kappa B(NF-κB)/NOD-like receptor family pyrin domain containing 3(NLRP3).RESULTS The ameliorative effects of JPGS on DN mice included the alleviation of renal injury and the control of inflammation and oxidative *** metabolomic analysis revealed that JPGS altered the metabolites of the kidneys in DN mice.A total of 51 differential metabolites were *** analysis results indicated that nine pathways significantly changed between the control and model groups,while six pathways significantly altered between the model and JPGS *** related to cysteine and methionine metabolism;alanine,tryptophan metabolism;aspartate and glutamate metabolism;and riboflavin metabolism were identified as the key pathways through which JPGS affects *** experimental validation showed that JPGS treatment reduced the expression of TLR4/NF-κB/NLRP3 pathways and JNK/P38 pathway-mediated apoptosis related *** JPGS could markedly treat mice with streptozotocin(STZ)-induced DN,which is possibly related to the regulation of several metabolic pathways found in ***,JPGS could improve kidney inflammatory responses and ameliorate kidney injuries in DN mice via the TLR4/NF-κB/NLRP3 pathway and inhibit JNK/P38 pathwaymediated apoptosis in DN mice.

关键词： Diabetic nephropathy Jianpi Gushen Huayu Decoction Oxidative stress Inflammation Untargeted metabolomics Toll-like receptor 4/nuclear factor-kappa B/NOD-like receptor family pyrin domain containing 3 pathway c-Jun N-terminal kinase/P38-mediated apoptosis

A Multi-strategy Improved Snake Optimizer Assisted with Population Crowding Analysis for Engineering Design Problems

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Journal of Bionic Engineering 2024年第3期21卷 1567-1591页

作者： Lei Peng Zhuoming yuan Guangming Dai maocai Wang Jian Li Zhiming Song Xiaoyu Chen School of Computer Science China University of GeosciencesWuhan430074China Hubei Key Laboratory of Intelligent Geo-Information Processing China University of GeosciencesWuhan430074China China Astronautics Standards Institute Beijing100071China

Snake Optimizer(SO)is a novel Meta-heuristic Algorithm(ma)inspired by the mating behaviour of snakes,which has achieved success in global numerical optimization problems and practical engineering ***,it also has certain drawbacks for the exploration stage and the egg hatch process,resulting in slow convergence speed and inferior solution *** address the above issues,a novel multi-strategy improved SO(MISO)with the assistance of population crowding analysis is proposed in this *** the algorithm,a novel multi-strategy operator is designed for the exploration stage,which not only focuses on using the information of better performing individuals to improve the quality of solution,but also focuses on maintaining population *** boost the efficiency of the egg hatch process,the multi-strategy egg hatch process is proposed to regenerate individuals according to the results of the population crowding *** addition,a local search method is employed to further enhance the convergence speed and the local search *** is first compared with three sets of algorithms in the CEC2020 benchmark functions,including SO with its two recently discussed variants,ten advanced mas,and six powerful CEC competition *** performance of MISO is then verified on five practical engineering design *** experimental results show that MISO provides a promising performance for the above optimization cases in terms of convergence speed and solution quality.

关键词： Snake optimizer Multi-strategy Population crowding analysis Engineering design problem

Beyond ribosomal function:RPS6 deficiency suppresses cholangiocarcinoma cell growth by disrupting alternative splicing

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Acta Pharmaceutica Sinica B 2024年第9期14卷 3931-3948页

作者： Wenkang Fu Yanyan Lin Mingzhen Bai Jia Yao Chongfei Huang Long Gao Ningning Mi Haidong ma Liang Tian Ping Yue Yong Zhang Jinduo zhang Yanxian Ren Liyun Ding Lunzhi Dai Joseph WLeung Jinqiu yuan Wenhua Zhang Wenbo Meng The First School of Clinical Medicne Lanzhou UniversityLanzhou 730030China Department of General Surgery the First Hospital of Lanzhou UniversityLanzhou 730030China Key Laboratory of Biotherapy and Regenerative Medicine of Gansu Province the First Hospital of Lanzhou UniversityLanzhou 730000China School of Physical Science and Technology Lanzhou UniversityLanzhou 730000China National Clinical Research Center for Geriatrics and Department of General Practice State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China Division of Gastroenterology UC Davis Medical Center and Sacramento VA Medical CenterSacramentoCA 95817USA Clinical Research Center Big Data Centerthe Seventh Affiliated HospitalSun Yat-sen UniversityShenzhen 518107China School of Life Sciences Lanzhou UniversityLanzhou 730000China

Cholangiocarcinoma(CCA)is a bile duct malignancy with a dismal *** study systematically investigated the role of the ribosomal protein S6(RPS6)gene,which is dependent in *** found that RPS6 upregulation in CCA tissues was correlated with a poor *** investigations have shown that alterations in RPS6 expression,both gain-and loss-of function could affect the proliferation of CCA *** xenograft tumor models,RPS6 overexpression enhances tumorigenicity,whereas RPS6 silencing reduces *** analysis using RNA-seq and proteomics elucidated downstream signaling pathways of RPS6 depletion by affecting the cell cycle,especially DNA *** followed by mass spectrometry has identified numerous spliceosome complex proteins associated with *** profiling revealed that RPS6 affects numerous alternative splicing(AS)events,and combined with RNA immunoprecipitation sequencing,revealed that minichromosome maintenance complex component 7(MCM7)binds to RPS6,which regulates its AS and increases oncogenic activity in *** RPS6 with vivo phosphorodiamidate morpholino oligomer(V-PMO)significantly inhibited the growth of CCA cells,patient-derived organoids,and subcutaneous xenograft *** together,the data demonstrate that RPS6 is an oncogenic regulator in CCA and that RPS6-V-PMO could be repositioned as a promising strategy for treating CCA.

关键词： Cholangiocarcinoma Ribosomal protein S6 Alternative splicing p53 Minichromosome maintenance complex component 7 Vivo morpholino Patient-derived organoids

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分布式驱动电动汽车状态与路面附着系数估计

太原理工大学学报 2024年第4期55卷 612-618页

作者：袁媛王航赵鹏举程青丽太原科技大学车辆与交通工程学院太原030024

【目的】准确获取车辆行驶状态参数和路面附着系数对于维持分布式驱动电动汽车的安全性和稳定性十分重要,针对于此,研究了一种能够准确估计其参数的算法,既能降低量产车辆的成本,又能达到车辆安全稳定的目的。【方法】首先,建立三自由... 详细信息

【目的】准确获取车辆行驶状态参数和路面附着系数对于维持分布式驱动电动汽车的安全性和稳定性十分重要,针对于此,研究了一种能够准确估计其参数的算法,既能降低量产车辆的成本,又能达到车辆安全稳定的目的。【方法】首先,建立三自由度车辆模型,应用基于奇异值分解方法(SVD)的容积卡尔曼滤波算法搭建参数估计器。然后,搭建Carsim/Simulink联合仿真实验平台,采用高、低附着和对接路面双移线工况进行仿真验证。【结果】仿真实验结果表明,估计器能够较准确地估计出参数的真实值。基于仿真的良好估计效果,搭建实车实验平台,进一步进行验证得出,实车实验结果与仿真结果趋势一致,该算法具有较好的估计准确性和时效性。

关键词：分布式驱动电动汽车容积卡尔曼滤波奇异值分解行驶状态参数路面附着系数

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Alkyl chain modulation of asymmetric hexacyclic fused acceptor synergistically with wide bandgap third component for high efficiency ternary organic solar cells

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International Journal of Minerals,Metallurgy and materials 2024年第7期31卷 1713-1719页

作者： Shufang Li Huilan Guan Can Zhu Chaoyuan Sun Qingya Wei Jun yuan Yingping Zou College of Chemistry and Chemical Engineering Central South UniversityChangsha 410083China Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Organic SolidsInstitute of ChemistryChinese Academy of SciencesBeijing 100190China Institute of Carbon Neutrality and New Energy School of Electronics and InformationHangzhou Dianzi UniversityHangzhou 310018China

Herein,two asymmetric hexacyclic fused small molecule acceptors(Smas),namely BP4F-HU and BP4F-UU,were *** elongated outside chains in the BP4F-UU molecule played a crucial role in optimizing the morphology of blend film,thereby improving charge mobility and reducing energy loss within the corresponding ***,the PM6:BP4F-UU device exhibited a higher open-circuit voltage(V_(oc))of 0.878 V compared to the PM6:BP4F-HU device with a V_(oc)of 0.863 ***,a new wide bandgap Sma named BTP-TA was designed and synthesized as the third component to the PM6:BP4F-UU host binary devices,which showed an ideal complementary absorption spectrum in PM6:BP4F-UU *** addition,BTP-TA can achieve efficient intermolecular energy transfer to BP4F-UU by fluorescence resonance energy transfer(FRET)pathway,due to the good overlap between the photoluminescence(PL)spectrum of BTP-TA and the absorption region of ***,ternary devices with 15wt%BTP-TA exhibits broader photon utilization,optimal blend morphology,and reduced charge recombination compared to the corresponding binary ***,PM6:BP4F-UU:BTP-TA ternary device achieved an optimal power conversion efficiency(PCE)of 17.83%with simultaneously increased V_(oc)of 0.905 V,short-circuit current density(J_(sc))of 26.14 ma/cm^(2),and fill factor(FF)of 75.38%.

关键词： asymmetric hexacyclic acceptor outside chain wide bandgap acceptor ternary organic solar cells

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基于螺旋形纤芯的长周期光纤光栅扭转传感器

光学学报 2024年第11期44卷 258-264页

作者：马一巍田甜耿涛苑立波哈尔滨工程大学纤维集成光学教育部重点实验室黑龙江哈尔滨150001 哈尔滨工程大学材料科学与化学工程学院黑龙江哈尔滨150001 桂林电子科技大学光子学研究中心广西桂林541004

提出并制备了一种基于螺旋形纤芯的长周期光纤光栅扭转传感器。首先利用激光器对单模光纤进行周期性的多面蚀刻,然后对加工完成的光纤结构进行熔融加热,在表面张力的作用下,结构表面的凹槽形状可以转化为内部纤芯的变形。当该传感器受... 详细信息

提出并制备了一种基于螺旋形纤芯的长周期光纤光栅扭转传感器。首先利用激光器对单模光纤进行周期性的多面蚀刻,然后对加工完成的光纤结构进行熔融加热,在表面张力的作用下,结构表面的凹槽形状可以转化为内部纤芯的变形。当该传感器受到外界施加的扭转时,其纤芯的螺旋状态会被改变,从而使得结构纤芯和包层的有效折射率发生改变,达到提升传感器扭转灵敏度的目的。实验结果表明螺旋芯长周期光纤光栅在-18.42 rad/m至18.42 rad/m的测量范围内的扭转灵敏度可以达到0.37 nm/(rad/m),同时该传感器具有1.75 mm的紧凑长度。

关键词：光纤光学光纤传感器长周期光纤光栅螺旋纤芯扭转

基于聚乙烯醇/聚吡咯导电有机凝胶的合成及其在人体活动监测中的应用

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分析化学 2024年第7期52卷 945-954页

作者：马星悦张媛媛孙福欣张凌宇马崇博东北师范大学化学学院分析测试中心多酸与网状材料化学教育部重点实验室动力电池国家地方联合工程实验室纳米生物传感分析吉林省高校重点实验室

针对传统水凝胶在力学性能和环境稳定性方面的不足，本研究制备了一种基于聚乙烯醇（PVA）和聚吡咯（PPy）的新型导电有机凝胶，通过引入二甲基亚砜（DMSO）作为溶剂，显著改善了凝胶的机械强度和耐久性。采用红外光谱、热重分析和扫描... 详细信息

针对传统水凝胶在力学性能和环境稳定性方面的不足，本研究制备了一种基于聚乙烯醇（PVA）和聚吡咯（PPy）的新型导电有机凝胶，通过引入二甲基亚砜（DMSO）作为溶剂，显著改善了凝胶的机械强度和耐久性。采用红外光谱、热重分析和扫描电子显微镜等表征手段，考察了材料的结构特征和热稳定性。实验结果表明，有机凝胶在8%(m/m)PVA浓度下表现出最优性能，其平均孔径为5.2μm，导电率为0.65 S/cm。将PVA/PPy有机凝胶作为可穿戴应变传感器，展示了优良的灵敏度和响应性，能够精确检测关节和肌肉的运动，而且能捕捉脉搏跳动和声带振动等细微的生理信号。此凝胶在室温下放置48 h后仍能保持稳定的传感性能，显示出良好的环境适应性和长期使用潜力。本研究制备的PVA/PPy有机凝胶材料为智能医疗、健康监测和人机交互等领域的相关研究工作提供了技术支持，具有广阔的应用前景。

关键词：导电有机凝胶聚乙烯醇聚吡咯可穿戴应变传感器环境稳定性

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Gastrointestinal manifestations of critical ill heatstroke patients and their associations with outcomes:A multicentre,retrospective,observational study

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World Journal of Gastroenterology 2024年第4期30卷 346-366页

作者： Yu-Cong Wang Xin-Yang Jin Zheng Lei Xiao-Jiao Liu Yu Liu Bang-Guo Zhang Jian Gong Lie-Tao Wang Lv-yuan Shi Ding-yuan Wan Xin Fu Lu-Ping Wang Ai-Jia ma Yi-Song Cheng Jing Yang Min He Xiao-Dong Jin Yan Kang Bo Wang Zhong-Wei Zhang Qin Wu Department of Critical Care Medicine West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina School of Pharmacy Macao University of Science and TechnologyMacao 999078China Department of Critical Care Medicine The First People's Hospital of Ziyang CityZiyang 641399Sichuan ProvinceChina Department of Critical Care Medicine The First People's Hospital of Guanghan CityChengdu 618399Sichuan ProvinceChina Department of Critical Care Medicine Lezhi County Traditional Chinese Medicine HospitalChengdu 641599Sichuan ProvinceChina Department of Critical Care Medicine Chengdu Qingbaijiang District People's HospitalChengdu 610399Sichuan ProvinceChina Department of Critical Care Medicine Ziyang People's HospitalChengdu 641399Sichuan ProvinceChina

BACKGROUND Extreme heat exposure is a growing health problem,and the effects of heat on the gastrointestinal(GI)tract is *** study aimed to assess the incidence of GI symptoms associated with heatstroke and its impact on *** To assess the incidence of GI symptoms associated with heatstroke and its impact on *** Patients admitted to the intensive care unit(ICU)due to heatstroke were included from 83 *** history,laboratory results,and clinically relevant outcomes were recorded at ICU admission and daily until up to day 15,ICU discharge,or *** symptoms,including nausea/vomiting,diarrhoea,flatulence,and bloody stools,were *** characteristics of patients with heatstroke concomitant with GI symptoms were *** regression analyses were performed to determine significant predictors of GI *** A total of 713 patients were included in the final analysis,of whom 132(18.5%)patients had at least one GI symptom during their ICU stay,while 26(3.6%)suffered from more than one *** with GI symptoms had a significantly higher ICU stay compared with those *** mortality of patients who had two or more GI symptoms simultaneously was significantly higher than that in those with one GI *** logistic regression analysis revealed that older patients with a lower GCS score on admission were more likely to experience GI *** The GI manifestations of heatstroke are common and appear to impact clinically relevant hospitalization outcomes.

关键词： Extreme heat Flatulence Sunstroke Intensive care units Diarrhea