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研究生“政产学研”联动培养模式存在的问题及对策

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中国现代教育装备 2023年第1期 172-174页

作者：高建雄袁逸萍阿地兰木•斯塔洪新疆大学机械工程学院新疆乌鲁木齐830046

通过剖析,指出现有研究生“政产学研”联动培养模式存在课程体系不完善、导师指导能力不足、研究生培养质量评价指标单一、各部门缺乏长远规划和有效协作等问题。在此基础上,从四个方面提出了相应建议和对策,分别是:构建合理完善的课程... 详细信息

通过剖析,指出现有研究生“政产学研”联动培养模式存在课程体系不完善、导师指导能力不足、研究生培养质量评价指标单一、各部门缺乏长远规划和有效协作等问题。在此基础上,从四个方面提出了相应建议和对策,分别是:构建合理完善的课程体系、建设实力雄厚的师资队伍、完善培养质量评价指标体系、加强三方协调与合作机制,以期为我国研究生“政产学研”联动培养模式的探究提供参考。

关键词： “政产学研”联动研究生培养产教融合

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国医大师金世元人参调剂技术的继承与发展

北京中医药大学学报 2016年第11期39卷 961-964页

作者：贾晓玉郭兆娟孔李婷袁一平王宁宁戴莹翟华强北京中医药大学中药学院北京100102

目的整理国医大师金世元人参调剂技术,探析国医大师金世元中药调剂学术思想,以期传承人参临床调剂技术。方法以《本草纲目》一书为线索,回溯核查书中所记载的有关人参调剂的相关论述及本草原著,查阅2015版《中华人民共和国药典》《金世... 详细信息

目的整理国医大师金世元人参调剂技术,探析国医大师金世元中药调剂学术思想,以期传承人参临床调剂技术。方法以《本草纲目》一书为线索,回溯核查书中所记载的有关人参调剂的相关论述及本草原著,查阅2015版《中华人民共和国药典》《金世元中药材传统鉴别经验》等相关书籍,分析人参调剂技术现状。结果人参调剂技术在《本草纲目》已有萌芽,主要体现在人参的炮制、剂型、服用注意事项、配伍禁忌、存储等方面。国医大师金世元教授首次从认药、制药、用药、发药等多方面,明确提出人参临床调剂的关键技术,包括人参的性状鉴别技术、临床炮制技术、处方审核技术、处方应付技术、发药交代技术、贮存养护技术。结论金世元教授传承李时珍的药学学术思想,发展完善了人参的临床调剂技术。

关键词：人参调剂技术性状鉴别炮制

亚热带退化森林不同恢复方式对土壤团聚体胶结物质及稳定性的影响

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生态学报 2023年第9期43卷 3689-3698页

作者：蔡琳杨予静种玉洁袁义平曾翔宇姚和风陈初明李中强魏立飞余海燕湖北大学资源环境学院区域开发与环境响应湖北省重点实验室武汉430062 湖北省黄冈市罗田县大别山薄刀峰国有林场黄冈438600

退化森林的恢复一直是林业和生态学研究的热点。良好的森林土壤结构有助于林木生长发育,作为土壤最基本的结构单元,土壤团聚体组成和稳定性是衡量土壤肥力和质量的重要指标,其团聚结构的形成依靠土壤胶结物质。然而,土壤胶结物质与团聚... 详细信息

退化森林的恢复一直是林业和生态学研究的热点。良好的森林土壤结构有助于林木生长发育,作为土壤最基本的结构单元,土壤团聚体组成和稳定性是衡量土壤肥力和质量的重要指标,其团聚结构的形成依靠土壤胶结物质。然而,土壤胶结物质与团聚体稳定性之间的关系尚不确定。为探明亚热带退化森林的不同恢复方式对团聚体稳定性的影响及其潜在机制,以自然恢复的次生林为对照(CK),选取了亚热带三种常见的人工林:一代杉木林(P1)、二代杉木林(P2)和黄山松林(P3),测定土壤团聚体稳定性及其胶结物质的含量,并分析了各胶结物质对团聚体稳定性的影响。研究发现:不同森林恢复方式显著影响了土壤pH值、碳氮比、速效磷含量、团聚体的组成和稳定性。所有森林类型中,三种人工林的团聚体稳定性显著高于CK,P2的大团聚体所占比例最大,团聚体稳定性最高。恢复方式显著影响了土壤游离氧化铁含量、菌根密度和易提取球囊霉素相关土壤蛋白(EEG)含量。团聚体稳定性与游离氧化铁含量、菌根密度呈正相关,但与EEG含量呈负相关。研究结果表明,亚热带退化森林的人工恢复比自然恢复更有助于增强土壤团聚体稳定性,土壤游离氧化铁、菌根密度和EEG是显著影响团聚体稳定性的胶结物质。

关键词：土壤团聚体稳定性土壤游离氧化铁、铝球囊霉素相关土壤蛋白森林恢复方式亚热带森林

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Eu(Ⅲ)配体聚合物荧光微球研究进展

中国稀土学报 2024年第5期42卷 801-815,I0001页

作者：袁玉文王云鹏黄谊平戴晓茹樊先平乔旭升浙江大学材料科学与工程学院硅及先进半导体全国重点实验室浙江杭州310027

Eu(Ⅲ)凭借其独特的光致发光性能、单色性优良、Stokes位移大、配位数高以及Eu(Ⅲ)有机配体聚合物具有高量子效率、窄发射带、高色纯度等优点,近年来在免疫分析、电子荧光、光纤通讯、发光成像等领域得到了广泛应用,特别是较多应用于生... 详细信息

Eu(Ⅲ)凭借其独特的光致发光性能、单色性优良、Stokes位移大、配位数高以及Eu(Ⅲ)有机配体聚合物具有高量子效率、窄发射带、高色纯度等优点,近年来在免疫分析、电子荧光、光纤通讯、发光成像等领域得到了广泛应用,特别是较多应用于生物体荧光标记。综述了Eu(Ⅲ)有机配体聚合物体系的研究与应用进展。首先,阐述了Eu(Ⅲ)有机配体聚合物的研究背景、性质及其化学发光基本原理;其次,总结了配体的选择原则,以及针对Eu(Ⅲ)有机配体聚合物存在浓度猝灭、分布不均匀等问题,总结梳理了Eu(Ⅲ)的有机配体与不同聚合物进行复合时的关键问题的已有策略;最后,对Eu(Ⅲ)有机配体聚合物的未来发展趋势进行了展望。

关键词：稀土有机配合物聚合物 Eu(Ⅲ) 发光强度

Updated overall survival and circulating tumor DNA analysis of ensartinib for crizotinib-refractory ALK-positive NSCLC from a phase II study

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Cancer Communications 2024年第4期44卷 455-468页

作者： Jing Zheng Tao Wang Yunpeng Yang Jie Huang Jifeng Feng Wu Zhuang Jianhua Chen Jun Zhao Wei Zhong Yanqiu Zhao yiping Zhang Yong Song Yi Hu Zhuang Yu Youling Gong yuan Chen Feng Ye Shucai Zhang Lejie Cao Yun Fan Gang Wu Yubiao Guo Chengzhi Zhou Kewei Ma Jian Fang Weineng Feng Yunpeng Liu Zhendong Zheng Gaofeng Li Huijie Wang Shundong Cang Ning Wu Wei Song Xiaoqing Liu Shijun Zhao Lieming Ding Giovanni Selvaggi Yang Wang Shanshan Xiao Qian Wang Zhilin Shen Jianya Zhou Jianying Zhou Li Zhang Department of Respiratory Disease Thoracic Disease CenterThe First Affiliated HospitalCollege of MedicineZhejiang UniversityZhejiang Provincial Clinical Research Center for Respiratory DiseaseHangzhouZhejiangP.R.China Hangzhou Repugene Technology Co. LtdHangzhouZhejiangP.R.China Department of Medical Oncology Sun Yat-sen University Cancer Cen-terState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdongP.R.China Department of Medical Oncology Jiangsu Cancer HospitalJiangsu Institute of Cancer ResearchThe Affiliated Cancer Hospital of Nanjing Medical UniversityNanjingJiangsuP.R.China Department of Thoracic Oncology Fujian Provincial Cancer HospitalFujian Medical University Cancer HospitalFuzhouFujianP.R.China Department of Medical Oncology-Chest Hunan Cancer HospitalChangshaHunanP.R.China Department of Thoracic Oncology Beijing Cancer HospitalBeijingP.R.China Department of Pulmonary Medicine Peking Union Medical College HospitalChinese Academy of Medical SciencesPeking Union Medical CollegeBeijingP.R.China Respiratory Department of Internal Medicine Henan Provincial Can-cer HospitalAffiliated Cancer Hospital of Zhengzhou UniversityZhengzhouHenanP.R.China Thoracic Medical Oncology Zhejiang Cancer HospitalHangzhouZhejiangP.R.China Division of Respiratory Medicine Jinling HospitalNanjing University School of MedicineNanjingJiangsuP.R.China Department of Oncology Chinese People’s Liberation Army(PLA)General HospitalBeijingP.R.China Department of Oncology The Affiliated Hospital of Qingdao UniversityQingdaoShandongP.R.China Department of Thoracic Oncology Cancer CenterWest China HospitalSichuan UniversityChengduSichuanP.R.China Department of Oncology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiP.R.China Department of Medical Oncology Cancer HospitalThe First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityTeaching Hospital of

Background:The initial phase II stuty(NCT03215693)demonstrated that ensartinib has shown clinical activity in patients with advanced crizotinib-refractory,anaplastic lymphoma kinase(ALK)-positive non-small cell lung cancer(NSCLC).Herein,we reported the updated data on overall survival(OS)and molecular profiling from the initial phase Ⅱ ***:In this study,180 patients received 225 mg of ensartinib orally once daily until disease progression,death or *** was estimated by Kaplan‒Meier methods with two-sided 95%confidence intervals(CIs).Next-generation sequencing was employed to explore prognostic biomarkers based on plasma samples collected at baseline and after initiating *** tumor DNA(ctDNA)was detected to dynamically monitor the genomic alterna-tions during treatment and indicate the existence of molecular residual disease,facilitating improvement of clinical ***:At the data cut-off date(August 31,2022),with a median follow-up time of 53.2 months,97 of 180(53.9%)patients had *** median OS was 42.8 months(95%CI:29.3-53.2 months).A total of 333 plasma samples from 168 patients were included for ctDNA *** inferior OS correlated sig-nificantly with baseline ALK or tumor protein 53(TP53)*** addition,patients with concurrent TP53 mutations had shorter OS than those without con-current TP53 *** ctDNA levels evaluated by variant allele frequency(VAF)and haploid genome equivalents per milliliter of plasma(hGE/mL)at baseline were associated with poor ***,patients with ctDNA clear-ance at 6 weeks and slow ascent growth had dramatically longer OS than those with ctDNA residual and fast ascent growth,***,patients who had a lower tumor burden,as evaluated by the diameter of target lesions,had a longer *** Cox regression analysis further uncovered the independent prognostic values of bone metastases,higher hGE,and elevated ALK mutation abundance at 6 we

关键词： anaplastic lymphoma kinase ctDNA ensartinib non-small cell lung cancer overall survival

Risk assessment of large-scale winter sports sites in the context of a natural disaster

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Journal of Safety Science and Resilience 2022年第3期3卷 263-276页

作者： Jiansong Wu Yuxuan Xing yiping Bai Xiaofeng Hu Shuaiqi yuan School of Emergency Management and Safety Engineering China University of Mining and TechnologyBeijing 100083China School of Information Technology People’s Public Security University of ChinaBeijing 100038China Safety and Security Science Section Faculty of TechnologyPolicy and ManagementTU DelftDelft2628 BXthe Netherlands

Accidents induced by natural disasters at sports sites may cause catastrophic loss of great ***,previous studies on risk assessments of sports sites have only focused on operational risk and equipment *** the frequent occurrence of extreme disasters,the risk of domino chains caused by natural disasters at large-scale events,such as large-scale winter sports sites,cannot be *** this study,a natural disaster-induced accident-chain evolution analysis model(NAEA model)is *** on the results of the NAEA model,a fuzzy Bayesian network for domino accidents triggered by an earthquake at large-scale winter sports sites was *** sensitivity analysis and scenario analysis,it was found that fire and explosion accidents and crowded stampede accidents are the main causes of serious loss in domino disaster chains in large-scale sports ***,improving the early warning capability,reliability of electrical equipment,and automatic sprinkler systems are the most effective ways to prevent and control major *** addition,an optimal safety strategy improvement analysis was performed to facilitate the decision-making of safety managers to prevent serious accidents and reduce accident loss.

关键词： Risk assessment Domino disaster chain Large-scale sports sites Bayesian network Natural disaster Fuzzy logic

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发酵石榴汁工艺优化及成分分析

西华大学学报（自然科学版） 2020年第6期39卷 37-46页

作者：马嫄殷晓翠罗钰湲李英凤郭睿苏凡车振明袁乙平徐娟西华大学食品与生物工程学院四川成都610039 四川福能源生物科技有限公司四川成都610031

以浓缩石榴汁为原料,复原后接种嗜酸乳杆菌、植物乳杆菌和酵母菌复合发酵,运用模糊数学结合响应面法对其发酵工艺进行优化,以感官模糊综合评价值为响应值,研究白砂糖糖液添加量、乳酸菌接种量、发酵时间及温度对发酵石榴汁感官品质的影... 详细信息

以浓缩石榴汁为原料,复原后接种嗜酸乳杆菌、植物乳杆菌和酵母菌复合发酵,运用模糊数学结合响应面法对其发酵工艺进行优化,以感官模糊综合评价值为响应值,研究白砂糖糖液添加量、乳酸菌接种量、发酵时间及温度对发酵石榴汁感官品质的影响,并利用顶空固相微萃取–气相质谱联用技术(HS-SPME/GC-MS)分析其挥发性香气成分。结果表明:石榴汁的最佳发酵工艺为白砂糖糖液添加量12.0%,植物乳杆菌、嗜酸乳杆菌和酵母菌接种量分别为1.5%、1.5%和0.02%,28℃发酵48 h;发酵石榴汁中共检测出38种香气成分,以醇类和酯类物质为主,醇类物质相对含量为35.75%,酯类物质相对含量为42.59%。

关键词：石榴汁发酵植物乳杆菌嗜酸乳杆菌香气成分

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不同年龄阶段大肠癌临床特点分析

胃肠病学和肝病学杂志 2008年第10期17卷 829-832页

作者：蒋绚田珂张葆袁一平陈捷刘玉兰北京大学人民医院消化科北京100044 江苏省徐州市中心医院消化科四川省雅安市第二人民医院消化科北京大学人民医院科研处临床流行病学室

目的了解不同年龄阶段大肠癌的发病特点，达到早期诊断及有效治疗的目的。方法检索我院2000年至今的原发性大肠癌病例并对其进行回顾性研究。共检索到大肠癌患者1308例，按不同年龄段分为：青年组，年龄≤40岁，66例（5．0％）；中年组... 详细信息

目的了解不同年龄阶段大肠癌的发病特点，达到早期诊断及有效治疗的目的。方法检索我院2000年至今的原发性大肠癌病例并对其进行回顾性研究。共检索到大肠癌患者1308例，按不同年龄段分为：青年组，年龄≤40岁，66例（5．0％）；中年组，年龄41～70岁，805例（61．5％），随机抽取86例；老年组，年龄≥71岁，437例（33．4％），随机抽取76例。分别比较三组间基本情况、临床表现、肿瘤好发部位、病理特点及就诊特点等。结果青年组、中年组及老年组男性比例分别为48．5％、60．5％、65．8％（X^2=4．34，P=0．04）；首发症状均为腹痛、便血及大便习惯改变等；确诊时间中位数分别为120、68、65d；确诊时晚期病例分别占50．0％、41．2％及28．6％（X^2=6．36，P=0．04），但分析首诊方式及误诊率三组之间差异无统计学意义。二三组合并大肠息肉的比例依次为53．8％、78．6％及87．3％（X^2=14．2，P=0．00）。青年组左半结肠癌占83．8％，高于中年组（67．4％）及老年组（64．9％）（X^2=7．38，P=0．03）；青年组直肠癌病例占48．5％，也高于中年组（24．1％）及老年组（26．6％）（X^2=12．1，P=0．00）；不同年龄阶段大肠癌病理类型均以腺癌为主，青年组黏液腺癌（X^2=16．2，P=0．04）及低分化肿瘤比例高（X^2=6．29，P=0．04）。结论不同年龄阶段大肠癌发病有其特点。青年发病确诊时间长，左半结肠癌占优势，确诊时晚期病例比例高，病理类型低分化多见，提示预后不良。老年人大肠癌男性患者比例增多，肿瘤好发部位向近端移位，合并大肠息肉的比例增加。

关键词：大肠癌临床特征不同年龄阶段

What kind of optical model potentials should be used for deuteron stripping reactions?

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Science China(Physics,Mechanics & Astronomy) 2020年第2期63卷 64-70页

作者： XiaoYan Yun DanYang Pang yiping Xu Zhi Zhang RuiRui Xu ZhongYu Ma CenXi yuan yuan51School of Physics Beihang UniversityBeijing 100191China Beijing Key Laboratory of Advanced Nuclear Materials and Physics Beihang UniversityBeijing 100191China China Nuclear Data Center China Institute of Atomic EnergyBeijing 102413China China Institute of Atomic Energy Beijing 102413China Sino-French Institute of Nuclear Engineering and Technology Sun Yat-Sen UniversityZhuhai 519082China

This paper presents the results of a study that compares CTOM, a microscopic optical model potential(OMP), which is an optical model co-created by the China Nuclear Data Center & Tuebingen University, to CH89, which is a typical phenomenological *** respective OMPs were tested by applying them to the modelling of nucleon elastic scattering and(d,p) transfer reactions involving14C,36S, and58Ni targets at both low and relatively high energies. The results demonstrated that although both potentials successfully accounted for the angular distributions of both the elastic scattering and transfer cross sections, the absolute values of the transfer cross sections calculated using CTOM were approximately 25% larger than those calculated using CH89. This increased transfer cross sections allowed CTOM to produce single particle strength reduction factors for the three reactions that were consistent with those extracted from(e,e′p) reactions as well as with more recent(p,2p) and(p,pn) reactions. Notch tests suggested that nucleon elastic scattering and transfer reactions are sensitive to different regions of the OMP;accordingly,phenomenological OMPs, which are constrained only by elastic scattering cross sections, may not be sufficient for nucleon transfer reactions. Therefore, we suggest that microscopic OMPs, which reflect more theoretical considerations, should be preferred over phenomenological ones in calculations of direct nuclear reactions.

关键词： optical model potentials elastic scattering transfer reactions spectroscopic factors