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Synthesis of azo derivatives of 4-aminosalicylic acid

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Chinese Chemical Letters 2007年第6期18卷 639-642页

作者： Zheng Bao Zhao Hui Xia Zheng yuan gui Wei Jiang Liu College of Pharmacy Shanxi Medical University Taiyuan 030001 China First Clinical College Shanxi Medical University Taiyuan 030001 China

For searching a better 4-aminosalicylic acid derivative with higher activity and less side effects against the inflammatory bowel disease, 4-aminosalicylic acid (4-ASA) was protected by benzyloxycarbonyl and acetyl, respectively. The resultant was hydrogenized to remove protective group of amino group, then the product was reacted with NaNO2 to give diazonium salt, which was conjugated with salicylic acid, hydroxybenzene, N-salicyloyl glycine acid to get azo derivatives of 4-ASA. The azo derivatives were hydrolyzed under the alkaline condition to get the target products. All compounds were characterized by FT-IR, (1)H NMR, (13)C NMR spectra in details. New derivatives of 4-ASA were characterized. The synthetic route was reasonable and feasible.

关键词： 4-Aminosalicylic acid Azo derivatives of 4-aminosalicylic acid Inflammatory bowel disease

A photometric study of the K-type contact binary EI CVn

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Research in Astronomy and Astrophysics 2011年第2期11卷 181-190页

作者： yuan-gui Yang School of Physics and Electronic Information,Huaibei Normal University,Huaibei 235000,China School of Physics and Electronic Information Huaibei Normal University Huaibei 235000 China

We present charge-coupled device （CCD） photometry for the short-period K-type binary EI CVn,observed on 2009 February 28 at the Xinglong Station of National Astronomical Observatories,Chinese Academy of *** using the Wilson-Devinney program,the photometric solution was first deduced from our V R *** results show that EI CVn is a W-type weak-contact binary with a mass ratio of qph=0.2834（±0.0010） and an overcontact degree of f=20.0%（±0.7%）.The distorted light curves were modeled by a dark spot on the cool primary component,whose area was up to 1.9% of the area of the *** on the period analysis,it is found that there exists a weak secular decrease at a rate of dP/dt= 3.11（±0.03） × 10-7 d yr-1,which may be attributed to mass transfer from the primary to the *** mass transfer occurring,the separation between both components will shrink,which may cause the degree of overcontact to ***,the weak-contact binary EI CVn may evolve into a deep-contact configuration.

关键词： stars: binaries: close -- stars: binaries: eclipsing -- stars: individual: EICVn

Acid-induced topological morphology modulation of graphitic carbon nitride homojunctions as advanced metal-free catalysts for OER and pollutant degradation

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Journal of Materials Science & Technology 2021年第27期86卷 210-218页

作者： Hua-Wei Zhang Yi-Xin Lu Bo Li gui-Fang Huang Fan Zeng yuan-yuan Li Anlian Pan Yi-Feng Chai Wei-Qing Huang Key Laboratory for Micro/Nano Optoelectronic Devices of Ministry of Education&Hunan Provincial Key Laboratory of Low-Dimensional Structural Physics and Devices School of Physics and ElectronicsHunan UniversityChangsha410082China College of Materials Science and Engineering Hunan UniversityChangshaHunan410082China School of Physics and Electronics Science Hunan University of Science and TechnologyXiangtan411201China

Topological morphology that dominates the surface electronic properties of nanostructures plays a key role in producing desired materials for versatile functions and applications in many fields,but its modulation for specific functions remains a big ***,we report an acid-induced method to prepare S-doped graphitic carbon nitride/graphitic carbon nitride(S-CN/CN)homojunction by simply pyrolyzing a supramolecular precursor synthesized from melamine and H_(2)SO_(4).The topological morphology and electronic structure of CN homojunction can be easily adjusted only by changing the ratio of raw ***,the topological morphology of S-CN/CN homojunction can be further adjusted from hollow cocoon to 2D nanosheets by changing the annealing *** optimized S-CN/CN homojunction shows highly efficient in charge transfer and separation and exhibits superior OER activity and high ability to degrade organic ***,S-CN/CN nanosheets only demand low overpotential of301 m V to drive a current density of 10 m Acm^(-2)in 1 M KOH media,and the corresponding Tafel slope is only 57.71 m V/dec,which is superior to the most advanced precious metal Ir O_(2)***,under visible light irradiation,its photodegradation kinetic rate of Rh B is 2.38,which is 47.6 times higher than that of bulk *** work provides useful guidance for designing and developing efficient multifunctional metal-free catalysts.

关键词： Topological morphology Acid-induced Molecular self-assembly S-CN/CN homojunction OER

Envelope Method and More General New Global Structures of Solutions for Multi-dimensional Conservation Law

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Communications on Applied Mathematics and Computation 2023年第3期5卷 1180-1234页

作者： gui-Qin Qiu Gao-Wei Cao Xiao-Zhou Yang yuan-An Zhao University of Chinese Academy of Sciences Beijing 100049China Wuhan Institute of Physics and Mathematics Innovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhan 430071HubeiChina Hubei Minzu University Enshi 445000HubeiChina

For the two-dimensional(2D)scalar conservation law,when the initial data contain two different constant states and the initial discontinuous curve is a general curve,then complex structures of wave interactions will be *** this paper,by proposing and investigating the plus envelope,the minus envelope,and the mixed envelope of 2D non-selfsimilar rarefaction wave surfaces,we obtain and the prove the new structures and classifications of interactions between the 2D non-selfsimilar shock wave and the rarefaction *** the cases of the plus envelope and the minus envelope,we get and prove the necessary and sufficient criterion to judge these two envelopes and correspondingly get more general new structures of 2D solutions.

关键词： Riemann problem Non-selfsimilar shock wave Non-selfsimilar rarefaction wave Envelope Multi-dimensional conservation law

Characteristics and origin of a new type of polyhalite potassium ore in the Lower Triassic Jialingjiang Formation, Puguang area, northeastern Sichuan Basin, SW China

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Journal of Palaeogeography 2021年第1期10卷 112-124页

作者： Wen-Jun Shang Mian-Ping Zheng Yong-Sheng Zhang Jia-Ai Zhong En-yuan Xing yuan Peng Bao-Ling gui Kong Li Institute of Mineral Resources Chinese Academy of GeosciencesBeijing 100037China Key Laboratory of Salt Lake Resources and Environment Ministry of Natural ResourcesBeijing 100037China Key Laboratory of Mineralization and Resource Evaluation Ministry of Natural ResourcesBeijing 100037China The 5th Detachment of Gold Force of the Chinese People's Armed Police Force Xi'an 710199Shaanxi ProvinceChina

A new type of polyhalite potassium ore(NTPPO) was found in the Lower Triassic Jialingjiang Formation, NE Sichuan Basin, SW China. It is water soluble, therefore can be exploited using the water-solution method, and is of great potential of economic value and research significance. Based on cores, thin sections, energy spectrum and SEM analyses, its microfeatures, macrofeatures and origin are discussed, and a genetic model is established to provide a scientific basis for future evaluation, prediction and exploration of potassium ore in the Sichuan Basin. It is proposed that the NTPPO was caused by storm activities:(1) the storm broke the original sedimentary polyhalite–gypsum beds, whose fragments were transported into the salt basin with high content of K+ and Mg2+;(2) in the basin, the polyhalite continued to be formed from gypsum by metasomatism with K-and Mg-rich brine;(3) during diagenesis, under high temperature and high pressure, K–Mg-rich brine from halite continued to replace anhydrite(or gypsum) to form polyhalite.

关键词： Puguang area Lower Triassic New type of polyhalite potassium ore Microfeatures and macrofeatures Storm event deposition

Change in expression of apoptosis genes after hyperthermia,chemotherapy and radiotherapy in human colon cancer transplanted into nude mice

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World Journal of Gastroenterology 2007年第32期13卷 4365-4371页

作者： Han Liang Hong-Jie Zhan Bao-gui Wang yuan Pan Xi-Shan Hao Department of Gastrointestinal Oncological Surgery Tianjin Cancer Hospital Tianjin Medical University Key Laboratory of Cancer Prevention and Therapy Tianjin 300060 China

AIM:To investigate the change in expression of p53 ,Bcl-2 ,and Bax genes in human colon cancer cells transplanted into nude mice after hyperthermia,chemotherapy,radiotherapy,thermochemotherapy,thermoradiotherapy and thermochemoradiotherapy. METHODS:Human colon cancer cell line (HT29) was transplanted into the hind limbs of nude mice. Under laboratory simulated conditions of hyperthermia (43℃,60 min),the actual radiation doses and doses of mitomycin C (MMC) were calculated in reference to the clinical radiotherapy for human rectal cancer and chemotherapy prescription for colon cancer. The mice were divided into 6 groups according to the treatment approaches:hyperthermia,chemotherapy,radiotherapy,thermochemotherapy,thermoradiotherapy,and thermochemoradiotherapy. The mice were sacrificed at different time points and the tumor tissue was taken for further procedures. The morphologic changes in membrane,cytoplasm and nuclei of tumor cells of p53,Bcl-2,and Bax after treatment,were observed by immunohistochemistry staining. RESULTS:All of the six treatment modalities down-regulated the expression of p53,Bcl-2 and up-regulated the expression of Bax at different levels. The combined therapy of hyperthermia,with chemotherapy,and/or irradiation showed a greater effect on down-regulating the expression of p53 (0.208 ± 0.009 vs 0.155 ± 0.0115,P < 0.01) and Bcl-2 (0.086 ± 0.010 vs 0.026 ± 0.0170,P < 0.01) and up-regulating Bax expression (0.091 ± 0.0013 vs 0.207 ± 0.027,P < 0.01) compared with any single ***:Hyperthermia enhances the effect of radio-and chemotherapy on tumors by changing the expression of apoptosis genes,such as p53,Bcl-2 and Bax.

关键词： Hyperthermia Apoptosis p53 Bcl-2 Bax Nude mice Colon cancer Cell line

Molecular Biomarker Characteristics of the Linxi Formation Source Rocks in the Middle-Western Region of Inner Mongolia:New evidence for late-stage tectonic evolution of the Paleo-Asian Ocean

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Acta Geologica Sinica(English Edition) 2017年第2期91卷 745-746页

作者： ZHANG Yongsheng PENG yuan SHI Lizhi XING Enyuan gui Baolin LI Kai MLR Key Laboratory of Saline Lake Resources and Environments Institute of Mineral ResourcesChinese Academy of Geological Sciences School of Earth Sciences and Resources China University of Geosciences (Beijing)

Objective Two important geological issues have long been controversial in the Xing-Meng area of North China. The first concerns the final closure of Paleo-Asian Ocean in Xing-Meng area, and the other concerns the folding and lifting of the Xing-Meng Trough. The focus of thses issues is the Late Permian sedimentary environment, which is generally considered to be either an exclusively continental environment or from the closed inland sea environment in the Early to Middle stage to continental lacustrine environment in the late stage. In recent years, we have successively discovered abundant typical marine fossils （e.g., bryozoans and calcareous algae） in the Upper Permian thick limestone layer from Linxi County and Ar Horqin Banner in eastern region of Inner Mongolia and Jiutain County in Jilin Province. These significant findings have attracted the attention from fellow academics.

关键词： In As Molecular Biomarker Characteristics of the Linxi Formation Source Rocks in the Middle-Western Region of Inner Mongolia:New evidence for late-stage tectonic evolution of the Paleo-Asian Ocean

Waveform Distortions in Femtosecond Laser Pulses Transmitting through Coated Optical Fiber Probes

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Chinese Physics Letters 2010年第6期27卷 221-224页

作者： LIU gui-yuan HAN Jun-Ling LIU Man TENG Shu-Yun CHENG Chuan-Fu College of Physics and Electronics Shandong Normal University Jinan 250014 School of Science Shandong 3ianzhu University Jinan 250101 Department of Electronic Engineering Jinan Vocational College Jinan 250103

We calculate the light field in metal-coated optical fiber probes under illumination of femtosecond laser pulses with the three-dimensional finite-difference time-domain method. By choosing the maximum of the calculated light field data in the time period of one light wave cycle at each spatial point, we obtain the amplitude distributions instead of the conventional light field distribution of a time instant. It is found that with an incident plane wave pulse of y-polarization, the output amplitude distributions of y-polarization have roughly a circled-cross-like pattern with two arc-like zero-amplitude zones. By analyzing the y-polarized waveforms versus time at the points near the arc-like zero-amplitude zones, we find that waveform distortions appear at points in the neighborhood of the zero amplitude lines and in the time intervals when two wave-packets overlap.

关键词： Computers Timing Time Grain legumes Fields Light Lighting Zoning Polarity Optical properties

Gorham-Stout syndrome in China's Mainland:a case series of 67 patients and review of the literature

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第8期14卷 729-735页

作者： Po HU Xiang-gui yuan Xin-yang HU Fa-rong SHEN Jian-an WANG Cardiovascular Key Lab of Zhejiang Province Department of Cardiology the Second Affiliated Hospital School of Medicine Zhejiang University Department of Cardiology Zhejiang Hospital Department of Internal Medicine Hangzhou Binjiang Hospital the Second Affiliated Hospital (Binjiang Branch) School of Medicine Zhejiang University

Objective:Gorham-Stout syndrome (GSS) is a rare disorder of uncertain etiology and unpredictable prognosis. This study aims to present a comprehensive understanding of this rare entity. Methods:A literature search in PubMed and three Chinese databases was performed to screen histologically proven GSS cases among Chinese residents in the mainland. We analyzed the patients' clinical characteristics, the value of different treatment modalities and their influence on the clinical outcome. Results:Sixty-seven cases were finally enrolled. There were 43 men (64.2%) and 24 women (35.8%). The mean age at diagnosis was 28 years (1.5-71 years). The most common clinical symptoms included pain (n=40, 59.7%), functional impairment (n=13, 19.4%), and swelling (n=12, 17.9%). The radiographic presentation of 37 cases (55.2%) was disappearance of a portion of the bone. The others presented as radiolucent foci in the intramedullary or subcortical regions. A total of 42 cases provided data on therapy, these included surgery (n=27, 40.3%), radiation therapy (n=6, 9.0%), surgery combined with radiation therapy (n=2, 3.0%), and medicine therapy (n=7, 10.4%). For 30 of these 42 cases, follow-up data were available:21 cases had the disorder locally controlled and 9 had a symptom progression. Fortunately, the disease is not fatal in the majority of cases. Conclusions:GSS has no specific symptoms and it should be taken into consideration when an unclear massive osteolysis occurs. The efficacies of different treatment modalities are still unpredictable and further research is required to assess the values of different treatments.

关键词： Gorham-Stout syndrome (GSS) Massive osteolysis Chinese