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基于改进遗传算法的航材装载优化

包装工程 2021年第23期42卷 249-258页

作者：袁福帅余震朱浩涛崔崇立空军勤务学院研究生大队江苏徐州221000 空军勤务学院航材四站系江苏徐州221000 空军装备部外场局北京100843

目的通过对现行航材装载问题进行分析,优化提高工作中航材的装载效率,为部队航材智能装载提供思路和方法。方法确定初始可理想化条件和装载过程中需满足的约束条件,以航材的摆放顺序和旋转方式为基因值,利用装载方案所需装载箱数量和重... 详细信息

目的通过对现行航材装载问题进行分析,优化提高工作中航材的装载效率,为部队航材智能装载提供思路和方法。方法确定初始可理想化条件和装载过程中需满足的约束条件,以航材的摆放顺序和旋转方式为基因值,利用装载方案所需装载箱数量和重心偏移度为适应度函数去评估解的优劣;采取精英选择策略去指导进化方向,子代的产生选择相对偏随机秘钥交叉及顺序变异,避免选择变异过程中可能产生基因值的冲突,并用最小二乘法对航材储运装载算法输入参数进行拟合,找到平衡时间和装载箱使用数量的最佳输入值。结果通过与实际人工装载进行比对,将装载箱平均使用率从78.1%提升至84.45%,并完成了对航材的分类。结论该方法具有优化航材装载方案的能力,能够提升装载工作效率,对部队航材智能装载发展具有重要意义。

关键词：航材装载改进遗传算法

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基于加权灰色推理的航材需求预测

数字技术与应用 2021年第9期39卷 219-221页

作者：袁福帅崔崇立(指导) 朱浩涛空军勤务学院研究生大队江苏徐州221000 空军勤务学院航材四站系江苏徐州221000

航材需求预测是航材保障工作的基础,对场站航材股实施保障任务有着至关重要的影响。而对于飞行任务而言,影响航材需求量的因素太多,随机性强,难以定量分析预测需求。因此,结合加权灰色关联分析的理念提出了案例推理方法,并利用熵值法确... 详细信息

航材需求预测是航材保障工作的基础,对场站航材股实施保障任务有着至关重要的影响。而对于飞行任务而言,影响航材需求量的因素太多,随机性强,难以定量分析预测需求。因此,结合加权灰色关联分析的理念提出了案例推理方法,并利用熵值法确定影响因素的灰色关联系数权重。最后,结合推理结果对航材需求进行预测,其结果具有一定的可行性和准确性。

关键词：灰色关联分析案例推理航材需求预测

Hemoglobin integrated red blood cell membrane-coated metalorganic framework nano-platform for improving the self-adaptive blood glucose management

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Nano Research 2025年第1期18卷 618-627页

作者： shuai Wu Li Zhu Sheng Ni Xiong Zhao Meng Yan yuan Zhong Karissa Kusuma Yi Liang Kaiwen Bao Kai Qu Xian Qin Kun Zhang Wuquan Deng Da Sun Wei Wu Key Laboratory of Biorheological Science and Technology Ministry of EducationCollege of BioengineeringChongqing UniversityChongqing 400044China Chongqing University Three Gorges Hospital Chongqing Municipality Clinical Research Center for Endocrinology and Metabolic DiseasesChongqing 404000China Institute of Life Sciences&Biomedical Collaborative Innovation Center of Zhejiang Province Wenzhou UniversityWenzhou 325035China Department of Endocrinology School of MedicineChongqing Emergency Medical CenterChongqing University Central HospitalChongqing 400014China

Diabetes,a prevalent chronic metabolic disorder,often leads to severe ***,existing treatment methods may pose life-threatening risks due to poor patient compliance and inaccurate dosing of subcutaneous insulin ***,a biomimetic red blood cell(RBC)membrane-coated glucose-responsive nanoplatform is developed for controlling insulin *** nanoplatforms with RBC membrane can prolong the half-life of nano-formulation in vivo mediated by the biomimetic immune ***,the cascade catalytic effect of glucose oxidase(GOx)encapsulated in metal-organic frameworks(MOFs)and hemoglobin(Hb)in the RBC membrane are able to not only facilitate glucose-responsive insulin release,but also eliminate the detrimental by-product hydrogen peroxide(H_(2)O_(2))resulting from the Hb mediated H_(2)O_(2)*** in vitro and in vivo studies have demonstrated the favorable glucose-responsive performances of this advanced nano-platform with a single intravenous injection maintaining blood glucose balance in Type 1 Diabetes(T1D)mice for an extended duration without the hypoglycemia ***,this biomimetic insulin delivery system is poised to function as a strategy for the intravenous insulin administration,offering a promising drug candidate for the self-adaptive long-term T1D treatment.

关键词： glucose-responsive metal-organic frameworks red blood cell membrane insulin delivery glucose oxidase hemoglobin

基于粗糙集-层次分析法的航材供应商选择模型

维普期刊数据库评论

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科技和产业 2021年第9期21卷 149-153页

作者：袁福帅崔崇立程成王启同空军勤务学院研究生大队江苏徐州221000 空军勤务学院航材四站系江苏徐州221000 空军装备部驻北京地区军事代表局北京100000 空军大兴综合仓库北京100000

航材筹措是航材保障工作的重要一环,是保证飞行任务遂行的基础,而供应商的选择是其关键问题。针对航材供应商的评估决策问题,综合考虑航材保障的经济效益与军事效益,分析航材供应商评价指标,建立评价指标体系;结合粗糙集理论和层次分析... 详细信息

航材筹措是航材保障工作的重要一环,是保证飞行任务遂行的基础,而供应商的选择是其关键问题。针对航材供应商的评估决策问题,综合考虑航材保障的经济效益与军事效益,分析航材供应商评价指标,建立评价指标体系;结合粗糙集理论和层次分析法,构建评价模型。充分吸收主、客观赋权评价法的优点,有机集成得到组合权重评价模型,在此基础上对各供应商打分评价。最后,通过实例进行评估验证,结果表明组合方法在航材供应商选择中具有可行性和有效性。

关键词：粗糙集层次分析法航材供应商

不同干扰荒漠生境中子午沙鼠的繁殖及种群动态特征

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动物学杂志 2017年第5期52卷 745-753页

作者：杨素文袁帅付和平包达尔罕满都呼叶丽娜岳闯武晓东内蒙古农业大学草原与资源环境学院草业与草地资源教育部重点实验室呼和浩特010011

子午沙鼠(Merionesmeridianus)广泛分布于我国西北部地区,是荒漠啮齿动物群落的优势鼠种。种群繁殖特征是动物生活史参数中的一个重要组成部分,是种群数量补充的重要来源,而干扰是影响繁殖特征的重要因素。本研究于2012~2014年,在位于... 详细信息

子午沙鼠(Merionesmeridianus)广泛分布于我国西北部地区,是荒漠啮齿动物群落的优势鼠种。种群繁殖特征是动物生活史参数中的一个重要组成部分,是种群数量补充的重要来源,而干扰是影响繁殖特征的重要因素。本研究于2012~2014年,在位于蒙古阿拉善左旗南部典型荒漠的野外实验区,设置禁牧、开垦、过牧、轮牧4种不同干扰样地,使用铗日法对实验样地子午沙鼠相对数量及繁殖特征进行调查。4种不同干扰生境中的子午沙鼠种群数量具有显著差异,禁牧<过牧<轮牧<开垦;雌雄性比在轮牧生境中最高,开垦生境次之,禁牧生境最低;4种干扰生境中,轮牧样地子午沙鼠雌鼠怀孕率显著高于禁牧、过牧和开垦样地;雄鼠的睾丸下降率在过牧干扰样地显著高于其他3种干扰方式样地,轮牧样地雄鼠睾丸下降率最低;雌鼠平均胎仔数在4种干扰生境间无显著性差异;轮牧干扰样地繁殖指数显著高于其他3种干扰方式样地;繁殖指数、怀孕率及睾丸下降率对密度的反馈作用最为明显,但在不同的干扰生境中其反馈特征有差异。综上,子午沙鼠在轮牧生境中各繁殖特征指数最高,繁殖能力最强,种群密度相对较高,更适合其生存,其密度制约效应表现最为明显。

关键词：子午沙鼠繁殖特征种群调节荒漠密度调节

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基于ABAQUS的胶筒密封性能分析

计量与测试技术 2017年第9期44卷 71-73页

作者：陈伟陈子辉刘吉成袁帅符剑上海大学机电工程与自动化学院上海200072

桥塞胶筒是桥塞密封的核心,其设计的合理性和有效性都直接影响到井下作业的可行性。本文利用ABAQUS建立胶筒的有限元模型,模拟胶筒在井下坐封的非线性接触行为,分析了坐封载荷、摩擦因素、端面斜角和胶筒长度四个方面对胶筒密封性能的... 详细信息

桥塞胶筒是桥塞密封的核心,其设计的合理性和有效性都直接影响到井下作业的可行性。本文利用ABAQUS建立胶筒的有限元模型,模拟胶筒在井下坐封的非线性接触行为,分析了坐封载荷、摩擦因素、端面斜角和胶筒长度四个方面对胶筒密封性能的影响。结果表明胶筒和套管内壁间的接触压力随着坐封载荷的增加能够使不断增加。当胶筒充分膨胀,稳定坐封情况下,压缩距基本稳定在21mm左右,接触压力在12MPa左右;相同坐封载荷的情况下,选取摩擦系数0.4,端面斜角大于等于45°有助于提高胶筒的密封性能。

关键词：胶筒有限元分析接触压力

Inhibition of the cGAS–STING pathway:contributing to the treatment of cerebral ischemia-reperfusion injury

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Neural Regeneration Research 2025年第7期20卷 1900-1918页

作者： Hang Yang Yulei Xia Yue Ma Mingtong Gao shuai Hou Shanshan Xu Yanqiang Wang School of Clinical Medicine Shandong Second Medical UniversityWeifangShandong ProvinceChina Department of Emergency The Affiliated Hospital of Weifang Medical UniversityWeifangShandong ProvinceChina Department of Neurology Ⅱ The Affiliated Hospital of Weifang Medical UniversityWeifangShandong ProvinceChina

The cGAS–STING pathway plays an important role in ischemia-reperfusion injury in the heart,liver,brain,and kidney,but its role and mechanisms in cerebral ischemia-reperfusion injury have not been systematically ***,we outline the components of the cGAS–STING pathway and then analyze its role in autophagy,ferroptosis,cellular pyroptosis,disequilibrium of calcium homeostasis,inflammatory responses,disruption of the blood–brain barrier,microglia transformation,and complement system activation following cerebral ischemia-reperfusion *** further analyze the value of cGAS–STING pathway inhibitors in the treatment of cerebral ischemia-reperfusion injury and conclude that the pathway can regulate cerebral ischemia-reperfusion injury through multiple *** of the cGAS–STING pathway may be helpful in the treatment of cerebral ischemia-reperfusion injury.

关键词： calcium homeostasis cellular autophagy cerebral ischemia-reperfusion injury cGAS–STING pathway ferroptosis gut–brain–microbiota axis inflammatory light chain 3 microglial cells Syntaxin-17 protein

Dynamic simulation of double-cased perforation in deepwater high temperature and high-pressure oil and gas wells

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Petroleum Science 2024年第5期21卷 3482-3495页

作者： Gang Bi Fei Han Jie-Min Wu Pei-Jie yuan shuai-shuai fu Ying Ma Shaanxi Key Laboratory of Well Stability and Fluid&Rock Mechanics in Oil and Gas Reservoirs Xi'an Shiyou UniversityXi'an710065ShaanxiChina College of Petroleum Engineering Xi'an Shiyou UniversityXi'an710065ShaanxiChina

In order to ensure the penetrability of double-cased perforation in offshore oil and gas fields and to maximize the capacity of perforation completion, This study establishes a dynamic model of double-cased perforation using ANSYS/LS-DYNA simulation technology. The combination of critical perforation parameters for double casing is obtained by studying the influencing factors of the jet-forming process,perforation depth, diameter, and stress changes of the inner and outer casing. The single-target perforation experiments under high-temperature and high-pressure(HTHP) conditions and ground full-scale ring target perforation tests are designed to verify the accuracy of numerical simulation results. The reduced factor is adopted as the quantitative measure of perforation depth and diameter for different types of perforation charge under different conditions. The results show that the perforation depth reduction increases with temperature and pressure, and the reduced factor is between 0.67 and 0.87 under HTHP conditions of 130℃/44 MPa and 137℃/60 MPa. Comparing the results of the numerical simulation and the full-scale test correction, the maximum error is less than 8.91%, and this numerical simulation has strong reliability. This research provides a basis for a reasonable range of double-cased perforation parameters and their optimal selection.

关键词： Deepwater HTHP Double-cased perforation Optimization of perforation parameters Dynamic simulation full-scale perforation simulation

Polymorphisms in genes involved in folate metabolism as maternal risk factors for Down syndrome in China

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第2期9卷 93-99页

作者： Shao-shuai WANG fu-yuan QIAO Ling FENG Juan-juan LV Department of Obstetrics and Gynecology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China

Objective: To explore the relationship between genetic polymorphisms in methylenetetrahydrofolate reductase (MTHFR), methionine synthase reductase (MTRR), the central enzymes in folate metabolism that affects DNA methylation and synthesis, and the risk of Down syndrome in China. Methods: Genomic DNA was isolated from the peripheral lymphocytes of 64 mothers of children with Down syndrome and 70 age matched control subjects. Polymerase chain reaction and restriction fragment length polymorphism were used to examine the polymorphisms of MTHFR 677C→T, MTRR 66A→G and the relationship between these genotypes and the risk of Down syndrome was analyzed. Results: The results show that the MTHFR 677C→T polymorphism is more prevalent among mothers of children with Down syndrome than among control mothers, with an odds ratio of 3.78 (95% confidence interval (CI), 1.78～8.47). In addition, the homozygous MTRR 66A→G polymorphism was independently associated with a 5.2-fold increase in estimated risk (95% CI, 1.90～14.22). The combined presence of both polymorphisms was associated with a greater risk of Down syndrome than the presence of either alone, with an odds ratio of 6.0 (95% CI, 2.058～17.496). The two polymorphisms appear to act without a multiplicative interaction. Conclusion: MTHFR and MTRR gene mutation alleles are related to Down syndrome, and CT, TT and GG gene mutation types increase the risk of Down syndrome.

关键词： Tetrahydrofllate dehydrogenase Ligases Down syndrome Folate