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Reduction of Glucose Metabolism in Olfactory Bulb is an Earlier Alzheimer＇s Disease-related Biomarker in 5XFAD Mice

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Chinese Medical Journal 2015年第16期128卷 2220-2227页

作者： Nai-An Xiao Jing Zhang Meng Zhou Zhen Wei Xi-Lin Wu Xiao-Man Dai yuan-gui zhu Xiao-Chun Chen Department of Neurology and Geriatrics Fujian Institute of Geriatrics Affiliated Union Hospital of Fujian Medical University Fuzhou Fujian 350001 China Key Laboratory of Brain Aging and Neurodegenerative Disease Fujian Key Laboratory of Molecular Neurology Fujian Medical University Fuzhou Fujian 350001 China

Background：Early diagnosis assumes a vital role in an effective treatment of Alzheimer＇s disease （AD）.Most of the current studies can only make anAD diagnosis after the manifestation of typical clinical *** present study aimed to investigate typical and other biomarkers of AD to find a possible early ***：A total of 14 5XFAD mice （at 3 and 6 months old）,with 14 age-matched wild-type （WT） mice as control,were enrolled in this case-control *** water maze test was performed to evaluate the cognitive function;buried food pellet test and olfactory maze test were employed to investigate the olfactory function;immunofluorescence to detect amyloid deposition and positron emission tomography to examine 2-deoxy-2-（18F） fluoro-D-glucose （[18F]-FDG） uptake in the hippocampus and cerebral ***：With the increasing age,cognitive performance （P =0.0262） and olfactory function were significantly deteriorated （day 1 P =0.0012,day 2 P =0.0031,day 3 P =0.0160,respectively） and the （18F）-FDG uptake was markedly decreased in multi-cerebral regions including the olfactory bulb （P 〈 0.0001）,hippocampus （P =0.0121）,and cerebral cortex （P 〈 0.0001）.Of note,in 3-month-old 5XFAD mice,a significant decline of （18F）-FDG uptake in the olfactory bulb was found when compared with that of age-matched WT mice （P =0.023） while no significant difference was present when the uptakes in other cerebral regions were ***：The decline of （18F）-FDG uptake in the olfactory bulb occurs earlier than other incidents,serving as an earlier in vivo biological marker of AD in 5XFAD mice and making early diagnosis of AD possibly.

关键词： Alzheimer's Disease Biomarker 2-deoxy-2-(18F) Fluoro-D-glucose Olfactory Bulb Positron EmissionTomography-computed Tomography

Amyloid 13 Protein Aggravates Neuronal Senescence an, d Cognitive Deficits in 5XFAD Mouse Model of Alzheimer s Disease

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Chinese Medical Journal 2016年第15期129卷 1835-1844页

作者： Zhen Wei Xiao-Chun Chen Yue Song Xiao-Dong Pan Xiao-Man Dai Jing Zhang Xiao-Li CUI Xi-Lin Wu yuan-gui zhu Department of Neurology Fujian Medical University Union Hospital Fuzhou Fujian 350001 China Fujian Institute of Geriatrics Fujian Medical University Union Hospital Fuzhou Fujian 350001 China Key Laboratory of Brain Aging and NeurodegenerativeDiseases Fujian KeyLaboratory of Molecular Neurology Fujian Medical University Fuzhou Fujian 350001 China

Background： Amyloid β （Aβ） has been established as a key factor for the pathological changes in the brains of patients with Alzheimer＇s disease （AD）, and cellular senescence is closely associated with aging and cognitive impairment. However, it remains blurred whether, in theAD brains, Aβ accelerates the neuronal senescence and whether this senescence, in turn, impairs the cognitive function. This study aimed to explore the expression of senescence-associated genes in the hippocampal tissue from young to aged 5XFAD mice and their age-matched wild type （WT） mice to determine whether senescent neurons are present in the transgenic AD mouse model. Methods： The 5XFAD mice and age-matched wild type mice, both raised from 1 to 18 months, were enrolled in the study. The senescence-associated genes in the hippocampus were analyzed and differentially expressed genes （DEGs） were screened by quantitative real-time polymerase chain reaction. Cognitive perfom3ance of the mice was evaluated by Y-maze and Morris water maze tests. Oligomeric Aβ（oAβ）（1-42） was applied to culture primary neurons to simulate the in vivo manifestation. Aging-related proteins were detected by Western blotting analysis and immunofluorescence. Results： In 5XFAD mice, of all the DEGs, the senescence-associated marker p16 was most significantly increased, even at the early age. It was mainly localized in neurons, with a marginal expression in astrocytes （labeled as glutamine synthetase）, nil expression in activated microglia （labeled as lba1）, and negatively correlated with the spatial cognitive impairments of 5XFAD mice. oAβ （1-42） induced the production of senescence-related protein p1 6, but not p53 in vitro, which was in line with the in vivo manifestation. Conclusions： oAβ-accelerated neuronal senescence may be associated with the cognitive impairment in 5XFAD mice. Senescence-associated marker p16 can serve as an indicator to estimate the cognitive prognosis for A D population.

关键词： Alzheimer's Disease Amyloid β Cognition P 16 Senescence

Observation of acoustic hybrid topological phases induced by the p-d orbital interactions

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 132-139页

作者： Xiao Xiang Feng Gao Yu-gui Peng Peng Wu Zong-Lin Li Xue-Feng zhu School of Physics and Innovation Institute Huazhong University of Science and Technology

In spinless systems,growing attention has recently been attracted to synthetic gauge fields,which redefine the fundamental crystal symmetries by utilizing the projective algebraic ***,synthetic gauge fields have been commonly investigated in single orbital systems,and explorations on hybrid orbitals remain elusive in ***,we report the experimental observation of hybrid topological phases induced by hybrid synthetic gauge flux,which is formed by the interaction between p and d orbitals embedded in acoustic *** breaking the translation symmetries of Lxand/or Ly,we unambiguously demonstrate the first-order M?bius edge states and higher-order corner *** work establishes a platform for seeking exotic topological phases induced by hybrid-orbitals interactions and initializing the framework of hybrid-orbitalsrelated topological *** applications can be anticipated in scenarios such as high-quality sensing and robust wave trapping due to the stepwise energy distribution of the hybrid topological phase.

关键词： topological insulator synthetic gauge field projective symmetry corner states

Endoplasmic Reticulum Stress Induces the Early Appearance of Pro-apoptotic and Anti-apoptotic Proteins in Neurons of Five Familial Alzheimer＇s Disease Mice

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Chinese Medical Journal 2016年第23期129卷 2845-2852页

作者： Hui Shen Xiao-Dong Pan Jing Zhang Yu-Qi Zeng Meng Zhou Lu-Meng Yang Bing Ye Xiao-Man Dai yuan-gui zhu Xiao-Chun Chen Department of Neurology and Geriatrics Fujian Institute of Geriatrics Fujian Medical University Union Hospital Fuzhou Fujian 350001 China Key Laboratory of Brain Aging and Neurodegenerative Diseases Fujian Key Laboratory of Molecular Neurology Fujian Medical University Fuzhou Fujian 350001 China

Background： Amyloid β （Aβ） deposits and the endoplasmic reticulum stress （ERS） are both well established in the development and progression of Alzheimer＇s disease （AD）. However, the mechanism and role of Aβ-induced ERS in AD-associated pathological progression remain to be elucidated. Methods： The five familial AD （5×FAD） mice and wild-type （WT） mice aged 2, 7, and 12 months were used in the present study. Monis water maze test was used to evaluate their cognitive performance, lmmunofluorescence and Western blot analyses were used to examine the dynamic changes of pro-apoptotic （CCAAT/enhancer-binding protein homologous protein [CHOP] and cleaved caspase-12） and anti-apoptotic factors （chaperone glucose-regulated protein [GRP] 78 and endoplasmic reticulum-associated protein degradation-associated ubiquitin ligase synovial apoptosis inhibitor 1 [SYVN 1]） in the ERS-associated unfolded protein response （UPR） pathway. Results： Compared with age-matched WT mice, 5 xFAD mice showed higher cleaved caspase-3, lower neuron-positive staining at the age of 12 months, but earlier cognitive deficit at the age of 7 months （all P 〈 0.05）. Interestingly, for 2-month-old 5×FAD mice, the related proteins involved in the ERS-associated UPR pathway, including CHOP, cleaved caspase-12, GRP 78, and SYVN 1, were significantly increased when compared with those in age-matched WT mice （all P 〈 0.05）. Moreover, ERS occurred mainly in neurons, not in astrocytes. Conclusions： These findings suggest that compared with those of age-matched WT mice, ERS-associated pro-apoptotic and anti-apoptotic proteins are upregulated in 2-month-old 5×FAD mice, consistent with intracellular Aβ aggregation in neurons.

关键词： Alzheimer's Disease Amyloid β Apoptosis: Endoplasmic Reticulum Stress Unfolded Protein Response Pathway

Curcumin protects mitochondria from oxidative damage and attenuates apoptosis in cortical neurons

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Acta Pharmacologica Sinica 2004年第12期25卷 40-46页

作者： yuan-gui zhu2, Xiao-chun CHEN3, Zhi-zhe CHEN4, Yu-qi ZENG, Guang-bin SHI, Yan-hua SU, Xu PENG Fujian Instituteof Geriatrics, Fujian Institute of Hematology, Union Hospital, Fujian Medical University, Fuzhou 350001, China 2Now in Rush University Medical Center, Chicago, IL 60612,USA. Fujian Institute of Geriatrics Union Hospital Fujian Medical University Fuzhou 350001 Fujian Institute of Hematology Union Hospital Fujian Medical University Fuzhou 350001

AIM: To investigate the effect of curcumin on tert-butyl hydroperoxide (t-BHP)-induced oxidative damage in rat cortical neurons and to explore the possible mechanism. METHODS: Primary cultured rat cortical neurons were performed in vitro and cell viability was measured by MTT assay. DNA fragmentation was used to evaluate cell apoptosis. Intracellular reactive oxygen species (ROS) and mitochondrial membrane potential (?Ψm) was deter- mined by flow cytometric assay. Cellular glutathione (GSH) content was measured by spectrophotometer. Bcl-2 family proteins, cytochrome c, cleaved caspase-3, and poly (ADP-ribose) polymerase (PARP) were detected by Western blot. RESULTS: Exposure of tBHP 100 μmol/L to neurons for 60 min resulted in ?Ψm loss and cyto- chrome c release from mitochondria and subsequent activationof caspase-3 and PARP cleavation, and cell apoptosis. After removal of tBHP and then further treatment with curcumin (2.5-20 μmol/L) for 18 h, curcumin abrogated ?Ψm loss and cytochrome c release, blocked activation of caspase3, and altered the expression of Bcl-2 family. Further curcumin treatment also prevented cellular GSH and decreased intracellular ROS generation markedly. Curcumin eventually attenuated tBHP-induced apoptosis in cortical neurons. CONCLUSION: Curcumin may attenuate oxidative damages in cortical neurons by reducing intracellular production of ROS and protecting mito- chondria from oxidative damage.

关键词： Curcumin tert-butyl hydroperoxide apoptosis oxidative stress Bcl-2 family proteins mitochondria Alzheimerdisease

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棉蚜对有机磷杀虫剂抗性的生化机理

昆虫学报 1987年第1期30卷 13-20页

作者：孙耘芹冯国蕾袁家珪祝平龚坤元中国科学院动物研究所

本文对有机磷抗性和感性棉蚜Aphis gossypii三个种群抗性生化机制进行了讲究。首先用解毒酶的抑制剂测定药剂的解毒途径。进一步测定乙酰胆碱酯酶活力及其敏感性和多功能氧化酶、谷胱甘肽s-转移酶、α-乙酸萘酯酶和α-乙酸萘酯羧酸酯酶... 详细信息

本文对有机磷抗性和感性棉蚜Aphis gossypii三个种群抗性生化机制进行了讲究。首先用解毒酶的抑制剂测定药剂的解毒途径。进一步测定乙酰胆碱酯酶活力及其敏感性和多功能氧化酶、谷胱甘肽s-转移酶、α-乙酸萘酯酶和α-乙酸萘酯羧酸酯酶等解毒酶的活力。结果表明,体内条件下,多功能氧化酶与抗性有关,但在离体条件下,在棉蚜匀浆液中有内源抑制剂存在。α-乙酸萘酯酶和α-乙酸萘酯羧酸酯酶活力的增加,乙酰胆碱酯酶对杀虫剂敏感性的降低也是造成棉蚜对有机磷产生抗性的原因。

关键词：棉蚜有机磷杀虫剂抗性机理多功能氧化酶谷胱甘肽S-转移酶羧酸酯酶胆碱酯酶

Molecule‑Level Multiscale Design of Nonflammable Gel Polymer Electrolyte to Build Stable SEI/CEI for Lithium Metal Battery

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Nano-Micro Letters 2025年第1期17卷 404-423页

作者： Qiqi Sun Zelong Gong Tao Zhang Jiafeng Li Xianli zhu Ruixiao zhu Lingxu Wang Leyuan Ma Xuehui Li Miaofa yuan Zhiwei Zhang Luyuan Zhang Zhao Qian Longwei Yin Rajeev Ahuja Chengxiang Wang Key Laboratory for Liquid‑Solid Structural Evolution and Processing of Materials(Ministry of Education) School of Materials Science and EngineeringShandong UniversityJinan 250061People’s Republic of China Condensed Matter Theory Department of Physics and AstronomyUppsala UniversityUppsala 75120Sweden

The risk of flammability is an unavoidable issue for gel polymer electrolytes(GPEs).Usually,flameretardant solvents are necessary to be used,but most of them would react with anode/cathode easily and cause serious interfacial instability,which is a big challenge for design and application of nonflammable ***,a nonflammable GPE(SGPE)is developed by in situ polymerizing trifluoroethyl methacrylate(TFMA)monomers with flame-retardant triethyl phosphate(TEP)solvents and LiTFSI–LiDFOB dual lithium *** is strongly anchored to PTFMA matrix via polarity interaction between-P=O and-CH_(2)CF_(3).It reduces free TEP molecules,which obviously mitigates interfacial reactions,and enhances flame-retardant performance of TEP *** TEP molecules are also inhibited in solvation of Li^(+),leading to anion-dominated solvation sheath,which creates inorganic-rich solid electrolyte interface/cathode electrolyte interface *** coordination structure changes Li^(+)transport from sluggish vehicular to fast structural transport,raising ionic conductivity to 1.03 mS cm^(-1) and transfer number to 0.41 at 30℃.The Li|SGPE|Li cell presents highly reversible Li stripping/plating performance for over 1000 h at 0.1 mA cm^(−2),and 4.2 V LiCoO_(2)|SGPE|Li battery delivers high average specific capacity>120 mAh g^(−1) over 200 *** study paves a new way to make nonflammable GPE that is compatible with Li metal anode.

关键词： Anchoring effect Nonflammable gel electrolyte In situ cross-linked Electrode-electrolyte interface Li metal battery

Role of the globus pallidus in motor and non-motor symptoms of Parkinson's disease

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Neural Regeneration Research 2025年第6期20卷 1628-1643页

作者： Yimiao Jiang Zengxin Qi Huixian zhu Kangli Shen Ruiqi Liu Chenxin Fang Weiwei Lou Yifan Jiang Wangrui yuan Xin Cao Liang Chen Qianxing zhuang Department of Physiology School of MedicineNantong UniversityNantongJiangsu ProvinceChina Department of Neurosurgery Huashan HospitalShanghai Medical CollegeFudan UniversityShanghaiChina National Center for Neurological Disorders ShanghaiChina Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration ShanghaiChina State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Institute of Brain ScienceFudan UniversityShanghaiChina

The globus pallidus plays a pivotal role in the basal ganglia circuit. Parkinson's disease is characterized by degeneration of dopamine-producing cells in the substantia nigra, which leads to dopamine deficiency in the brain that subsequently manifests as various motor and non-motor symptoms. This review aims to summarize the involvement of the globus pallidus in both motor and non-motor manifestations of Parkinson's disease. The firing activities of parvalbumin neurons in the medial globus pallidus, including both the firing rate and pattern, exhibit strong correlations with the bradykinesia and rigidity associated with Parkinson's disease. Increased beta oscillations, which are highly correlated with bradykinesia and rigidity, are regulated by the lateral globus pallidus. Furthermore,bradykinesia and rigidity are strongly linked to the loss of dopaminergic projections within the cortical-basal ganglia-thalamocortical loop. Resting tremors are attributed to the transmission of pathological signals from the basal ganglia through the motor cortex to the cerebellum-ventral intermediate nucleus circuit. The cortico–striato–pallidal loop is responsible for mediating pallidi-associated sleep disorders. Medication and deep brain stimulation are the primary therapeutic strategies addressing the globus pallidus in Parkinson's disease. Medication is the primary treatment for motor symptoms in the early stages of Parkinson's disease, while deep brain stimulation has been clinically proven to be effective in alleviating symptoms in patients with advanced Parkinson's disease,particularly for the movement disorders caused by levodopa. Deep brain stimulation targeting the globus pallidus internus can improve motor function in patients with tremordominant and non-tremor-dominant Parkinson's disease, while deep brain stimulation targeting the globus pallidus externus can alter the temporal pattern of neural activity throughout the basal ganglia–thalamus network. Therefore, the comp

关键词： anxiety basal ganglia bradykinesia deep brain stimulation depression globus pallidus externus globus pallidus internus lateral globus pallidus medial globus pallidus neural circuit Parkinson's disease

Zinc-based fiber-shaped rechargeable batteries:Insights into structures,electrodes,and electrolytes

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Nano Research 2025年第1期18卷 278-293页

作者： Xuan Zhang Hongcheng Zhang Mengxiang Chen Jingqi Lu Evgeny zhuravlev Jing Jiang Pin Liu Shengyang Dong Du yuan Guoyin zhu Lianbo Ma Yizhou Zhang Institute of Advanced Materials and Flexible Electronics(IAMFE) School of Chemistry and Materials ScienceNanjing University of Information Science and TechnologyNanjing 210044China School of Materials Science and Engineering Anhui University of TechnologyMaanshan 243002China College of Materials Science and Engineering Changsha University of Science and TechnologyChangsha 410004China

The rapid evolution of flexible wearable electronics has spurred a growing demand for energy storage devices,characterized by low-cost manufacturing processes,high safety standards,exceptional electrochemical performance and robust mechanical *** novel flexible devices,fiber-shaped batteries(FSBs)have emerged as prominent solutions exceptionally suited to future applications,owing to their unique one-dimensional(1D)architecture,remarkable flexibility,potential for miniaturization,adaptability to deformation and compatibility with the conventional textile *** the forefront research on fiber-shaped batteries,zincbased FSBs(ZFSBs)have garnered significant attentions,featured by the promising electrochemical properties of metallic *** enthusiasm is driven by the impressive capacity of Zn(820 mAh·g^(-1))and its low redox potential(Zn/Zn^(2+):-0.76 V *** hydrogen electrode).This review aims to consolidate recent achievements in the structural design,fabrication processes and electrode materials of flexible ***,we highlight three representative structural configurations:parallel type,twisted type and coaxial *** also place special emphasis on electrode modifications and electrolyte ***,we delve into the promising development opportunities and anticipate future challenges associated with ZFSBs,emphasizing their potential roles in powering the next generation of wearable electronics.

关键词： zinc-based batteries fiber-shape parallel type twisted type coaxial type