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N6-methyladenosine(m6A)modification of ribosomal RNAs(rRNAs):Critical roles in mRNA translation and diseases

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Genes & Diseases 2023年第1期10卷 126-134页

作者： Kexin lei Shuibin Lin Quan yuan State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases West China Hospital of StomatologySichuan UniversityChengduSichuan 610041China Center for Translational Medicine Precision Medicine InstituteThe First Affiliated Hospital of Sun Yat-senUniversityGuangzhouGuangdong510080China

key components of the ribosome and the most abundant RNA species,the rRNAs are modified during ribosome formation.N^(6)-methyladenosine(m^(6)A)is a conserved RNA modification occurring on different RNA species including ***,it has been reported that ZCCHC4 and METTL5 are methyltransferases that mediate m^(6)A modification of human 28S and 18S rRNA,*** newly discovered biological functions of the two methyltransferases include regulation of mRNA translation,cell proliferation,cell differentiation,stress response,and other biological *** of them,especially METTL5,have been proved to be associated with a variety of diseases such as intellectual disability,cancer,congenital dysplasia and have potential clinical application as biomarkers and therapeutic targets.

关键词： Biological processes Diseases m^(6)A METTL5 ZCCHC4

Design of the upstream decay pipe window of the long baseline neutrino facility

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Nuclear Science and Techniques 2021年第11期32卷 134-145页

作者： Hai-Jing Wang Ye yuan Jing-Yu Tang Quan Ji Ling kang Chang-Jun Ning Ji-lei Sun Shao-Hong Wei Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China

The beam windows of high-energy beam lines are important,and it is sometimes difficult to design because it is necessary to ensure particle propagation with minimum disturbance and fulfill mechanical requirements at the same *** upstream decay pipe window of the long baseline neutrino facility at Fermilab has an extremely large diameter(1.8 m),with a thickness of only 1.5 mm to separate the helium atmosphere in the decay pipe and the nitrogen atmosphere on the other ***,the center of this dish-shaped window is expected to be a200-mm-diameter beryllium dish welded to the outside aluminum alloy A6061,and this welded combination must withstand extreme conditions of a 2.4-MW,high-energy proton beam without *** severe conditions make the design of this window an unprecedented *** paper describes the static thermal-structural analyses based on which the structure has been optimized,as well as dynamic analyses for understanding the shockwave effects originating in the *** optimization,the maximum von Mises stresses in the window decreased significantly in both normal operation and accident cases,making our design very reasonable.

关键词： Decay pipe window Structure optimization Dynamic analyses Long baseline neutrino facility

Ni-mediated C–N activation of amides and derived catalytic transformations

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Science China Chemistry 2017年第11期60卷 1413-1424页

作者： yuan Gao Chong-lei Ji Xin Hong Department of Chemistry Zhejiang UniversityHangzhou 310027China

Amide, as a ubiquitous functional group, is essential in various aspects of chemistry and biology. Although the history of studying amide is rich and fruitful, the synthetic application of amide is very limited due to the inertness of amide C–N bond. Recently,significant advances have been achieved towards the nickel-mediated C–N activation of amides. This approach allows a facile generation of acyl-nickel intermediates, and a number of unique transformations have been designed and realized based on the amide C–N bond activation. Focused on the catalytic transformation, this review summarizes and categorizes the recent advances on the synthetic applications of Ni-mediated C–N bond activation of amides.

关键词： C-N activation amide nickel homogeneous catalysis cross coupling

An enhanced anti-disturbance control law for systems with multiple disturbances

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Science China(Information Sciences) 2020年第10期63卷 273-275页

作者： Yukai ZHU lei GUO Xiang YU yuan yuan School of Automation Science and Electrical Engineering Beihang University Department of Computer Science Brunel University London

Dear editor,The requirements for control performances (e.g.,the control accuracy) are highly increasing in practical engineering ***,multiple disturbances,which consist of internal disturbances,external disturbances,and model uncertainties in complex control systems may degrade the control performance[1].How to effectively attenuate and

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基于第一性原理研究CO在C_(21)Si上的吸附

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原子与分子物理学报 2025年第5期42卷 22-26页

作者：张玲尹成斌杨蕾雷声马贝贝赵德永王远云南中烟工业有限责任公司技术中心昆明650231 西南林业大学机械与交通学院昆明650224

通过密度泛函理论(DFT)计算研究了单个CO分子分别在C_(21)Si上的吸附.由于结构中含有21个C原子以及引入一个Si原子,命名为(C_(21)Si).计算了体系中最稳定的几何结构、吸附能、吸附高度和态密度,研究了吸附的CO分子与基底之间的相互作用... 详细信息

通过密度泛函理论(DFT)计算研究了单个CO分子分别在C_(21)Si上的吸附.由于结构中含有21个C原子以及引入一个Si原子,命名为(C_(21)Si).计算了体系中最稳定的几何结构、吸附能、吸附高度和态密度,研究了吸附的CO分子与基底之间的相互作用.研究发现,当CO放置在C_(21)Si上吸附时,C原子靠近吸附优于O原子靠近时的吸附,吸附能分别为-0.86 eV和-0.36 eV,当O原子靠近吸时二者之间的吸附反应较弱,为物理吸附.C原子靠近时的吸附高度小,吸附反应更强,为化学吸附.根据态密度轨道之间的杂化程度,说明二者之间存在吸附反应,相较于O原子靠近吸附,基底对C原子靠近时的吸附能力更强,敏感度更高.

关键词： C_(21)Si 第一性原理 CO 吸附

Intrinsically Anti-Flammable Apigenin-derived Epoxy Thermosets with High Glass Transition Temperature and Mechanical Strength

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Chinese Journal of Polymer Science 2022年第10期40卷 1259-1268,I0011页

作者： Hafezeh Nabipour Xin Wang lei Song yuan Hu State Key Laboratory of Fire Science University of Science and Technology of ChinaHefei 230026China

In this work,apigenin was chosen as a raw material to synthesize a novel epoxy monomer(DGEA),while the bio-based epoxy resin was further obtained after curing with 4,4’-diaminodiphenylmethane(DDM).The control samples were prepared by curing diglycidyl ether of bisphenol A(DGEBA)with *** non-isothermal differential scanning calorimeter(DSC)method was utilized to further investigate the curing behavior and curing kinetics of the DGEA/DDM *** no flame retardant active elements,the DGEA/DDM thermoset still exhibited exceptional ***,the DGEA/DDM thermoset reached a V-0 rating in the UL-94 test and owned a high limiting oxygen index(LOI)value of 37.0%,while DGEBA/DDM resins were consumed completely in the vertical combustion test with a low LOI of 23.0%.Furthermore,the microscale combustion calorimetry(MCC)results manifested that compared with DGEBA/DDM resins,both PHRR and THR values of the DGEA/DDM resins were dropped by 84.0%and 57.6%,***,the DGEA/DDM resin also presented higher storage modulus and tensile strength compared with DGEBA/DDM ***,in contrast with that of the cured DGEBA/DDM one(156℃),the DGEA/DDM thermoset displayed an extremely high glass transition temperature(232℃).This study breaks new ground on how to produce biobased monomers with aromatic structures and achieve high-performance thermosetting polymers.

关键词： Bio-based epoxy thermosets Apigenin Intrinsic anti-flammability

Some conditional results for conditionally strong mixing sequences of random variables

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Science China Mathematics 2013年第4期56卷 845-859页

作者： yuan DeMei lei Lan School of Mathematics and Statistics Chongqing Technology and Business University

The relation between strong mixing and conditionally strong mixing is answered by examples,that is,the strong mixing property of random variables does not imply the conditionally strong mixing property,and the opposite implication is also not *** equivalent definitions and basic properties of conditional strong mixing random variables are derived,and several conditional covariance inequalities are *** means of these properties and conditional covariance inequalities,a conditional central limit theorem stated in terms of conditional characteristic functions is established,which is a conditional version of the earlier result under non-conditional case.

关键词： strong mixing conditionally strong mixing conditional covariance inequality conditional inde- pendence conditional stationarity conditional central limit theorem

Sm-like 5 knockdown inhibits proliferation and promotes apoptosis of colon cancer cells by upregulating p53,CDKN1A and TNFRSF10B

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2716-2726页

作者： Cai-Jing Mo Xiao-yuan Deng Ru-Lan Ma Kun Zhu lei Shi kang Li Department of Surgical Oncology The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina Department of Infectious Diseases The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina

BACKGROUND The role of Sm-like 5(LSM5)in colon cancer has not been *** this study,we investigated the role of LSM5 in progression of colon cancer and the potential underlying mechanism *** To determine the role of LSM5 in the progression of colon cancer and the potential underlying mechanism *** The Gene Expression Profiling Interactive Analysis database and the Human Protein Atlas website were used for LSM5 expression analysis and prognosis ***-time quantitative polymerase chain reaction and Western blotting were utilized to detect the expression of mRNAs and proteins.A lentivirus targeting LSM5 was constructed and transfected into colon cancer cells to silence LSM5 *** and apoptosis assays were also conducted to evaluate the growth of the colon cancer *** GeneChip assay and bioinformatics analysis were performed to identify the potential underlying mechanism of LSM5 in colon *** LSM5 was highly expressed in tumor tissue and colon cancer cells.A high expression level of LSM5 was related to poor prognosis in patients with colon *** of LSM5 suppressed proliferation and promoted apoptosis in colon cancer *** of LSM5 also facilitates the expression of p53,cyclin-dependent kinase inhibitor 1A(CDKN1A)and tumor necrosis factor receptor superfamily 10B(TNFRSF10B).The inhibitory effect of LSM5 knockdown on the growth of colon cancer cells was associated with the upregulation of p53,CDKN1A and *** LSM5 knockdown inhibited the proliferation and facilitated the apoptosis of colon cancer cells by upregulating p53,CDKN1A and TNFRSF10B.

关键词： Sm-like 5 Colon cancer Proliferation Apoptosis Knockdown

Fair k-Center Problem with Outliers on Massive Data

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Tsinghua Science and Technology 2023年第6期28卷 1072-1084页

作者： Fan yuan Luhong Diao Donglei Du lei Liu Beijing Institute for Scientific and Engineering Computing Faculty of ScienceBeijing University of TechnologyBeijing 100124China Faculty of Management University of New BrunswickFrederictonE3B 5A3Canada

The clustering problem of big data in the era of artificial intelligence has been widely *** of the huge amount of data,distributed algorithms are often used to deal with big data *** distributed computing model has an attractive feature:it can handle massive datasets that cannot be put into the main *** the other hand,since many decisions are made automatically by machines in today’s society,algorithm fairness is also an important research area of machine *** this paper,we study two fair clustering problems:the centralized fair k-center problem with outliers and the distributed fair k-center problem with *** these two problems,we have designed corresponding constant approximation ratio *** theoretical proof and analysis of the approximation ratio,and the running space of the algorithm are given.

关键词： machine learning distributed algorithm fairness constraints outlier constraints k-center problem