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Dynamic mechanisms controlling the topography of Longmenshan area

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Science China Earth Sciences 2020年第1期63卷 121-131页

作者： yuan xie Yongdong LI Xiong XIONG Hubei Subsurface Multi-Scale Imaging Key Laboratory Institute of Geophysics and GeomaticsChina University of Geosciences

The Longmenshan fault, which defines the eastern edge of the Tibetan Plateau, is one of the steepest margins of the plateau with a sharp elevation drop of about 4 km over a distance less than 100 km across the Longmenshan fault. The mechanism which is responsible for controlling and maintaining the elevation difference is highly debated. Using multiple observations including seismic velocity model, Moho depth, effective elastic thickness of the lithosphere, we conducted a quantitative study for elucidating the contributions from crust and lithospheric mantle by an integrated analysis of lithospheric isostasy and flexure. It is shown that the topography of the Longmenshan fault is supported by both lithospheric isostasy and flexure statically, and lower crustal channel flow and mantle convection dynamically. Different mechanisms have different weights for contribution to the topography of the Songpan-Ganzi block and the Sichuan Basin. The static and dynamic support contribute roughly the same to the topographic difference of ~4 km between the two sides of the Longmenshan fault. The static topographic difference of ~2 km is mainly resulted from the lithospheric isostasy, while the dynamic one of ~2 km is contributed by the uprising of the accumulated material in the lower crust beneath the Songpan-Ganzi block and the downward drag force caused by the upper mantle convection under the Sichuan Basin. It is thus suggested that the lower crustal flow and upper mantle convection are dynamic forces which should be taken into account in the studies on the dynamics in the Longmenshan and surrounding regions.

关键词： Topography Longmenshan fault zone Lithospheric isostasy Lithospheric flexure Dynamic topography

Elliptic Function Waves of Spinor Bose-Einstein Condensates in an Optical Lattice

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Communications in Theoretical Physics 2009年第3期51卷 445-449页

作者： xie yuan-Dong School of Physics and Telecommunication Engineering South China Normal University Guangzhou 510006 China Laboratory of Photonic Information Technology South China Normal University Guangzhou 510006 China

An improved nonlinear Schrodinger equation different from usual one of spinor Bose-Einstein condensates （BECs） in an optical lattice are obtained by taking into account a nonlinear term in the equation of motion for probability amplitude of spins carefully. The elliptic function wave solutions of the model are found under specific boundary condition, for example, the two ends of the atomic chain are fixed. In the case of limit the elliptic function wave solutions are reduced into spin-wave-like or solitons.

关键词： spinor Bose Einstein condensates optical lattice elliptic tunction wave solution soliton

The debut of all-boron fullerene

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National Science Review 2015年第1期2卷 2-3页

作者： Su-yuan xie College of Chemistry and Chemical Engineering Xiamen University

Boron is the ith element and next to carbon in the periodic table of the elements,but boron has been researched less than its neighbor *** sourced from a natural boronrich mine in Yamdrok Lake,Tibet,China,has been use... 详细信息

关键词： cage The debut of all-boron fullerene

Role and prospects of regenerative biomaterials in the repair of spinal cord injury

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Neural Regeneration Research 2019年第8期14卷 1352-1363页

作者： Shuo Liu yuan-yuan xie Bin Wang Clinical Stem Cell Center The Affiliated Drum Tower Hospital of Nanjing University Medical School

Axonal junction defects and an inhibitory environment after spinal cord injury seriously hinder the regeneration of damaged tissues and neuronal functions. At the site of spinal cord injury, regenerative biomaterials can fill cavities, deliver curative drugs, and provide adsorption sites for transplanted or host cells. Some regenerative biomaterials can also inhibit apoptosis, inflammation and glial scar formation, or further promote neurogenesis, axonal growth and angiogenesis. This review summarized a variety of biomaterial scaffolds made of natural, synthetic, and combined materials applied to spinal cord injury repair. Although these biomaterial scaffolds have shown a certain therapeutic effect in spinal cord injury repair, there are still many problems to be resolved, such as product standards and material safety and effectiveness.

关键词： nerve regeneration spinal cord injury regenerative biomaterials scaffolds tissue engineering regeneration transplantation combination functional recovery repair strategy microenvironment neural regeneration

Controlled Self-assembly of Thermo-responsive Amphiphilic H-shaped Polymer for Adjustable Drug Release

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Chinese Journal of Polymer Science 2018年第3期36卷 406-416页

作者： Yang Bai Fang-yuan xie Wei Tian College of Chemistry and Chemical Engineering Shaanxi University of Science and TechnologyXi'an 710021China Ministry of Education Key Laboratory of Material Physics and Chemistry under Extraordinary Conditions and Shaanxi Key Laboratory of Macromolecular Science and Technology School of ScienceNorthwestern Polytechnical UniversityXi’an 710072China Department of Pharmacy Eastern Hepatobiliary Surgery HospitalThe Second Military Medical UniversityShanghai 200438 China

Despite the fact that some progress has been made in the self-assembly of H-shaped polymers, the corresponding self-assemblies that respond to external stimulus and are further utilized to adjust the release of drugs are still deficient. The stimuli-responsive segments with amphiphilic H-shaped structure are generally expected to enhance the controllability of self-assembly process. The synthesis and self-assembly behavior of thermo-responsive amphiphilic H-shaped polymers with poly（ethylene glycol）（PEG）, polytetrahydrofuran （PTHF） and poly（N-isopropyl acrylamide）（PNIPAM） as building blocks are reported in this paper. The inner architecture structure and size of complex micelles formed by H-shaped self-assemblies were effectively adjusted when the solution temperature was increased above the lower critical solution temperature of PNIPAM segments. Furthermore, it was found that the architecture of self-assemblies underwent a transition from the complex micelles based on primary micelles with hybrid PEG/PNIPAM shells to large complex micelles based on primary micelles with hybrid PTHF/PNIPAM cores and PEG shells during the thermal-induced self-assembly process. The adjustable release rate ofdoxorubicin （DOX） from the DOX-loaded complex micelles and basic cell experiments further proved the feasibility of these self-assemblies as the thermal-responsive drug delivery system.

关键词： H-shaped polymer Thermo-responsive polymer Amphiphilic polymer Self-assembly Drug release

Comprehensive review of targeted therapy for colorectal cancer

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Signal Transduction and Targeted Therapy 2020年第1期5卷 2155-2184页

作者： yuan-Hong xie Ying-Xuan Chen Jing-yuan Fang Division of Gastroenterology and Hepatology Shanghai Institute of Digestive DiseaseState Key Laboratory for Oncogenes and Related GenesKey Laboratory of Gastroenterology&HepatologyMinistry of HealthRenji HospitalSchool of MedicineShanghai Jiao Tong University145 Middle Shandong Road200001 ShanghaiChina

Colorectal cancer(CRC)is among the most lethal and prevalent malignancies in the world and was responsible for nearly 881,000 cancer-related deaths in *** and chemotherapy have long been the first choices for cancer ***,the prognosis of CRC has never been satisfying,especially for patients with metastatic *** therapy is a new optional approach that has successfully prolonged overall survival for CRC *** successes with the anti-EGFR(epidermal growth factor receptor)agent cetuximab and the anti-angiogenesis agent bevacizumab,new agents blocking different critical pathways as well as immune checkpoints are emerging at an unprecedented *** worldwide are currently updating the recommended targeted drugs on the basis of the increasing number of high-quality clinical *** review provides an overview of existing CRC-targeted agents and their underlying mechanisms,as well as a discussion of their limitations and future trends.

关键词： Surgery drugs chemotherapy

Perfluoroalkylation of aromatic compounds with perfluoroalkyl radical generated from the oxidation of sodium perfluoroalkanesulfinate

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Chinese Journal of Chemistry 1990年第6期8卷 536-541页

作者： HUANG Wei-yuan xie yuan Shanghai Institute of Organic Chemistry Academia SinicaShanghai 200032

Sodium perfluoroalkanesulfinates [R_fSO_2Na(1), Rf=CI(CF_2)_n; a, n=4; b, n=6; c, n=8] on oxidation with various single eletron oxidizing agents, such as Mn (OAc)_3·2H_2O and Ce (SO_4)_2, yielded perfluoroalkyl radicals capable of perfluoroalkylating aromatic compounds to give a mixture of o-and p-monoperfluoroalkylated products. Thus, this reaction provides a new method for the synthesis of o-and p-monoperfluoroalkyl substituted aromatic compounds.

关键词： CF Hs CI ppm Perfluoroalkylation of aromatic compounds with perfluoroalkyl radical generated from the oxidation of sodium perfluoroalkanesulfinate

Fuzzy sliding mode control guidance law with terminal impact angle and acceleration constraints

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Journal of Systems Engineering and Electronics 2016年第3期27卷 664-679页

作者： Qingchun Li Wensheng Zhang Gang Han yuan xie Institute of Automation Chinese Academy of Sciences

In this paper, a novel fuzzy sliding mode control（FSMC） guidance law with terminal constraints of miss distance, impact angle and acceleration is presented for a constant speed missile against the stationary or slowly moving target. The proposed guidance law combines the sliding mode control algorithm with a fuzzy logic control scheme for the lag-free system and the first-order lag system. Through using Lyapunov stability theory, we prove the sliding surface converges to zero in finite time. Furthermore, considering the uncertain information and system disturbances, the guidance gains are on-line optimized by fuzzy logic technique. Numerical simulations are performed to demonstrate the performance of the FSMC guidance law and the results illustrate the validity and effectiveness of the proposed guidance law.

关键词： guidance law sliding mode control fuzzy logic impact angle

BACH： A Bandwidth-Aware Hybrid Cache Hierarchy Design with Nonvolatile Memories

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Journal of Computer Science & Technology 2016年第1期31卷 20-35页

作者： Jishen Zhao Cong Xu Tao Zhang yuan xie Department of Computer Engineering University of California at Santa Cruz Santa Cruz CA 95064 U.S.A. Hewlet-Packard Labs Palo Alto CA 94304 U.S.A. NVIDIA Corporation Santa Clara CA 95050 U.S.A. Department of Electrical and Computer Engineering University of California at Santa Barbara Santa Barbara CA 93106 U.S.A.

Limited main memory bandwidth is becoming a fundamental performance bottleneck in chipmultiprocessor （CMP） design. Yet directly increasing the peak memory bandwidth can incur high cost and power consumption. In this paper, we address this problem by proposing a memory, a bandwidth-aware reconfigurable cache hierarchy, BACH, with hybrid memory technologies. Components of our BACH design include a hybrid cache hierarchy, a reconfiguration mechanism, and a statistical prediction engine. Our hybrid cache hierarchy chooses different memory technologies with various bandwidth characteristics, such as spin-transfer torque memory （STT-MRAM）, resistive memory （ReRAM）, and embedded DRAM （eDRAM）, to configure each level so that the peak bandwidth of the overall cache hierarchy is optimized. Our reconfiguration mechanism can dynamically adjust the cache capacity of each level based on the predicted bandwidth demands of running workloads. The bandwidth prediction is performed by our prediction engine. We evaluate the system performance gain obtained by BACH design with a set of multithreaded and multiprogrammed workloads with and without the limitation of system power budget. Compared with traditional SRAM-based cache design, BACH improves the system throughput by 58% and 14% with multithreaded and multiprogrammed workloads respectively.

关键词： memory bandwidth hybrid cache reconfigurable cache nonvolatile memory