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Hepatitis A virus infection and hepatitis A vaccination in human immunodeficiency virus-positive patients: A review

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World Journal of Gastroenterology 2017年第20期23卷 3589-3606页

作者： Kuan-Yin Lin Guan-Jhou Chen Yu-Lin Lee Yi-Chia Huang Aristine Cheng Hsin-Yun Sun sui-yuan Chang Chun-Eng Liu Chien-Ching Hung Department of Medicine National Taiwan University Hospital Jin-Shan Branch Department of Internal Medicine National Taiwan University Hospital Department of Internal Medicine Changhua Christian Hospital National Taiwan University College of Medicine Department of Clinical Laboratory Sciences and Medical Biotechnology National Taiwan University College of Medicine Department of Laboratory Medicine National Taiwan University Hospital and National Taiwan University College of Medicine Department of Parasitology National Taiwan University College of Medicine Department of Medical Research China Medical University Hospital China Medical University

Hepatitis A virus(HAV)is one of the most common infectious etiologies of acute hepatitis *** virus is known to be transmitted fecal-orally,resulting in symptoms ranging from asymptomatic infection to fulminant *** can also be transmitted through oral-anal *** from regions of low endemicity for HAV infection often remain susceptible in their ***,clustered HAV infections or outbreaks of acute hepatitis A among men who have sex with men and injecting drug users have been reported in countries of low endemicity for HAV *** duration of HAV viremia and stool shedding of HAV may be longer in human immunodeficiency virus(HIV)-positive individuals compared to HIV-negative individuals with acute hepatitis *** guidelines recommend HAV vaccination for individuals with increased risks of exposure to HAV(such as from injecting drug use,oral-anal sex,travel to or residence in endemic areas,frequent clotting factor or blood transfusions)or with increased risks of fulminant disease(such as those with chronic hepatitis).The seroconversion rates following the recommended standard adult dosing schedule(2doses of HAVRIX 1440 U or VAQTA 50 U administered6-12 mo apart)are lower among HIV-positive individuals compared to HIV-negative *** the response rates may be augmented by adding a booster dose at week 4 sandwiched between the first dose and the 6-mo dose,the need of booster vaccination remain less clear among HIV-positive individuals who have lost anti-HAV antibodies.

关键词： Epidemiology Viral hepatitis Acute hepatitis Fecal-oral transmission Oral-anal sex Men who have sex with men Injecting drug use Immunosuppression Immunization

TrkA regulates the regenerative capacity of bone marrow stromal stem cells in nerve grafts

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Neural Regeneration Research 2019年第10期14卷 1765-1771页

作者： Mei-Ge Zheng Wen-yuan sui Zhen-Dan He Yan Liu Yu-Lin Huang Shu-Hua Mu Xin-Zhong Xu Ji-Sen Zhang Jun-Le Qu Jian Zhang Dong Wang Department of Orthopedics The Seventh Hospital of Sun Yat-sen UniversityShenzhenGuangdong ProvinceChina Department of Orthopedics The Second Hospital of Anhui Medical UniversityHefeiAnhui ProvinceChina School of Medicine Shenzhen UniversityShenzhenGuangdong ProvinceChina Department of Scientific Research The Seventh Hospital of Sun Yat-sen UniversityShenzhenGuangdong ProvinceChina Psychology & Social College of Shenzhen University ShenzhenGuangdong ProvinceChina Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Optoelectronic EngineeringShenzhen UniversityShenzhenGuangdong ProvinceChina

We previously demonstrated that overexpression of tropomyosin receptor kinase A(TrkA)promotes the survival and Schwann celllike differentiation of bone marrow stromal stem cells in nerve grafts,thereby enhancing the regeneration and functional recovery of the peripheral *** the present study,we investigated the molecular mechanisms underlying the neuroprotective effects of TrkA in bone marrow stromal stem cells seeded into nerve *** marrow stromal stem cells from Sprague-Dawley rats were infected with recombinant lentivirus vector expressing rat TrkA,TrkA-shRNA or the respective *** cells were then seeded into allogeneic rat acellular nerve allografts for bridging a 1-cm right sciatic nerve ***,8 weeks after surgery,hematoxylin and eosin staining showed that compared with the control groups,the cells and fibers in the TrkA overexpressing group were more densely and uniformly arranged,whereas they were relatively sparse and arranged in a disordered manner in the TrkA-shRNA *** blot assay showed that compared with the control groups,the TrkA overexpressing group had higher expression of the myelin marker,myelin basic protein and the axonal marker neurofilament *** TrkA overexpressing group also had higher levels of various signaling molecules,including TrkA,pTrkA(Tyr490),extracellular signal-regulated kinases 1/2(Erkl/2),pErk1/2(Thr202/Tyr204),and the anti-apoptotic proteins Bcl-2 and *** contrast,these proteins were downregulated,while the pro-apoptotic factors Bax and Bad were upregulated,in the TrkA-shRNA *** levels of the TrkA effectors Akt and pAkt(Ser473)were not different among the *** results suggest that TrkA enhances the survival and regenerative capacity of bone marrow stromal stem cells through upregulation of the Erk/Bcl-2 *** procedures were approved by the Animal Ethical and Welfare Committee of Shenzhen University,China in December 2014(approval ***-2014-001219).

关键词： nerve regeneration bone marrow stromal stem cells tropomyosin receptor kinase A receptor lentiviral vector shRNA extracellular signal-regulated protein kinases 1/2 Bcl-2 nerve grafts peripheral nerve regeneration survival neural regeneration

Recently acquired hepatitis C virus infection among people living with human immunodeficiency virus at a university hospital in Taiwan

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World Journal of Gastroenterology 2021年第37期27卷 6277-6289页

作者： Miao-Hui Huang Hsin-Yun Sun Shu-yuan Ho sui-yuan Chang Szu-Min Hsieh Wang-Huei Sheng Yu-Chung Chuang Yu-Shan Huang Li-Hsin Su Wen-Chun Liu Yi-Ching Su Chien-Ching Hung Department of Internal Medicine Hualien Tzu Chi HospitalBuddhist Tzu Chi Medical Foundation and Tzu Chi UniversityHualien 970410Taiwan Department of Internal Medicine National Taiwan University Hospital and National Taiwan University College of MedicineTaipei 100008Taiwan Department of Laboratory Medicine National Taiwan University Hospital and National Taiwan University College of MedicineTaipei 100008Taiwan Department of Clinical Laboratory Sciences and Medical Biotechnology National Taiwan University College of MedicineTaipei 100233Taiwan Department of Tropical Medicine and Parasitology National Taiwan University College of MedicineTaipei 100233Taiwan Department of Medical Research China Medical University Hospital and China Medical UniversityTaichung 404394Taiwan

BACKGROUND Little is known about the engagement in hepatitis C virus(HCV)care and completion of HCV treatment in people living with human immunodeficiency virus(HIV)(PLWH)who have HCV coinfection in the Asia-Pacific *** the HCV care cascade can identify barriers to the completion of HCV treatment and facilitate achievement of HCV micro-elimination in *** To investigate the care cascade of incident HCV infections among PLWH in *** PLWH with incident HCV infections,defined as HCV seroconversion,were retrospectively identified by sequential anti-HCV testing of all archived blood samples at National Taiwan University Hospital between 2011 and *** PLWH with incident HCV infections were followed until December 31,*** care cascade of HCV examined included all incident HCV-infected patients,the percentages of anti-HCV antibodies detected by HIV-treating physicians in clinical care,plasma HCV RNA load tested,HCV RNA positivity diagnosed,referral to treatment assessment made,anti-HCV treatment initiated,and sustained virologic response *** who had HCV seroconversion during the interferon(IFN)era(2011–2016)and the direct-acting antiviral(DAA)era(2017–2018)were analyzed *** duration of HCV viremia—from the date of seroconversion to viral clearance by treatments or until the end of observation—and the incidence of sexually transmitted infections(STIs)during the HCV viremic period were *** During the study period,287 of 3495(8.2%)PLWH(92.3%being men who have sex with men)who were HCV-seronegative at baseline developed HCV seroconversion by retrospective testing of all archived blood *** the 287 incident HCV infections,277(96.5%)had anti-HCV antibodies detected by HIV-treating physicians,270(94.1%)had plasma HCV RNA determined and 251(87.5%)tested positive for HCV *** those with HCV viremia,226(78.7%)were referred to treatment assessment,215(74.9%)initiated anti-HCV treatment,and 202(70.4%)achieve

关键词： Recent hepatitis C virus infection Cascade of care Direct-acting antivirals People living with human immunodeficiency virus Sustained virologic response Sexually transmitted infections

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基于叶绿素荧光光谱指数的温室黄瓜病害预测

光谱学与光谱分析 2016年第6期36卷 1779-1782页

作者：隋媛媛王庆钰于海业吉林大学生物与农业工程学院吉林长春130022 吉林大学植物科学学院吉林长春130022

温室蔬菜病害的发生及大面积流行严重影响设施农业的生产管理,大大降低设施农业的经济效益。为了实现温室蔬菜病害的无损准确预测,以黄瓜霜霉病害为例,利用激光诱导叶绿素荧光构建光谱特征指数,建立了温室蔬菜病害的预测模型。在试验中... 详细信息

温室蔬菜病害的发生及大面积流行严重影响设施农业的生产管理,大大降低设施农业的经济效益。为了实现温室蔬菜病害的无损准确预测,以黄瓜霜霉病害为例,利用激光诱导叶绿素荧光构建光谱特征指数,建立了温室蔬菜病害的预测模型。在试验中采用对比分析的方法,通过对作物健康叶片接种病菌孢子,分别采集健康、接种2d、接种6d和出现明显病症共4组试验样本的光谱曲线,定性分析了荧光强度随叶片样本感染病菌孢子的变化规律;利用光谱曲线不同波段峰谷值创建了叶绿素荧光光谱指数k_1=F_(685)/F^(512)和k_2=F_(734)/F^(512),根据数值的变化范围,设定k_1和k_2分别为20和10时可以作为判断样本出现明显病症与未出现明显病症的特征值,其判断的准确率分别达到96%和94%;利用构建的光谱指数与样本健康状况的分类结果,选择光谱指数F_(685)/F^(512),F_(685)-F_(734),F_(715)/F_(612)可以定性判断样本健康状况,并选择光谱指数F_(685)/F^(512),F_(734)/F^(512),F_(685)-F_(734),F_(715)/F_(612)作为建立定量分析模型的输入量,以预测集分类准确率作为评价标准,对比判别分析、BP神经网络、支持向量机三种数据建模方法,结果表明支持向量机作为霜霉病害预测的建模方法,其预测能力达到91.38%。利用激光诱导叶绿素荧光构建光谱指数方法,研究植物病害的预测问题,具有很好的分类和鉴别效果。

关键词：光谱指数病害预测叶绿素荧光支持向量机

High pressure EIGA preparation and 3D printing capability of Ti-6Al-4V powder

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Transactions of Nonferrous Metals Society of China 2020年第1期30卷 147-159页

作者： Kuai-kuai GUO Chang-sheng LIU sui-yuan CHEN Huan-huan DONG Si-yu WANG School of Material Science and Engineering Northeastern UniversityShenyang 110819China Key Laboratory for Laser Application Technology and Equipment of Liaoning Province Northeastern UniversityShenyang 110819China

Ti-6 Al-4 V alloy powder was processed by electrode induction melting gas atomization(EIGA)at high gas pressure(5.5-7.0 MPa).The effects of atomizing gas pressure on the powder characteristics and the microstructure,along with the mechanical properties of the as-fabricated block by laser melting deposition(LMD),were *** results indicate that the diameters of powders are distributed in a wide range of sizes from 1 to 400μm,and the median powder size(d50)decreases with increasing gas *** powders with a size fraction of 100-150μm obtained at gas pressures of 6.0 and 6.5 MPa have better *** oxygen content is consistent with the change trend of gas pressure within a low range of 0.06%-0.20%.Specimens fabricated by LMD are mainly composed ofα+βgrains with a fine lamellar Widmanstatten structures and have the ultimate tensile strength(UTS)and yield strength of approximately 1100 and 1000 MPa,***,the atomized powders have a favorable 3 D printing capability,and the mechanical properties of Ti-6 Al-4 V alloys manufactured by LMD typically exceed those of their cast or wrought counterparts.

关键词： Ti-6Al-4V powder high pressure gas atomization particle size flowability 3D printing capability

Analysis of long non-coding RNAs and mRNAs in harvested kiwifruit in response to the yeast antagonist,Wickerhamomyces anomalus

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Analysis of long non-coding RNAs and mRNAs in harvested kiwi...

共在时空下的电子文本游戏——虚拟主体的符号化生存探析(之一)

中国植物病理学会2021年学术年会

作者： ZHAO Qianhua YANG Qiya WANG Zhenshuo sui yuan WANG Qi LIU Jia ZHANG Hongyin School of Food and Biological Engineering Jiangsu University Department of Plant Pathology MOA Key Lab of Pest Monitoring and Green ManagementCollege of Plant ProtectionChina Agricultural University Chongqing Key Laboratory of Economic Plant Biotechnology College of Landscape Architecture and Life Science/Institute of Special PlantsChongqing University of Arts and Sciences

Biological control utilizing antagonistic yeasts is an effective method for controlling postharvest *** non-coding RNAs（lncRNAs） have been found to be involved in a variety of plant growth and development processes,including those associated with plant disease *** the present study,the yeast antagonist,Wickerhamomyces anomalus,was found to strongly inhibit postharvest blue mold（Pencillium expansum） and gray mold（Botrytis cinerea） decay of ***,lncRNA high-throughput sequencing and bioinformatics analysis was used to identify lncRNAs in ***-treated wounds in kiwifruit and predict their function based on putative target *** results indicate that lncRNAs may be involved in activating ethylene（ET）,jasmonic acid（JA）,abscisic acid（ABA）,auxin（IAA） and signal transduction pathways that regulate the expression of several transcription factors（WRKY72,WRKY53,BHLH167,BHLH162,ZIP3,AP2）.These transcription factors（TFs） then mediate the expression of downstream,defense-related genes（ZAR1,PAD4,CCR4,NPR4） and the synthesis of secondary metabolites,thus,potentially enhancing disease ***,by stimulating the accumulation of antifungal compounds such as phenols and lignin,the antifungal ability of kiwifruit was also *** study provides new information on the mechanism of disease resistance induced by *** in kiwifruit,as well as a new disease resistance strategy that can be used to enhance the defense response of fruit to pathogenic fungi.

关键词： Kiwifruit lncRNAs Postharvest disease Resistance Wickerhamomyces anomalus

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湘潭大学学报（哲学社会科学版） 2011年第2期35卷 111-114页

作者：樊昌志袁佳穗惠州学院中文系广东惠州516007 湘潭大学文学与新闻学院湖南湘潭411105

E时代来临,互联网得到普及。数字技术背景下,广大网民在超时空传播环境中"心临其境",以电子符号为表征,通过"我说故我在"的符号化生存方式浸淫于电子文本游戏当中。从网络技术中介的视角看,赛伯空间独特的时空构成,造就了虚拟个体在虚... 详细信息

E时代来临,互联网得到普及。数字技术背景下,广大网民在超时空传播环境中"心临其境",以电子符号为表征,通过"我说故我在"的符号化生存方式浸淫于电子文本游戏当中。从网络技术中介的视角看,赛伯空间独特的时空构成,造就了虚拟个体在虚拟环境下的符号化生存形态。

关键词：时空共在媒介技术电子文本游戏

LC4表面纳米SiC和PTFE双颗粒复合阳极氧化膜的制备

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东北大学学报（自然科学版） 2013年第3期34卷 352-355页

作者：陈岁元王静梁京刘常升东北大学材料各向异性与织构教育部重点实验室辽宁沈阳110819

以250 g/L硫酸+15 g/L草酸为基础电解液,通过添加2 g/L表面改性的纳米SiC颗粒和15 ml/L PTFE乳液,组成双颗粒复合阳极氧化电解液,利用脉冲电源在LC4铝合金表面制备双颗粒复合的阳极氧化膜.结果表明:在脉冲电源频率80 Hz、占空比80%、电... 详细信息

以250 g/L硫酸+15 g/L草酸为基础电解液,通过添加2 g/L表面改性的纳米SiC颗粒和15 ml/L PTFE乳液,组成双颗粒复合阳极氧化电解液,利用脉冲电源在LC4铝合金表面制备双颗粒复合的阳极氧化膜.结果表明:在脉冲电源频率80 Hz、占空比80%、电流密度3 A/dm2、温度0℃、氧化时间40 min等条件下,在LC4铝合金表面成功制备出厚度为20μm,硬度为4 340 MPa的双颗粒复合的Al2O3-SiC-PTFE阳极氧化膜;复合氧化膜结构中存在着大量的微米级的孔隙缺陷为复合沉积双颗粒提供了复合场所,形成了具有纳米SiC颗粒增强膜的硬度和PTFE颗粒增强膜的自润滑性能的双颗粒复合氧化膜.

关键词： LC4铝合金复合阳极氧化颗粒增强氧化膜结构硬度

Neuronal apoptosis and neurofilament protein expression in the lateral geniculate body of cats following acute optic nerve injuries

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Neural Regeneration Research 2007年第10期2卷 577-581页

作者： Feng Yu Shao ji yuan Gang sui Rong wei Zhang Zi sheng Liu Pei gang Lu Department of Neurosurgery General Hospital of Ji＇nan Military Area Command of Chinese PLAJi＇nan 250031Shandong ProvinceChina

The visual pathway have 6 parts, involving optic nerve, optic chiasm, optic tract, lateral geniculate body, optic radiation and cortical striatum area. Corresponding changes may be found in these 6 parts following optic nerve injury. At present, studies mainly focus on optic nerve and retina, but studies on lateral geniculate body are few. OBJECTIVE： To prepare models of acute optic nerve injury for observing the changes of neurons in lateral geniculate body, expression of neurofilament protein at different time after injury and cell apoptosis under the optical microscope, and for investigating the changes of neurons in lateral geniculate body following acute optic nerve injury. DESIGN： Completely randomized grouping design, controlled animal experiment. SETTING： Department of Neurosurgery, General Hospital of Ji＇nan Military Area Command of Chinese PLA. MATERIALS： Twenty-eight adult healthy cats of either gender and common grade, weighing from 2.0 to 3.5 kg, were provided by the Animal Experimental Center of Fudan University. The involved cats were divided into 2 groups according to table of random digit： normal control group （n=3） and model group （n=25）. Injury 6 hours, l, 3, 7 and 14 days five time points were set in model group for later observation, 5 cats at each time point. TUNEL kit （Bohringer-Mannheim company ）and NF200＆ Mr 68 000 mouse monoclonal antibody （NeoMarkers Company） were used in this experiment. METHODS： This experiment was carded out in the Department of Neurosurgery, General Hospital of Ji＇nan Military Area Command of Chinese PLA between June 2004 and June 2005.① The cats of model group were developed into cat models of acute intracranial optic nerve injury as follows： The anesthetized cats were placed in lateral position. By imitating operation to human, pterion approach was used. An incision was made at the joint line between outer canthus and tragus, and deepened along cranial base until white optic nerve via optic nerve pore and further to

关键词： optic nerve injuries lateral geniculate bodies apoptosis neurofilament proteins