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Dearomatized Isoprenylated Acylphloroglucinol Derivatives with Potential Antitumor Activities from Hypericum henryi

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Natural Products and Bioprospecting 2020年第1期10卷 1-11页

作者： Yan-Song Ye Man Wu Na-Na Jiang yuan-zhi lao Wen-Wei Fu Xia Liu Xing-Wei Yang Juan Zhang Hong-Xi Xu Gang Xu State Key Laboratory of Phytochemistry and Plant Resources in West China and Yunnan Key Laboratory of Natural Medicinal Chemistry Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China School of Pharmacy Shanghai University of Traditional Chinese MedicineShanghai 201203China Department of Pharmacy Chongqing Traditional Chinese Medicine HospitalChongqing 400021China University of Chinese Academy of Sciences Beijing 100049China

A series of dearomatized isoprenylated acylphloroglucinols derivatives,hyperhenols A-E(1-5),as well as seven known analogues(6-12),were characterized from Hypericum henryi.Their structures were determined by combination of NMR,ECD spectroscopy,and X-ray difraction analysis.Compounds 1 and 6-8 were tested to exhibit potential antitumor properties,of which 6 and 7 inhibited cell growth through inducing apoptosis and cell cycle arrest.In addition,these compounds could induce autophagy and PINK1/Parkin-mediated mitophagy in cancer cell lines,as well as suppress lung cancer A549 cells metastasis in vitro.

关键词： Hypericum henryi Dearomatized isoprenylated acylphloroglucinols(DIAPs) Apoptosis Cell cycle arrest

Synergic action of linear dispersion, second-order nonlinearity, and third-order nonlinearity in shaping the spectral profile of a femtosecond pulse transporting in a lithium niobate crystal

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Photonics Research 2024年第4期12卷 774-783页

作者： LIHONG HONG yuanyuan LIU zhi-yuan LI State Key Laboratory of High Field Laser Physics Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghai 201800China School of Physics and Optoelectronics South China University of TechnologyGuangzhou 510640China

We present a detailed theoretical and numerical analysis on the temporal-spectral-spatial evolution of a highpeak-power femtosecond laser pulse in two sets of systems:a pure lithium niobate(LN)plate and a periodically poled lithium niobate(PPLN)plate.We develop a modified unidimensional pulse propagation model that considers all the prominent linear and nonlinear processes and carried out the simulation process based on an improved split-step Fourier transformation method.We theoretically analyze the synergic action of the linear dispersion effect,the second-order nonlinearity(2nd-NL)second-harmonic generation(SHG)effect,and the third-order nonlinearity(3rd-NL)self-phase modulation(SPM)effect,and clarify the physical mechanism underlying the peculiar and diverse spectral broadening patterns previously reported in LN and PPLN thin plate experiments.Such analysis and discussion provides a deeper insight into the synergetic contribution of these linear and nonlinear effects brought about by the interaction of a femtosecond laser pulse with the LN nonlinear crystal and helps to draw a picture to fully understand these fruitful optical physical processes,phenomena,and laws.

关键词： pulse nonlinearity lithium

Guttiferone K Sensitizes HeLa Cells to Nutrient Stress Induced Cell Death through JNK Activation and Akt-mTOR-mediated Signaling

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Guttiferone K Sensitizes HeLa Cells to Nutrient Stress Induc...

第十四届全国中药和天然药物学术研讨会

作者： Man Wu Xiao-yu Wang yuan-zhi lao Hong-xi Xu Shanghai University of Traditional Chinese Medicine

＜正＞Medicinal plants are excellent sources of pharmaceutical agents.In a screen designed to identify autophagic regulators from Garcinia yunnanensis,we found that Guttiferone K（GUTK）could regulate the autophagic process in cancer cell lines.GUTK dramatically induced GFP-LC3 puncta formation,leading to the accumulation of LC3-Ⅱand the

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Identification and Characterization of Anticancer Compounds Targeting Apoptosis and Autophagy from Chinese Native Garcinia Plants

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Identification and Characterization of Anticancer Compounds ...

第十四届全国中药和天然药物学术研讨会

作者： Dan-qing Xu Wen-wei Fu yuan-zhi lao Hong-xi Xu Shanghai University of Traditional Chinese Medicine

＜正＞Natural compounds from medicinal plants are important resources for drug development.Active compounds targeting apoptosis and autophagy are candidates for anti-cancer drugs.In this study,we collected Garcinia plants from China and extracted them into water or ethanol fractions.Then,we performed a functional screen in search of novel apoptosis and autophagy

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Single-atom Ag-loaded carbon nitride photocatalysts for efficient degradation of acetaminophen:The role of Ag-atom and O_(2)

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Journal of Environmental Sciences 2024年第5期139卷 12-22页

作者： Yi yuan Wen-Long Wang zhi-Wei Wang Jin Wang Qian-yuan Wu Key Laboratory of Microorganism Application and Risk Control of Shenzhen Guangdong Provincial Engineering Research Center for Urban Water Recycling and Environmental SafetyInstitute of Environment and EcologyShenzhen International Graduate SchoolTsinghua UniversityShenzhen 518055China Shenzhen Environmental Science and New Energy Technology Engineering Laboratory Tsinghua-Berkeley Shenzhen InstituteShenzhen 518055China College of Materials Science and Engineering Shenzhen UniversityShenzhen 518071China

Carbon nitride has been extensively used as a visible-light photocatalyst,but it has the disadvantages of a low specific surface area,rapid electron-hole recombination,and relatively low light absorbance.In this study,single-atom Ag was successfully anchored on ultrathin carbon nitride(UTCN)via thermal polymerization,the catalyst obtained is called AgUTCN.The Ag hardly changed the carbon nitride's layered and porous physical *** exhibited efficient visible-light photocatalytic performances in the degradation of various recalcitrant pollutants,eliminations of 85% were achieved by visible-light irradiation for 1hr.Doping with Ag improved the photocatalytic performance of UTCN by narrowing the forbidden band gap from 2.49 to 2.36 e V and suppressing electron-hole pair recombination.In addition,Ag doping facilitated O_(2) adsorption on UTCN by decreasing the adsorption energy from -0.2 to -2.22 e V and favored the formation of O_(2)^(·-).Electron spin resonance and radical-quenching experiments showed that O_(2)^(·-)was the major reactive species in the degradation of Acetaminophen(paracetamol,APAP).

关键词： Ag single atom Carbon nitride Photocatalysis Visible light Adsorption energy Reactive species

Guttiferone K,a Compound Isolated from Garcinia yunnanensis Blocks Cell Cycle Re-entry of Quiescent Prostate Cancer Cells

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Guttiferone K,a Compound Isolated from Garcinia yunnanensis ...

第十四届全国中药和天然药物学术研讨会

作者： zhi-chao Xi Mu Yao Yang Li yuan-zhi lao Qi-han Dong Hong-xi Xu Shanghai University of Traditional Chinese Medicine

＜正＞Prostate cancer has become the most prevalent male cancer,with cancer recurrence being the main cause of mortality.Quiescent prostate cancer cells may cause cancer recurrence via cell cycle re-entry.Guttiferone K（GUTK）,isolated from the fruit or twigs of Garcinia yunnanensis,has been shown to have anti-cancer potential.Our previous study suggested

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Microstructure and mechanical properties of Ti/Al/Ti clad plates prepared via powder-in-tube method

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Journal of Iron and Steel Research(International) 2024年第3期31卷 670-687页

作者： Xian-lei Hu Qin-cheng Xie Yi yuan Ying zhi State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang 110819LiaoningChina Suzhou Dongbao Haixing Metal Material Technology Co. Ltd.Suzhou 215600JiangsuChina School of Material Science and Engineering Northeastern UniversityShenyang 110819LiaoningChina

The Ti/Al/Ti clad plates exhibit a broad spectrum of potential applications.However,the conventional techniques of hot-pressing composite and explosive composite are intricate and environmentally hazardous.A novel method was introduced for preparing clad plates,namely,the powder-in-tube method.This method involves a combination of cold rolling,annealing at a temperature of 550℃,and double rolling.The morphology of the intermetallic compound layer was analyzed through the utilization of interface stripping test,tensile test,and microscopic characterization.The interface morphology,interface bonding properties,tensile fracture structures,and properties of plates under the first and second rolling were compared,along with the effects of intermetallic compounds on the interface properties.The results indicate that the powder-in-tube method,when annealed at 550℃,can produce a composite plate featuring a complete and uniform Ti/Al interface.The obtained plate exhibits a peeling strength of 21.5 N/mm,tensile strength of 424 MPa,and elongation of 11.5%.Furthermore,a systematic analysis was conducted to determine the causes of performance degra-dation observed during annealing at temperatures of 600 and 650℃.

关键词： Powder-in-tube method-Ti/Al/Ti clad plate Annealing Cold rolling-Mechanical property

Oblongifolin C from Garciniayunnanesis Hu Inhibits Metastasis Cancer Cell

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Oblongifolin C from Garciniayunnanesis Hu Inhibits Metastasi...

第十四届全国中药和天然药物学术研讨会

作者： Xiao-yu Wang yuan-zhi lao zhi-chao Xi Man Wu Si-ran Zhu Hong-xi Xu Shanghai University of Traditional Chinese Medicine

＜正＞Tumor metastasis accounts for the majority of cancer-related deaths of patients.Therefore,it is necessary to develop anti-tumor drugs targeting metastasis.We have discovered many anticancer compounds from Garcinia species based on bioassay guided fractionation.In a wound healing migration assay,we found that oblongifolin C,a natural compound extracted

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Nujiangexathone A Induces Cell Death and Inhibits Autophagic Flux in Cervical Cancer

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Nujiangexathone A Induces Cell Death and Inhibits Autophagic...

第十四届全国中药和天然药物学术研讨会

作者： Xiao-xiao Meng Xiao-yu Wang Zheng-xiang Xia yuan-zhi lao Hong-xi Xu Shanghai University of Traditional Chinese Medicine

＜正＞Cancer is a leading cause of mortality worldwide.Cervical cancer is among the most frequently diagnosed female cancers in China.Autophagy has been referred to as a double-edged sword in tumorigenesis and tumor p...

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