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Protective effect of TMP on pancreas function of acute pancreatitis rats

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Asian Pacific Journal of Tropical Medicine 2015年第6期8卷 474-477页

作者： yuan-Chi weng Jia-Qiao Fan Department of General Surgery Rui-Jin HospitalShanghai Jiao Tong University School of Medicine First Affiliated Hospital of Dalian Medical University

Objective:To explore the protective effect and mechanism of Tetramethyl Pyrazine(TMP)on the pancreas function of acute pancreatitis ***:A total of 75 SD rats were randomly divided into three groups(A,B,C) with 25 rats in each *** A served as sham operation *** the groups B and C,AP model was prepared as by injecting taurocholic acid *** B was model *** modeling,rats were administrated by intraperitoneal injection of normal *** C was TMP treatment group,which was administrated by intraperitoneal injection of 0.6% TMP after *** rat blood specimens in each group were collected with 1 mL/100 g solution after modeling of 2,6.12 and 24 *** of amylase(AMS).blood urea nitrogen(BUN),creatinine(CR).TNF-α and IL-6 were detected,and 5 rats were *** examination was performed in he pancreatic tissue specimens of each group to observe pancreatic tissue ***:After modeling in each time ***,***-α and IL-6 in groups B and C were significantly higher than that of in group A(P<0.05).After modeling of 2 *** and CR in group B increased significantly and reached the peak value at6 *** modeling of 12 *** level of TNF-α and IL-6 were significantly lower than that of in control group,while after 24 h of modeling,serum level of ***,CR,TNF-α and IL-6 were significantly lower than that of in control group(P<0.05).The histological observation showed that pancreatic tissue in rats of group A was normal without damage *** bleeding,necrosis and serious injury were visible in pancreatic tissue of group *** rut pancreatic tissue was bleeding in group C with small pieces of necrotic *** degree of inflammatory cell infiltration was lower than group *** the degree of injury was significantly lower than group ***:TMP can significantly decrease the serum level of TNF- α and IL-6 in AP rats,inhibits inflammatory response of *** has significant

关键词： TMP Acute pancreatitis TNF-α IL-6

Nucleophilic Trifluoromethylthiolation of Allylic Bromides： A Facile Preparation of Allylic Trifluoromethyl Thioethers

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Chinese Journal of Chemistry 2013年第7期31卷 921-926页

作者： Jianwei Tan Guoting Zhang Yangli Ou Yaofeng yuan Zhiqiang weng Department of Chemistry Fuzhou University Fuzhou Fujian 350108 China

A facile preparation of allylic trifluoromethyl thioethers was achieved by using a copper reagent. The reaction of （bpy）Cu（SCF3） with various allylic bromides afforded the desired trifluoromethylthiolation products in good to excellent yields with high stereo- and regioselectivity. Common functional groups such as alkyl, alkoxy, trifluoromethyl, nitro, halides and geranyl are well tolerated.

关键词： trifluoromethylthiolation allylic halides copper

A Novel PoW Scheme Implemented by Probabilistic Signature for Blockchain

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Computer Systems Science & Engineering 2021年第11期39卷 265-274页

作者： Bo Mi yuan weng Darong Huang Yang Liu Yuqing Gan Institute of Information Science and Engineering Chongqing Jiaotong UniversityChongqing400074China Electrical and Electronics Engineering Department The University of SheffieldSheffieldS102TTUnited Kingdom

PoW(Proof of Work)plays a significant role in most blockchain systems to grant an accounting right over decentralized participants and ensure tamper *** hash functions are generally exploited for PoW due to their merits on summering,anti-collision,and irreversibility,they cannot certify that the bookkeeper is exactly the ***,such insistence may lead to abuse or even embezzlement of computing power for the benefit of malicious *** preserve the functionality of PoW but also bind the miners’signing keys with their works,we build a post-quantum PoW scheme by changing the approximate closest vector norm for probabilistic *** from the schemes based on hash functions,our scheme takes signing as the proof of work where signature verification is just the evidence of block *** also presented a method to adjust the difficulty of signing by modifying the probability of generating a correct *** performance of our scheme is also analyzed theoretically and experimentally,which implies its practicability and advantages.

关键词： Proof of work NTRUSign Burr distribution blockchain

Research on the Maintenance of Ascending node Longitude of IGSO Satellite

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Research on the Maintenance of Ascending node Longitude of I...

Effectiveness of cardioneuroablation in different subtypes of vasovagal syncope

第五届中国卫星导航学术年会

作者： PENG Cheng-long weng yuan-lan ZHANG Zhi College of Aerospace Science and Engineering National University of Defense Technology

ISBN: (纸本)9783642547362

IGSO satellite plays important part to COMPASS Navigation Satellite System and its position significantly impacts performance of the whole navigation system service. With various of perturbations and initial orbit error, ascending node longitude of IGSO satellite drift continued, which varies service area of navigation system. It’s necessary to amendment longitude of the satellite ascending node to keep navigation precision periodically. Control strategies were analyzed alone, and offset of semi-major axis is determined base d on the change law of ascending node longitude. optimum control velocity increment to amendment orbit by the means of Lagrange multiplier and a control method to maintain satellite orbit are presented. Simulation results have verified the effectiveness and convenience. This paper also provides reference of Maintenance of navigation constellation.

关键词： IGSO Ascending node longitude Position maintenance Optimization control

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Journal of Geriatric Cardiology 2024年第6期21卷 651-657页

作者： Bin TU Zi-Hao LAI Ai-Yue CHEN Zhi-yuan weng Si-Min CAI Zhu-Xin ZHANG Li-Kun ZHOU Li-Hui ZHENG Yan YAO Arrhythmia Center Fuwai HospitalNational Center for Cardiovascular DiseasesNational Key LaboratoryChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Cardiac Center Beijing Chaoyang HospitalCapital Medical UniversityBeijingChina Cardiovascular Department The First Affiliated HospitalFujian Medical UniversityFujian Institute of HypertensionFujianChina Department of Cardiovascular The Second Affiliated Hospital of Zhejiang University School of MedicineZhejiangChina

BACKGROUND Cardioneuroablation(CNA)has shown encouraging results in patients with vasovagal syncope(VVS).However,data on different subtypes was *** This observational study retrospectively enrolled 141 patients[mean age:40±18 years,51 males(36.2%)]with the diagnosis of *** characteristics among different types of VVS and the outcomes after CNA were *** After a mean follow-up of 4.3±1.5 years,41 patients(29.1%)experienced syncope/pre-syncope events after ***/pre-syncope recurrence significantly differed in each subtype(P=0.04).The cardioinhibitory type of VVS had the lowest recurrence rate after the procedure(n=6,16.7%),followed by mixed(n=26,30.6%)and vasodepressive(n=9,45.0%).Additionally,a significant difference was observed in the analyses of the Kaplan-Meier survival curve(P=0.02).Syncope/pre-syncope burden was significantly reduced after CNA in the vasodepressive type(P<0.01).Vasodepressive types with recurrent syncope/pre-syncope after CNA have a lower baseline deceleration capacity(DC)level than those without(7.4±1.0 ms vs.9.0±1.6 ms,P=0.01).Patients with DC<8.4 ms had an 8.1(HR=8.1,95%CI:2.2-30.0,P=0.02)times risk of syncope/pre-syncope recurrence after CNA compared to patients with DC≥8.4 ms,and this association still existed after adjusting for age and sex(HR=8.1,95%CI:2.2-30.1,P=0.02).CONCLUSIONS Different subtypes exhibit different event-free *** vasodepressive type exhibited the lowest event-free rate,but those patients with DC≥8.4 ms might benefit from CNA.

关键词： syncope subtypes diagnosis

Structural insight into the dual-antagonistic mechanism of AB928 on adenosine A_(2)receptors

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Science China(Life Sciences) 2024年第5期67卷 986-995页

作者： yuan weng Xinyu Yang Qiansen Zhang Ying Chen Yueming Xu Chenyu Zhu Qiong Xie Yonghui Wang Huaiyu Yang Mingyao Liu Weiqiang Lu Gaojie Song Shanghai Key Laboratory of Regulatory Biology Institute of Biomedical Sciences and School of Life SciencesEast China Normal UniversityShanghai 200241China Department of Medicinal Chemistry School of PharmacyFudan UniversityShanghai 201203China

The adenosine subfamily G protein-coupled receptors A_(2A)R and A_(2B)R have been identified as promising cancer immunotherapy *** of the A_(2A)R/A_(2B)R dual antagonists,AB928,has progressed to a phaseⅡclinical trial to treat rectal ***,the precise mechanism underlying its dual-antagonistic properties remains ***,we report crystal structures of the A_(2A)R complexed with AB928 and a selective A_(2A)R antagonist *** structures revealed a common binding mode on A_(2A)R,wherein the ligands established extensive interactions with residues from the orthosteric and secondary *** contrast,the cAMP assay and A_(2A)R and A_(2B)R molecular dynamics simulations indicated that the ligands adopted distinct binding modes on A_(2B)*** analysis of their chemical structures suggested that AB928 readily adapted to the A_(2B)R pocket,while 2-118 did not due to intrinsic *** disparity potentially accounted for the difference in inhibitory efficacy between A_(2B)R and A_(2A)*** study serves as a valuable structural template for the future development of selective or dual inhibitors targeting A_(2A)R/A_(2B)R for cancer therapy.

关键词： adenosine receptor A2AR A2BR inhibitor dual-antagonism drug discovery

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基于时间序列模型的文本数据压缩存储算法

吉林大学学报（工学版） 2023年第7期53卷 2109-2114页

作者：翁渊瀚李南南京航空航天大学经济与管理学院南京211000 南京工业大学理学院南京211800

为了降低文本数据历史数据量,提升文本数据压缩存储效率,提出一种基于时间序列模型的文本数据压缩存储算法。采用小波阈值去噪方法估计并消除文本数据的误差和噪声;从文本数据特征角度,通过细节描述特征,设定特征类型之间的组合和继承关... 详细信息

为了降低文本数据历史数据量,提升文本数据压缩存储效率,提出一种基于时间序列模型的文本数据压缩存储算法。采用小波阈值去噪方法估计并消除文本数据的误差和噪声;从文本数据特征角度,通过细节描述特征,设定特征类型之间的组合和继承关系,组建时间序列模型。将经过预处理的文本数据采用时间序列模型转换为结构近似的二进制编码字节,通过异或操作对结果中的冗余部分进行压缩处理,同时将压缩的数据存储到对应的数据库中,最终完成文本数据压缩存储。仿真实验结果表明,本文算法可以有效提升压缩性能,获取更优的文本数据压缩存储结果。

关键词：时间序列模型文本数据压缩存储算法小波阈值去噪方法非线性函数预处理

Oxygen vacancies enriched Ir/WOx catalysts for the directly chem-catalytic conversion of cellulose to ethanol

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Tungsten 2025年第1期7卷 88-99页

作者： Yu-Jing weng Zhao-Ying Ding Ying-Chao Li yuan-Feng Wu yuan-Yang Xu Rui Chen Xiao-Lei Zhao Hai-Yong Wang Da-Lei Zhang Yu-Long Zhang Henan Key Laboratory of Coal Green Conversion and International Joint Laboratory of Coal Clean Utilization College of Chemistry and Chemical Engineering Henan Polytechnic University Key Laboratory of Renewable Energy Guangzhou Institute of Energy Conversion Chinese Academy of Sciences Liaoning Institute of Energy Technology

Tungsten and its oxides are highly versatile catalysts with unique properties that hold great promise for a wide array of applications,including biological pathways and chemical *** chemo-catalysis of cellulose to ethanol presents a promising avenue for ethanol synthesis with the potential for enhanced efficiency compared to conventional methods,offering a sustainable and carbon-neutral alternative to existing petrochemical and biological ***,Ir/WOxcatalysts enriched with oxygen vacancies were meticulously prepared and demonstrated remarkable catalytic performance in converting cellulose to ethanol directly in the presence of tungstic *** catalyst achieved a high ethanol yield of 66.5%under optimal reaction conditions,approaching the theoretical yield limit of traditional ethanol *** results revealed the presence of oxygen defects,Bronsted/Lewis acidity,and Ir nanoclusters on the catalyst surface,working synergistically to facilitate the cascade catalysis of cellulose hydrolysis,sugar retro-aldol condensation reaction,and C2 intermediate hydrodeoxygenation to *** situ Fourier transform infrared spectrometer analysis confirmed the catalyst's ability to enhance the adsorption and activation of ethylene glycol for ethanol *** manipulating subtle structural features,this study offers a fresh perspective on tungsten group catalyst design and underscores the importance of synergistic effects among catalytic sites for the efficient production of ethanol from cellulose.

关键词： Cellulosic ethanol Chem-catalysis Hydrogenolysis Retro-aldol condensation Tungsten

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定海古城民居屋脊地域特征及文化刍谈

东南文化 2009年第4期 85-87页

作者：翁源昌浙江国际海运职业技术学院浙江舟山316021

定海由于其特殊的地理气候条件以及文化背景,古民居建筑有较明显的地域特征,反映在屋脊上主要有坚实厚重的屋脊、装饰卷草纹的脊翼以及佛教文化思想等。

关键词：定海民居屋脊特征