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Green Chemical Engineering 2024年第1期5卷 60-67页

作者： Zhe Liu Juncong yuan Zongzhuang Sun Xiang feng Yibin Liu Huihong Zhu Chong Peng Chaohe yang State Key Laboratory of Heavy Oil Processing China University of PetroleumQingdao266580China Dalian Research Institute of Petroleum and Petrochemicals SINOPECDalian116045China State Key Laboratory of Fine Chemicals Dalian University of TechnologyDalian116024China

Upgrading of vacuum residue is of prime industrial significance due to the increasing demand for light *** the effect of catalyst morphology on vacuum residue hydrotreating performance by kinetic modeling is therefore of great ***,kinetic analysis of hydrodemetallization(HDM)and hydrodeconradsoncarbon-residue(HDCCR)performances on industrial Ni-Mo/Al_(2)O_(3)catalysts with spherical and cylindrical morphologies in ebullated-bed were evaluated for more than 1600 *** was found that the percentage of light impurities easier to be removed on spherical catalysts were 78.20%and 39.43%in HDM and HDCCR reactions,respectively,higher than 65.20%and 17.50%on cylindrical *** suggests that catalyst morphology affects the impurity removal ability and the impurity properties,resulting in better hydrotreating performance of spherical *** work not only combines catalyst morphology with impurity removal capability through kinetic modeling,but also provides new insights into the design of efficient hydrotreating catalysts.

关键词： Morphology effect Kinetic analysis Vacuum residue Hydrotreating

GNAS mutations suppress cell invasion by activating MEG3 in growth hormone–secreting pituitary adenoma

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Oncology Research 2024年第6期32卷 1079-1091页

作者： CHAO TANG CHUNYU ZHONG JUNHAO ZHU feng yuan JIN yang YONG XU CHIyuan MA Department of Neurosurgery Affiliated Jinling HospitalMedical School of Nanjing UniversityNanjing210002China Department of Neurosurgery Children’s Hospital of Nanjing Medical UniversityNanjing210019China Affiliated Eye Hospital Nanjing Medical UniversityNanjing210029China Department of Neurosurgery Jinling HospitalSouthern Medical UniversityNanjing210002China Department of Neurosurgery Jinling HospitalNanjing Medical UniversityNanjing210002China

Approximately 30%–40%of growth hormone–secreting pituitary adenomas(GHPAs)harbor somatic activating mutations in GNAS(αsubunit of stimulatory G protein).Mutations in GNAS are associated with clinical features of smaller and less invasive ***,the role of GNAS mutations in the invasiveness of GHPAs is *** mutations were detected in GHPAs using a standard polymerase chain reaction(PCR)sequencing *** expression of mutation-associated maternally expressed gene 3(MEG3)was evaluated with ***3 was manipulated in GH3 cells using a lentiviral expression *** invasion ability was measured using a Transwell assay,and epithelial–mesenchymal transition(EMT)-associated proteins were quantified by immunofluorescence and western ***,a tumor cell xenograft mouse model was used to verify the effect of MEG3 on tumor growth and *** invasiveness of GHPAs was significantly decreased in mice with mutated GNAS compared with that in mice with wild-type ***,the invasiveness of mutant GNASexpressing GH3 cells ***3 is uniquely expressed at high levels in GHPAs harboring mutated ***,MEG3 upregulation inhibited tumor cell invasion,and conversely,MEG3 downregulation increased tumor cell ***,GNAS mutations inhibit EMT in ***3 in mutated GNAS cells prevented cell invasion through the inactivation of the Wnt/β-catenin signaling pathway,which was further validated in *** data suggest that GNAS mutations may suppress cell invasion in GHPAs by regulating EMT through the activation of the MEG3/Wnt/β-catenin signaling pathway.

关键词： GHPAs GNAS mutation MEG3 β-catenin EMT

Superior Latent Heat Eutectic Salt Na_(2)CO_(3)-Li_(2)CO_(3)-LiF for Thermal Energy Storage:Preparation and Performance Investigation

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Journal of Thermal Science 2024年第2期33卷 501-508页

作者： LI Weiwei MIAO Qi ZHANG Yelong DING Hongliang yang Sa LAI yuan feng Daili DING Yulong JIN Yi TAN Linghua School of Chemistry and Chemical Engineering Nanjing University of Science&TechnologyNanjing210094China National Special Superfine Powder Engineering Research Center Nanjing University of Science and TechnologyNanjing210094China Nanjing Jinhe Energy Material Co. LtdNanjing210047China School of Chemical Engineering University of BirminghamBirminghamB152TTUK School of Energy&Environmental Engineering University of Science and Technology BeijingBeijing100083China

In this paper,a novel ternary eutectic salt Na_(2)CO_(3)-Li_(2)CO_(3)-LiF was designed and investigated for concentrated solar power(CSP).The FactSage software was used to predict the composition and eutectic point of Na_(2)CO_(3)-Li_(2)CO_(3)-*** microstructure,thermophysical properties,and thermal stability of eutectic salts were experimentally measured using various analytical *** a mass ratio of 57%:32%:11%,the eutectic salt exhibited excellent thermal storage properties with a fusion enthalpy of 413 J/g and a melting point of 426.8℃.The excellent thermal stability of the eutectic salt was reflected by a weight loss of only 0.8% at 600℃.

关键词： phase change materials ternary eutectic salt latent heat thermal stability

An Efficient Radar Detection Method of Maneuvering Small Targets

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Journal of Beijing Institute of Technology 2024年第1期33卷 1-8页

作者： Hongchi Zhang yuan feng Shengheng Liu School of Information and Electronics Beijing Institute of Technology and Beijing Key Laboratory of Fractional Signals and SystemsBeijing 100081China School of Information Science and Engineering Southeast UniversityNanjing 210096China

Detection of maneuvering small targets has always been an important yet challenging task for radar signal *** primary reason is that target variable motions within coherent processing interval generate energy migrations across multiple resolution bins,which severely deteriorate the parameter estimation performance.A coarse-to-fine strategy for the detection of maneuvering small targets is *** of small points segmented coherently is performed first,and then an optimal inter-segment integration is utilized to derive the coarse estimation of the chirp *** fractional Fourier transform(FrFT)is then employed to refine the coarse estimation at a significantly reduced computational *** results verify the proposed scheme that achieves an efficient and reliable maneuvering target detection with-16dB input signal-to-noise ratio(SNR),while requires no exact a priori knowledge on the motion parameters.

关键词： small target chirp sparse fractional Fourier transform(FrFT)

Safer solid-state lithium metal batteries:Mechanisms and strategies

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InfoMat 2024年第2期6卷 1-27页

作者： Shi-Jie yang Jiang-Kui Hu feng-Ni Jiang Hong yuan Ho Seok Park Jia-Qi Huang School of Materials Science&Engineering Beijing Institute of TechnologyBeijingthe People's Republic of China Advanced Research Institute of Multidisciplinary Science Beijing Institute of TechnologyBeijingthe People's Republic of China College of Chemical Engineering and Technology Taiyuan University of TechnologyTaiyuanShanxithe People's Republic of China Beijing Key Laboratory of Green Chemical Reaction Engineering and Technology Department of Chemical EngineeringTsinghua UniversityBeijingthe People's Republic of China Center for Next-Generation Energy Materials and School of Chemical Engineering Sungkyunkwan UniversitySuwonRepublic of Korea

Solid-state batteries that employ solid-state electrolytes(SSEs)to replace routine liquid electrolytes are considered to be one of the most promising solutions for achieving high-safety lithium metal *** with high mechanical modulus,thermal stability,and non-flammability can not only inhibit the growth of lithium dendrites but also enhance the safety of lithium metal ***,several internal materials/electrodes-related thermal hazards demonstrated by recent works show that solid-state lithium metal batteries(SSLMBs)are not ***,understanding the potential thermal hazards of SSLMBs is critical for their more secure and widespread *** this contribution,we provide a comprehensive overview of the thermal failure mechanism of SSLMBs from materials to ***,strategies to improve the thermal safety performance of SSLMBs are included from the view of material enhancement,battery design,and external ***,the future directions are further *** hope that this work can shed bright insights into the path of constructing energy storage devices with high energy density and safety.

关键词： lithium metal batteries safety improvements solid-state batteries thermal failures thermal runaway

Effect of movability of water on the low-velocity pre-Darcy flow in clay soil

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第8期16卷 3299-3310页

作者： Hui Cheng Fugang Wang Shengwei Li Xiaotong Guan Guohua yang Zhongle Cheng Ceting Yu Yilong yuan Guanhong feng Key Laboratory of Groundwater Resources and Environment Ministry of EducationJilin UniversityChangchun130012China Jilin Provincial Key Laboratory of Water Resources and Water Environment Jilin UniversityChangchun130012China Chengdu Center China Geological SurveyChengdu610081China

Water seepage in soil is a fundamental problem involving various scientific and engineering *** to the literature,low-velocity water seepage in low-permeability porous media,such as clay,does not follow Darcy's law,also known as pre-Darcy *** formation of immovable water due to water adsorption on the pore wall is believed to be responsible for the formation of pre-Darcy ***,this view lacks direct solid *** investigate the pre-Darcy water flow in clay,head permeability experiments are conducted on six clay samples with different *** results indicate that water seepage in clay at low hydraulic gradients does not follow Darcy's law.A clear nonlinear relationship between flow velocity and hydraulic gradient is *** flow in clay can be divided into the pre-Darcy flow and Darcy flow regions by the critical hydraulic gradient,which is 10-12 for the Albic soil with dry density between 1.3 g/cm^(3)and 1.8 g/cm^(3).According to the disjoining pressure theory,immovable water due to water adsorption on the pore wall is the primary reason for water flow deviating from Darcy's law in *** results indicate that the percentage of movable water ranges from 39.7%to 59.3%for the six samples at a hydraulic gradient of *** the hydraulic gradient increases,the percentage of moveable water also ***,there is a strong correlation between the percentage of movable water and the variation in hydraulic conductivity with the hydraulic ***,a quantitative relationship between the percentage of movable water and the hydraulic conductivity has been *** results of this study suggest that water adsorption on the pore wall not only affects the water movability,but is also closely related to the pre-Darcy flow phenomenon in clay.

关键词： Pre-Darcy flow Clay Critical hydraulic gradient Water movability analysis

Severe liver injury and clinical characteristics of occupational exposure to 2-amino-5-chloro-N,3-dimethylbenzamide: A case series

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Hepatobiliary & Pancreatic Diseases International 2024年第2期23卷 186-194页

作者： Meng-Xiao feng Hua Zou yuan-Qiang Lu Department of Emergency Medicine The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Key Laboratory for Diagnosis and Treatment of Aging and Physic-chemical Injury Diseases of Zhejiang Province Hangzhou 310003China Occupational Health and Radiation Protection Institute Zhejiang Provincial Center for Disease Control and PreventionHangzhou 310051China

Background:The 2-amino-5-chloro-N,3-dimethylbenzamide is a key intermediate in the synthesis of pesticides and ***,no literature currently exists on 2-amino-5-chloro-N,3-dimethylbenzamide poisoning in *** study aimed to reveal the health hazard of this chemical for humans and summarize the clinical characteristics of patients with occupational 2-amino-5-chloro-N,3-dimethylbenzamide ***:This observational study included four patients with 2-amino-5-chloro-N,3-dimethylbenzamide poisoning from June 2022 to July *** entire course of the incidents was described in *** 2-amino-5-chloro-N,3-dimethylbenzamide concentrations were detected by a mass ***-toxylin and eosin staining was performed to assess liver injury,and immunofluorescence was used to evaluate hepatic ***:The 2-amino-5-chloro-N,3-dimethylbenzamide powder(99%purity)entered the human body mainly via the skin and respiratory tract due to poor personal protective *** typical course of 2-amino-5-chloro-N,3-dimethylbenzamide poisoning was divided into latency,rash,fever,organic dam-age,and recovery phases in accordance with the clinical *** and fever may be the important premonitory symptoms for further organ *** chemical was detected in the blood of all patients and caused multiple organ injuries,predominantly liver injury,including kidney,myocardium,and *** patients recovered smoothly after comprehensive treatments,including artificial liver therapy,continuous renal replacement therapy,glucocorticoids,and other symptomatic and supportive *** patient survived by liver *** postoperative pathological findings of the removed liver showed acute liver failure,and immunofluorescence staining confirmed the abundance of mitophagy in residual ***:This study is the first to elaborate the clinical characteristics of patients with 2-amino-5-chloro-N,

关键词： 2-amino-5-chloro-N,3-dimethylbenzamide Poisoning Clinical characteristics Liver injury

Clinical characteristics of postoperative necrotizing enterocolitis in patients with congenital jejunoileal atresia and its risk factors

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World Journal of Pediatric Surgery 2024年第1期7卷 42-46页

作者： Xiaofeng Xiong Wei Lu Fuzhong Xing yuan Cai Jixin yang Yuhang yuan Jiexiong feng Xuyong Chen Department of Pediatric Surgery Tongji Hospital of Tongji Medical College of Huazhong University of Science and TechnologyWuhanHubeiChina Department of Neonate Surgery Wuhan Children's HospitalHuazhong University of Science and TechnologyWuhanHubeiChina Department of Pediatric Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenanChina

Objective To review postoperative necrotizing enterocolitis(NEC)in patients with jejunoileal atresia(JIA)and to explore the potential risk factors related to the concurrence *** Patients diagnosed with JIA who received surgical treatment from January 2016 to June 2021 were ***,viral infection of the fetus,transfusion within 48 hours before NEC,sepsis before JIA repair,pathological and anatomical classification of JIA,combined malformation,occurrence time of NEC after the operation,treatment,and prognosis of patients were *** were divided into NEC group and non-NEC group,and all patients were followed up for 3-6 months to observe for *** A total of 180 patients with JIA were included,of whom 12 were diagnosed with NEC after surgery and 1 patient with NEC died during *** average age,birth weight,gestational age,proportion of premature infants,proportion of preoperative infections,and pathological classification of JIA did not significantly differ between the two *** probability of patients with proximal jejunal atresia(PJA)in the NEC group(58.3%)was higher than that in the non-NEC group(22.6%)(p=0.011),and patients with PJA had longer parenteral nutrition time than patients without PJA(26.64±9.21 days vs 15.11±6.58 days,p<0.001).Conclusion PJA was more likely to be associated with concurrent NEC after surgery,which is a highly NEC-related risk factor inherent in JIA.

关键词： patients postoperative transfusion

Zircon Hf Isotope Mapping for Understanding Crustal Architecture and Its Controls on Mineralization during Early Cretaceous in the Southern Great Xing'an Range,NE China

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Journal of Earth Science 2024年第1期35卷 41-50页

作者： feng yuan Huanan Liu Shengjin Zhao Mingjing Fan State Key Laboratory of Geological Processes and Mineral Resources Collaborative Innovation Center for Exploration of Strategic Mineral ResourcesSchool of Earth ResourcesChina University of GeosciencesWuhan 430074China State Key Laboratory of Geological Processes and Mineral Resources School of Earth Sciences and ResourcesChina University of GeosciencesBeijing100083China No.10 Institute of Geological Exploration Inner Mongolia Bureau of Geology and Mineral ResourcesChifeng 024000China Key Laboratory of Metallogeny and Mineral Assessment Institute of Mineral ResourcesChinese Academy of Geological SciencesBeijing 100037China

Voluminous Early Cretaceous granitoids and associated large-scale ore deposits are distributed within the southern Great Xing'an Range(SGXR),NE *** on previously published geochronology and zircon Hf-isotope data,Hf isotope mapping is undertaken to improve our understanding of crustal architecture and its controls on ore *** ore-related Early Cretaceous granitoids were sourced predominantly from juvenile crust,with the involvement of variable proportions of ancient crustal *** crustal architecture,as inferred from Hf isotopic contour maps,indicates two distinct Hf isotopic domains in SGXR,including(1)a higher-ε_(Hf)(+7 to+11)juvenile crust containing minor ancient crustal material,and(2)a lower-ε_(Hf)(+2 to+6)juvenile crust containing a greater proportion of ancient crustal *** Hf isotopic maps identify links between crustal architecture and regional *** deposits and other deposits with significant Cu production are restricted mainly to the higher-ε_(Hf)juvenile crustal regions in the northern and eastern *** dominated by other metals(e.g.,Mo,Sn,W,Pb,Zn,and Ag)occur mainly in the lower-ε_(Hf)juvenile crustal regions in the southern and western *** between juvenile crust-derived melts and ancient crustal components played an important role on the distribution of various ore metals.

关键词： Hf isotope mapping crustal architecture large-scale Early Cretaceous granitoids distribution of ore deposits southern Great Xing'an Range zircon

Lossless Compression Method for the Magnetic and Helioseismic Imager(MHI)Payload

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Research in Astronomy and Astrophysics 2024年第4期24卷 214-221页

作者： Li-Yue Tong Jia-Ben Lin yuan-Yong Deng Kai-Fan Ji Jun-feng Hou Quan Wang Xiao yang National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China Key Laboratory of Solar Activity and Space Weather National Space Science CenterChinese Academy of SciencesBeijing 100190China School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 100049China Yunnan Observatories Chinese Academy of SciencesKunming 650216China

The Solar Polar-orbit Observatory(SPO),proposed by Chinese scientists,is designed to observe the solar polar regions in an unprecedented way with a spacecraft traveling in a large solar inclination angle and a small ***,one of the most significant challenges lies in ultra-long-distance data transmission,particularly for the Magnetic and Helioseismic Imager(MHI),which is the most important payload and generates the largest volume of data in *** this paper,we propose a tailored lossless data compression method based on the measurement mode and characteristics of MHI *** background out of the solar disk is removed to decrease the pixel number of an image under *** predictive coding methods are combined to eliminate the redundancy utilizing the correlation(space,spectrum,and polarization)in data set,improving the compression *** results demonstrate that our method achieves an average compression ratio of *** compression time is also less than the general observation *** method exhibits strong feasibility and can be easily adapted to MHI.

关键词： methods:data analysis techniques:image processing Sun:magnetic fields Sun:photosphere