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World Journal of Clinical Oncology 2024年第8期15卷 1061-1077页

作者： gan-Bin Li Wei-Kun Shi Xiao Zhang Xiao-yuan Qiu Guo-Le Lin Department of General Surgery Peking Union Medical College HospitalPeking Union Medical CollegeBeijing 100730China

BACKGROUND Chemoresistance is the primary contributor to distant metastasis in the context of neoadjuvant chemoradiotherapy(nCRT)for rectal ***,the underlying mechanisms remain *** To detect the differential expression profiles of plasma exosomal microRNAs(miRNAs)in poor and good responders and explore the potential mechanisms of *** In this study,the profiles of plasma exosomal miRNAs were compared in two dimensions according to treatment responses(poor/good responders)and treatment courses(pre/post-nCRT)using RNA *** Exosome hsa-miR-483-5p was up-regulated in good responders *** analysis revealed that the target genes of hsa-miR-483-5p were mainly enriched in tumor-specific pathways,such as the MAPK signaling pathway,EGFR tyrosine kinase inhibitor resistance,Toll-like receptor signaling pathway,VEGF signaling pathway,and mTOR signaling *** analysis indicated that MAPK3,RAX2,and RNF165 were associated with inferior recurrence-free survival in patients with rectal cancer,and the profiles of MAPK3,TSPYL5,and ZNF-417 were correlated with tumor *** addition,the expression profiles of MAPK3,RNF165,and ZNF417 were negatively correlated with inhibitory concentration 50 ***,an hsa-miR-483-5p/MAPK3/RNF 165/ZNF417 network was *** This study provides insights into the mechanism of chemoresistance in terms of exosomal ***,further research is required within the framework of our established miRNA-mRNA network.

关键词： Locally advanced rectal cancer Neoadjuvant chemoradiotherapy Poor-responders Good responders Exosome miRNA

gan-DIRNet:A Novel Deformable Image Registration Approach for Multimodal Histological Images

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Computers, Materials & Continua 2024年第7期80卷 487-506页

作者： Haiyue Li Jing Xie Jing Ke Ye yuan Xiaoyong Pan Hongyi Xin Hongbin Shen Institute of Image Processing and Pattern Recognition Shanghai Jiao Tong Universityand Key Laboratory of System Control and Information ProcessingMinistry of Education of ChinaShanghai200240China Department of Pathology Ruijin HospitalShanghai Jiao Tong UniversitySchool of MedicineShanghai200025China Department of Computer Science and Engineering Shanghai Jiao Tong UniversityShanghai200240China Global Institute of Future Technology Shanghai Jiao Tong UniversityShanghai200240China

Multi-modal histological image registration tasks pose significant challenges due to tissue staining operations causing partial loss and folding of *** neural network(CNN)and generative adversarial network(gan)are pivotal inmedical image ***,existing methods often struggle with severe interference and deformation,as seen in histological images of conditions like Cushing’s *** argue that the failure of current approaches lies in underutilizing the feature extraction capability of the discriminator *** this study,we propose a novel multi-modal registration approach gan-DIRNet based on gan for deformable histological image *** begin with,the discriminators of two gans are embedded as a new dual parallel feature extraction module into the unsupervised registration networks,characterized by implicitly extracting feature descriptors of specific ***,modal feature description layers and registration layers collaborate in unsupervised optimization,facilitating faster convergence and more precise ***,experiments and evaluations were conducted on the registration of the Mixed National Institute of Standards and Technology database(MNIST),eight publicly available datasets of histological sections and the Clustering-Registration-Classification-Segmentation(CRCS)dataset on the Cushing’s *** results demonstrate that our proposed gan-DIRNet method surpasses existing approaches like DIRNet in terms of both registration accuracy and time efficiency,while also exhibiting robustness across different image types.

关键词： Histological images registration deformable registration generative adversarial network cushing’s disease machine learning computer vision

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甲基化修饰在牙根发育中作用的研究进展

中华口腔医学杂志 2024年第5期59卷 502-506页

作者：甘鑫琰李奇文袁泉四川大学华西口腔医院种植科、口腔疾病防治全国重点实验室、国家口腔医学中心、国家口腔疾病临床医学研究中心成都610041

甲基化修饰是真核生物中最常见的表观修饰调控,包括组蛋白甲基化、DNA甲基化、RNA甲基化等,在生理和病理过程中发挥重要的调控作用。牙根发育由上皮和间充质细胞共同完成,涉及多种细胞与分子的相互作用。近年大量研究显示,甲基化修饰对... 详细信息

甲基化修饰是真核生物中最常见的表观修饰调控,包括组蛋白甲基化、DNA甲基化、RNA甲基化等,在生理和病理过程中发挥重要的调控作用。牙根发育由上皮和间充质细胞共同完成,涉及多种细胞与分子的相互作用。近年大量研究显示,甲基化修饰对牙根发育发挥关键调控作用,这逐渐拓展了牙根发育的调控机制网络。本文综述牙根发育过程中甲基化修饰的作用和机制研究新进展,以期为牙根缺失或短根畸形诊治提供新的理论基础。

关键词：牙根甲基化组蛋白类 DNA修饰甲基酶类表观遗传

Suppression of the regrowth interface leakage current in Algan/gan HEMTs by Fe doped gan substrate

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Science China(Information Sciences) 2024年第6期67卷 461-462页

作者： Xiao WANG Zhi-Yu LIN yuan-Hang SUN Long YUE Yu-Min ZHANG Jian-Feng WANG Ke XU School of Nano-Tech and Nano-Bionics University of Science and Technology of China Suzhou Institute of Nano-tech and Nano-bionics Chinese Academy of Sciences Information Materials Research Department Suzhou laboratory Suzhou Nanowin Science and Technology Co. Ltd. Jiangsu Institute of Advanced Semiconductors

In the process of homoepitaxy Algan/gan heterojunction by metal-organic chemical vapor deposition (MOCVD) on free-standing substrates,Si impurities from the air and reaction chamber accumulate at the regrowth interfac...

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噬菌体治疗多重耐药细菌感染性肺炎的应用现状

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中国药学杂志 2024年第6期59卷 549-554页

作者：付涵宇曹玲甘霖袁静首都儿科研究所附属儿童医院呼吸内科北京100020 首都儿科研究所细菌研究室北京100020

目的由于多重耐药细菌的不断出现,噬菌体疗法再次出现在公众的视野里,笔者着重介绍噬菌体疗法在临床上用于多种多重耐药细菌性肺炎的现状,以期为噬菌体应用于肺部感染提供文献证据。方法采用关键词“噬菌体”或“噬菌体疗法”或“噬菌... 详细信息

目的由于多重耐药细菌的不断出现,噬菌体疗法再次出现在公众的视野里,笔者着重介绍噬菌体疗法在临床上用于多种多重耐药细菌性肺炎的现状,以期为噬菌体应用于肺部感染提供文献证据。方法采用关键词“噬菌体”或“噬菌体疗法”或“噬菌体裂解酶”或“工程噬菌体”和“肺炎”在知网和pubmed网站进行文献检索,并将检索到的病例报告按照病原分类进行介绍。结果用于治疗肺炎的噬菌体疗法随机对照试验(randomized controlled trial,RCT)临床研究尚无公开报道,但噬菌体在铜绿假单胞菌、金黄色葡萄球菌、肺炎克雷伯菌和鲍曼不动杆菌感染性肺炎的治疗中取得了较好的疗效,且仅有一例不良反应报告。同时,笔者探讨了噬菌体疗法目前面临的细菌耐药、自身的安全性或免疫系统对其疗效的影响等困难及噬菌体裂解酶和工程噬菌体两种噬菌体疗法的最新发展方向。结论噬菌体在治疗呼吸道感染,特别是那些由多重耐药细菌引起的感染方面还是具有应用前景。未来会有更多的体内研究来回答噬菌体衍生物或是工程噬菌体治疗的有效性和安全性。

关键词：噬菌体多重耐药菌噬菌体裂解酶工程噬菌体肺炎

The RNA binding protein EHD6 recruits the m^(6)A reader YTH07 and sequesters OsCOL4 mRNA into phase-separated ribonucleoprotein condensates to promote rice flowering

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Molecular Plant 2024年第6期17卷 935-954页

作者： Song Cui Peizhe Song Chaolong Wang Saihua Chen Benyuan Hao Zhuang Xu Liang Cai Xu Chen Shanshan Zhu Xiangchao gan Hui Dong yuan Hu Liang Zhou Haigang Hou Yunlu Tian Xi Liu Liangming Chen Shijia Liu Ling Jiang Haiyang Wang Guifang Jia Shirong Zhou Jianmin Wan State Key Laboratory for Crop Genetics&Germplasm Enhancement and Utilization Zhongshan Biological Breeding LaboratoryNational Observation and Research Station of Rice Germplasm ResourcesNanjing Agricultural UniversityNanjing 210095China State Key Laboratory for Crop Gene Resources and Breeding Institute of Crop ScienceChinese Academy of Agricultural SciencesBeijing 100081China Synthetic and Functional Biomolecules Center Beijing National Laboratory for Molecular SciencesKey Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of EducationCollege of Chemistry and Molecular EngineeringPeking-Tsinghua Center for Life SciencesBeijing Advanced Center of RNA BiologyPeking UniversityBeijingChina Jiangsu Key Laboratory of Crop Genomics and Molecular Breeding Agricultural College of Yangzhou UniversityYangzhou 225009China Max Planck Institute for Plant Breeding Research Carl-von-Linne´-Weg 1050829 KolnGermany

N6-Methyladenosine(m^(6)A)is one of the most abundant modifications of eukaryotic mRNA,but its comprehensive biological functionality remains further *** this study,we identified and characterized a new flowering-promoting gene,EARLY HEADING DATE6(EHD6),in ***6 encodes an RNA recognition motif(RRM)-containing RNA binding protein that is localized in the non-membranous cytoplasm ribonucleoprotein(RNP)granules and can bind both m^(6)A-modified RNA and unmodified RNA *** found that EHD6 can physically interact with YTH07,a YTH(YT521-B homology)domain-containing m^(6)A *** showed that their interaction enhances the binding of an m^(6)A-modified RNA and triggers relocation of a portion of YTH07 from the cytoplasm into RNP granules through phase-separated *** these condensates,the mRNA of a rice flowering repressor,CONSTANS-like 4(OsCOL4),becomes sequestered,leading to a reduction in its protein abundance and thus accelerated flowering through the Early heading date 1 *** together,these results not only shed new light on the molecular mechanism of efficient m^(6)A recognition by the collaboration between an RNA binding protein and YTH family m^(6)A reader,but also uncover the potential for m^(6)A-mediated translation regulation through phaseseparated ribonucleoprotein condensation in rice.

关键词： N6-methyladenosine m^(6)A EHD6 YTH domain-containing protein phase separation heading date

基于联合增强图像对的红外可见光深度展开图像融合网络

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计算机科学 2024年第10期51卷 311-319页

作者：袁天蕙干宗良南京邮电大学通信与信息工程学院南京210003

受到采集环境的影响,红外可见光融合图像有时会存在亮度不足、细节信息不够的问题。为此,提出了一种基于联合增强图像对的红外可见光深度展开图像融合网络,同时将原始红外-可见光图像对和红外-可见光图像增强对作为输入,提高网络信息融... 详细信息

受到采集环境的影响,红外可见光融合图像有时会存在亮度不足、细节信息不够的问题。为此,提出了一种基于联合增强图像对的红外可见光深度展开图像融合网络,同时将原始红外-可见光图像对和红外-可见光图像增强对作为输入,提高网络信息融合能力。文中首先提出了一种残差展开模块,在此基础上构建了基于迭代的残差展开卷积网络用于特征提取,使其根据不同的初始化参数提取对应图像的背景和细节信息。此外,在特征融合卷积融合网络中引入了维度拼接操作和上下采样卷积块,实现联合红外-可见光图像增强对的特性汇聚,最大限度地保留源图像的差异特征。同时,优化了损失函数权重设计,以获得最佳的融合结果。在多个数据库上进行了大量实验,结果表明,与现有典型的融合方法相比,所提算法的融合图像在主观视觉和客观指标评价上均具有较好性能,在暗照度环境下优于其他方法。

关键词：图像融合深度算法展开网络图像增强特征提取特征融合

金纳米团簇所发射荧光的稳定性及其表面的光催化氧化还原

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Chinese Journal of Chemical Physics 2024年第2期37卷 429-438,I0099,I0100,I0105页

作者： Johar Zeb 郭慧君袁群惠干为哈尔滨工业大学(深圳)理学院深圳市柔性印刷电子技术重点实验室深圳518055 哈尔滨工业大学(深圳)材料科学与工程学院深圳市柔性印刷电子技术重点实验室深圳518055

金纳米团簇的荧光和光催化活性是其重要性质.本文合成了水溶性的卡托普利(Capt)和谷胱甘肽(GSH)覆盖的Au_(25)(Capt)_(18)和Au_(15)(GSH)_(13)纳米团簇,并研究了与其表面光氧化还原过程相关的荧光稳定性。发现Au_(25)(Capt)_(18)在氧气... 详细信息

金纳米团簇的荧光和光催化活性是其重要性质.本文合成了水溶性的卡托普利(Capt)和谷胱甘肽(GSH)覆盖的Au_(25)(Capt)_(18)和Au_(15)(GSH)_(13)纳米团簇,并研究了与其表面光氧化还原过程相关的荧光稳定性。发现Au_(25)(Capt)_(18)在氧气环境和近红外飞秒激光(810nm,300mW)照射下,出现了因表面氧化导致的双光子荧光效率衰减。而Au_(15)(GSH)_(13)的双光子荧光效率在相同的激发下保持稳定.两种金纳米团簇荧光稳定性不同的原因被归因于其不同的带隙,并使用光子能量高于两种金纳米团簇带隙的单光子激发证实了这一解释。通过添加不同试剂进行对比实验,对Au_(25)(Capt)_(18)表面金原子的光催化氧化还原活性进行了调控和理解.

关键词：金纳米团簇带隙双光子荧光光催化氧化还原

基于BERT和TextCNN的智能制造成熟度评估方法

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计算机集成制造系统 2024年第3期30卷 852-863页

作者：张淦袁堂晓汪惠芬柳林燕南京理工大学机械工程学院江苏南京210000 洛林大学LCOMS 法国梅斯57000

随着智能制造2025目标的临近,企业为了解自身能力水平纷纷加入到智能制造成熟度评估的行列中。然而,由于智能制造成熟度评估标准的复杂性,企业缺乏其对行业水平的了解,导致企业贸然申请,浪费自身时间的同时又占用大量评估资源。鉴于此,... 详细信息

随着智能制造2025目标的临近,企业为了解自身能力水平纷纷加入到智能制造成熟度评估的行列中。然而,由于智能制造成熟度评估标准的复杂性,企业缺乏其对行业水平的了解,导致企业贸然申请,浪费自身时间的同时又占用大量评估资源。鉴于此,设计了一种新的评估流程,采用文本处理算法对整个评估过程进行了重构,通过利用国标文件中智能制造成熟度评估标准,将其作为训练集,采用基于预训练语言模型与文本神经网络(BERT+TextCNN)相结合的智能评估算法代替人工评估。在真实的企业智能制造数据集上的验证表明,当BERT+TextCNN评估模型在卷积核为[2,3,4]、迭代次数为6次、学习率为3e-5时,对智能制造成熟度进行评估,准确率达到85.32%。这表明所设计的评估方法能够较准确地帮助企业完成智能制造成熟度自评估,有助于企业了解自身智能制造能力水平,制定正确的发展方向。

关键词：智能制造成熟度模型 BERT预训练语言模型文本卷积神经网络评估过程重构

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粉煤灰微珠-沙漠砂陶粒混凝土力学性能试验

复合材料学报 2024年第1期41卷 348-360页

作者：许建疆郭军林甘丹袁康何明胜石河子大学水利建筑工程学院石河子832000 重庆大学土木工程学院重庆400045 新疆兵团高烈度寒区建筑抗震节能技术工程实验室石河子832000

以沙漠砂(DS)和粉煤灰微珠(FAC)部分代替河砂,并掺入聚合物乳液(PL)制备新型陶粒混凝土−粉煤灰微珠-沙漠砂陶粒混凝土(FDCC)。通过单因素变量研究DS替代率、FAC替代率和PL掺量对FDCC工作性能及力学性能影响规律,并建立了FDCC抗压强度预... 详细信息

以沙漠砂(DS)和粉煤灰微珠(FAC)部分代替河砂,并掺入聚合物乳液(PL)制备新型陶粒混凝土−粉煤灰微珠-沙漠砂陶粒混凝土(FDCC)。通过单因素变量研究DS替代率、FAC替代率和PL掺量对FDCC工作性能及力学性能影响规律,并建立了FDCC抗压强度预测模型。研究结果表明:DS和FAC可部分替代河砂用于制备轻骨料混凝土。FDCC表观密度与抗压强度呈线性关系,坍落度随DS替代率的增加而降低,随FAC替代率和PL掺量的增加而增加。FDCC抗压强度随DS替代率增加先上升后下降,随FAC替代率增加先下降后上升。DS、FAC最优替代率及PL最优掺量分别为20vol%、30vol%和1wt%。FDCC劈裂抗拉强度随DS替代率、FAC替代率和PL掺量增加而降低。DS和FAC的掺入能促进水化产物生成,对FDCC混凝土微观结构有利。

关键词：沙漠砂粉煤灰微珠聚合物乳液陶粒混凝土力学性能