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World Journal of Clinical Oncology 2025年第2期16卷 18-28页

作者： zhong-yuan Hu Ding Ding Yu Song Ya-Feng Deng Cheng-Ming Zhang Tao Yu First School of Clinical Medicine Shaanxi University of Chinese MedicineXianyang 712000Shaanxi ProvinceChina College of Acupuncture and Massage Shaanxi University of Chinese MedicineXianyang 712000Shaanxi ProvinceChina Graduate School Guangzhou University of Chinese MedicineGuangzhou 510000Guangdong ProvinceChina Digestive Department I Shaanxi Provincial Hospital of Traditional Chinese MedicineXi’an 710000Shaanxi ProvinceChina

Pancreatic ductal adenocarcinoma stands out as an exceptionally fatal cancer owing to the complexities associated with its treatment and diagnosis,leading to a notably low five-year survival *** study offers a detailed exploration of epidemiological trends in pancreatic cancer and key molecular drivers,such as mutations in CDKN2A,KRAS,SMAD4,and TP53,along with the influence of cancer-associated fibroblasts(CAFs)on disease *** particular,we focused on the pivotal roles of signaling pathways such as the transforming growth factor-βand Wnt/β-catenin pathways in the development of pancreatic cancer and investigated their application in emerging therapeutic *** study provides new scientific perspectives on pancreatic cancer treatment,especially in the development of precision medicine and targeted therapeutic strategies,and demonstrates the importance of signaling pathway research in the development of effective therapeutic *** studies should explore the subtypes of CAFs and their specific roles in the tumor microenvironment to devise more effective therapeutic methods.

关键词： Pancreatic cancer Fibroblasts Signaling pathways Tumor microenvironment

On the Existence of Solutions for an Elliptic System of Equations with Arbitrary Order Growth

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Acta Mathematicae Applicatae Sinica 2013年第2期29卷 415-424页

作者： zhong-yuan LIU Academy of Mathematics and Systems Science Chinese Academy of Sciences

Let BR be the ball centered at the origin with radius R in RN （N≥2）. In this paper we study the existence of solution for the following elliptic systemwhere λ 〉 0,μ 〉 0 p ≥ 2, q ≥ 2, u is the unit outward normal at the boundary OBR. Under certain assumptions on K（｜x｜）, using variational methods, we prove the existence of a positive and radially increasing solution for this problem without growth conditions on the nonlinearity.

关键词： elliptic system Nehari manifold variational method

Large number of bubble solutions for the equation ?u + K(y)u^((N+2)/(N- 2)± ε)= 0 on R^N

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Science China Mathematics 2016年第3期59卷 459-478页

作者： LIU zhong yuan School of Mathematics and Statistics Henan University

This paper concerns the following nonlinear elliptic equation:{?u + K(y)u^((N+2)/(N-2)±ε)= 0, u > 0, y ∈ R^N,u ∈ D^(1,2)(R^N),where ε > 0, N≥5, K(y) is positive and radially symmetric. We show that, under some local conditions on K(y), this problem has large number of bubble solutions if ε is small enough. Moreover, for each m ∈ [2, N- 2),there exists solutions whose functional energy is in the order of ε^(-(N-2-m)/((N-2)~2)).

关键词： bubble solutions critical Sobolev exponent finite dimensional reduction

Newtonian Limit in Generalized Brans-Dicke Theory

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Chinese Physics Letters 1993年第9期10卷 513-515页

作者： ZHANG yuan zhong Internatiojial Centre for Theoretical Physics TriesteItaly and Institute of Theoretical PhysicsAcademia SinicaBeijing 100080

Newtonian limit in the generalised Jorclan-Brans-Dicke theory is discussed,and some ambiguities are clarified.

关键词： Brans Dicke Newtonian

Neuromodulation of Chemical Synaptic Transmission Driven by THz Photons

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Research 2023年第3期2022卷 221-228页

作者： Xiaoxuan Tan yuan zhong Ruijie Li Chao Chang Innovation Laboratory of Terahertz Biophysics National Innovation Institute of Defense Technology.Beijing 100071China Astronaut Center of China Beijing 100084China Department of Engineering Physics Tsinghua UniversityBeijing 100084China Brain Research Center and State Key Laboratory of Trauma Burnsand Combined InjuryThird Military Medical UniversityChongqing 400038China

Postsynaptic currents of chemical synapse are modulated by multitudinous neurotransmitters,such as acetylcholine,dopamine,glutamate,andγ-aminobutyric acid,many of which have been used in the treatment of neurological ***,based on molecular dynamics simulations and quantum chemical calculation,we propose that 30-to 45-THz photons can resonate with a variety of typical neurotransmitter molecules and make them absorb photon energy to activate the transition to high energy state,which is expected to be a new method of neural ***,we verified the calculated results through experiments that THz irradiation could substantively change neuronal signal emission and enhance the frequency,amplitude,and dynamic properties of excitatory postsynaptic current and inhibitory postsynaptic *** addition,we demonstrated the potential of neural information regulation by THz photons through 2-photon imaging in *** findings are expected to improve the understanding of the physical mechanism of biological phenomena and facilitate the application of terahertz technology in neural regulation and the development of new functional materials.

关键词： materials verified finding

New lignan glycosides from Glehnia littoralis

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Chinese Chemical Letters 2008年第12期19卷 1459-1461页

作者： Wei Xue Kong zhong yuan School of Traditional Chinese Materia Medica Shenyang Pharmaceutical University Shenyang 110016 China

From the roots ethanol extract of Glehnia littoralis, two new lignan glycosides, named glehlinoside E （1） and F （2）, were obtained. Their structures were determined to be （-）-secoisolariciresinol 4-O-β-D-（6-O-feruloyl） glucopyranoside （1） and （-）- secoisolariciresinol 4-O-f-β-D-（6-O-caffeloyl） glucopyranoside （2） by analysis of their spectral data, respectively.

关键词： Glehnia littoralis Lignan glycoside Glehlinoside E and F

A New Triterpenoid Saponin from Codonopsis lanceolata

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Chinese Chemical Letters 2006年第11期17卷 1460-1462页

作者： zhong yuan Zhi Min LIANG School of Traditional Chinese Materia Medica Shenyang Pharmaceutical University Shenyang 110016

A new triterpenoid saponin, named codonolaside （1） was isolated from the root of Codonopsis lanceolata. Its structure was determined by analysis of its spectral and chemical data.

关键词： Codonopsis lanceolata triterpenoid saponin codonolaside.

Cosmological twinlike models with multi scalar fields

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Science China(Physics,Mechanics & Astronomy) 2018年第9期61卷 31-36页

作者： yuan zhong Chun E Fu Yu Xiao Liu School of Science Xi'an Jiaotong University Institute of Theoretical Physics Lanzhou University

In this study, we consider cosmological models driven by several canonical or noncanonical scalar fields, and we show the manner in which twinlike models for a canonical model can be constructed from noncanonical ones using the superpotential method. We conclude that it is possible to construct twinlike models for multifield cosmological models, even with a nonzero spatial *** work extends the discussions of [D. Bazeia, and J. D. Dantas, Phys. Rev. D 85, 067303(2012)] to cases with multi scalar fields and with non-vanished spatial curvature, by using a different superpotential method.

关键词： cosmological twinlike models superpotential method noncanonical scalar field

Grüneisen ratio quest for self-duality of quantum criticality in a spin-1/2 XY chain with Dzyaloshinskii–Moriya interaction

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Communications in Theoretical Physics 2021年第9期73卷 145-152页

作者： Lin-Jie Ding yuan zhong Department of Physics ChongQing Three Gorges UniversityWanzhou 404100China

The quantum phase transition(QPT)and quantum criticality of an anisotropic spin-1/2 XY chain under the interplay of magnetic field and Dzyaloshinskii-Moriya(DM)interaction,which is interpreted as an electric field,are investigated,wherein the anisotropic parameter plays a similar role as the superconducting pairing gap in the interacting Kitaev topological superconductor model that protects the topological *** is shown that the thermal Drude weight is a good quantity to characterize the gapped(D_(th)=0)and gapless(D_(th)>0)ground *** continuous QPT is marked by a quantum critical point(QCP)associated with entropy accumulation,which is manifested by a characteristic Güneisen ratio(GR)with or without selfduality *** is shown that at a self-dual QCP,the GR keeps a finite value as T→0,while at a general QCP without self-duality symmetry,it displays a power-law temperature dependent divergence:Γ(T,r_(c))∼±T^(−1),which provides a novel thermodynamic means for probing QPT.

关键词： Grüneisen ratio self-duality of quantum critical point XY spin model Dzyaloshinskii-Moriya interaction

Dissipative Particle Dynamics Simulations of Domain Growth and Phase Separation in Binary Immiscible Fluids

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Chinese Journal of Chemical Physics 2008年第5期21卷 451-456页

作者： Ying Zhao Hong Liu zhong-yuan Lu Chia-chung Sun State Key Laboratory of Theoretical and Computational Chemistry Institute of Theoretical ChemistryJilin University Changchun 130023 China

It was investigated that the domain growth processes of spinodal decomposition with different quenching depth in two and three dimensional binary immiscible fluids by using parallel dissipative particle dynamics simulations. In two dimensions, the dynamic scaling exponent 1/2 for coalescence and 2/3 for inertial regimes in the shallow quench and strong finite size effects in the cases of deep quenching were obtained. In three dimensions, it was used that the diffusive regime with exponent n=l/3 in the shallow quench and the inertial hydrodynamic regime with n=2/3 for different quenches. The viscous effects are not clearly reflected, showing n=1/2 in both shallow and deep quenches in this time period, due to the soft nature of interaction potential adopted in dissipative particle dynamics.

关键词： Dissipative particle dynamics Binary immiscible fluids Domain growth