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Co-culture of oligodendrocytes and neurons can be used to assess drugs for axon regeneration in the central nervous system

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Neural Regeneration Research 2015年第10期10卷 1612-1616页

作者： Lin Gang Yu-chen Yao Ying-fu Liu Yi-peng Li Kai Yang Lei Lu yuan-chi cheng Xu-yi Chen Yue Tu Neurological Hospital of Affiliated Hospital of Logistics University of chinese People’s Armed Police Force Tianjin University of Traditional chinese Medicine Logistics University of chinese People’s Armed Police Forces Liaoning Medical University Key Laboratory of Nerve Trauma Repair

We present a novel in vitro model in which to investigate the efficacy of experimental drugs for the promotion of axon regeneration in the central nervous system. We co-cultured rat hippocampal neurons and cerebral cortical oligodendrocytes, and tested the co-culture system using a Nogo-66 receptor antagonist peptide（NEP1–40）, which promotes axonal growth. Primary cultured oligodendrocytes suppressed axonal growth in the rat hippocampus, but NEP1–40 stimulated axonal growth in the co-culture system. Our results confirm the validity of the neuron-oligodendrocyte co-culture system as an assay for the evaluation of drugs for axon regeneration in the central nervous system.

关键词： nerve regeneration experimental models NEP1–40 oligodendrocytes neurons axon regeneration Nogo PC12 cells neural regeneration

Exendin-4 inhibits high-altitude cerebral edema by protecting against neurobiological dysfunction

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Neural Regeneration Research 2018年第4期13卷 653-663页

作者： Zhong-Lei Sun Xian-Feng Jiang yuan-chi cheng Ying-Fu Liu Kai Yang Shuang-Long Zhu Xian-Bin Kong Yue Tu Ke-Feng Bian Zhen-Lin Liu Xu-Yi Chen Affiliated Hospital of Logistics University of chinese People's Armed Police Forces Institute of Traumatic Brain Trauma and Neurological of CAPF Neurotrauma Repair Key Laboratory of Tianjin Tianjin China Jinzhou Medical University Jinzhou Liaoning Province China Tianjin Medical University Tianjin China Central Hospital of Fengxian District of Shanghai Shanghai China Logistics University of People's Armed Police Force Tianjin China The No. 2 Hospital of Nanjing Nanjing Jiangsu Province China Tianjin University of Traditional chinese Medicine Tianjin China

The anti-inflammatory and antioxidant effects of exendin-4（Ex-4） have been reported ***,whether（Ex-4） has anti-inflammatory and antioxidant effects on high-altitude cerebral edema（HACE） remains poorly *** this study,two rat models of HACE were established by placing rats in a hypoxic environment with a simulated altitude of either 6000-or 7000-m above sea level（MASL） for 72 *** altitude of 7000 MASL with 72-hours of hypoxia was found to be the optimized experimental paradigm for establishing HACE ***,in rats where a model of HACE was established by introducing them to a 7000 MASL environment with 72-hours of hypoxia treatment,2,10 and,100 μg of Ex-4 was intraperitoneally *** open field test and tail suspension test were used to test animal *** methods were used to detect change in inflammatory ***-eosin staining was performed to determine pathological changes to brain ***/dry weight ratios were used to measure brain water *** blue leakage was used to determine blood-brain barrier ***-linked immunosorbent assay（ELISA） was performed to measure markers of inflammation and oxidative stress including superoxide dismutase,glutathione,and malonaldehyde values,as well as interleukin-6,tumor necrosis factor-alpha,cyclic adenosine monophosphate levels in the brain *** blot analysis was performed to determine the levels of occludin,ZO-1,SOCS-3,vascular endothelial growth factor,EPAC1,nuclear factor-kappa B,and *** results demonstrate that Ex-4 preconditioning decreased brain water content,inhibited inflammation and oxidative stress,alleviated brain tissue injury,maintain blood-brain barrier integrity,and effectively improved motor function in rat models of *** findings suggest that Ex-4 exhibits therapeutic potential in the treatment of HACE.

关键词： high-altitude cerebral edema exendin-4 cyclic adenosine monophosphate EPACI suppressor of cytokine signaling 3 vascular endothelial growth factor hypoxia inflammation oxidative stress

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中心变异差分进化算法

系统工程与电子技术 2010年第5期32卷 1105-1108页

作者：池元成方杰蔡国飙北京航空航天大学宇航学院北京100191

针对高维复杂优化问题,提出了基于中心变异和自适应交叉概率的差分进化算法——中心变异差分进化(center mutation-based differential evolution,CMDE)算法。该算法首先改进了个体的变异形式,即把当前代的群体中心作为基向量,依据参加... 详细信息

针对高维复杂优化问题,提出了基于中心变异和自适应交叉概率的差分进化算法——中心变异差分进化(center mutation-based differential evolution,CMDE)算法。该算法首先改进了个体的变异形式,即把当前代的群体中心作为基向量,依据参加变异的三个随机个体向量间的函数适应值的大小关系,确定差向量的方向;然后给出了自适应交叉概率策略,即依据交叉的作用,通过分析个体向量间的函数适应值在群体内部的分布情况,确定每个个体的交叉概率。通过几个Benchmark函数的测试表明,CMDE算法具有较快的收敛速度,且对于高维复杂问题的求解精度高,寻优性能好。

关键词：差分进化中心变异自适应交叉概率函数优化

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基于蚁群算法的多目标优化

计算机工程 2009年第15期35卷 168-169,172页

作者：池元成蔡国飙北京航空航天大学宇航学院北京100083

针对多目标优化问题,提出一种用于求解多目标优化问题的蚁群算法。该算法定义连续空间内求解多目标优化问题的蚁群算法的信息素更新方式,根据信息素的概率转移和随机选择转移策略指导蚂蚁进行搜索,保证获得的Pareto前沿的均匀性以及Par... 详细信息

针对多目标优化问题,提出一种用于求解多目标优化问题的蚁群算法。该算法定义连续空间内求解多目标优化问题的蚁群算法的信息素更新方式,根据信息素的概率转移和随机选择转移策略指导蚂蚁进行搜索,保证获得的Pareto前沿的均匀性以及Pareto解集的多样性。对算法的收敛性进行分析,利用2个测试函数验证算法的有效性。

关键词：蚁群算法多目标优化收敛性分析

自适应中心变异差分进化算法及其在涡轮叶型优化设计中的应用

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航空动力学报 2010年第8期25卷 1849-1854页

作者：池元成方杰饶大林蔡国飙北京航空航天大学宇航学院北京100191

为了更好地求解多维复杂函数优化问题,提出了自适应中心变异差分进化算法(SCDE),并以低温火箭发动机多级氧涡轮叶片的高精度气动型面优化设计为例进行了验证.使用商业软件进行三维叶片几何造型和单通道流场分析,计算得到涡轮效率作为优... 详细信息

为了更好地求解多维复杂函数优化问题,提出了自适应中心变异差分进化算法(SCDE),并以低温火箭发动机多级氧涡轮叶片的高精度气动型面优化设计为例进行了验证.使用商业软件进行三维叶片几何造型和单通道流场分析,计算得到涡轮效率作为优化设计评价指标.最终得到了合理的优化结果,涡轮效率相比初始设计提高了5.25%.

关键词：差分进化自适应中心变异涡轮叶片气动优化

多目标蚁群算法及其在固液混合火箭发动机系统优化设计中的应用

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宇航学报 2010年第5期31卷 1482-1486页

作者：池元成饶大林方杰蔡国飙北京航空航天大学宇航学院北京100191

为了提高求解多目标优化问题的Pareto解集的效率,建立了适用于多维、多目标优化问题的多目标蚁群算法(Multi-objective Ant Colony Algorithm,简称MACA)。该算法首先修正了蚁群算法的信息素更新机制和转移概率,然后改进了蚂蚁的行进策略... 详细信息

为了提高求解多目标优化问题的Pareto解集的效率,建立了适用于多维、多目标优化问题的多目标蚁群算法(Multi-objective Ant Colony Algorithm,简称MACA)。该算法首先修正了蚁群算法的信息素更新机制和转移概率,然后改进了蚂蚁的行进策略,即提出了依概率选择搜索策略。最后,应用该算法对某型号固液混合火箭发动机系统进行了优化设计。计算结果表明,多目标蚁群算法获得的Pareto解集分布均匀、散布范围广,可以有效解决多目标优化问题,能为决策者进行目标权衡提供充分依据。

关键词：蚁群算法多目标优化固液混合火箭发动机优化设计 Pareto解集

基于差分进化和粒子群优化算法的混合优化算法

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计算机工程与设计 2009年第12期30卷 2963-2965,2980页

作者：池元成方杰蔡国飙北京航空航天大学宇航学院北京100191

为了发挥差分进化和粒子群优化算法各自拥有的特点,并克服自身存在的问题,提出了一种混合优化算法(简称DPA)。该算法首先利用差分进化的变异和选择算子产生新的群体,然后通过使用粒子群优化算法和交叉、选择算子进行局部搜索。在整个算... 详细信息

为了发挥差分进化和粒子群优化算法各自拥有的特点,并克服自身存在的问题,提出了一种混合优化算法(简称DPA)。该算法首先利用差分进化的变异和选择算子产生新的群体,然后通过使用粒子群优化算法和交叉、选择算子进行局部搜索。在整个算法过程中,群体寻优范围先扩散再收缩,反复迭代渐进收敛。通过3个标准算例的测试表明,新的混合优化算法与差分进化和粒子群优化算法相比,具有收敛速度快、搜索能力强、鲁棒性好的特点。

关键词：差分进化粒子群优化算法混合算法优化基准测试函数

Pancreatic stent improves the success rate of needle-knife papillotomy in patients with difficult biliary cannulation

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World Journal of Gastroenterology 2025年第1期31卷 58-67页

作者： Mu-Hsien Lee cheng-Hui Lin chi-Huan Wu Yung-Kuan Tsou Kai-Feng Sung Sheng-Fu Wang Nai-Jen Liu Department of Gastroenterology and Hepatology Chang Gung Memorial Hospital and Chang Gung University College of MedicineTaoyuan 33305Taiwan School of Medicine Chang Gung UniversityTaoyuan 33305Taiwan

BACKGROUND Needle-knife precut papillotomy(NKP)is typically performed ***,it remains unclear whether pancreatic stent(PS)placement can improve the outcomes of *** To explore whether PS placement improves the success rate of NKP in patients with difficult biliary *** This single-center retrospective study included 190 patients who underwent NKP between January 2017 and December 2021 after failed conventional biliary *** cases with incidental pancreatic duct cannulation during conventional biliary cannulation,the decision for pre-NKP PS placement was made at the endoscopist's *** primary outcome was the difference in the NKP success rate between patients with and without PS placement;the secondary outcome was the adverse event *** Among the 190 participants,82 received pre-NKP PS(PS-NKP group)whereas 108 did not[freehand or freehand NKP(FH-NKP)group].Post-NKP selective biliary cannulation was successful in 167(87.9%)patients,and the PS-NKP had a significantly higher success rate than the FH-NKP group(93.9%vs 83.3%,P=0.027).The overall adverse event rates were 7.3%and 11.1%in the PS-NKP and FH-NKP groups,respectively(P=0.493).A periampullary diverticulum(PAD)and significant intraoperative bleeding during NKP were independently associated with NKP failure;however,a pre-NKP PS was the only predictor of NKP *** the 44 participants with PADs,the PS-NKP group had a non-significantly higher NKP success rate than the FH-NKP group(87.5%and 65%,respectively;P=0.076).CONCLUSION PS significantly improved the success rate of NKP in patients with difficult biliary cannulation.

关键词： Difficult biliary cannulation Endoscopic retrograde cholangiopancreatography Needle-knife papillotomy Pancreatic stent Selective biliary cannulation

“Zero‑Strain” NiNb_(2)O_(6) Fibers for All‑Climate Lithium Storage

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Nano-Micro Letters 2025年第1期17卷 348-360页

作者： Yan Zhao Qiang yuan Liting Yang Guisheng Liang Yifeng cheng Limin Wu Chunfu Lin Renchao Che College of Physics Donghua UniversityShanghai 201620People’s Republic of China School of Materials Science and Engineering Institute of Materials for Energy and EnvironmentQingdao UniversityQingdao 266071People’s Republic of China Laboratory of Advanced Materials Shanghai Key Laboratory of Molecular Catalysis and Innovative MaterialsAcademy for Engineering&TechnologyFudan UniversityShanghai 200438People’s Republic of China Zhejiang Laboratory Hangzhou 311100People’s Republic of China Inner Mongolia University Hohhot 010021People’s Republic of China

Niobates are promising all-climate Li^(+)-storage anode material due to their fast charge transport,large specific capacities,and resistance to electrolyte ***,their moderate unit-cellvolume expansion(generally 5%–10%)during Li^(+)storage causes unsatisfactory long-term ***,“zero-strain”NiNb_(2)O_(6) fibers are explored as a new anode material with comprehensively good electrochemical *** Li^(+)storage,the expansion of electrochemical inactive NiO_(6) octahedra almost fully offsets the shrinkage of active NbO_(6) octahedra through reversible O *** superior volume-accommodation capability of the NiO_(6) layers guarantees the“zero-strain”behavior of NiNb_(2)O_(6) in a broad temperature range(0.53%//0.51%//0.74%at 25//−10//60℃),leading to the excellent cyclability of the NiNb_(2)O_(6) fibers(92.8%//99.2%//91.1%capacity retention after 1000//2000//1000 cycles at 10C and 25//−10//60℃).This NiNb_(2)O_(6) material further exhibits a large reversible capacity(300//184//318 mAh g−1 at 0.1C and 25//−10//60℃)and outstanding rate performance(10 to 0.5C capacity percentage of 64.3%//50.0%//65.4%at 25//−10//60℃).Therefore,the NiNb_(2)O_(6) fibers are especially suitable for large-capacity,fast-charging,long-life,and all-climate lithium-ion batteries.

关键词： NiNb_(2)O_(6)porous fiber “Zero-strain”mechanism Electrochemical property Harsh-temperature operation Operando characterization