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Chinese Physics B 2018年第9期27卷 322-326页

作者： Yi-Fei Sun Zi-Jing Zhang li-yuan zhao Wei-Min Sun yuan zhao Department of Physics Harbin Institute of TechnologyHarbin 150001China Key Laboratory of In-fiber Integrated Optics Harbin Engineering UniversityHarbin 150001China

Geiger mode avalanche photodiode detector （Gm-APD） possesses the ultra-high sensitivity. Photon counting chirped amplitude modulation （PCCAM） light detection and ranging （lidar） uses the counting results of the returned signal detected by Gm-APD to mix with the reference signal, which makes PCCAM lidar capable of realizing the ultra-high sensitivity, and this is very important for detecting the remote and weak signal. However, Gm-APD is a nonlinear device, different from traditional linear detectors. Due to the nonlinear response of Gm-APD, the counting results of the returned signal detected by Gm-APD are different from those of both the original modulation signal and the reference signal. This will affect the mixing effect and thus degrade the detection performance of PCCAM lidar. In this paper, we propose a response probability correction method. First, the response probability correction model is established on the basis of Gm-APD Poisson prob- ability response model. Then, the response probability correction model is used to adjust the original modulation signal that is used to drive laser, in order to make the counting results of the returned signal detected by Gm-APD better mix with the local reference signal in the same form. Through this method, the detection performance of PCCAM lidar is enhanced efficiently.

关键词： photon counting chirping lidar

Schistosoma japonicum ova maintains epithelial barrier function during experimental colitis

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World Journal of Gastroenterology 2011年第43期17卷 4810-4816页

作者： Chen-Mei Xia yuan zhao li Jiang Jie Jiang Shun-Cai Zhang Department of Gastroenterology Zhongshan Hospital Fudan University Shanghai 200032 China

AIM:To evaluate the impacts of Schistosoma japoni-cum(***) ova on the tight junction barriers in a trinitrobenzenesulfonic acid(TNBS)-induced colitis ***:Balb/c mice were randomly divided into three groups:control group;TNBS + ovagroup and TNBS + ova + *** was used intracolonic to in-duce colitis and mice of the TNBS + ova + group were pre-exposed to *** ova as a prophylactic *** inflammation was quantified using following variables:mouse mortality,weight loss,co-lon extent and microscopic inflammation *** expression of tumor necrosis factor-αand interferon-γ were assessed to evaluate the systemic inflamma-tory ***2 and its mRNA were also *** translocations were tested by culturing blood and several ***-1 and occludin were chosen as the representations of tight junction *** the proteins and mRNA were ***:Ova pre-treatment contributed to the reliefof colitis and decreased the mortality of the ***2 expression was significantly downregulated when pretreated with the *** TNBS injection caused a significant downregulation of ZO-1 and oc-cludin mRNA together with their proteins in the colon;ova pre-exposure reversed these ***-ment with *** ova in the colitis model caused lower intestinal bacterial translocation ***:*** ova can maintain epithelial barrier function through increasing tight junction pro-teins,thus causing less exposure of NOD2 to the lumi-nal antigens which may activate a series of inflamma-tory factors and induce colitis.

关键词： Crohn's disease Schistosoma japonicum ova Tight junction protein ZO-1 Occludin

Curvature-aware simplification for point-sampled geometry

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Journal of Zhejiang University-Science C(Computers and Electronics) 2011年第3期12卷 184-194页

作者： Zhi-xun SU Zhi-yang li yuan-di zhao Jun-jie CAO School of flCathematical Sciences Dalian University of Technology Dalian 116024 China

We propose a novel curvature-aware simplification technique for point-sampled geometry based on the locally optimal projection(LOP) *** algorithm includes two new ***,a weight term related to surface variation at each point is introduced to the classic LOP *** produces output points with a spatially adaptive ***,for speeding up the convergence of our method,an initialization process is proposed based on geometry-aware stochastic *** to the initialization,the relaxation process achieves a faster convergence rate than those initialized by uniform *** simplification method possesses a number of distinguishing *** particular,it provides resilience to noise and outliers,and an intuitively controllable distribution of ***,we show the results of our approach with publicly available point cloud data,and compare the results with those obtained using previous *** method outperforms these methods on raw scanned data.

关键词： Point-sampled geometry Particle simulation Locally optimal projection Simplification

Prognostic values of optic nerve sheath diameter for comatose patients with acute stroke:An observational study

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World Journal of Clinical Cases 2022年第33期10卷 12175-12183页

作者： Sha Zhu Chao Cheng liu-liu Wang Dian-Jiang zhao yuan-li zhao Xian-Zeng liu Department of Neurology Peking university international hospitalBeijing 102206China Department of Radiology Peking University International HospitalBeijing 102206China Department of Intensive Care Unit Peking University International HospitalBeijing 102206China Department of Neurosurgery China National Clinical Research Center for Neurological DiseasesBeijing Tiantan HospitalBeijing 100070China

BACKGROUND Optic nerve sheath diameter(ONSD)measurement is one of the non-invasive methods recommended for increased intracranial pressure(ICP)*** This study aimed to evaluate the roles of optic nerve sheath diameter(ONSD)and ONSD/eyeball transverse diameter(ETD)ratio in predicting prognosis of death in comatose patients with acute stroke during their *** A total of 67 comatose patients with acute stroke were retrospectively *** ONSD and ETD were measured by cranial computed tomography(CT)*** patients underwent cranial CT scan within 24 h after coma *** were divided into death group and survival group according to their survival status at *** differences of the ONSD and ONSD/ETD ratio between the two groups and their prognostic values were *** The ONSD and ONSD/ETD ratio were 6.07±0.72 mm and 0.27±0.03 in the comatose patients,*** ONSD was significantly greater in the death group than that in the survival group(6.32±0.67 mm vs 5.65±0.62 mm,t=4.078,Plity increased in comatose patients with acute stroke when the ONSD was>5.7 mm or the ONSD/ETD ratio was>*** indexes could be used as prognostic tools for comatose patients with acute *** ONSD/ETD ratio was more stable than the ONSD alone,which would be preferred in clinical practice.

关键词： Optic nerve sheath diameter Eyeball transverse diameter Coma Intracranial pressure Stroke Prognosis

Triple-transforming gel prepared byβ-cyclodextrin,diphenylamine and lithium chloride in N,N-dimethylacetamide

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Chinese Chemical Letters 2010年第10期21卷 1251-1254页

作者： yuan yuan li Wen Jing zhao Hua Cheng Zhang Tao Sun Wei An Fei Fei Xin Ai You Hao School of Chemistry and Chemical Engineering Shandong University Jinan 250100 China

This paper describes a triple-transforming gel system （gel-sol-gel＇） for the first time, which is a thermo-responsive and multi- component organogel prepared by β-cyclodextrin （β-CD）, diphenylamine （DPA） and lithium chloride （liCl） in N,N-dimethyla- cetamide （DMAC） in a suitable proportion based on the supramolecular interactions. In the triple-transfomaing gel system, a gel （gel A） could be formed by β-CD, DPA and liCl in DMAC at room temperature based on stirring, then the gel could transform into a clear solution based on heating, and then the other gel （gel B） can be formed at a relatively high temperature （Tget, the gelation temperature by heating）. The two gel states in the triple-transforming gel system have different microstructures. This gel system was characterized by OM, SEM, IR and theology.

关键词： Gel Triple-transforming β-Cyclodextrin lithium N,N-Dimethylacetamide

New Industrialization Path： The Strategic Choice of Chinese Iron and Steel Industry

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Chinese Business Review 2006年第4期5卷 34-41页

作者： yuanguan She li yuan Xia zhao University of Science and Technology Beijing

The fact-developing iron and steel industry provides the base for China economy to grow continually, stably and healthily for many years. This paper analyzes the situation and the disparity, which the iron and steel industry faces, and attests that the new industrialization path is the strategic choice for the Chinese iron and steel industry to develop continuously, and carries on the thorough discussion to the connotation of this choice.

关键词： iron and steel industry new industrialization transformation

Postoperative recovery from posterior communicating aneurysm complicated by oculomotor palsy

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Chinese Medical Journal 2008年第12期121卷 1065-1067页

作者： YANG Ming-qi WANG Shuo zhao yuan-li ZHANG Dong zhao Ji-zong Department of Neurosurgery Beijing Tiantan Hospital Capital Medical University Beijing 100050 China

Background Oculomotor palsy is a common complication in patients with posterior communicating aneurysm. This study was conducted to investigate the postoperative recovery of patients with posterior communicating aneurysm complicated with oculomotor palsy and to analyze the factors influencing length of recovery.Methods From 2000 to 2006, 148 patients with posterior communicating aneurysm were treated at our hospital, with 74 of them having concurrent unilateral oculomotor palsy. All of the patients underwent craniotomy after the diagnosis by means of whole-brain digital subtraction angiography （DSA）. The patients were divided into two groups for observation of postoperative recovery during the follow-up period. Patients in group A were treated with simple pedicle clipping of the aneurysm while patients in group B were treated with pedicle clipping of the aneurysm and decompression of the oculomotor nerve.Results Of the 40 patients in group A, 20 underwent surgery within 14 days and completely recovered from oculomotor palsy in 10-40 days. Fourteen patients underwent surgery within 14-30 days, of whom 12 completely recovered within 30-90 days and 2 cases recovered incompletely. The remaining six patients underwent surgery after more than 30 days; of these, four patients recovered completely and two recovered incompletely. Of the 34 cases in group B, 15 underwent surgery within 14 days and completely recovered from oculomotor palsy in 10-40 days. Sixteen patients underwent surgery in 14-30 days, of whom 14 completely recovered in 30-90 days and 2 recovered incompletely. The remaining three patients underwent surgery after more than 30 days, of whom two patients recovered completely and one recovered incompletely.Conclusions Early diagnosis and surgical treatment of patients with unilateral oculomotor palsy induced by posterior communicating aneurysm are important to full postoperative recovery of the oculomotor nerve. No correlation was found, however, between d

关键词： oculomotor palsy cerebral angiography intracranial aneurysm

Clinical and pathological changes in cerebral arteriovenous malformations after stereotactic radiosurgery failure

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Chinese Medical Journal 2008年第12期121卷 1076-1079页

作者： liU Wei-ming YE Xun zhao yuan-li WANG Shuo zhao Ji-zong Department of Neurosurgery Beijing Tiantan Hospital Capital Medical University Beijing 100050 China

Background Stereotactic radiosurgery is an altemative to resection of intracranial cerebral arteriovenous malformations （AVMs）, while it will fail in some cases. This study aimed to evaluate the changes after stereotactic radiosurgery for AVMs.Methods Nineteen cases with cerebral AVMs had failure after stereotactic radiosurgery therapy. The symptoms and angiography were assessed. All patients underwent microsurgery. Pathologic examination was performed for all cases and electron microscopic examination was carried out in 6 patients.Results Seven cases had hemorrhage from 12 to 98 months after stereotactic radiosurgery, 5 had headache, 4 had refractory encephalon edema, 2 had epilepsy as a new symptom and 1 had a pressure cyst 5 years after radiosurgery. Angiography in 18 cases, 8-98 months after radiation therapy, demonstrated no significant changes in 5 cases, slight reduction in 9, near complete obliteration in 1 and complete obliteration in 3. An abnormal vessel was found on pathologic examination in 17 cases, even one case had obliterated in angiography. Electron microscopy examination showed vessel wall weakness, but the vessels remained open and blood circulated. One case died because of a moribund state before surgery. The other 18 cases had no new neurological deficiencies, seizure control and no hemorrhage occurred after microsurgery at an average follow-up of 3 years.Conclusion Stereotactic radiotherapy for AVMs should have a long period follow-up. If serious complications occur, microsurgery can be performed as salvage treatment.

关键词： cerebral arteriovenous malformations stereotactic radiosurgery microsurgery complications

Biphasic effect of aspirin on apoptosis of bovine vascular endothelial cells and its molecular mechanism

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Acta Pharmacologica Sinica 2007年第3期28卷 353-358页

作者： Qing-quan CHEN Wen-lan liU Xun GUO yuan-jian li zhao-gui GUO~1 Department of Pharmacology,School of Pharmaceutical Sciences,Central South University,Changsha 410078,China Department of Pharmacology School of Pharmaceutical Sciences Central South University Changsha China

Aim:To investigate the effect of aspirin on the apoptosis of cultured bovineaortic endothelial cells(BAEC)and the signal pathways involved in this ***:BAEC were cultured and passaged in Dulbecco’s modified Eagle’smedium culture *** changes and quantification of apoptoticcells were determined using fluorescence microscope after staining the cells withHoechst *** viability was measured by 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide(MTT)*** fragmentation was visualizedby agarose gel ***-p38 mitogen-activated protein kinase(MAPK)expression was detected by Western ***:Aspirin at lowconcentrations from 1×10-10mol/L to 1×10-8mol/L decreased the apoptosis andp38 MAPK pbosphorylation induced by H2O2in BAEC,while high doses of aspi-rin(1×10-7-1×10-4mol/L)induced typical apoptotic changes in BAEC and stimu-lated the expression of phospho-p38 MAPK in a concentration-dependent ***203580,a specific p38 MAPK inhibitor,blocked such ***:Aspirin exhibits a biphasic effect on the apoptosis in BAEC,reducing apoptosisat low concentration and inducing apoptosis at high concentration,p38 MAPKmay be an important signal molecule mediating the effects of aspirin.

关键词： aspirin hydroperoxide apoptosis mitogen activated protein kinase endothelial cells

Decision making module based on stochastic magnetic tunnel junctions

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 202-209页

作者： Yifan Miao li zhao Yajun Zhang Zhe yuan Center for Advanced Quantum Studies and Department of Physics Beijing Normal University Institute for Nanoelectric Devices and Quantum Computing Fudan University Interdisciplinary Center for Theoretical Physics and Information Sciences Fudan University

In biological neural systems, noise is ubiquitous but does not affect the correct decisions made in the complex cognitive ***-making in biological neural system is typically achieved by accumulating input information over a period of *** by recent developments in neurosciences, we design a decision-making module based on spintronic devices, utilizing superparamagnetic tunnel junctions as artificial neurons. The feasibility of this decision-making module is verified through circuit simulations. Taking a multi-layer perceptron as an example, the module significantly improves the accuracy of the perceptron in the handwritten digit recognition task. Furthermore, the spintronic decision-making module offers advantages over the conventional pooling methods, such as adaptive decision time, high performance and the absence of analog-to-digital conversion. The decision-making module is flexible to be integrated into artificial neural networks and provides a general yet effective solution to enhance performance against device noise.

关键词： neuromorphic computing spintronics magnetic tunnel junction neural networks