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Population Genetic Structure of the Medicinal Plant Vitex rotundifolia in China: Implications for its Use and Conservation

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Journal of Integrative Plant Biology 2008年第9期50卷 1118-1129页

作者： yuan Hu Yu zhu Qiao-Yan Zhang Hai-Liang Xin Lu-Ping Qin Bao-Rong Lu Khalid Rahman Han-Chen Zheng Department of Pharmacognosy School of Pharmacy Second Military Medical University Shanghai 200433 China Chinese People's Liberation Army General Hospital Beijing 100853 China Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering Department of Ecology and Evolutionary Biology Fudan University Shanghai 200433 China Faculty of Science School of Biomolecular Sciences Liverpool John Moores University Liverpool L3 3AF England UK

Vitex rotundifolia L. is an important plant species used in traditional Chinese medicine. For its efficient use and conservation, genetic diversity and clonal variation of V. rotundifolia populations in China were investigated using inter-simple sequence repeat markers. Fourteen natural populations were included to estimate genetic diversity, and a large population with 135 individuals was used to analyze clonal variation and fine-scale spatial genetic structure. The overall genetic diversity （GD） of V. rotundifolia populations in China was moderate （GD=0.190）, with about 40% within-population variation. Across all populations surveyed, the average within-population diversity was moderate （P = 22.6%; GD = 0.086）. A relatively high genetic differentiation （Gst = 0.587） among populations was detected based on the analysis of molecular variance data. Such characteristics of V. rotundifofia are likely attributed to its sexual/asexual reproduction and limited gene flow. The genotypic diversity （D = 0.992） was greater than the average values of a clonal plant, indicating its significant reproduction through seedlings. Spatial autocorrelation analysis showed a clear within-population structure with gene clusters of approximately 20 m. Genetic diversity patterns of V. rotundifolia in China provide a useful guide for its efficient use and conservation by selecting particular populations displaying greater variation that may contain required medicinal compounds, and by sampling individuals in a population at 〉20 m spatial intervals to avoid collecting individuals with identical or similar genotypes.

关键词： beach vitex medicinal plant conservation Vitex rotundifolia gene cluster genetic diversity sampling strategy spatial structure.

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Relationship between contrast sensitivity and corneal shape following overnight orthokeratology

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International Journal of Ophthalmology(English edition) 2019年第2期12卷 275-279页

作者： Li-Li Liu Li-Ping Gong Yue-yuan Xu Xuan zhu Kaddie Kwok Chen Wei-Feng Liu The Eye Hospital of Nanchang University The Second Affiliated Hospital of Nanchang University The Third Affiliated Hospital of Nanchang University Department of Ophthalmology University of California San Francisco

AIM: To evaluate the relationship between contrast sensitivity(CS) and corneal shape following overnight orthokeratology(OK). METHODS: We conducted a retrospective clinical study of 80 lens-wearing myopia patients, all of whom had undergone OK and had been evaluated by Orbscan II topography. We measured the surface irregularity index(SIRI) of corneal topography at 3 and 5 mm, the size of the flattened central corneal curvature of OK lens(zone A), the size of the cornea altered by OK lens(zone B), the size of the pupillary area at the corneal level(zone C), the area of crossover between zones A and C(zone AC), the area of crossover between zones B and C(BC), the ratio of BC to B(BC/B), and the ratio of AC to C(AC/C). CS was evaluated using the CSV-1000 with spatial frequencies of 3, 6, 12, and 18 cycles/degree(CPD). RESULTS: Multiple correlation analyses indicated significant negative correlations between CS, zone C, BC/B, and 3-mm SIRI(all P<0.01). There were no significant differences between CS, zone B, AC/A, or 5-mm SIRI(P=0.60, 0.94 and 0.11, respectively). Zone C was negatively correlated with 3, 6, 12, and 18 CPD. 5-mm SIRI were negatively correlated with 6, 12, and 18 CPD. BC/C was negatively correlated with 6 and 18 CPD. AC/C was positively correlated with 3 CPD. CONCLUSION: Zone C, 3-mm SIRI and BC/B affect the CS following overnight OK.

关键词： orthokeratology contrast sensitivity pupil size area shaped cornea myopia

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组织瓣环运动位移评价心室肥厚患者左室收缩功能

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临床医学研究与实践 2024年第10期9卷 85-89页

作者：贾玄慧亢春苗沈亚梅马盼盼朱媛陕西省人民医院超声诊断中心陕西西安710068

目的探讨组织瓣环运动位移(TMAD)自动追踪技术定量评价心室肥厚患者左室收缩功能的应用价值。方法纳入60例心室肥厚患者,原发性高血压亚组30例,尿毒症亚组30例,纳入35例健康体检者作为对照组。应用二维斑点追踪技术自动获取心尖四腔心... 详细信息

目的探讨组织瓣环运动位移(TMAD)自动追踪技术定量评价心室肥厚患者左室收缩功能的应用价值。方法纳入60例心室肥厚患者,原发性高血压亚组30例,尿毒症亚组30例,纳入35例健康体检者作为对照组。应用二维斑点追踪技术自动获取心尖四腔心切面、心尖两腔心切面二尖瓣环四个位点TMAD值、左心室整体纵向应变(LVGLS)及左室整体圆周应变(LVGCS),应用Bland-Altman法检验TMAD参数一致性及绘制受试者工作特性(ROC)曲线评价TMAD参数的诊断效能。结果原发性高血压亚组和尿毒症亚组的收缩压(SBP)、舒张压(DBP)明显高于对照组(P<0.05);尿毒症亚组的心率(HR)高于原发性高血压亚组及对照组(P<0.05)。尿毒症亚组的TMAD参数及应变参数均明显低于对照组(P<0.05)。原发性高血压亚组的LVGLS、T-AP4sep、T-AP4mid%、T-AP2int、T-AP2ant及T-AP2mid%低于对照组(P<0.05)。ROC曲线结果显示,TMAD各参数对心室肥厚患者左室收缩功能降低具有中等预测价值。结论TMAD可以定量评价心室肥厚患者的左室收缩功能,且可重复性好。

关键词：组织瓣环运动位移心室肥厚尿毒症原发性高血压左室收缩功能斑点追踪技术

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Microstructural characteristics and mechanical properties of bronze/steel bimetallic laminated composite prepared by protective atmosphere casting process

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China Foundry 2021年第5期18卷 497-504页

作者： Bin Liu Da-shan Sui Zhi-min Guo yuan-long Wang Xiao-lin Yang Guang-hong Hu Ji-xian Zhang Chang-zeng Luo Research Institute of Hydraulic Transmission Linde Hydraulics(China)Co.Ltd.Weifang 261061ShandongChina National Engineering Research Center of Die&Mold CAD Shanghai Jiao Tong UniversityShanghai 200030China

The bonding quality of bronze/steel bimetallic laminated composite is the key factor to whether it can be used in poor working *** this study,bimetallic billets were prepared by the protective atmosphere casting *** microstructural characteristics,mechanical properties and interface bonding mechanism of the bronze/steel bimetallic composites were analyzed comprehensively through a series of microstructure analysis(inicluding OM,SEM,and EDS)and mechanical properties *** experimental results demonstrate that the vaporization of lead(Pb)element in the bronze is only 0.4%in weight,and alloy elements are diffused into both sides at the ***,the hardness in the bronze region exceeds 100.0 HV which indicates excellent wear *** and shear tests indicate that the fractures mainly occur on the bronze side with the interaction of the brittle fracture of Pb particles and the ductile fracture of Cu-Sn solid *** maximum tensile strength and shear strength reach 204.0 MPa and 211.0 MPa,*** results demonstrate that the protective atmosphere casting process is applicable for the preparation of bronze/steel bimetallic laminated composite with high quality.

关键词： protective atmosphere casting process lead bronze bimetallic composite microstructure mechanical properties

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西洞庭湖洲滩植物物种与功能多样性空间分布特征及其相关性

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生态与农村环境学报 2024年第6期40卷 780-789页

作者：王婉婉陈明珠雷霆北京林业大学生态与自然保护学院北京100083 林之源(北京)林业工程咨询有限公司北京100013 湖南洞庭湖湖泊湿地生态系统国家野外科学观测研究站湖南长沙415904

洞庭湖是长江中下游重要的通江湖泊,具有调蓄洪水和维护周边湿地生态系统及生物多样性等生态功能。研究植物群落物种多样性与功能多样性在异质环境条件下的特征及其相关关系,对认识植物群落分布规律、保护修复生态系统结构和功能具有重... 详细信息

洞庭湖是长江中下游重要的通江湖泊,具有调蓄洪水和维护周边湿地生态系统及生物多样性等生态功能。研究植物群落物种多样性与功能多样性在异质环境条件下的特征及其相关关系,对认识植物群落分布规律、保护修复生态系统结构和功能具有重要意义。以西洞庭湖沅江和澧水水流方向上的洲滩植物群落为研究对象,采集优势种并测定其根和叶的碳氮磷含量、叶面积和根长等8个功能性状来研究群落间物种多样性差异、水流方向上洲滩群落功能多样性差异、物种多样性和群落功能多样性的关系及多样性指数间的相关性。研究结果表明:(1)沿水流方向不同位置植物群落物种多样性有显著差异。其中,沅江和澧水的水流方向上入湖口物种丰富度均较低;在所有调查区域中,沅江中游洲滩植物群落物种丰富度、香农指数均较高,出湖口的物种多样性最低。(2)澧水上游洲滩植物群落的碳氮磷含量的群落加权平均值(community weighted-mean,CWM)和Rao二次熵指数较高;澧水中游植物群落所有性状的CWM值和Rao二次熵指数最低;沅江上游植物群落具有较高的叶性状值,优势种中一年生草本植物的快速生长策略可能贡献较高的叶性状值。(3)西洞庭湖洲滩植物群落物种多样性与CWM值具有显著相关性,根碳含量的CWM值与物种丰富度、香农指数呈负相关;水流方向上不同位置植物群落物种多样性与Rao二次熵指数没有相关性。研究结果说明,沅、澧两水及沿水流方向不同调查区域的水文地貌特征差异对洲滩湿地植物群落物种和功能多样性都有影响,但拥有更高物种多样性(优势种组成、丰富度等)的植物群落适应能力并不一定更强。此外,沿水流方向,湖泊洲滩植物群落的物种与功能多样性趋异。因此,在西洞庭湖洲滩植物群落的保护和修复工作中需要综合考虑更多因素(如土壤、地形等),以便更全面地了解其生态系统的复杂性和特殊性。

关键词：水流方向物种丰富度香农指数功能性状群落加权平均指数 Rao二次熵

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真空贴体包装保鲜金丝皇菊的工艺优化

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食品工业 2024年第9期45卷 1-5页

作者：朱源董昱昇王舒嫣李昭莹蔡婉玉阙斐浙江经贸职业技术学院应用工程学院杭州310018

金丝皇菊在贮存的过程中易出现褐变、花瓣掉落等现象。为解决该问题,试验以真空贴体包装技术的膜厚度、加热温度、抽气时间为参数,以褐变指数、总黄酮含量、感官评价为考察因素,运用熵权法计算权重系数并以综合评分为指标,通过正交分析... 详细信息

金丝皇菊在贮存的过程中易出现褐变、花瓣掉落等现象。为解决该问题,试验以真空贴体包装技术的膜厚度、加热温度、抽气时间为参数,以褐变指数、总黄酮含量、感官评价为考察因素,运用熵权法计算权重系数并以综合评分为指标,通过正交分析优化真空贴体包装技术对金丝皇菊的保鲜工艺。研究结果表明,采用15丝膜,在110℃的高温下真空贴体压缩20 s处理金丝皇菊,可较好保持花的色泽,抑制褐变现象并保留营养成分。此试验结果可为金丝皇菊在贮藏与运输中的保鲜工作提供理论和技术支持。

关键词：金丝皇菊真空贴体包装食品保鲜褐变

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宫颈高级别神经内分泌癌11例临床病理分析

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现代肿瘤医学 2024年第1期32卷 130-134页

作者：吴敏付敏袁俊清朱慧庭葛军辉廖玲明光市人民医院病理科安徽滁州239400 上海阿克曼医学检验所有限公司上海200331 上海市第一妇婴保健院上海201204 明光市人民医院妇科安徽滁州239400

目的:探讨宫颈原发性高级别神经内分泌癌的临床病理特征、诊断与鉴别诊断、治疗及预后。方法:回顾性分析11例原发于宫颈的高级别神经内分泌癌的临床资料及病理资料,通过形态学、免疫表型进行观察分析。结果:11例患者平均年龄59岁,其中9... 详细信息

目的:探讨宫颈原发性高级别神经内分泌癌的临床病理特征、诊断与鉴别诊断、治疗及预后。方法:回顾性分析11例原发于宫颈的高级别神经内分泌癌的临床资料及病理资料,通过形态学、免疫表型进行观察分析。结果:11例患者平均年龄59岁,其中9例为小细胞神经内分泌癌,肿瘤呈菜花状或结节状,直径1.5~4.0 cm,切面灰黄、灰红色相间。光镜下,肿瘤由大小较一致的小圆形或卵圆形细胞构成,胞质少,核分裂象多见,排列呈片状、梁状、岛状,部分病例伴鳞状细胞癌、腺癌成分。2例为大细胞神经内分泌癌,肿瘤呈岛状、梁状、腺样和实性生长,可见坏死,可见嗜酸性胞质颗粒,核分裂象多见。免疫表型:肿瘤细胞Syn、CgA、CD56、p16、CKpan、Ki-67多为阳性,CK5/6、p40、p63多为阴性。结论:宫颈高级别神经内分泌癌少见,临床多为绝经后女性,主要症状为阴道不规则出血,易误诊为宫颈低分化癌,常合并鳞状细胞癌、腺癌、伴坏死等,需通过形态学及免疫表型进行诊断。

关键词：宫颈神经内分泌临床病理

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Neuroprotective Effects of Dexmedetomidine Preconditioning on Oxygen-glucose Deprivation-reoxygenation Injury in PC12 Cells via Regulation of Ca^2+-STIM1/Orail Signaling

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Current Medical Science 2020年第4期40卷 699-707页

作者： Yi-da HU Chao-liang TANG Jia-zhen JIANG Hai-yan LV yuan-bo WU Xiu-de QIN Si SHI Bo ZHAO Xiao-nan zhu Zhong-yuan XIA Department of Anesthesiology Renmin Hospital of Wuhan UniversityWuhan 430060China Deparment of Anesihesiology the Firsi Affiliated Hospital of University of Science and Technology of ChinaDivision of LifeSciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Department of Emergency Huashan Hospital NorthFudan UniversiryShanghai 201907China Department of Neurology Shanghai General HospitalShanghai Jiao Tong UniversityShanghai 201620China Department of Neurology the First Affiliated Hospital of University of Science and Technology of ChinaDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Department of Neurology Shenzhen Traditional Chinese Medicine Hospitalthe Fourth Clinical Medical College of GuangzhouUniversity of Chinese MedicineShenzhen 518033.China Department of Neurosurgery Renmin Hospital of Wuhan UniversityWuhan 430060China

Summary:Dexmedetomidine(DEX),a potent and highly selective agonist for a2-adrenergic receptors(a2AR),exerts neuroprotective effects by reducing apoptosis through decreased neuronal Ca^2+***,the exact action mechanism of DEX and its effects on oxygen-glucose deprivation-reoxygenation(OGD/R)injury in vitro are *** demonstrate that DEX pretreatment reduced OGD/R injury in PC12 cells,as evidenced by decreased oxidative stress,autophagy,and neuronal ***,DEX pretreatment decreased the expression levels of stromal interaction molecule 1(STIM1)and calcium release-activated calcium channel protein 1(Orail),and reduced the concentration of intracellular calcium *** addition,variations in cytosolic calcium concentration altered apoptosis rate of PC12 cells after exposure to hypoxic conditions,which were modulated through STIM 1/Orail ***,DEX pretreatment decreased the expression levels of Beclin-1 and microtubule-associated protein 1A/1B-light chain 3(LC3),hallmark markers of autophagy,and the formation of *** conclusion,these results suggested that DEX exerts neuroprotective effects against oxidative stress,autophagy,and neuronal apoptosis afier OGD/R injury via modulation of Caf-STIM1/Orai1 *** results offer insights into the molecular mechanisms of DEX in protecting against neuronal ischemia-reperfusion injury.

关键词： dexmedetomidine neuroprotection Ca^2+ STIM1/Orai 1 autophagy PC12 cells neuronal apoptosis

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Microsurgical treatment of posterior inferior cerebellar aneurysms based on angioarchitecture supplemented by high-resolution vessel wall MRI:a case series report

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Stroke & Vascular Neurology 2022年第4期7卷 337-344,I0046-I0050页

作者： Zixiao Yang Jianping Song Kai Quan Peiliang Li Qingzhu An yuan Shi Peixi Liu Guo Yu Yanlong Tian Liangfu Zhou Wei zhu Department of Neurosurgery Huashan Hospital Fudan UniversityShanghaiChina National Center for Neurological Disorders ShanghaiChina Neurosurgical Institute of Fudan University ShanghaiChina Shanghai Clinical Medical Center of Neurosurgery ShanghaiChina

Background Surgical treatment of posterior inferior cerebellar artery(PICA)aneurysms is challenging because many are nonsaccular and *** report our tailored approach to PICA aneurysms,which is based on angioarchitecture supplemented by high-resolution vessel wall MRI(HR-VW MRI)*** From March 2010 to September 2020,27 patients with 29 PICA aneurysms underwent surgical treatment in our *** October 2016,HR-VW MRI has been used for aneurysmal wall *** characteristics,radiological data and surgical outcomes were *** Nineteen proximal PICA aneurysms(vertebral artery(VA),P1,P2 and P3)were treated using the far-lateral *** distal PICA aneurysms(P4,P5)were treated using the suboccipital midline *** clipping or clip reconstruction was achieved in 19 *** were trapped in conjunction with extracranial-intracranial or intracranial-intracranial bypass,including three occipital artery-PICA reimplantations,three PICA-VA reimplantations,two PICA-PICA side-to side anastomoses,one PICA-PICA reimplantation and one PICA-PICA *** aneurysms were eventually completely obliterated and all bypasses remained *** the last follow-up,26 patients(96.2%)achieved a good outcome(modified Rankin Scale score<3).Eight patients underwent HR-VW *** these,the six aneurysms with focal wall enhancement required bypass and the two with negative enhancement were successfully *** PICA aneurysms have a higher frequency of complex features such as large or giant size and fusiform or dissecting *** outcomes were achieved with individualised microsurgical strategies based on ***-VW MRI may be used as a promising technique to predict aneurysmal atherosclerosis.

关键词： aneurysm treatment implantation

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1例稀有CisAB血型的鉴定及家系分析

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中国优生与遗传杂志 2024年第6期32卷 1234-1237页

作者：骆宏朱洁好邵媛叶伙梅陈景旺罗广平广州血液中心广州市血液安全重点实验室广东广州510095 云浮市人民医院输血科广东云浮527300

目的对1例血清学检测疑为CisAB型的患者血液样本进行进一步确认和家系调查,以探究其分子背景及遗传方式。方法收集患儿及家系成员EDTA抗凝血液样本,采用血型血清学方法进行ABO血型鉴定,血样抽提DNA后PCR扩增ABO基因第6和第7外显子,对扩... 详细信息

目的对1例血清学检测疑为CisAB型的患者血液样本进行进一步确认和家系调查,以探究其分子背景及遗传方式。方法收集患儿及家系成员EDTA抗凝血液样本,采用血型血清学方法进行ABO血型鉴定,血样抽提DNA后PCR扩增ABO基因第6和第7外显子,对扩增产物进行测序分析。结果患者和母亲的血液样本血清学正定型分别呈现A_(1)B_(x)和A_(2)B型,红细胞表面检出较强的H抗原,血浆中含有弱的抗-B,为CisAB表型;患儿父亲和哥哥为正常的A型和O型。克隆测序表明患儿在ABO^(*)B.01基础上发生c.796A>C突变形成新的CisAB等位基因,其基因型为ABO^(*)***/ABO^(*)A1.01,母亲基因型为ABO^(*)***/ABO^(*)O.01.01,父亲基因型为ABO^(*)A1.01/ABO^(*)O.01.01,哥哥基因型为ABO^(*)O.01.01/ABO^(*)O.01.01。结论患儿和母亲为稀有的CisAB型,ABO^(*)B.01发生c.796A>C突变形成新的CisAB等位基因并能稳定遗传给子代。

关键词： ABO血型 CisAB型等位基因家系分析

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