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Determination of berberine in Phellodendron amurense from different sites of Changbai Mountain

Journal of Forestry Research 2015年第1期26卷 201-207页

作者： Lin Ma Jun-qing Li yuan-dong hu Key Laboratory for Silviculture and Conservation of Ministry of Education Forest CollegeBeijing Forestry University Landscape Architecture School Northeast Forestry University

Phellodendron amurense has been used for many years as a medical plant in traditional Chinese medicine and has shown great prospect in recent clinical trials for future applications. Berberine is an essential active compound contained in P. amurense. Our objective in this study was to quantify the content of berberine in *** from sites at different elevations on Changbai Mountain. We collected samples of P. amurense from five different elevations on Changbai Mountain. Berberine in samples was extracted by ultrahigh pressure extraction（UPE）. And the quantity was measured by high performance liquid chromatography（HPLC）. First, the optimal HPLC conditions for berberine were identified with satisfactory precision（relative standard deviation, R SD／5.6 %）, good accuracy（relative error, R E／ 3.6 %） and good linear relation（R2= 0.9998） in the range of 6.576–328.8 mg L-1. Second, the combination of UPE and HPLC methods in quantitative analysis of berberine showed high repeatability（R SD= 3.28 %）, reproducibility（R SD= 4.72 %）,stability（R SD／ 1.27 %） and good recovery（99.54 %） for real plant materials. Samples from Heilongjiang Province at the lowest elevation contained the highest amount of ***, the lowest amount of berberine was recorded in samples from Changbai Forest Bureau of Jilin Province collected at the highest elevation in this paper. The proposed UPE–HPLC method is simple, reliable and low-cost for quantitative analysis of berberine. Content of berberine in *** varied significantly by site on Changbai Mountain.

关键词： Phellodendron amurense Berberine Changbai Mountain Altitudes Ultrahigh pressure extraction High performance liquid chromatography

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A model of 3D-structure of H+, K+-ATPase catalytic subunit derived by homology modeling

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Acta Pharmacologica Sinica 2004年第4期25卷 76-81页

作者： dong YAN, yuan-dong hu1, Song LI1, Mao-sheng CHENG2 Shenyang Pharmaceutical University, Shenyang 110016 1Academy of Military Medical Sciences, Beijing 100850, China Shenyang Pharmaceutical University cademy of Military Medical Sciences

AIM: To build a model of 3D-structure of H+, K+-ATPase catalytic subunit for theoretical study and anti-ulcer drug design. METHODS: The model was built on the basis of structural data from the Ca2+-ATPase. Structurally conserved regions were defined by amino acid sequence comparisons, optimum interconnecting loops were se- lected from the protein databank, and amino (N)- and carboxyl (C)-terminal ends were generated as random coil structures. Applying molecular mechanics method then minimized the model energy. Molecular dynamics tech- nique was used to do further structural optimization. RESULTS: The model of 3D-structure of H+, K+-ATPase was derived. The model is reasonable according to several validation criteria. There were ten transmembrane helices (TM1-TM10) in the model and inhibitor-binding site was identified on the TM5-8 riched negatively charged residues. CONCLUSION: The 3D-structure model from our study is informative to guide future molecular biology study about H+, K+-ATPase and drug design based on database searching.

关键词： peptic ulcer H(+)-K(+)-exchanging ATPase protein structural homology drug design

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Effects of a fatty acid synthase inhibitor on adipocyte differentiation of mouse 3T3-L1 cells

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Acta Pharmacologica Sinica 2004年第8期 78-83页

作者： Li-hong LIU, Xiao-kui WANG, yuan-dong hu, Jian-lei KANG, Li-li WANG, Song LIBeijing Institute of Pharmacology and Toxicology, Beijing 100850, China

AIM: To investigate the influence of C75, a fatty acid synthase inhibitor, on adipocyte differentiation. METHODS: Mouse 3T3-L1 preadipocytes were induced to differentiation by insulin, isobutylmethylxanthine, and dexamethasone. Oil red O staining was performed and activity of glycerol-3-phosphate dehydrogenase (GPDH) was measured. The level of peroxisome proliferators-activated receptor y (PPARy) mRNA was assayed by semi-quantitative reverse transcription PCR. RESULTS: C75 blocked the adipogenic conversion in a dose-dependent manner and the inhibitory effects occurred both in the early phases (48 h) and in the latter phases (8 d) of the process. Treatment with C75 for 8 d induced more decrease in lipid content than 48 h (P<0.01). Treatment with C75 50 mg/L for 48 h or 8 d decreased GPDH activity by 52.8 % and 31.2 % of Vehicle, respectively. Treatment with C75 10-50 mg/L for 48 h or 8 d down-regulated PPARy mRNA expression compared with control (P<0.01). CONCLUSION: C75 blocked the adipocyte differentiat

关键词： adipocytes 3T3-L1 preadipocyte cell differentiation fatty acid synthetase complex C75 cpd peroxisome proliferators-activated receptor y

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多重分形维数在语音分割和语音识别中的应用

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上海交通大学学报 1999年第11期33卷 1406-1408页

作者：董远胡光锐上海交通大学电子工程系上海200030

语音气流中具有混沌特征，而分形可以定量地分析混沌现象，故分形可作为分析语音信号的数学工具．由于传统的Ｈａｕｓｄｏｒｆｆ－Ｂｅｓｉｃｏｖｉｔｃｈ维数没有考虑关于集合中点的分布信息，本文引入多重分形维数来克服上述缺点．... 详细信息

语音气流中具有混沌特征，而分形可以定量地分析混沌现象，故分形可作为分析语音信号的数学工具．由于传统的Ｈａｕｓｄｏｒｆｆ－Ｂｅｓｉｃｏｖｉｔｃｈ维数没有考虑关于集合中点的分布信息，本文引入多重分形维数来克服上述缺点．实验表明，多重分形维数语音分割方法明显好于单一Ｈａｕｓｄｏｒｆｆ－Ｂｅｓｉｃｏｖｉｔｃｈ

关键词：分形多重分形语音分割语音识别维数

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天然气/汽油两用燃料发动机润滑油优化试验

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长安大学学报（自然科学版） 2007年第2期27卷 94-98页

作者：董元虎尹兴林冯豫川长安大学汽车学院陕西西安710064 西安市公交公司第六公司陕西西安710016

针对公交车用天然气(CNG)/汽油两用燃料发动机使用汽油发动机润滑油出现的积炭多、早期磨损、换油周期缩短等问题,结合公交车用CNG/汽油两用燃料发动机的工作特点,通过大量的试验,研究了基础油对清净分散剂、抗氧抗腐剂、降凝剂等功能... 详细信息

针对公交车用天然气(CNG)/汽油两用燃料发动机使用汽油发动机润滑油出现的积炭多、早期磨损、换油周期缩短等问题,结合公交车用CNG/汽油两用燃料发动机的工作特点,通过大量的试验,研究了基础油对清净分散剂、抗氧抗腐剂、降凝剂等功能添加剂的感受性及添加剂之间的配伍性;运用正交试验进行方案设计,通过对试验数据处理和分析,得出了各因素的影响程度,并确定出了公交车用15W/40 CNG/汽油两用燃料发动机润滑油的优化配方。结果表明:新研制的15W/40 CNG公交车用CNG/汽油两用燃料发动机润滑油具有良好的高低温清净性、抗氧抗腐性和抗磨性能。

关键词：汽车工程两用燃料发动机油基础油功能添加剂优化配方

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深入贯彻落实科学发展观

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毛泽东邓小平理论研究 2011年第5期 1-6页

作者：庞元正董振华中共中央党校哲学部

深入贯彻落实科学发展观,需找准着力点和突破口:第一,必须充分认识贯彻落实科学发展观所取得的巨大成就和我国当前所面临的严峻挑战,增强贯彻落实科学发展观的自觉性和坚定性;第二,必须以经济结构调整为主攻方向,加快推进经济发展方式... 详细信息

深入贯彻落实科学发展观,需找准着力点和突破口:第一,必须充分认识贯彻落实科学发展观所取得的巨大成就和我国当前所面临的严峻挑战,增强贯彻落实科学发展观的自觉性和坚定性;第二,必须以经济结构调整为主攻方向,加快推进经济发展方式转变的基本路径;第三,必须把民生问题提高到战略高度来认识,以民生建设为重点推进经济社会协调发展;第四,必须重视不同社会群体之间的利益博弈关系,以利益关系的调整为突破口,大力推进体制机制的改革创新;第五,必须在破解发展难题的实践中推进理论创新,构建科学发展观的理论体系,为夺取中国特色社会主义事业的新胜利提供强大的思想武器。

关键词：科学发展观经济发展方式民生改革理论创新

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Computed tomography enterography-based radiomics for assessing mucosal healing in patients with small bowel Crohn's disease

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World Journal of Gastroenterology 2025年第3期31卷 62-72页

作者： Hao Ding yuan-yuan Fang Wen-Jie Fan Chen-Yu Zhang Shao-Fei Wang Jing hu Wei Han Qiao Mei Department of Gastroenterology The First Affiliated Hospital of Anhui Medical UniversityHefei 230022Anhui ProvinceChina Department of Radiation Oncology The First Affiliated Hospital of Anhui Medical UniversityHefei 230022Anhui ProvinceChina Department of Gastroenterology Suzhou First People's HospitalSuzhou 234099Anhui ProvinceChina

BACKGROUND Mucosal healing(MH)is the major therapeutic target for Crohn's disease(CD).As the most commonly involved intestinal segment,small bowel(SB)assessment is crucial for CD ***,it poses a significant challenge due to its limited accessibility through conventional endoscopic *** To establish a noninvasive radiomic model based on computed tomography enterography(CTE)for MH assessment in SBCD *** Seventy-three patients diagnosed with SBCD were included and divided into a training cohort(n=55)and a test cohort(n=18).Radiomic features were obtained from CTE images to establish a radiomic *** demographics were analysed to establish a clinical model.A radiomic-clinical nomogram was constructed by combining significant clinical and radiomic *** diagnostic efficacy and clinical benefit were evaluated via receiver operating characteristic(ROC)curve analysis and decision curve analysis(DCA),*** Of the 73 patients enrolled,25 patients achieved *** radiomic-clinical nomogram had an area under the ROC curve of 0.961(95%confidence interval:0.886-1.000)in the training cohort and 0.958(0.877-1.000)in the test cohort and provided superior clinical benefit to either the clinical or radiomic models alone,as demonstrated by *** These results indicate that the CTE-based radiomic-clinical nomogram is a promising imaging biomarker for MH and serves as a potential noninvasive alternative to enteroscopy for MH assessment in SBCD patients.

关键词： Crohn’s disease Computed tomography enterography Mucosal healing Nomogram Radiomics

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共线和非共线模式下单光子探测器定标比对实验研究

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光子学报 2017年第2期46卷 181-188页

作者：郭园园高冬阳胡友勃李健军郑小兵闫静中国科学院安徽光学精密机械研究所通用光学定标与表征技术重点实验室合肥230031 中国科学技术大学合肥230026

采用相关光子法定标单光子探测器的量子效率对提高光学载荷的辐射定标准确度具有重要意义.利用355nm连续激光泵浦BBO晶体产生Ⅰ类自发参量下转换,在共线和非共线两种相位匹配模式下分别测量了单光子探测器雪崩光电二极管在736nm波段的... 详细信息

采用相关光子法定标单光子探测器的量子效率对提高光学载荷的辐射定标准确度具有重要意义.利用355nm连续激光泵浦BBO晶体产生Ⅰ类自发参量下转换,在共线和非共线两种相位匹配模式下分别测量了单光子探测器雪崩光电二极管在736nm波段的量子效率.结果表明,共线和非共线两种模式测量结果的合成不确定度分别为0.71%和0.39%,相对偏差均优于0.4%,这两种模式都可以定标探测器量子效率,且具有很好的一致性.最后比较了两种模式定标探测器量子效率的优缺点,该研究为以后利用相关光子法对遥感器进行辐射定标提供了晶体相位匹配模式选择的依据.

关键词：光电子量子效率相关光子单光子探测器比对相位匹配

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Exploring the performance of large language models on hepatitis B infection-related questions:A comparative study

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World Journal of Gastroenterology 2025年第3期31卷 103-112页

作者： Yu Li Chen-Kai huang Yi hu Xiao-dong Zhou Cong He Jia-Wei Zhong Department of Gastroenterology Jiangxi Provincial Key Laboratory of Digestive DiseasesJiangxi Clinical Research Center for GastroenterologyDigestive Disease HospitalThe First Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina huanKui Academy Nanchang UniversityNanchang 330006Jiangxi ProvinceChina

BACKGROUND Patients with hepatitis B virus(HBV)infection require chronic and personalized care to improve *** language models(LLMs)can potentially provide medical information for *** To examine the performance of three LLMs,ChatGPT-3.5,ChatGPT-4.0,and Google Gemini,in answering HBV-related *** LLMs’responses to HBV-related questions were independently graded by two medical professionals using a four-point accuracy scale,and disagreements were resolved by a third *** question was run three times using three *** was assessed via the Gunning Fog index and Flesch-Kincaid grade *** Overall,all three LLM chatbots achieved high average accuracy scores for subjective questions(ChatGPT-3.5:3.50;ChatGPT-4.0:3.69;Google Gemini:3.53,out of a maximum score of 4).With respect to objective questions,ChatGPT-4.0 achieved an 80.8%accuracy rate,compared with 62.9%for ChatGPT-3.5 and 73.1%for Google *** the six domains,ChatGPT-4.0 performed better in terms of diagnosis,whereas Google Gemini demonstrated excellent clinical ***,in the readability analysis,the mean Gunning Fog index and Flesch-Kincaid grade level scores of the three LLM chatbots were significantly higher than the standard level eight,far exceeding the reading level of the normal *** Our results highlight the potential of LLMs,especially ChatGPT-4.0,for delivering responses to HBV-related *** may be an adjunctive informational tool for patients and physicians to improve ***,current LLMs should not replace personalized treatment recommendations from physicians in the management of HBV infection.

关键词： ChatGPT-3.5 ChatGPT-4.0 Google Gemini Hepatitis B infection Accuracy

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生物柴油与轻柴油混合燃料的理化特性

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长安大学学报（自然科学版） 2008年第3期28卷 88-91页

作者：耿莉敏董元虎边耀璋陈昊魏秋兰长安大学汽车学院陕西西安710064

用0#柴油与大豆毛油制成的生物柴油配成10种不同掺混比的混合燃料,测定了混合燃料的兼容性、密度、闪点、馏程、运动粘度、酸值、凝点和冷滤点等指标。结果表明:生物柴油与0#柴油具有良好的兼容性,其混合燃料的密度、闪点、蒸馏温度、... 详细信息

用0#柴油与大豆毛油制成的生物柴油配成10种不同掺混比的混合燃料,测定了混合燃料的兼容性、密度、闪点、馏程、运动粘度、酸值、凝点和冷滤点等指标。结果表明:生物柴油与0#柴油具有良好的兼容性,其混合燃料的密度、闪点、蒸馏温度、运动粘度和酸值随生物柴油掺混比的增大而增大,生物柴油的凝点和冷滤点偏高;掺混比小于或等于20%的混合燃料基本符合国家轻柴油标准;而使用较高掺混比的混合燃料时,必须对馏程、酸值和冷滤点等指标进行改进。

关键词：汽车工程生物柴油轻柴油混合燃料理化特性

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