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Analytical solution for the effective elastic properties of rocks with the tilted penny-shaped cracks in the transversely isotropic background

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Petroleum Science 2024年第1期21卷 221-243页

作者： Zheng-Qian Ma Xing-Yao Yin Zhao-Yun Zong yuan-yuan tan Ya-Ming Yang National Key Laboratory of Deep Oil and Gas China University of Petroleum(East China)Qingdao266580ShandongChina School of Geosciences China University of Petroleum(East China)Qingdao 266580ShandongChina Pilot National Laboratory for Marine Science and Technology(Qingdao) Qingdao266200ShandongChina

Seismic prediction of cracks is of great significance in many disciplines,for which the rock physics model is ***,up to now,multitudinous analytical models focus primarily on the cracked rock with the isotropic background,while the explicit model for the cracked rock with the anisotropic background is rarely investigated in spite of such case being often encountered in the ***,we first studied dependences of the crack opening displacement tensors on the crack dip angle in the coordinate systems formed by symmetry planes of the crack and the background anisotropy,respectively,by forty groups of numerical *** on the conclusion from the experiments,the analytical solution was derived for the effective elastic properties of the rock with the inclined penny-shaped cracks in the transversely isotropic ***,we comprehensively analyzed,according to the developed model,effects of the crack dip angle,background anisotropy,filling fluid and crack density on the effective elastic properties of the cracked *** analysis results indicate that the dip angle and background anisotropy can significantly either enhance or weaken the anisotropy degrees of the P-and SH-wave velocities,whereas they have relatively small effects on the SV-wave velocity ***,the filling fluid can increase the stiffness coefficients related to the compressional modulus by reducing crack compliance parameters,while its effects on shear coefficients depend on the crack dip *** increasing crack density reduces velocities of the dry rock,and decreasing rates of the velocities are affected by the crack dip *** comparing with exact numerical results and experimental data,it was demonstrated that the proposed model can achieve high-precision estimations of stiffness ***,the assumption of the weakly anisotropic background results in the consistency between the proposed model and Hudson's published theory for the or

关键词： Effective elastic property Tilted crack Transverse isotropy Analytical solution Crack opening displacement

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Neutrophils inhibit CD8^(+)T cells immune response by arginase-1 signaling in patients with sepsis

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World Journal of Emergency Medicine 2022年第4期13卷 266-273页

作者： Xiao-kang Dai Zhen-xing Ding yuan-yuan tan Hua-rui Bao Dong-yao Wang Hong Zhang Department of Emergency the First Affiliated Hospital of Anhui Medical UniversityHefei 230027China Department of Hematology the First Affiliated Hospital of University of Science and Technology of ChinaDivision of Life Sciences and MedicineHefei 230001China Division of Molecular Medicine Hefei National Laboratory for Physical Sciences at Microscalethe Chinese Academy of Sciences Key Laboratory of Innate Immunity and Chronic DiseaseSchool of Life SciencesUniversity of Science and Technology of ChinaHefei 230001China Anhui Province Key Laboratory of Immunology in Chronic Diseases Bengbu Medical CollegeBengbu 233030China

BACKGROUND:Patients with sepsis often exhibit an acute inflammatory response,followed by an immunosuppressive phase with a poor immune ***,the underlying mechanisms have not been fully ***:We sought to comprehensively characterize the transcriptional changes in neutrophils of patients with sepsis by transcriptome ***,we conducted a series of experiments,including real-time quantitative polymerase chain reaction(RT-qPCR)and flow cytometry to investigate the role of arginase-1 signaling in ***:Through the analysis of gene expression profiles,we identified that the negative regulation of T cell activation signaling was enriched,and the expression of arginase-1 was high in neutrophils from patients with ***,we conducted flow cytometry and found that the function of CD8^(+)T cells in septic patients was ***,neutrophils from septic patients inhibited the percentage of polyfunctional effector CD8^(+)T cells through ***,the proportions of granzyme B^(+)IFN^(-)γ^(+)CD8^(+)T and TNF^(-)α^(+)IFN^(-)γ^(+)CD8^(+)T cells increased after inhibition of arginase-1 ***:The impaired effector function of CD8^(+)T cells could be restored by blocking arginase-1 signaling in patients with sepsis.

关键词： Sepsis Effector CD8+T cells Neutrophils Arginase-1 Interferon-γ

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Eutectic high entropy alloy syntactic foam

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Journal of Materials Science & Technology 2023年第18期149卷 177-189页

作者： Jin Meng Yu Qiao Tian-Wei Liu yuan-yuan tan Fu-Hua Cao Yan Chen Hai-Ying Wang Lan-Hong Dai State Key Laboratory of Nonlinear Mechanics Institute of MechanicsChinese Academy of Sciences(CAS)Beijing 100190China State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing 100081China School of Engineering Science University of Chinese Academy of SciencesBeijing 101408China CAS Key Laboratory of Mechanical Behavior and Design of Materials Department of Modern MechanicsUniversity of Science and Technology of ChinaHefei 230027China

High-strength metallic foams have a wide range of applications in engineering as lightweight structural and energy-absorbing ***,it is challenging to obtain metallic foam with both good energy absorption performance and high ***,we developed a novel metal matrix syntactic foam fabri-cated with AlCoCrFeNi_(2.1) eutectic high entropy alloy and alumina cenospheres that exhibits a remarkable combination of high strength and energy absorption performance under both quasi-static and dynamic *** porous structure of syntactic foam fully exploits the properties of the AlCoCrFeNi_(2.1) alloy matrix with a unique FCC/B2 dual-phase eutectic microstructure and thus yields exceptional *** discovered that this dual-phase microstructure not only provides high strength but also allows the pores to collapse in a progressive and diffusive way,which enables the formation of a high and smooth energy absorption *** is found that the heterogeneity between the two phases in the matrix can provide back stress strengthening,and it also induces multiple micro shear bands and microcracks as additional energy dissipation modes as the deformation *** unique mechanism ensures the strength of microstructures and makes them fracture promptly,which causes the balance of strengthening and softening on the macro *** work opens the avenue for developing advanced high-strength lightweight structural and energy-absorbing materials.

关键词： Eutectic high entropy alloy Foams Metal matrix composites(MMCs) Energy absorption

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Lattice distortion and magnetic property of high entropy alloys at low temperatures

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Journal of Materials Science & Technology 2022年第9期104卷 236-243页

作者： yuan-yuan tan Zhong-Jun Chen Ming-Yao Su Gan Ding Min-Qiang Jiang Zhou-Can Xie Yu Gong Tao Wu Zhong-Hua Wu Hai-Ying Wang Lan-Hong Dai State Key Laboratory of Nonlinear Mechanics Institute of MechanicsChinese Academy of SciencesBeijing 100190China Institute of High Energy Physics Chinese Academy of Sciences&GraduateUniversity of Chinese Academy of SciencesBeijing 100049China School of Engineering Science University of Chinese Academy of SciencesBeijing 100049China Zhejiang Institute of Mechanical&Electrical Engineering Hangzhou 310053China State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing 100081China

Deformation mechanisms and magnetic properties of medium and high entropy alloys(MEA/HEAs)closely relate to lattice distortion and are strongly temperature-dependent,in particular,at low temperature ***,little attention has been paid to the evolution of lattice distortion with temperature decreasing and its effects on deformation behavior and magnetic state *** this work,we carry out in situ synchrotron radiation based X-ray powder diffraction(SR-XRD)experiments from 293 to 123 K aiming for determining lattice distortion evolutions of Cr Co Ni MEA,Cr Fe Co Ni and Cr Mn Fe Co Ni *** measurements at corresponding low temperatures and cryogenic ranges are further *** in situ SR-XRD results demonstrate a general reduction of lattice distortion magnitude with temperature decreasing,which shows a similar tendency with that of reported stacking fault energy(SFE)*** is thus suggested that lattice distortion reduction possibly makes a critical contribution to deformation mechanism *** magnetic measurement results show a clear ferromagnetic transition of Cr Fe Co Ni HEA when temperature is below 173 ***,no obvious magnetic state transition is observed for Cr Co Ni MEA and Cr Mn Fe Co Ni *** present findings on lattice distortion evolutions will pave the way for designing targeted HEAs with particular properties.

关键词： High entropy alloy Lattice distortion Magnetic property Low temperature In situ SR-XRD

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Gene editing: an instrument for practical application of gene biology to plant breeding

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2020年第6期21卷 460-473页

作者： yuan-yuan tan Hao DU Xia WU Yan-hua LIU Meng JIANG Shi-yong SONG Liang WU Qing-yao SHU National Key Laboratory of Rice Biology Institute of Crop SciencesZhejiang UniversityHangzhou 310058China The Rural Development Academy Zhejiang UniversityHangzhou 310058China

Plant breeding is well recognized as one of the most important means to meet food security challenges caused by the ever-increasing world population. During the past three decades, plant breeding has been empowered by both new knowledge on trait development and regulation(e.g., functional genomics) and new technologies(e.g., biotechnologies and phenomics). Gene editing, particularly by clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein(Cas) and its variants, has become a powerful technology in plant research and may become a game-changer in plant breeding. Traits are conferred by coding and non-coding genes. From this perspective, we propose different editing strategies for these two types of genes. The activity of an encoded enzyme and its quantity are regulated at transcriptional and post-transcriptional, as well as translational and post-translational, levels. Different strategies are proposed to intervene to generate gene functional variations and consequently phenotype changes. For non-coding genes, trait modification could be achieved by regulating transcription of their own or target genes via gene editing. Also included is a scheme of protoplast editing to make gene editing more applicable in plant breeding. In summary, this review provides breeders with a host of options to translate gene biology into practical breeding strategies, i.e., to use gene editing as a mechanism to commercialize gene biology in plant breeding.

关键词： Gene editing Expression regulation Novel allele Trait development Plant breeding

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Tissue-specific expression, developmentally and spatially regulated alternative splicing, and protein subcellular localization of OsLpa1 in rice

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2016年第2期17卷 100-109页

作者： Hai-ping LU Wei-qin PANG Wen-xu LI yuan-yuan tan Qing WANG Hai-jun ZHAO Qing-yao SHU State Key Laboratory of Rice Biology Institution of Crop Science Zhejiang University Hangzhou 310029 China Wuxi Hupper Bioseed Technology Academy Ltd. Wuxi 214000 China

The OsLpa1 gene（LOC_Os02g57400） was identified to be involved in phytic acid（PA） metabolism because its knockout and missense mutants reduce PA content in rice grain. However, little is known about the molecular characteristics of OsLpa1 in rice and of its homologues in other plants. In the present study, the spatial pattern of OsLpa1 expression was revealed using OsLpa1 promoter：：GUS transgenic plants（GUS： β-glucuronidase）; GUS histochemical assay showed that OsLpa1 was strongly expressed in stem, leaf, and root tissues, but in floral organ it is expressed mainly and strongly in filaments. In seeds, GUS staining was concentrated in the aleurone layers; a few blue spots were observed in the outer layers of embryo, but no staining was observed in the endosperm. Three OsLpa1 transcripts（OsLpa1.1, OsLpa1.2, OsLpa1.3） are produced due to alternative splicing; quantitative reversetranscriptase polymerase chain reaction（RT-PCR） analysis revealed that the abundance of OsLpa1.3 was negligible compared with OsLpa1.1 and OsLpa1.2 in all tissues. OsLpa1.2 is predominant in germinating seeds（about 5 times that of OsLpa1.1）, but its abundance decreases quickly with the development of seedlings and plants, whereas the abundance of OsLpa1.1 rises and falls, reaching its highest level in 45-d-old plants, with abundance greater than that of OsLpa1.2 in both leaves and roots. In seeds, the abundance of OsLpa1 continuously increases with seed growth, being 27.5 and 15 times greater in 28-DAF（day after flowering） seeds than in 7-DAF seeds for OsLpa1.1 and OsLpa1.2, respectively. Transient expression of chimeric genes with green fluorescence protein（GFP） in rice protoplasts demonstrated that all proteins encoded by the three OsLpa1 transcripts are localized to the chloroplast.

关键词： OsLpa1 Low phytic acid Expression pattern Alternative splicing Subcellular localization

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Co/Co_(7)Fe_(3)heterostructures with controllable alloying degree on carbon spheres as bifunctional electrocatalyst forrechargeable zinc-air batteries

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 476-487页

作者： Junkang Chen Yongyue Zhuang Yanxin Qiao Yu Zhang Aihua yuan Hu Zhou School of Materials Science and Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China School of Environmental and Chemical Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China

Exploring efficient and nonprecious metal electrocatalysts of oxygen reduction reaction(ORR)and oxygen evolution reaction(OER)is crucial for developing rechargeable zinc-air batteries(ZABs).Herein,an alloying-degree control strategy was employed to fabricate nitrogen-doped carbon sphere(NCS)decorated with dual-phase Co/Co_(7)Fe_(3)heterojunctions(CoFe@NCS).The phase composition of materials has been adjusted by controlling the alloying *** optimal CoFe_(0.08)@NCS electrocatalyst displays a half-wave potential of 0.80 V for ORR and an overpotential of 283 mV at 10 mA·cm^(-2)for OER in an alkaline *** intriguing bifunctional electrocatalytic activity and durability is attributed to the hierarchically porous structure and interfacial electron coupling of highly-active Co_(7)Fe_(3)alloy and metallic Co *** the CoFe_(0.08)@NCS material is used as air-cathode catalyst of rechargeable liquid-state zinc-air battery(ZAB),the device shows a high peak power-density(157 mW·cm^(-2))and maintains a stable voltage gap over 150 h,outperforming those of the benchmark(Pt/C+RuO_(2))-based *** particular,the as-fabricated solid-state flexible ZAB delivers a reliable compatibility under different bending *** work provides a promising strategy to develop metal/alloy-based electrocatalysts for the application in renewable energy conversion technologies.

关键词： bifunctional electrocatalysts oxygen reduction reaction oxygen evolution reaction zinc-air battery metal/alloy carbon sphere

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The dopaminergic system and Alzheimer's disease

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Neural Regeneration Research 2025年第9期20卷 2495-2512页

作者： Yuhan Zhang yuan Liang Yixue Gu International Medical College Chongqing Medical UniversityChongqingChina College of Pharmacy Chongqing Medical UniversityChongqingChina Department of Neurology The First Affiliated Hospital of Chongqing Medical UniversityChongqing Key Laboratory of NeurologyChongqingChina

Alzheimer's disease is a common neurodegenerative disorder in older *** its prevalence,its pathogenesis remains unclea *** addition to the most widely accepted causes,which in clude excessive amyloid-beta aggregation,tau hyperphosphorylation,and deficiency of the neurotransmitter acetylcholine,numerous studies have shown that the dopaminergic system is also closely associated with the occurrence and development of this *** is a crucial catecholaminergic neurotransmitter in the human ***-associated treatments,such as drugs that target dopamine receptor D and dopamine analogs,can improve cognitive function and alleviate psychiatric symptoms as well as ameliorate other clinical *** r,therapeutics targeting the dopaminergic system are associated with various adverse reactions,such as addiction and exacerbation of cognitive *** review summarizes the role of the dopaminergic system in the pathology of Alzheimer's disease,focusing on currently available dopamine-based therapies for this disorder and the common side effects associated with dopamine-related *** aim of this review is to provide insights into the potential connections between the dopaminergic system and Alzheimer's disease,thus helping to clarify the mechanisms underlying the condition and exploring more effective therapeutic options.

关键词： adverse drug reaction Alzheimer's disease catecholamine dopamine receptor dopamine receptor heterodimers dopaminergic system neurodegenerative disease neurotransmitter signaling pathways traditional Chinese medicine treatment

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Sex differences in aging and injured brain

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Neural Regeneration Research 2025年第10期20卷 2901-2902页

作者： Jordan N.Williamson yuan Yang University of Illinois Urbana-Champaign Grainger College of EngineeringDepartment of BioengineeringUrbanaILUSA Carle Foundation Hospital Stephenson Family Clinical Research InstituteClinical Imaging Research CenterUrbanaILUSA University of Illinois Urbana-Champaign Beckman Institute for Advanced Science and TechnologyUrbanaILUSA Northwestern University Department of Physical Therapy and Human Movement SciencesChicagoILUSA

Background:The prevalence,age of onset,and symptomatology of traumatic brain injury,stroke,and neurodegenerative diseases(such as Alzheimer’s disease(AD),Parkinson’s disease,amyotrophic lateral sclerosis,and Huntington’s disease)differ substantially between males and *** higher prevalence of these brain disorders has been attributed to females having a greater longevity compared with *** one of the greatest risk factors of acquired brain injury(such as stroke,traumatic brain injury caused by fall)and neurodegenerative disease is age.

关键词： Huntington prevalence traumatic

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Peripheral mitochondrial DNA as a neuroinflammatory biomarker for major depressive disorder

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Neural Regeneration Research 2025年第6期20卷 1541-1554页

作者： Jinmei Ye Cong Duan Jiaxin Han Jinrong Chen Ning Sun yuan Li Tifei yuan Daihui Peng Division of Mood Disorder Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Department of Psychiatry First Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Shanghai Key Laboratory of Psychotic Disorders Brain Health InstituteNational Center for Mental DisordersShanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Co-Innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina

In the pathogenesis of major depressive disorder, chronic stress-related neuroinflammation hinders favorable prognosis and antidepressant response. Mitochondrial DNA may be an inflammatory trigger, after its release from stress-induced dysfunctional central nervous system mitochondria into peripheral circulation. This evidence supports the potential use of peripheral mitochondrial DNA as a neuroinflammatory biomarker for the diagnosis and treatment of major depressive disorder. Herein, we critically review the neuroinflammation theory in major depressive disorder, providing compelling evidence that mitochondrial DNA release acts as a critical biological substrate, and that it constitutes the neuroinflammatory disease pathway. After its release, mitochondrial DNA can be carried in the exosomes and transported to extracellular spaces in the central nervous system and peripheral circulation. Detectable exosomes render encaged mitochondrial DNA relatively stable. This mitochondrial DNA in peripheral circulation can thus be directly detected in clinical practice. These characteristics illustrate the potential for mitochondrial DNA to serve as an innovative clinical biomarker and molecular treatment target for major depressive disorder. This review also highlights the future potential value of clinical applications combining mitochondrial DNA with a panel of other biomarkers, to improve diagnostic precision in major depressive disorder.

关键词： biomarker cytokine exosomes inflammasome major depressive disorder microglia mitochondrial DNA mitochondrial dysfunction neuroinflammation Toll-like receptor

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