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Deep genome skimming reveals the hybrid origin of Pseudosasa gracilis (Poaceae: Bambusoideae)

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Plant Diversity 2024年第3期46卷 344-352页

作者： Xiang-Zhou Hu Cen Guo sheng-yuan Qin De-Zhu Li Zhen-Hua Guo Germplasm Bank of Wild Species Kunming Institute of BotanyChinese Academy of SciencesKunmingYunnan 650201China University of Chinese Academy of Sciences Beijing 100049China

Pseudosasa gracilis(Poaceae:Bambusoideae)is a temperate woody bamboo species endemic to Southcentral China with a narrow *** phylogenetic studies revealed an unexpected,isolated phylogenetic position of *** we conducted phylogenomic analysis by sampling populations of *** and its sympatric species *** and Sinosasa polytricha reflecting different genomic signals,by deep genome *** molecular evidence from chloroplast genes and genome-wide SNPs,we deciphered the phylogenetic relationships of *** plastid and nuclear data indicate that *** is more closely related to Sinosasa,which is discordant with the taxonomic *** further explore this molecular-morphological conflict,we screened 411“perfect-copy”syntenic genes to reconstruct phylogenies using both the concatenation and coalescent *** observed extensive discordance between gene trees and the putative species tree.A significant hybridization event was detected based on 411 genes from the D subgenome,showing *** was a hybrid descendant between Sinosasa longiligulata and ***,with 63.56%and 36.44%inheritance probabilities of each ***,introgression events were detected in the C subgenome between *** and *** in the same distribution *** findings suggest that sympatric hybridization and introgression play a crucial role in the origin of *** providing an empirical example of bamboo of hybrid origin using comprehensive analyses based on genomic data from different inheritance systems and morphological characters,our study represents a step forward in understanding of reticulate evolution of bamboos.

关键词： Phylogenomics Hybridization Introgression Pseudosasa gracilis Pseudosasa Sinosasa

New clinical trial design in precision medicine:discovery,development and direction

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1293-1321页

作者： Xiao-Peng Duan Bao-Dong Qin Xiao-Dong Jiao Ke Liu Zhan Wang yuan-sheng Zang Department of Medical Oncology Changzheng HospitalNaval Medical UniversityShanghaiChina

In the era of precision medicine,it has been increasingly recognized that individuals with a certain disease are complex and different from each *** to the underestimation of the significant heterogeneity across participants in traditional"one-sizefits-all"trials,patient-centered trials that could provide optimal therapy customization to individuals with specific biomarkers were developed including the basket,umbrella,and platform trial designs under the master protocol *** recent years,the successive FDA approval of indications based on biomarker-guided master protocol designs has demonstrated that these new clinical trials are ushering in tremendous *** the rapid increase in the number of basket,umbrella,and platform trials,the current clinical and research understanding of these new trial designs,as compared with traditional trial designs,remains *** majority of the research focuses on methodologies,and there is a lack of in-depth insight concerning the underlying biological logic of these new clinical trial ***,we provide this comprehensive review of the discovery and development of basket,umbrella,and platform trials and their underlying logic from the perspective of precision ***,we discuss future directions on the potential development of these new clinical design in view of the"Precision Pro","Dynamic Precision",and"Intelligent Precision".This review would assist trial-related researchers to enhance the innovation and feasibility of clinical trial designs by expounding the underlying logic,which be essential to accelerate the progression of precision medicine.

关键词： clinical approval successive

Selective photosynthesis of Z-olefins through crystalline metal-organic cage-initiated expeditious cascade reactions

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Carbon Energy 2024年第3期6卷 118-131页

作者： Jia-Ni Lu Yunze Huang yuan-sheng Xia Long-Zhang Dong Lei Zhang Jing-Jing Liu Lan-Gui Xie Jiang Liu Ya-Qian Lan Jiangsu Key Laboratory of New Power Batteries School of Chemistry and Materials ScienceJiangsu Collaborative Innovation Centre of Biomedical Functional MaterialsNanjing Normal UniversityNanjingChina School of Chemistry South China Normal UniversityGuangzhouChina

The semi-hydrogenation of alkyne to form Z-olefins with high conversion and high selectivity is still a huge challenge in the chemical ***,flammable and explosive hydrogen as the common hydrogen source of this reaction increases the cost and danger of industrial ***,we connect the photocatalytic hydrogen evolution reaction and the semihydrogenation reaction of alkynes in series and successfully realize the high selective production of Z-alkenes using low-cost,safe,and green water as the proton *** the cascade reaction,a series of isomorphic metal–organic cage catalysts(Co_(x)Zn_(8−x)L_(6),x=0,3,4,5,and 8)are designed and synthesized to improve the yield of the photocatalytic hydrogen *** them,Co_(5)Zn_(3)L_(6) shows the highest photocatalytic activity,with a H_(2) generation rate of 8.81 mmol g^(−1) h^(−1).Then,Co_(5)Zn_(3)L_(6) is further applied in the above tandem reaction to efficiently reduce alkynes to Z-alkenes under ambient conditions,which can reach high conversion of>98%and high selectivity of>99%,and maintain original catalytic activity after multiple ***“one-pot”tandem reaction can achieve a highly selective and safe stepwise conversion from water into hydrogen into Z-olefins under mild reaction conditions.

关键词： alkyne semi-hydrogenation hydrogen evolution reaction metal-organic cages photocatalysis Z-olefins

Development and validation of a model integrating clinical and coronary lesion-based functional assessment for longterm risk prediction in PCI patients

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Journal of Geriatric Cardiology 2024年第1期21卷 44-63页

作者： Shao-Yu WU Rui ZHANG sheng yuan Zhong-Xing CAI Chang-Dong GUAN Tong-Qiang ZOU Li-Hua XIE Ke-Fei DOU State Key Laboratory of Cardiovascular Disease BeijingChina Cardiometabolic Medicine Center Fu Wai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Catheterization Laboratories Fu Wai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Cardiology Fu Wai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

OBJECTIVES To establish a scoring system combining the ACEF score and the quantitative blood flow ratio(QFR) to improve the long-term risk prediction of patients undergoing percutaneous coronary intervention(PCI).METHODS In this population-based cohort study, a total of 46 features, including patient clinical and coronary lesion characteristics, were assessed for analysis through machine learning models. The ACEF-QFR scoring system was developed using 1263consecutive cases of CAD patients after PCI in PANDA Ⅲ trial database. The newly developed score was then validated on the other remaining 542 patients in the *** In both the Random Forest Model and the Deep Surv Model, age, renal function(creatinine), cardiac function(LVEF)and post-PCI coronary physiological index(QFR) were identified and confirmed to be significant predictive factors for 2-year adverse cardiac events. The ACEF-QFR score was constructed based on the developmental dataset and computed as age(years)/EF(%) + 1(if creatinine ≥ 2.0 mg/d L) + 1(if post-PCI QFR ≤ 0.92). The performance of the ACEF-QFR scoring system was preliminarily evaluated in the developmental dataset, and then further explored in the validation dataset. The ACEF-QFR score showed superior discrimination(C-statistic = 0.651;95% CI: 0.611-0.691, P < 0.05 versus post-PCI physiological index and other commonly used risk scores) and excellent calibration(Hosmer–Lemeshow χ^(2)= 7.070;P = 0.529) for predicting 2-year patient-oriented composite endpoint(POCE). The good prognostic value of the ACEF-QFR score was further validated by multivariable Cox regression and Kaplan–Meier analysis(adjusted HR = 1.89;95% CI: 1.18–3.04;log-rank P < 0.01) after stratified the patients into high-risk group and low-risk *** An improved scoring system combining clinical and coronary lesion-based functional variables(ACEF-QFR)was developed, and its ability for prognostic prediction in patients with PCI was further validated to be signi

关键词： patients coronary prediction

Plexin domain-containing 1 may be a biomarker of poor prognosis in hepatocellular carcinoma patients,may mediate immune evasion

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 2091-2112页

作者： Ming-Yue Tang Xue Shen Run-sheng yuan Hui-yuan Li Xin-Wei Li Yi-Ming Jing Yue Zhang Hong-Hong Shen Zi-Shu Wang Lei Zhou Yun-Chuan Yang He-Xin Wen Fang Su Department of Medical Oncology The First Affiliated Hospital of Bengbu Medical CollegeBengbu 233000Anhui ProvinceChina Otolaryngology and Head and Neck Surgery The First Affiliated Hospital of Bengbu Medical CollegeBengbu 233000Anhui ProvinceChina Department of Neurology The First Affiliated Hospital of Bengbu Medical CollegeBengbu 233000Anhui ProvinceChina Department of Hepatobiliary Surgery The First Affiliated Hospital of Bengbu Medical CollegeBengbu 233000Anhui ProvinceChina Department of Gastrointestinal Surgery The First Affiliated Hospital of Bengbu Medical CollegeBengbu 233000Anhui ProvinceChina

BACKGROUND For the first time,we investigated the oncological role of plexin domain-containing 1(PLXDC1),also known as tumor endothelial marker 7(TEM7),in hepatocellular carcinoma(HCC).AIM To investigate the oncological profile of PLXDC1 in *** Based on The Cancer Genome Atlas database,we analyzed the expression of PLXDC1 in *** immunohistochemistry,quantitative real-time polymerase chain reaction(qRT-PCR),and Western blotting,we validated our *** prognostic value of PLXDC1 in HCC was analyzed by assessing its correlation with clinicopathological features,such as patient survival,methylation level,tumor immune microenvironment features,and immune cell surface checkpoint ***,to assess the immune evasion potential of PLXDC1 in HCC,we used the tumor immune dysfunction and exclusion(TIDE)website and immunohistochemical staining *** Based on immunohistochemistry,qRT-PCR,and Western blot assays,overexpression of PLXDC1 in HCC was associated with poor *** and multivariate Cox analyses indicated that PLXDC1 might be an independent prognostic *** HCC patients with high methylation levels,the prognosis was worse than in patients with low methylation *** enrichment analysis of HCC tissues indicated that genes upregulated in the high-PLXDC1 subgroup were enriched in mesenchymal and immune activation signaling,and TIDE assessment showed that the risk of immune evasion was significantly higher in the high-PLXDC1 subgroup compared to the low-PLXDC1 *** high-risk group had a significantly lower immune evasion rate as well as a poor prognosis,and PLXDC1-related risk scores were also associated with a poor *** As a result of this study analyzing PLXDC1 from multiple biological perspectives,it was revealed that it is a biomarker of poor prognosis for HCC patients,and that it plays a role in determining immune evasion status.

关键词： Plexin domain-containing 1 Biomarker Immune evasion Prognosis Immunotherapy Hepatocellular carcinoma

Temporal lobe malacia as a rare cause of gelastic seizure:A case report

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World Journal of Clinical Cases 2024年第20期12卷 4440-4445页

作者： yuan-sheng Liao Li-Li Gao Min Lin Cheng-Han Wu Department of Neurology The Second Affiliated Hospital of Fujian Traditional Chinese Medical UniversityFuzhou 350003Fujian ProvinceChina

BACKGROUND Gelastic seizure(GS)is a rare type of epilepsy that most commonly appears in patients with hypothalamic *** is rarely associated with other types of brain *** particular type of epilepsy is relatively rare and has few links to other brain *** lobe malacia is mostly caused by cerebral infarction or cerebral hemorrhage,which can lead to *** report a case of GS in a woman with temporal lobe malacia which was reported for the first time in the *** SUMMARY A 73-year-old female,diagnosed case of GS,presented with repetitive stereotyped laughter a month prior to presentation,happening multiple times daily and with each time lasting for *** displayed a focal seizure seen in the right temporal *** resonance imaging head with contrast showed a right temporal lobe *** patient was started on levetiracetam *** patient indicated that they had fully recovered and were not experiencing any recurrent or stereotyped laughter during their daily *** results remained consistent even after a one-year follow-up *** GS can be caused by temporal lobe malacia,which is an uncommon but potentially grave *** outcome of this present case exhibited the importance of the temporal lobe in the genesis of GS.

关键词： Epilepsy Gelastic seizure Malacia Temporal lobe Cerebral ischemia Case report

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音乐评论与争鸣

人民音乐 2024年第2期 84-86页

作者：盛原中央音乐学院钢琴系

“巴赫的作品自然不足,浮夸和混淆有余,它的美感被过多地雕琢掩盖……人们为巴赫工作之异常努力感到惊叹,但是这一切都是徒劳,因为他的作品无法让人理解。”“……对胡梅尔的《钢琴练习详解》,我也开始怀疑,作为一位优秀的演奏家,在当... 详细信息

“巴赫的作品自然不足,浮夸和混淆有余,它的美感被过多地雕琢掩盖……人们为巴赫工作之异常努力感到惊叹,但是这一切都是徒劳,因为他的作品无法让人理解。”“……对胡梅尔的《钢琴练习详解》,我也开始怀疑,作为一位优秀的演奏家,在当时对于那些追随他的人来说是否是最好的教师。很多东西是有用的,也有很多是无目的、仅仅是垫充的;有些是好的忠告,也有很多简直是荒谬可笑……我没有认识到的是,胡梅尔完全没有跟上时代。”

关键词：音乐评论钢琴练习胡梅尔巴赫演奏家

PPC斜拉桥主梁多状态疲劳及疲劳后静力性能试验研究

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土木工程学报 2024年第6期57卷 169-179,189页

作者：袁晟颜东煌刘昀彭坤帅郭鑫袁明长沙理工大学湖南长沙410114 湖南交通职业技术学院湖南长沙410132

为研究大跨径部分预应力混凝土(PPC)斜拉桥主梁的抗疲劳性能,进一步探究混凝土斜拉桥主梁采用部分预应力设计的可行性及合理性,制作了斜拉桥缩尺节段模型,并对主梁采用部分预应力设计,开展4轮共4×250万次主梁具有不同初始损伤及带裂缝... 详细信息

为研究大跨径部分预应力混凝土(PPC)斜拉桥主梁的抗疲劳性能,进一步探究混凝土斜拉桥主梁采用部分预应力设计的可行性及合理性,制作了斜拉桥缩尺节段模型,并对主梁采用部分预应力设计,开展4轮共4×250万次主梁具有不同初始损伤及带裂缝工作状态下的疲劳试验;疲劳试验结束后,以4种不同主梁裂缝宽度(0.1mm、0.2mm、0.3mm和0.5mm)为控制工序,反复加载一定倍数的等效活载至主梁裂缝宽度逐步达到0.5mm,以全面研究PPC斜拉桥主梁多状态疲劳后的受力性能。试验结果表明:在等效设计疲劳荷载作用下,主梁无初始损伤时,体系刚度基本无退化,主梁最大裂缝宽度预损伤分别为0.1mm、0.2mm时,跨中截面体系刚度下降量仅为3.35%、4.44%,且未发现裂缝张开;主梁带裂缝工作状态下,跨中截面体系刚度平缓下降7.46%,上峰值静载下,裂缝数量及高度略有增加,但卸载后裂缝均闭合,说明PPC斜拉桥具有良好的抗疲劳性能;疲劳后主梁大损伤静载试验中,主梁裂缝平稳发展,各工序反复加载过程中,主梁挠度、裂缝状态及斜拉索索力均具有较好的恢复能力,当主梁最大裂缝宽度为0.5mm时,荷载达到了7.49倍活载,斜拉桥体系仍然具有较大的剩余承载力。该文试验研究结果表明混凝土斜拉桥主梁采用部分预应力设计具有工程应用的可行性。

关键词：混凝土斜拉桥部分预应力疲劳性能静力性能模型试验

受损PPC斜拉桥主梁灌缝加固后疲劳性能试验研究

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中南大学学报（自然科学版） 2024年第3期55卷 1068-1081页

作者：袁晟颜东煌王文熙刘昀潘权袁明长沙理工大学土木工程学院湖南长沙410114 长沙理工检测咨询有限责任公司湖南长沙410076 湖南大学土木工程学院湖南长沙410082 湖南交通职业技术学院路桥工程学院湖南长沙410132

为进一步研究受损部分预应力混凝土(PPC)斜拉桥主梁裂缝灌浆加固后的疲劳性能,对受较大疲劳及静力损伤的PPC斜拉桥节段缩尺模型主梁进行裂缝灌浆加固,并开展疲劳及疲劳后静载试验研究。研究结果表明:在疲劳荷载作用下,灌浆裂缝未重新开... 详细信息

为进一步研究受损部分预应力混凝土(PPC)斜拉桥主梁裂缝灌浆加固后的疲劳性能,对受较大疲劳及静力损伤的PPC斜拉桥节段缩尺模型主梁进行裂缝灌浆加固,并开展疲劳及疲劳后静载试验研究。研究结果表明:在疲劳荷载作用下,灌浆裂缝未重新开裂,在疲劳加载初期(约20万次),结构体系刚度下降较快,后期下降较平缓;250万次疲劳加载后,主梁L/4、L/2和3L/4截面处的结构体系刚度分别降低12.83%、9.48%、13.62%,较原主梁第4轮疲劳加载下结构体系刚度下降幅度大,但疲劳结束时结构体系刚度仍然比原主梁第4轮疲劳加载初始结构体系刚度大;对裂缝进行灌浆处置能有效恢复PPC斜拉桥主梁的抗裂强度及结构体系刚度;随着荷载增大,灌浆裂缝逐步张开,但最大裂缝宽度对应位置发生转移,同时不断有新裂缝产生,且裂缝分布区域范围增大,环氧树脂胶的作用极大地延缓了裂缝宽度的增大,提高了主梁的抗裂性能;环氧树脂胶不仅能修复混凝土裂缝界面,同时能有效恢复钢筋与混凝土间的黏结滑移损伤;对受严重损伤的PPC斜拉桥主梁仅进行裂缝灌浆处置后,主梁仍然具有良好的抗疲劳性能,同时,其疲劳后的抗裂性能及刚度也得到较大恢复。

关键词：桥梁工程混凝土斜拉桥部分预应力灌缝加固疲劳性能模型试验