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Gene and protein expression profiles of olfactory ensheathing cells from olfactory bulb versus olfactory mucosa

Neural Regeneration Research 2022年第2期17卷 440-449页

作者： yuan-xiang lan Ping Yang Zhong Zeng Neeraj Yadav Li-Jian Zhang Li-Bin Wang He-Chun Xia School of Clinical Medicine Ningxia Medical UniversityYinchuanNingxia Hui Autonomous RegionChina Ningxia Human Stem Cell Institute General Hospital of Ningxia Medical UniversityYinchuanNingxia Hui Autonomous RegionChina Department of Neurosurgery General Hospital of Ningxia Medical UniversityYinchuanNingxia Hui Autonomous RegionChina Clinical Laboratory Center General Hospital of Ningxia Medical UniversityYinchuanNingxia Hui Autonomous RegionChina School of International Education Ningxia Medical UniversityYinchuanNingxia Hui Autonomous RegionChina Biochip Research Center General Hospital of Ningxia Medical UniversityYinchuanNingxia Hui Autonomous RegionChina

Olfactory ensheathing cells(OECs) from the olfactory bulb(OB) and the olfactory mucosa(OM) have the capacity to repair nerve injury. However, the difference in the therapeutic effect between OB-derived OECs and OM-derived OECs remains unclear. In this study, we extracted OECs from OB and OM and compared the gene and protein expression profiles of the cells using transcriptomics and non-quantitative proteomics techniques. The results revealed that both OB-derived OECs and OM-derived OECs highly expressed genes and proteins that regulate cell growth, proliferation, apoptosis and vascular endothelial cell regeneration. The differentially expressed genes and proteins of OB-derived OECs play a key role in regulation of nerve regeneration and axon regeneration and extension, transmission of nerve impulses and response to axon injury. The differentially expressed genes and proteins of OM-derived OECs mainly participate in the positive regulation of inflammatory response, defense response, cytokine binding, cell migration and wound healing. These findings suggest that differentially expressed genes and proteins may explain why OB-derived OECs and OM-derived OECs exhibit different therapeutic roles. This study was approved by the Animal Ethics Committee of the General Hospital of Ningxia Medical University(approval No. 2017-073) on February 13, 2017.

关键词： biological process cellular component gene Gene Ontology Kyoto Encyclopedia of Genes and Genomes molecular function olfactory bulb olfactory ensheathing cells olfactory mucosa protein

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对Talbot自成像和几何成像关系的分析

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光子学报 2008年第11期37卷 2332-2335页

作者：冯婕周仁魁赵建科袁湘兰陈永权张周峰中国科学院西安光学精密机械研究所西安710119 中国科学院研究生院北京100049

针对Talbot自成像与几何光学成像毫无关系的传统观点,本文提出了一种用于几何光学成像原理和物理光学成像原理对光栅成像进行对比分析的方法,发现在某一特殊的Talbot成像距离处,光栅自成像和几何成像有相同的成像规律,当光源为单色光照... 详细信息

针对Talbot自成像与几何光学成像毫无关系的传统观点,本文提出了一种用于几何光学成像原理和物理光学成像原理对光栅成像进行对比分析的方法,发现在某一特殊的Talbot成像距离处,光栅自成像和几何成像有相同的成像规律,当光源为单色光照射时可以认为光栅的几何成像实际上是某一个特殊位置的Talbot像.

关键词： Talbot自成像几何成像信息光学透镜后置几何畸变

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Effects of temperature on conversion of Li2CO3 to LiOH in Ca（OH）2 suspension

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Particuology 2017年第5期15卷 97-102页

作者： Bo yuan Jing Wang Wei Cai Yurong Yang Meigui Yi lan xiang College of Chemical Engineering Sichuan University Chengdu 610065 China Department of Chemical Engineering Tsinghua University Beijing 100084 China

The effects of temperature on the convecsion of Li2 CO3 Co LiOH in a Ca（OH）2 suspension were investigated. Li2CO3 microplates were used as the Li source. The results showed that Li2CO3 was converted to LiOH via in situ ion-exchange and dissolution-precipitation routes. The formation of mixed CaxLiz-2xCO3 inter- mediate species confirmed that at 25℃ need/e-like CaCO3 was formed heterogeneously on the Li2CO3 surface via in situ ion-exchange. At 60-100℃, isolated CaCO3 agglomerates were formed homogeneously via dissolution-precipitation. Temperature increases accelerated the dissolution and conversion of Li2 CO3 to LiOH, producing solutions with high [CO32-1][Ca^2＋] ratios; this favored homogeneous precipitation of isolated CaCO3 agglomerates,

关键词： Lithium carbonate (Li2CO3)CausticizationIn sitn ion-exchangeDissolution-precipitation

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Mine disaster survivor’s pelvic floor hernia treated with laparoscopic surgery and a perineal approach:A case report

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World Journal of Clinical Cases 2020年第18期8卷 4228-4233页

作者： Kai Chen yuan-Zhi lan Jing Li yuan-yuan xiang Dong-Zhu Zeng Department of General Surgery The Third Affiliated Hospital of Chongqing Medical UniversityChongqing 401120China

BACKGROUND A pelvic floor hernia is defined as a pelvic floor defect through which the intraabdominal viscera may *** is an infrequent complication following abdominoperineal *** type of hernia requires surgical repair by conventional or reconstructive *** main treatments could be transabdominal,transperineal or a *** SUMMARY In this article,we present the case of a recurrent perineal incisional hernia,postresection of the left side of the pelvis,testis and lower limbs resulting from a mine disaster 18 years *** laparoscopic surgery with a perineal approach was *** pelvic floor defect was repaired by a biological mesh and one pedicle skin *** signs of recurrence were indicated during the 2 years of *** The combination of laparoscopic surgery with a perineal approach was *** use of the biological mesh and pedicle skin flap to restructure the pelvic floor was effective.

关键词： Case report Pelvic floor hernia Hernioplasty Biological mesh Laparoscopic surgery Perineal approach

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Complete response of gallbladder cancer treated with gemcitabine and cisplatin chemotherapy combined with durvalumab:A case report and review of literature

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 226-232页

作者： Kai Chen Xu Feng yuan Shi Xin-Lin Li Zheng-Rong Shi xiang lan Department of Hepatobiliary Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

BACKGROUND Gallbladder cancer(GBC)is the most common and aggressive subtype of biliary tract cancer(BTC)and has a poor prognosis.A newly developed regimen of gemcitabine,cisplatin,and durvalumab shows promise for the treatment of advanced ***,the efficacy of this treatment for GBC remains *** SUMMARY In this report,we present a case in which the triple-drug regimen exhibited marked effectiveness in treating locally advanced GBC,thus leading to a long-term survival benefit.A 68-year-old man was diagnosed with locally advanced GBC,which rendered him ineligible for curative *** three cycles of therapy,a partial response was *** one year of combined therapy,a clinical complete response was successfully *** maintenance therapy with durvalumab monotherapy resulted in a disease-free survival of 9 months for the *** patient experienced tolerable toxicities of reversible grade 2 nausea and *** adverse events were observed in the patient throughout the entirety of the *** The combination of gemcitabine and cisplatin chemotherapy with durvalumab was proven to be an effective treatment approach for advanced GBC,with manageable adverse *** research is warranted to substantiate the effectiveness of the combined regimen in the context of GBC.

关键词： Gallbladder cancer Chemotherapy Immunotherapy Durvalumab Complete response Case report

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The synthesis and biological evaluation of a series of novel 2-COOC_2H_5/COONa substituted 1,5-benzothiazepine derivatives as antimicrobial agents

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Chinese Chemical Letters 2009年第6期20卷 660-662页

作者： Ping Zhang lan Zhi Wang Hui Shu Wu Jia Ming lan yuan Li Yong xiang Wang The College of Chemistry & Material Science Hebei Normal University Shijiazhuang 050016 China Department of Pathogenic Biology Hebei Medical University Shijiazhuang 050017 China

A series of novel 1,5-benzothiazepine derivatives containing COOC2H5/COONa groups at the C（2）-position were synthesized and evaluated for their antifungal and antibacterial activities by both disc diffusion and minimal inhibition concentration （MIC） methods. Most of the compounds have been shown to have moderate to good antibacterial activity against S. aureus, S. epidermidis and excellent antifungal activity against C. albicans.

关键词： 1,5-Benzothiazepine Antifungal Antibacterial activities

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Effect of the surface properties of an activated coke on its desulphurization performance

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Mining Science and Technology 2009年第6期19卷 769-774页

作者： ZHANG xiang-lan ZHANG Yan DING Fang-sheng HUANG Qi-jiang LI yuan School of Chemical and Environmental Engineering China University of Mining ＆ Technology Beijing 100083 China

Commercial coke was modified by H2O2 and/or NH3.H2O to obtain an activated coke containing additional oxygen functional groups and/or nitrogen functional groups. The aim of the modification was to enhance the SO2 adsorption capacity of the activated coke. Several techniques, including total nitrogen content measurements, SO2 adsorption, XPS and FTIR analysis, were used to characterize the coke samples. The XPS and FTIR spectra suggest the existence of -CONH2 groups in the H2O2 plus ammonia modified coke. The SO2 adsorption capacity of an activated coke increases slightly with an increase in H2O2 concentration during the modification process. The desulphurization performance of a modified coke is considerably enhanced by increasing the treatment temperature during ammonia modification. The amount of nitrogen in a coke modified by H2O2 plus NH3.H2O is the highest, and the SO2 adsorption capacity of the coke is also the highest (89.9 mg/gC). The NH3.H2O (only) modified sample has lower nitrogen content and lower desulphurization capacity (79.9 mg/gC). H2O modification gives the lowest SO2 adsorption capacity (28.9 mg/gC). The H2O2 pre-treatment is beneficial for the introduction of nitrogen onto the surface of a sample during the following ammonia treatment process.

关键词： activated coke surface property desulphurization property

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Wide-ranging Force Responsive Composites based on 1,2-Dioxetane and ZnS as Luminescent Probes in Polyurethanes

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Chinese Journal of Polymer Science 2023年第8期41卷 1162-1168,I0005页

作者： Jin-Hui Zhang Shuang Liu yuan yuan Yu-lan Chen Department of Chemistry Tianjin Key Laboratory of Molecular Optoelectronic ScienceTianjin UniversityTianjin 300354Chin State Key Laboratory of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchun 130012Chin

Combining the advantages of mechanochemiluminescence from 1,2-dioxetane and elastico-mechanoluminescence from ZnS particles,a new kind of mechanoluminescent polymer composites are *** can emit bright luminescence with two distinct colors at different strains,empowering a verstaile mechanochemical strategy for force sensing and damage detection at a wider force responsive range.

关键词： Mechanochemiluminescence 1,2-Dioxetane Elastico-mechanoluminescence ZnS Polymer composites

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Engineered M2 macrophage-derived extracellular vesicles with platelet membrane fusion for targeted therapy of atherosclerosis

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Bioactive Materials 2024年第5期35卷 447-460页

作者： lan Xie Jinyong Chen Haochang Hu yuan Zhu Xiying Wang Siyu Zhou Feifan Wang Meixiang xiang Department of Cardiology The Second Affiliated HospitalZhejiang University School of Medicine88 Jiefang RoadHangzhou310009China State Key Laboratory of Transvascular Implantation Devices Hangzhou310009China Cardiovascular Key Laboratory of Zhejiang Province Hangzhou310009China Department of Rheumatology The Second Affiliated HospitalZhejiang University School of Medicine88 Jiefang RoadHangzhou310009China Department of Gastroenterology The Second Affiliated HospitalZhejiang University School of Medicine88 Jiefang RoadHangzhou310009China

Atherosclerosis is featured as chronic low-grade inflammation in the arteries,which leads to the formation of plaques rich in lipids.M_(2)macrophage-derived extracellular vesicles(M_(2)EV)have significant potential for anti-atherosclerotic ***,their therapeutic effectiveness has been hindered by their limited targeting capability in *** objective of this study was to create the P-M_(2)EV(platelet membrane-modified M_(2)EV)using the membrane fusion technique in order to imitate the interaction between platelets and macrophages.P-M_(2)EV exhibited excellent physicochemical properties,and microRNA(miRNA)-sequencing revealed that the extrusion process had no detrimental effects on miRNAs carried by the ***,miR-99a-5p was identified as the miRNA with the highest expression level,which targeted the mRNA of Homeobox A1(HOXA1)and effectively suppressed the formation of foam cells in *** an atherosclerotic low-density lipoprotein receptor-deficient(Ldlr􀀀^(-/-)􀀀)mouse model,the intravenous injection of P-M_(2)EV showed enhanced targeting and greater infiltration into atherosclerotic plaques compared to regular extracellular ***,P-M_(2)EV successfully suppressed the progression of atherosclerosis without causing systemic *** findings demonstrated a biomimetic platelet-mimic system that holds great promise for the treatment of atherosclerosis in clinical settings.

关键词： Atherosclerosis Extracellular vesicles M2 macrophage MiR-99a-5p Platelet-mimetic

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Decomposition of λK_v into Five Graphs with Six Vertices and Eight Edges

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Acta Mathematicae Applicatae Sinica 2012年第4期28卷 823-832页

作者： lan-dang yuan Qing-de KANG College of Mathematics and Information Science Hebei Normal University Institute of Math. Hebei Normal University

In this paper, we discuss the G-decomposition of λKv （G-GD）, （v）） into five graphs with six vertices and eight edges. We present some recursive structures and a number of G-designs of small orders, holey G- designs, and incomplete G-designs are constructed. Finally, the spectrum of the existence of G-GD）λ（v） is determined.

关键词： graph design holey graph design quasi-group

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