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Betaine combined with traditional Chinese medicine ointment to treat skin wounds in microbially infected diabetic mice

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World Journal of Diabetes 2025年第1期16卷 104-120页

作者： Wen-Yan Xu yuan-yuan dai Shi-Xian Yang Hao Chen Yan-Qiang Huang Pei-Pei Luo Zhong-Heng Wei Guangxi Technology Innovation Cooperation Base of Prevention and Control Pathogenic Microbes with Drug Resistance Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Guangxi Clinical Medical Research Center for Hepatobiliary Diseases Affiliated Hospital of Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Department of Pathology Wannan Medical CollegeWuhu 241002Anhui ProvinceChina Guangxi Zhuang Autonomous Region Engineering Research Center of Clinical Prevention and Control Technology and Leading Drug for Microorganisms with Drug Resistance in Border Ethnic Areas Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Department of Gastroenterology Wujin People’s Hospital Affiliated to Jiangsu UniversityChangzhou 213004Jiangsu ProvinceChina

BACKGROUND Skin wounds are highly common in diabetic patients,and with increasing types of pathogenic bacteria and antibiotic resistance,wounds and infections in diabetic patients are difficult to treat and *** To explore the effects of betaine ointment(BO)in promoting the healing of skin wounds and reducing the inflammation and apoptosis of skin cells in microbially infected diabetic *** By detecting the minimum inhibitory concentrations(MICs)of betaine and plant monomer components such as psoralen,we prepared BO with betaine as the main ingredient,blended it with traditional Chinese medicines such as gromwell root and psoralen,and evaluated its antibacterial effects and safety in vitro and in *** skin infection wound models of ordinary mice and diabetic mice were constructed,and the OTC drugs mupirocin ointment and Zicao ointment were used as controls to evaluate the antibacterial effects in vivo and the anti-inflammatory and anti-apoptotic effects of *** The MICs of betaine against microorganisms such as Staphylococcus aureus(***),Candida albicans and Cryptococcus neoformans ranged from 4 to 32μg/*** root and psoralea,both of which contain antimicrobial components,mixed to prepare BO with MICs ranging from 16 to 64μg/mL,which is 32-256 times lower than those of Zicao ointment,although the MIC is greater than that of *** 15 days of treatment with BO for USA300-infected ordinary mice,the wound scab removal rates were 83.3%,while those of mupirocin ointment and Zicao ointment were 66.7%and 0%,respectively,and the differences were statistically *** diabetic mice,the wound scab removal rate of BO and mupirolacin ointment was 80.0%,but BO reduced wound inflammation and the apoptosis of skin cells and facilitated wound *** The ointment prepared by mixing betaine and traditional Chinese medicine can effectively inhibit common skin microorganisms and has a strong effect on the skin wounds of sensit

关键词： Betaine ointment Staphylococcus aureus Drug resistance Skin infection Diabetes mellitus

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Linolenic acid-metronidazole inhibits the growth of Helicobacter pylori through oxidation

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World Journal of Gastroenterology 2023年第32期29卷 4860-4872页

作者： Wen-Ting Zhou yuan-yuan dai Li-Juan Liao Shi-Xian Yang Hao Chen Liang Huang Juan-Li Zhao Yan-Qiang Huang School of Basic Medicine Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina School of Basic Medicine Youjiang Medical University for NationalitiesAffiliated Hospital of Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Department of Laboratory Affiliated Hospital of Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina School of Basic Medicine Department of PathologyWannan Medical CollegeWuhu 533000Anhui ProvinceChina Key Laboratory of the Prevention and Treatment of Drug Resistant Microbial Infecting Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina School of Basic Sciences Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina

BACKGROUND Resistance to antibiotics is one the main factors constraining the treatment and control of Helicobacter pylori(***)***,there is an urgent need to develop new antimicrobial agents to replace *** previous study found that linolenic acid-metronidazole(Lla-Met)has a good antibacterial effect against ***,both antibiotic-resistant and sensitive ***,*** does not develop resistance to ***,it could be used for preparing broad-spectrum antibacterial ***,since the antibacterial mechanism of Lla-Met is not well understood,we explored this phenomenon in the present *** To understand the antimicrobial effect of Lla-Met and how this could be applied in treating corresponding *** *** cells were treated with the Lla-Met compound,and the effect of the compound on the cell morphology,cell membrane permeability,and oxidation of the bacteria cell was ***,the differently expressed genes in *** in response to Lla-Met treatment were *** Lla-Met treatment induced several changes in *** cells,including roughening and *** vivo experiments revealed that Lla-Met induced oxidation,DNA fragmentation,and phosphatidylserine ectropionation in *** *** Lla-Met with L-cysteine abrogated the above *** analysis revealed that Lla-Met treatment up-regulated the expression of superoxide dismutase SodB and MdaB genes,both anti-oxidation-related *** Lla-Met kills *** mainly by inducing oxidative stress,DNA damage,phosphatidylserine ectropionation,and changes on cell morphology.

关键词： Helicobacter pylori Oxidation Superoxide dismutase SodB genes MdaB genes

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Preparation and hypoglycemic effects of chromium-and zinc-rich Acetobacter aceti

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World Journal of Diabetes 2022年第6期13卷 442-453页

作者： Yong-Yi Huang Xiang-Kun Qin yuan-yuan dai Liang Huang Gan-Rong Huang Yan-Chun Qin Xian Wei Yan-Qiang Huang Research Center for the Prevention and Treatment of Drug Resistant Microbial Infection Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina

BACKGROUND At present,there is no ideal method to cure diabetes,and there are few reports on the treatment of diabetes with *** To propose a method for preparing a new type of chromium-and zinc-rich Acetobacter aceti(***)and explore its ability to enhance the hypoglycemic effects of probiotics in the treatment of *** *** was cultured in a liquid medium that contained chromium trichloride and zinc chloride,both at a concentration of 64 mg/mL,with the initial concentration of the bacterial solution 1×10^(4) CFU/*** the bacterial solution had been inducted for 48 h,the culture media was changed and the induction was repeated *** levels of chromium and zinc in the bacteria were detected by inductively coupled plasma mass spectrometry,and the contents of NADH and glucose dehydrogenase were determined using an NAD/NADH kit and glucose dehydrogenase kit,*** was used to establish a mouse model to evaluate the hypoglycemic effects of the proposed chromium-and zincrich ***-times the therapeutic dose was administered to evaluate its biological *** effect on MIN6 islet cells was also assessed in *** The levels of chromium metal,metallic zinc,NADH coenzyme,and glucose dehydrogenase in *** prepared by this method were 28.58-34.34 mg/kg,5.35-7.52 mg/kg,5.13-7.26μM,and 446.812-567.138 U/g,*** use of these bacteria resulted in a better hypoglycemic effect than metformin,promoting the repair of tissues and cells of pancreatic islets in vivo and facilitating the growth of MIN6 pancreatic islet cells and increasing insulin secretion in ***-times the therapeutic dose of treatment was non-toxic to *** Chromium trichloride and zinc chloride can be employed to induce the preparation of chromiumand zinc-rich ***,which can then promote the hypoglycemic effect found in normal *** bacteria biotransforms the chromium and zinc in a way that could increase thei

关键词： Acetobacter aceti Chromium Zinc Enrichment Blood sugar decrease

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Application of traditional Chinese medicine in treatment of Helicobacter pylori infection

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World Journal of Clinical Cases 2021年第35期9卷 10781-10791页

作者： Ru-Jia Li yuan-yuan dai Chun Qin Gan-Rong Huang Yan-Chun Qin Yong-Yi Huang Zan-Song Huang Xian-Ke Luo Yan-Qiang Huang Research Center for the Prevention and Treatment of Drug Resistant Microbial Infections Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina National Hospital of Guangxi Zhuang Autonomous Region Nanning 530001Guangxi Zhuang Autonomous RegionChina

Helicobacter pylori(***)has a high rate of infection and antibiotic resistance and poses a serious threat to human *** of the main strategies to overcome drug resistance is to develop new treatment *** Chinese medicine(TCM)that is commonly used to treat many diseases in China can reduce drug resistance and increase the eradication rate of *** this paper,we review the research progress on TCM in the treatment of *** *** mechanism of action of TCM is reviewed and research and applications of TCM in the treatment of *** are ***,we discuss problems confronting the use of TCM for the treatment of *** infection and propose possible *** addition,the plans of TCM in *** treatment were also screened:Dampness-heat syndrome in the spleen and stomach,deficiency of spleen and stomach,and cold-heat complicated syndrome,and the effective components therein are *** antibacterial effect of TCM is relatively slow;for rapid improvement of the treatment effect of refractory *** gastritis,we provide an appropriate treatment regime combining TCM and Western medicine with immune-regulatory and synergistic antibacterial effects.

关键词： Helicobacter pylori Traditional Chinese medicine Treatment Antibacterial effect Antibiotic resistance

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Early genetic diagnosis of clarithromycin resistance in Helicobacter pylori

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World Journal of Gastroenterology 2021年第24期27卷 3595-3608页

作者： Xiao-Hua Li Yong-Yi Huang Lin-Ming Lu Li-Juan Zhao Xian-Ke Luo Ru-Jia Li yuan-yuan dai Chun Qin Yan-Qiang Huang Hao Chen Research Center for the Prevention and Treatment of Drug Resistant Microbial Infection Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Department of Pathology Wannan Medical CollegeWuhu 241002Anhui ProvinceChina Department of Gastroenterology National Hospital of Guangxi Zhuang Autonomous RegionNanning Guangxi Zhuang Autonomous Region530001China

BACKGROUND The drug resistance rate of clinical Helicobacter pylori(***)isolates has ***,the mechanism of drug resistance remains *** this study,drug-resistant *** strains were isolated from different areas and different populations of Chinese for genomic *** To investigate drug-resistant genes in *** and find the genes for the early diagnosis of clarithromycin *** Three drug-resistant *** strains were isolated from patients with gastritis in Bama County,*** inhibitory concentrations of clarithromycin,metronidazole,and levofloxacin were determined and complete genome sequencing was performed with ***1181 and hp1184 genes were found in these strains and then detected by reverse transcription polymerase chain *** relationships between hp1181 or hp1184 and clarithromycin resistance were ascertained with gene mutant and drug-resistant *** homology of the strains with hp26695 was assessed through complete genome detection and *** in genome sequences,gene quantity,and gene characteristics were detected amongst the three *** and analysis of the function of drug-resistant genes indicated that the RNA expression of hp1181 and hp1184 increased in the three strains,which was the same in the artificially induced clarithromycin-resistant *** gene knockout,the drug sensitivity of the strains was *** The strains showing a high degree of homology with hp26695,hp1181,and hp1184 genes were found in these strains;the expression of the genes hp1184 and hp1181 was associated with clarithromycin *** Hp1181 and hp1184 mutations may be the earliest and most persistent response to clarithromycin resistance,and they may be the potential target genes for the diagnosis,prevention,and treatment of clarithromycin *** Hp1181 and hp1184 mutations may be the earliest and most persistent response to cla

关键词： Helicobacter pylori Clarithromycin-resistance Diagnostic gene Early genetic diagnosis Helicobacter pylori strains

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Glycemic Variation in Tumor Patients with Total Parenteral Nutrition

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Chinese Medical Journal 2015年第15期128卷 2034-2039页

作者： Jin-Cheng Yang yuan-yuan dai Li-Ming Wang Yi-Bin Xie Hai-Yan Zhou Guo-Hui Li Department of Pharmacy Cancer Hospital/Institute Chinese Academy of Medical Sciences Beijing 100021 China Department of Abdominal Surgery Cancer Hospital/Institute Chinese Academy of Medical Sciences Beijing 100021 China

Background：Hyperglycemia is associated with poor clinical outcomes and mortality in several ***,studies evaluating hyperglycemia variation in tumor patients receiving total parenteral nutrition （TPN） are *** aim of this study was to assess the relationship between glycemia and tumor kinds with TPN by monitoring glycemic variation in tumor ***：This retrospective clinical trial selected 312 patients with various cancer types,whose unique nutrition treatment was TPN during the monitoring *** patients had blood glucose （BG） values assessed at least six times daily during the TPN *** glycemic variation before and after TPN was set as the indicator to evaluate the factors influencing ***：The clinical trial lasted 7.5 ± 3.0 days adjusted for age,gender,family cancer history and blood *** were six cancer types：Hepatic carcinoma （HC,21.8%）,rectal carcinoma （17.3%）,colon carcinoma （CC,14.7%）,gastric carcinoma （29.8%）,pancreatic carcinoma （11.5%）,and duodenal carcinoma （DC,4.8%）.The patients were divided into diabetes and nondiabetes *** statistical differences in TPN glucose content between diabetes and nondiabetes groups were found;however,the tumor types affected by BG values were *** increasing BG values,DC,HC and CC were more represented than other tumor types in this sequence in diabetic individuals,as well as in the nondiabetic *** was inclined to be more easily influenced in the nondiabetes *** factors did not impact BG values,includiug gender,body mass index,and TPN infusion duration ***：When tumor patients are treated with TPN,BG levels should be monitored according to different types of tumors,besides differentiating diabetes or nondiabetes *** BG control is needed for DC,HC and CC in both diabetic and nondiabetic *** BG overtly increases,positive measurements are needed to control BG *** *** ID is NCT02024321.

关键词： Blood Glucose Total Parenteral Nutrition Tumor Patients

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Treatment strategies and preventive methods for drug-resistant Helicobacter pylori infection

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World Journal of Meta-Analysis 2020年第2期8卷 98-108页

作者： Ru-Jia Li yuan-yuan dai Chun Qin Xiao-Hua Li Yan-Chun Qin Yong Pan Yong-Yi Huang Zan-Song Huang Yan-Qiang Huang Research Center for Prevention and Treatment of Drug Resistant Microbial Infections Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina

The infection and drug resistance rates of Helicobacter pylori(***)are high and must be prevented and treated by better *** on recent research advances in this field as well as the results from our team and those on traditional Chinese medicine,we review the causes of drug resistance,and prevention and treatment strategies for drug-resistant *** infection,with an aim to make suggestions for the development of new drugs,such as establishment of new target identification and screening systems,modification of existing drug structures,use of new technologies,application of natural products,and using a commercial compound *** article may provide reference for eradication of drug-resistant ***.

关键词： Helicobacter pylori Drug-resistant Strategies Methods Treatment Prevention

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核质蛋白在精核染色体重建过程中的作用研究

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生殖与避孕 2011年第10期31卷 685-690页

作者：代元元刘树真李丛丛王磊刘愿孟小倩山东师范大学生命科学学院动物抗性重点实验室济南250014 山东医学高等专科学校济南250002 诸城市人民医院潍坊262200

核质蛋白(nucleoplasmin,NP)是一种酸性的、具有热稳定性的蛋白质,能与组蛋白结合从而介导核小体组装和染色质重建,是一种重要的核分子伴侣。受精后,NP在精核去浓缩过程中发挥重要作用,将特异性精子碱性蛋白去除,并用卵母细胞中的组蛋白... 详细信息

核质蛋白(nucleoplasmin,NP)是一种酸性的、具有热稳定性的蛋白质,能与组蛋白结合从而介导核小体组装和染色质重建,是一种重要的核分子伴侣。受精后,NP在精核去浓缩过程中发挥重要作用,将特异性精子碱性蛋白去除,并用卵母细胞中的组蛋白H2A、H2B替代,从而调控精核染色体重组。

关键词：核质蛋白(NP) 卵母细胞受精精核染色体重组

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Glycine protects against hypoxic-ischemic brain injury by regulating mitochondria–mediated autophagy via AMPK pathway

Glycine protects against hypoxic-ischemic brain injury by re...

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2019长三角围产医学学术会议暨浙江省围产医学学术大会

作者： Chen-chen Cai Jiang-hu Zhu Li-xia Ye yuan-yuan dai Ming-chu Fang Ying-ying Hu Shu-lin Pan Si Chen Pei-jun Li Xiao-qin Fu Zhen-lang Lin

Hypoxic-ischemic encephalopathy(HIE) is detrimental to newborns and is associated with high mortality and poor prognosis. Thus, the primary aims of the present study were to determine whether glycine could 1) attenuate HIE injury in rats and hypoxic stress in PC12 cells and 2) down regulate mitochondria-mediated autophagy dependent on the adenosine monophosphate(AMP)-activated protein kinase(AMPK) pathway. Experiments conducted using an in vivo HIE animal model and in vitro hypoxic stress to PC12 cells revealed that intense autophagy associated with mitochondrial function occurred during in vivo HIE injury and in vitro hypoxic stress. However, glycine treatment effectively attenuated mitochondria-mediated autophagy. Additionally, after identifying alterations in proteins within the AMPK pathway in rats and PC12 cells following glycine treatment, Cyclosporin A(CsA) and 5-aminoimidazole-4-carboxamide-1-b-4-ribofuranoside(AICAR) were administered in these models and indicated that glycine protected against HIE and CoCl2 injury by down regulating mitochondria–mediated autophagy that was dependent on the AMPK pathway. Overall, glycine attenuated hypoxic-ischemic injury in neurons via reductions in mitochondria–mediated autophagy through the AMPK pathway both in vitro and in vivo.

关键词： Glycine HIE Mitochondria–mediated Autophagy AMPK

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罗非鱼供给侧结构改革的思考

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中国农学通报 2018年第8期34卷 118-122页

作者：袁媛袁永明代云云龚赟翀中国水产科学研究院淡水渔业研究中心/国家罗非鱼产业技术研发中心/农业部淡水渔业和种质资源利用重点实验室江苏无锡214081

为提高罗非鱼养殖的三大效益,总结了罗非鱼产业供给侧存在的突出问题如供需失衡、生产成本持续上涨、市场结构单一、抗风险能力小等,分析其成因包括中国罗非鱼主要依赖出口市场,出口消费不景气、加工厂盲目扩大产能、产品附加值低等。... 详细信息

为提高罗非鱼养殖的三大效益,总结了罗非鱼产业供给侧存在的突出问题如供需失衡、生产成本持续上涨、市场结构单一、抗风险能力小等,分析其成因包括中国罗非鱼主要依赖出口市场,出口消费不景气、加工厂盲目扩大产能、产品附加值低等。笔者从罗非鱼苗种生产、成鱼养殖,产品加工和出口贸易4个产业主要环节概述了中国罗非鱼产业生产现状,提出了罗非鱼供给侧结构改革的技术经济与政策路径,即通过推广健康养殖模式、加强加工产品关键配套技术研发、加大产品质量安全检测力度、开拓国内市场和大力发展产业化经营组织等措施,以促进罗非鱼产业的健康可持续发展。

关键词：罗非鱼供给侧改革

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