检索结果-南通市图书馆

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基于语义和结构的UML类图的检索

东北大学学报（自然科学版） 2020年第1期41卷 23-28页

作者：袁中臣马宗民东北大学软件学院辽宁沈阳110169 沈阳工业大学化工过程自动化学院辽宁辽阳111003

以软件重用为背景提出基于语义和结构的UML类图检索.构建了UML类图的重用模型,定义了存储UML类图的重用库结构.提出将本体的概念语义距离应用到UML类图的语义相似性度量和使用图表示UML类图的结构进行结构相似性度量.基于检索流程形式... 详细信息

以软件重用为背景提出基于语义和结构的UML类图检索.构建了UML类图的重用模型,定义了存储UML类图的重用库结构.提出将本体的概念语义距离应用到UML类图的语义相似性度量和使用图表示UML类图的结构进行结构相似性度量.基于检索流程形式化检索需求,提出了UML类图的检索算法.基于提出的衡量标准,从语义、结构和混合三种检索类型对提出的算法进行了验证.实验结果表明,所提出的检索算法在检索质量和检索效率上要优于其他方法.

关键词： UML类图语义结构相似性度量检索

Suppressing high mobility group box-1 release alleviates morphine tolerance via the adenosine5'-monophosphate-activated protein kinase/heme oxygenase-1 pathway

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Neural Regeneration Research 2023年第9期18卷 2067-2074页

作者： Tong-Tong Lin Chun-Yi Jiang Lei Sheng Li Wan Wen Fan Jin-Can Li Xiao-Di Sun Chen-Jie Xu liang Hu Xue-Feng Wu yuan Han Wen-Tao Liu Yin-Bing Pan Jiangsu Key Laboratory of Neurodegeneration Department of PharmacologyNanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Anesthesiology The First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Anesthesiology and Pain Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina State Key Laboratory of Pharmaceutical Biotechnology Nanjing UniversityNanjingJiangsu ProvinceChina Department of Anesthesiology Eye&ENT HospitalFudan UniversityShanghaiChina Institute of Translational Medicine Nanjing Medical UniversityNanjingJiangsu ProvinceChina

Opioids,such as morphine,are the most potent drugs used to treat ***-term use results in high tolerance to *** mobility group box-1(HMGB1) has been shown to participate in neuropathic or inflammatory pain,but its role in morphine tolerance is *** this study,we established rat and mouse models of morphine tolerance by intrathecal injection of morphine for 7 consecutive *** found that morphine induced rat spinal cord neurons to release a large amount of ***1 regulated nuclear factor κB p65 phosphorylation and interleukin-1β production by increasing Toll-like receptor 4receptor expression in microglia,thereby inducing morphine ***,an HMGB1 inhibito r,markedly attenuated chronic morphine tole rance in the mouse ***,compound C(adenosine 5’-monophosphate-activated protein kinase inhibitor) and zinc protoporphyrin(heme oxygenase-1 inhibitor)alleviated the morphine-induced release of HMGB1 and reduced nuclear factor κB p65 phosphorylation and interleukin-1β production in a mouse model of morphine tolerance and an SH-SY5Y cell model of morphine tole rance,and alleviated morphine tolerance in the mouse *** findings suggest that morphine induces HMGB1 release via the adenosine 5’-monophosphate-activated protein kinase/heme oxygenase-1 signaling pathway,and that inhibiting this signaling pathway can effectively reduce morphine tole rance.

关键词： adenosine 5’-monophosphate-activated protein kinase heme oxygenase-1 high mobility group box-1 interleukin-1β microglia morphine tolerance neuroinflammation neuron nuclear factor-κB p65 Toll-like receptor 4

Intracerebroventricular transplanted bone marrow stem cells survive and migrate into the brain of rats with Parkinson's disease

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Neural Regeneration Research 2012年第13期7卷 978-984页

作者： Ping Gu Zhongxia Zhang Dongsheng Cui Yanyong Wang Lin ma yuan Geng Mingwei Wang Brain Aging and Cognitive Neuroscience Laboratory of Hebei Province Shijiazhuang 050031 Hebei Province China Department of Neurology First Hospital of Hebei Medical University Shijiazhuang 050031 Hebei Province China

In this study, 6-hydroxydopamine was stereotaxically injected into the right substantia nigra compact and ventral tegmental area of rats to establish Parkinson＇s disease models. The rats then received a transplantation of bone marrow stromal cells that were previously isolated, cultured and labeled with 5-bromo-2＇-deoxyuridine in vitro. Transplantation of the bone marrow stromal cells significantly decreased apomorphine-induced rotation time and the escape latency in the Morris water maze test as compared with rats with untreated Parkinson＇s disease. Immunohistochemical staining showed that, 5-bromo-2＇-deoxyuridine-immunoreactive cells were present in the lateral ventricular wall and the choroid plexus 1 day after transplantation. These immunoreactive cells migrated to the surrounding areas of the lateral cerebral ventricle along the corpus callosum. The results indicated that bone marrow stromal cells could migrate to tissues surround the cerebral ventricle via the cerebrospinal fluid circulation and fuse with cells in the brain, thus altering the phenotype of cells or forming neuron-like cells or astrocytes capable of expressing neuron-specific proteins. Taken together, the present findings indicate that bone marrow stromal cells transplanted intracerebroventricularly could survive, migrate and significantly improve the rotational behavior and cognitive function of rats with experimentally induced Parkinson＇s disease.

关键词： bone marrow stromal cells lateral ventricle Parkinson's disease behavior cognition neural regeneration

基于级联角度的AIRS辅助大规模MIMO系统波束跟踪方案

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系统工程与电子技术 2024年第7期46卷 2515-2524页

作者：马露洁梁彦李飞南京邮电大学通信与信息工程学院江苏南京210003

智能反射表面(intelligent reflecting surface,IRS)可以通过提供额外的视线(line of sight,LoS)路径补偿传播损耗或解决阻塞问题,有效地提高毫米波(millimeter wave,mmWave)通信系统的性能,被认为是下一代移动通信的核心技术。与传统... 详细信息

智能反射表面(intelligent reflecting surface,IRS)可以通过提供额外的视线(line of sight,LoS)路径补偿传播损耗或解决阻塞问题,有效地提高毫米波(millimeter wave,mmWave)通信系统的性能,被认为是下一代移动通信的核心技术。与传统的地面IRS相比,部署在无人机、热气球等空中平台上的空中IRS(aerial IRS,AIRS)结合了空中平台的高移动特性/旋转特性和IRS提供的优质链路特性,可以提供更广阔的信号覆盖范围。考虑到现实场景中用户的移动性,通信系统有必要实时调整波束成形以使波束对准移动用户。然而,AIRS不具备有源射频链,难以在AIRS处获取离开角和到达角,增加了波束跟踪的复杂性。针对这一问题,建立了具有时变信道的AIRS辅助mmWave大规模多输入多输出(multiple input multiple output,MIMO)系统模型,结合基站端有源波束成形、AIRS的旋转角度和无源波束成形设计,提出了一种基于级联角度的无迹卡尔曼滤波波束跟踪方案。仿真结果表明,提出的方案具有较高的跟踪精度,同时AIRS的旋转特性对提升系统可达速率起着重要作用。

关键词：空中智能反射面波束成形波束跟踪大规模多输入多输出毫米波

新疆西天山艾日垦其垦铜钼矿床成矿过程及其找矿潜力

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岩石矿物学杂志 2014年第1期33卷 79-94页

作者：马元黄河张招崇金子梁中国地质大学地质过程与矿产资源国家重点实验室北京100083

艾日垦其垦矿床是近年发现的铜钼矿床,位于中国西天山东部,处在中亚成矿带腹地。主要赋矿岩石为二长花岗岩,可划分为钾化带、硅化带、青磐岩化带和绢英岩化带等4个明显的蚀变带,且成带状分布,主要受那拉提南缘断裂控制。本文对矿脉中钾... 详细信息

艾日垦其垦矿床是近年发现的铜钼矿床,位于中国西天山东部,处在中亚成矿带腹地。主要赋矿岩石为二长花岗岩,可划分为钾化带、硅化带、青磐岩化带和绢英岩化带等4个明显的蚀变带,且成带状分布,主要受那拉提南缘断裂控制。本文对矿脉中钾长石和岩体中绢云母进行了年龄测试,结果显示热液作用时限为268.35±4.05 ma,岩浆作用时限为321.43±4.24 ma。主微量元素分析测试显示出赋矿岩体富Si(SiO2=71.01%～73.94%),富碱(Na2O+K2O=5.53%～7.80%),贫钙(CaO=1.95%～2.93%),高Sr(>417×10-6)低Y(<12.3×10-6),总体上富集大离子亲石元素LILE(Ba、Th、Rb、K),亏损高场强元素HFSE(Nb、Ta、Ti),微量元素比值暗示曾发生下地壳加厚作用。流体包裹体测试结果显示出本矿床含矿脉体主要为变质流体包裹体,且近定向排列,具有低温低盐度特征,这与典型斑岩型矿床区别很大。研究认为本区在石炭纪岩浆侵入阶段并未形成矿床,但形成了铜钼等金属的预富集,二叠纪的热液作用是形成矿床的关键过程,与当时发生的韧性剪切作用关系密切,断裂为成矿热液上移提供动力和通道。

关键词：西天山铜钼矿床变质流体韧性剪切带

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具有防碳化作用界面剂的配制研究

混凝土 2011年第10期 139-141,144页

作者：袁群马峰曹洪亮袁宾河南省水利科学研究院河南郑州450003 河南省水利工程安全技术重点实验室河南郑州450003 华北水利水电学院河南郑州450008 河南省人民胜利渠管理局河南新乡453003

在水泥净浆的基础上添加减水剂、减缩剂、膨胀剂等外加剂,以及掺入粉煤灰、硅灰、混合掺合料(粉煤灰+硅灰)等成分配制出多种界面剂,然后在人工快速碳化条件下,系统研究了涂抹界面剂混凝土试块的碳化深度变化规律,确定了防碳化效果最好... 详细信息

在水泥净浆的基础上添加减水剂、减缩剂、膨胀剂等外加剂,以及掺入粉煤灰、硅灰、混合掺合料(粉煤灰+硅灰)等成分配制出多种界面剂,然后在人工快速碳化条件下,系统研究了涂抹界面剂混凝土试块的碳化深度变化规律,确定了防碳化效果最好的三种界面剂配制方案。

关键词：新老混凝土黏结界面剂防碳化作用

一氧化氮介导去甲肾上腺素与经穴的皮肤低电阻特性

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针刺研究 2008年第3期33卷 213-216页

作者：梁媛马胜兴陈家旭北京中医药大学基础医学院北京100029 美国加利福尼亚大学洛杉矶分校加利福尼亚90502

经脉/穴位具有皮肤低电阻特性。我们进行了3次实验,结果证明:经脉区皮肤组织的一氧化氮(NO)含量和神经一氧化氮合酶(nNOS)蛋白表达较高,外源性NO和nNOS抑制剂能够调节穴位皮肤中去甲肾上腺素(NE)的合成与释放,L-精氨酸衍生的NO复合物和N... 详细信息

经脉/穴位具有皮肤低电阻特性。我们进行了3次实验,结果证明:经脉区皮肤组织的一氧化氮(NO)含量和神经一氧化氮合酶(nNOS)蛋白表达较高,外源性NO和nNOS抑制剂能够调节穴位皮肤中去甲肾上腺素(NE)的合成与释放,L-精氨酸衍生的NO复合物和NE可以调节皮肤低电阻穴位的皮肤电导。说明经穴的皮肤低电阻特性可能与NO和NE有关。

关键词：皮肤低电阻特性一氧化氮去甲肾上腺素

Long-term feeding of sand rice(Agriophyllum squarrosum seed)can improve the antioxidant capacity of mice

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Research in Cold and Arid Regions 2023年第2期15卷 105-112页

作者： PengShu Zhao liang Shi Xia Yan ChaoJu Qian WeiJia Zhao Yan Chang XiaoYue Yin XingKe Fan TingZhou Fang YuQiu Liao ShanShan Zhou XiaoFei ma Key Laboratory of Ecological Safety and Sustainable Development in Arid Lands Northwest Institute of Eco-Environments and ResourcesChinese Academy of SciencesLanzhouGansu730000China Key Laboratory of Stress Physiology and Ecology in Cold and Arid Regions of Gansu Province Northwest Institute of Eco-Environments and ResourcesChinese Academy of SciencesLanzhouGansu730000China University of Chinese Academy of Sciences Beijing100049China Key Laboratory of Inland River Ecohydrology Cold and Arid Regions Environmental and Engineering ResearchNorthwest Institute of Eco-Environments and ResourcesChinese Academy of SciencesLanzhouGansu730000China School of Life Sciences Nantong UniversityNantongJiangsu226019China Institute of Qinghai-Tibetan Plateau Research Southwest Minzu UniversityChengduSichuan610041China Shanxi Institute of Science and Technology Faculty of Environmental Science and EngineeringJinchengShanxi048000China

Unhealthy eating habits with sugar-rich and high-fat foods can bring nutritional imbalance and other chronic diseases. At present, there is an increasing demand in regulating human sub-health through functional foods. Agriophyllum squarrosum(L.) Moq., a pioneer plant native to sand dunes with ecological restoration function, is a traditional food plant of sand regions and Mongolian folk medicine. Numerous studies have confirmed that A. squarrosum seed, also called sand rice, has high nutritional value. However, the long-term health effects of eating sand rice remain unclear. To better explore and evaluate its long-term effects, hereby, ICR mice were fed with sand rice flour at different ratios(control, 60% and 95%) for 100 days. Results show that the growth and blood glucose level curve of these experimental mice were lower and more stable than that of the control. In addition, mice fed pure sand rice ingredient(95%) gained more stable body weight and blood glucose after 28 days, which revealed that sand rice is a food with comprehensive nutritional value and rarely negatively impacts the body growth performance. Our data also demonstrates that, the content of triglyceride(TG), total cholesterol(TC), low-density lipoprotein cholesterol(LDL-C) and high-density lipoprotein cholesterol(HDL-C) provided the lowest level in the blood of mice with a diet of pure sand rice ingredient, 0.48, 4.14, 0.91, 3.03 mmol/L, respectively. Also, T-SOD and GSH-PX activity provided a high level in mice with pure sand rice gradient, which significantly increased by 36%(T-SOD)and 19%(GSH-PX) compared to the control. These results suggest that long term intake of the pure sand rice ingredients is more helpful for stabilizing blood lipid and improve antioxidant capacity and beneficial to people suffering from chronic disease. This study supplies the first animal evidence to support the claim that sand rice is a promising functional food with comprehensive nutrition in the future. We are con

关键词： Sand rice Functional food Long-term effects Health evaluation Antioxidant capacity

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预应力索杆结构模型相似理论及其验证

建筑结构学报 2021年第7期42卷 95-103页

作者：马烁袁行飞杨柳浙江大学建筑工程学院浙江杭州310058

缩尺模型试验可用于评估大型预应力索杆结构的静动力性能,而按照相似理论设计的缩尺模型、施加外荷载和边界条件等均对静动力试验结果的准确性至关重要。为此,对需要考虑几何大变形的预应力索杆结构的静力、动力相似理论进行研究。采用... 详细信息

缩尺模型试验可用于评估大型预应力索杆结构的静动力性能,而按照相似理论设计的缩尺模型、施加外荷载和边界条件等均对静动力试验结果的准确性至关重要。为此,对需要考虑几何大变形的预应力索杆结构的静力、动力相似理论进行研究。采用方程分析法建立了索杆结构的静力非线性相似准则,进一步研究了自振频率与振动模态的相似性关系。采用量纲分析法建立了索杆结构时程分析相似性条件,并结合算例进行了验证。结果表明:当杆件长度、截面积、内力、外力以及材料弹性模量等存在相似性,且外力、轴向刚度、内力相似比相同时,缩尺模型与实际结构的静力非线性变形具备相似性;材料弹性模量、质量密度、杆件长度、截面积、内力存在相似性,且内力与轴向刚度相似比相同时,缩尺模型与实际结构的振型相同、频率满足相似性;要达到索杆结构的时程分析相似性,需考虑时间、杆件长度、截面积、外力、内力、材料弹性模量以及边界条件的相似性。

关键词：预应力索杆结构相似理论几何非线性方程分析量纲分析