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Rapid quantification of the metabolite of valacyclovir hydrochloride in human plasma by liquid chromatography-tandem mass spectrometry

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Journal of Pharmaceutical Analysis 2010年第2期22卷 83-90页

作者： yuan tian1,2.hui lin1,{2.,2.zun-jian zhang1,2.guo-guang mao31. key laboratory of drug quality control and pharmacovigilance (China Pharmaceutical University),ministry of education,Nanjing 2.0009 2. Center for Instrumental Analysis,China Pharmaceutical University,Nanjing 2.0009 3. Department of Clinical Pharmacology,Wannan Medical College,Wuhu 2.1000,China. key laboratory of {2. quality control and pharmacovigilance (China Pharmaceutical University) Ministry of Education Nanjing 210009 China Center for Instrumental Analysis China Pharmaceutical University Nanjing 210009 China Department of Clinical Pharmacology Wannan Medical College Wuhu 241000 China

Objective To establish a rapid,sensitive and selective liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the determination of acyclovir (the metabolite of valacyclovir hydrochloride) in human plasma. Methods After addition of ganciclovir as internal standard (IS),plasma samples were prepared by one-step protein precipitation using acetonitrile as precipitant,followed by an isocratic elution with 0.1% formic acid solution-methanol (95∶5,v/v) on an Agilent ZORBAX SB-C18 (150mm×2.1mm i.d.,3.5μm) column. Detection was performed on a triple-quadrupole mass spectrometer utilizing electrospray ionization (ESI) interface operating in positive ion and selected reaction monitoring (SRM) mode with the precursor to product ion transitions m/z 2.6.2.152.1 for acyclovir and m/z 2.6.2.152.1 for the IS. Results The analytical results demonstrated a good linearity over the ranges from 0.005 to 4μg/mL (r=0.9999) for valacyclovir hydrochloride. The relative standard deviations (RSD) of intra-batch and inter-batch were less than 4.06% and 9.2.%,respectively. The limit of detection and lower limit of quantification in human plasma were 2.g/mL and 5ng/mL,respectively. Conclusion The method was simple,sensitive,accurate and reproducible and has been successfully applied to a bioequivalence study of valacyclovir hydrochloride capsules in Chinese healthy male volunteers.

关键词： valacyclovir hydrochloride acyclovir liquid chromatography-tandem mass spectrometry method validation human plasma

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Searching for^(76)Ge neutrinoless double beta decay with the CDEX-1B experiment

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Chinese Physics C 2024年第10期48卷 11-22页

作者： Bing-Tao zhang Jun-Zheng Wang Li-Tao Yang Qian yue Ke-Jun Kang yuan-Jing Li Hai-Peng An C.Greeshma jian-Ping Chang yun-Huan Chen jian-Ping Cheng Wen-Han Dai Zhi Deng Chang-Hao Fang Xin-Ping Geng hui Gong Qiu-Ju guo Xu-yuan guo Li He Sheng-Ming He Jin-Wei Hu Han-Xiong Huang Tu-Chen Huang Hai-Tao Jia Xi jiang S.Karmakar Hao-Bin Li jian-Min Li Jin Li Qian-yun Li Ren-Ming-Jie Li xue-Qian Li yu-Lan Li Yi-Fan Liang Bin Liao Fong-Kay lin Shin-Ted lin Jia-Xuan Liu Shu-Kui Liu Yan-Dong Liu yu Liu yuan-yuan Liu Zhong-Zhi Liu Hao Ma yu-Cai mao Qi-yuan Nie Jin-Hua Ning hui Pan Ning-Chun Qi Jie Ren Xi-Chao Ruan Ze She Manoj Kumar Singh tian-Xi Sun Chang-jian Tang Wei-You Tang Yang tian guang-Fu Wang Li Wang Qing Wang yu-Feng Wang yun-Xiang Wang Henry-Tsz-King Wong Shi-Yong Wu yu-Cheng Wu Hao-Yang Xing Rui Xu Yin Xu Tao xue yu-Lu Yan Nan Yi Chun-Xu yu Hai-Jun yu jian-Feng yue Ming Zeng Zhi Zeng Feng-Shou zhang Lei zhang Zhen-Hua zhang Zhen-yu zhang Kang-Kang Zhao Ming-Gang Zhao Ji-Fang Zhou Zu-Ying Zhou Jing-Jun Zhou key laboratory of Particle and Radiation Imaging({2.)and Department of Engineering Physics Tsinghua UniversityBeijing 100084 Department of Physics Tsinghua UniversityBeijing 100084 Institute of Physics Academia SinicaTaipei 11529 NUCTECH Company Beijing 100084 YaLong River Hydropower Development Company Chengdu 610051 College of Nuclear Science and Technology Beijing Normal UniversityBeijing 100875 College of Physics Sichuan UniversityChengdu 610065 School of Physics Peking UniversityBeijing 100871 Department of Nuclear Physics China Institute of Atomic EnergyBeijing 102413 Sino-French Institute of Nuclear and Technology Sun Yat-sen UniversityZhuhai 519082 School of Physics Nankai UniversityTianjin 300071 Department of Physics Banaras Hindu UniversityVaranasi 221005 Department of Physics Beijing Normal UniversityBeijing 100875

We operated a p-type point contact high purity germanium(PPCGe)detector(CDEX-1B,1.008 kg)in the China Jinping Underground laboratory(CJPL)for 500.3 days to search for neutrinoless double beta(0νββ)decay of^(76)Ge.A total of 504.3 kg⋅day effective exposure data was *** anti-coincidence and the multi/single-site event(MSE/SSE)discrimination methods were used to suppress the background in the energy region of interest(ROI,1989–2.89 keV for this work)with a factor of 2..A background level of 0.33 counts/(keV⋅kg⋅yr)was *** lower limit on the half life of^(76)Ge 0νββdecay was constrained as T_(1/2.^(0ν)>1.0×10^(2.)yr(90%C.L.),corresponding to the upper limits on the effective Majorana neutrino mass:2.7.5 eV.

关键词： neutrinoless double beta decay CDEX point-contact germanium detector ^(76)Ge

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Identification and comparative analysis of the major chemical constituents in the extracts of single Fuzi herb and FuziGancao herb-pair by UFLC-IT-TOF/MS

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Chinese Journal of Natural Medicines 2014年第7期12卷 542-553页

作者： YANG Yan YIN Xin-Juan guo hui-Min WANG Ru-{2. SONG Rui tian yuan zhang zun-jian key laboratory of {2. quality control and pharmacovigilance China Pharmaceutical UniversityMinistry of Education State key laboratory of Natural Medicines China Pharmaceutical University

AIM: The aim of this work was to establish a specific and sensitive method to comprehensively investigate and compare chemical constituents of Fuzi-Gancao herb pair(FG), consisting of Aconitum carmichaelii Debeaux(Fuzi, Chinese) and Roast Radix Glycyrrhizae(Glycyrrhiza glabra L., Gancao, in Chinese) and Fuzi alone to explore the underlying interaction mechanism of FG. METHOD: An ultra-fast liquid chromatography-ion trap/time-of-flight mass spectrometry(UFLC/MS-IT-TOF) method using diazepam as internal standard was developed for the identification and semi-quantitative analysis of the phytochemical constituents of Fuzi and FG. Chromatographic separation was achieved on a UFLC column using a gradient program with 40 mmol?L-1 ammonium acetate and acetonitrile as the mobile phase. RESULTS: Fifty-one of the sixty compounds, including forty-five C19-diterpenoid alkaloids and six C2.-diterpenoid alkaloids were tentatively identified in the extracts of Fuzi and FG through accurate mass measurements and fragmentation patterns. Comparing the contents of these alkaloids in these two extracts, it was found that the diester-diterpenoid alkaloids(DDAs) and the alkylolamine-diterpenoid alkaloids(ADAs) were increased, while the monoester-diterpenoid alkaloids(MDAs) were decreased in the extracts of FG. CONCLUSION: This work provided comprehensive information for the quality control of Fuzi preparations, and the further investigation on the compatibility mechanisms of FG.

关键词： Aconitum carmichaelii Radix Rhizoma Glycyrrhizae Diterpenoid alkaloids UFLC-IT-TOF/MS

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CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi yuanjie Bi tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang guofu Cao jianshe Cao Antoine Chance xuejun Chang yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen guoming Chen Hua-Xing Chen huirun Chen Jinhui Chen Ji-yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi ling-yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2.s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2.15)and the Conceptual Design Report(CDR,2.18),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2.2.-2.2.,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2.30s.

关键词： initiated exceeding precise

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Original article Efficacy and safety of Changfu peritoneal dialysis solution： a multi-center prospective randomized controlled trial

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Chinese Medical Journal 2013年第22期126卷 4204-4209页

作者： ZHOU jian-hui NI Zhao-hui MEI Chang-lin yu xue-qing LIU Fu-you MIAO Li-ning LIU Zhi-hong yuan Wei-jie zhang Ai-ping lin Hong-li CHEN Meng-hua CHEN jiang-hua zhang Jin-yuan HE Ya-ni CHEN jian ZHAO Jiu-yang DING Xiao-qiang LI Ying LI Rong-shan XIE Ru-juan LIU Wen-hu XING Chang-ying WANG Rong DENG yue-yi CAO xue-ying CAI guang-yan MOU Shan mao Zhi-guo YANG Xiao LIU Hong SUN Jing yu yu-sheng LIU Jun SHI Shu-mei LI Long-kai tian Na zhang Xiao-hui ZHOU Wei YANG Jie zhang Yong SUN Jing-di JI Jun zhang Tao YAN Yan LIU Xiao-gang WANG Gang zhang Li zhang Hong LUO jian-hua CHEN Xiang-mei Department of Nephrology State Key Laboratory of Kidney Disease Chinese People's Liberation Army General Hospital Beijing 100853 China Renal Division Renji Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200127 China

Background A multi-center large scale study is needed to confirm the efficacy and safety of domestic peritoneal dialysis （PD） solutions. Some researchers believe that 6 Lid is enough for adequate dialysis, but there is no multi-center prospective study on Chinese population to confirm this. In this study, we evaluated the efficacy and safety of domestic PD solution （Changfu） and its difference between 6 L and 8 L dosage. Methods Adult PD patients who had taken PD therapy for at least one month were selected and divided into four groups according to two dialysis solution brands and two dialysis dosages, i.e., 6 L dose with Changfu dialysis solution, 6 L dose with Baxter dialysis solution, 8 L dose with Changfu dialysis solution, and 8 L dose with Baxter dialysis solution. After 48 weeks, the changes of primary and secondary efficacy indices were compared between different types and different dosages. We also analyzed the changes of safety indices. Results Changes of Kt/V from baseline to 48 weeks between Changfu and Baxter showed no statistical differences; so did those of creatinine clearance rate （Ccr）. Normalized protein catabolic rate （nPCR） from baseline to 48 weeks between Changfu and Baxter showed no statistical differences; so did those of net ultrafiltration volume （nUF） and estimated glomerular filtration rate （eGFR）. Changes of nPCR from baseline to 48 weeks between 6 L and 8 L showed no statistical differences; so did those of nUF and eGFR. The decline of Kt/V from baseline to 48 weeks in 6 L group was more than that in 8 L group. Change of Ccr was similar. During the 48-week period, the mean Kt/V was above 1.7/w, and mean Ccr was above 50 L.1.73 m-2.w1. More adverse events were found in Changfu group before Changfu Corporation commenced technology optimization, and the statistical differences disappeared after that. Conclusions The domestic PD solution （Changfu） was proven to be as effective as Baxter dialysis solution. During 48- week period, a dosage o

关键词： Changfu peritoneal dialysis solution efficacy safety

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Expert Consensus on Pathological Diagnosis of Intrahepatic Cholangiocarcinoma(2.2. version)

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Journal of Clinical and Translational Hepatology 2023年第7期11卷 1553-1564页

作者： Han Wang Jun Chen Xin zhang Xia Sheng Xiao-Yan Chang Jie Chen Min-Shan Chen hui Dong {2.-Jie Duan He-Ping Hu Zhi-Yong Huang Wei-Dong Jia Xiao-Qing jiang Dong Kuang Shan-Shan Li Zeng-Shan Li Chang-Li Lu Shu-Kui Qin xue-Shan Qiu Li-Juan Qu Chun-Kui Shao Feng Shen guo-Ming Shi Su-Sheng Shi yu-Jun Shi hui-Chuan Sun Xiao-Dong Teng Bin Wang Zhan-Bo Wang tian-Fu Wen Jia-Mei Yang Qiao-Qiao Yang Sheng-Long Ye Hong-Fang Yin Zhen-Gang yuan Jing-Ping yun Feng-lin Zang Hong-Qi zhang Li-Hong zhang Jing-Min Zhao jian Zhou Wei-Xun Zhou Jia Fan Xiao-Ping Chen Wan Yee Lau yuan Ji Wen-Ming Cong Chinese Society of Liver Cancer of Chinese Anti-Cancer Association Digestive Disease Group of Chinese Society of Pathology,Chinese Medical Association Chinese Society of Pathology of Chinese Anti-Cancer Association Hepatic Surgery Group of Chinese Society of Surgery,Chinese Medical Association Biliary Tract Tumor Committee of China Anti-Cancer Association Chinese Society of Clinical Oncology IDepartment of Pathology Eastern Hepatobilary Surgery HospitalNaval Medical UniversityShanghaiChina Department of Pathology the Affiliated Drum Tower HospitalNanjing University Medical SchoolNanjingJiangsuChina Department of Pathology Zhongshan HospitalFudan UniversityShanghaiChina Department of Pathology Minhang HospitalFudan Uni-versityShanghaiChina Department of Pathology Peking Union Medical College HospitalChinese Academy of Medical Sci-ences and Peking Union Medical CollegeBeijingChina Department of Liver Surgery Sun Yat-Sen University Cancer CenterGuangzhouGuangdongChina Department of Pathology The First Affiliated HospitalArmy Medical UniversityChongqingChina Department of Hepatobiliary Medicine Eastern Hepatobiliary Surgery HospitalNaval Medical UniversityShanghaiChina Hepatic Surgery Center Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWu-hanHubeiChina Department of General Surgery The First Affliated Hospital of USTCDivision of Life Science and Medi-cineUniversity of Science and Technology of ChinaHefeiAnhuiChina Department of Biliary Surgery I Eastern Hepatobil-iary Surgery HospitalNaval Medical UniversityShanghaiChina Department of Pathology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiChina Department of Pathology The First Afiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenanChina Department of Pathology Xijing Hospi-talAir Force Medical UniversityXi'anShaanxiChina Department of Pathology West China HospitalSichuan UniversityChengduSichuanChina Cancer Center of Jinling Hospital Nanjing University of Chinese MedicineNanjingJiangsuChina Department of Pathology The First Affiliated HospitalChina Medical UniversityShenyangLiaoningChina Department of Pathology The 900 Hospital of the Chinese People's Liberation Army Joint Logistics TeamFuzhouFujianChina Department of Pathology The Third Affiliated HospitalSun Yat-Sen UniversityGuangz

Intrahepatic cholangiocarcinoma(iCCA)can originate from the large bile duct group(segment bile ducts and area bile ducts),small bile duct group(septal bile ducts and interlobular bile ducts),and terminal bile duct group(bile ductules and canals of Hering)of the intrahepatic biliary tree,which can be histopathological corresponding to large duct type iCCA,small duct type iCCA and iCCA with ductal plate malformation pattern,and cholangiolocarcinoma,*** challenge in pathological diagnosis of above subtypes of iCCA falls in the distinction of cellular morphologies,tissue structures,growth patterns,invasive behaviors,immunophenotypes,molecular mutations,and surgical *** these reasons,this expert consensus provides nine recommendations as a reference for standardizing and refining the diagnosis of pathological subtypes of iCCA,mainly based on the 5th edition of the World Health Organization Classification of Tumours of the Digestive System.

关键词： Intrahepatic cholangiocarcinoma Pathology Histological type Immunohistochemistry Molecular variation

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Prevalence, awareness, treatment, and control of hypertension in the non-dialysis chronic kidney disease patients

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Chinese Medical Journal 2013年第12期126卷 2276-2280页

作者： ZHENG Ying CAI guang-yan CHEN Xiang-mei FU Ping CHEN jiang-hua DING Xiao-qiang yu xue-qing lin Hong-li LIU jian XIE Ru-juan WANG Li-ning NI Zhao-hui LIU Fu-you YIN Ai-ping XING Chang-ying WANG Li SHI Wei LIU jian-she HE Ya-ni DING guo-hua LI Wen-ge WU guang-li MIAO Li-ning CHEN Nan SU Zhen MEI Chang-lin ZHAO Jiu-yang GU Yong BAI yun-kai LUO hui-min lin Shan CHEN Meng-hua GONG Li YANG Yi-bin YANG Xiao-ping LI Ying WAN jian-xin WANG Nian-song LI Hai-ying XI Chun-sheng HAO Li XU Yan FANG Jing-ai LIU Bi-cheng LI Rong-shan WANG Rong zhang Jing-hong WANG jian-qin LOU Tan-qi SHAO Feng-min MEI Feng LIU Zhi-hong yuan Wei-jie SUN Shi-ren zhang ling ZHOU Chun-hua CHEN Qin-kai JIA Shun-lian GONG Zhi-feng GUAN guang-ju XIA tian ZHONG Liang-bao Department of Nephrology State key Laboratory of Kidney Disease Chinese PLA General Hospital Beijing 100853 China Nephrology Institute of the Chinese People's Liberation Army Chinese People's Liberation Army Key Laboratory of Nephrology Beijing 100853 China Department of Nephrology West China Hospital of Sichuan University Chengdu Sichuan 610041 China Department of Nephrology First Affiliated Hospital School of Medicine Zhejiang University Hangzhou Zhejiang 310003 China Department of Nephrology Zhongshan Hospital Fudan University Shanghai 200032 China Department of Nephrology First Affiiated Hospital of Sun Yat-sen University Guangzhou Guangdong 510080 China Department of Nephrology First Affiliated Hospital of Dalian Medical University Dalian Liaoning 116011 China Department of Nephrology First Affiliated Hospital of Xinjiang Medical University Urumqi Xinjiang 830054 China Department of Nephrology First Affiliated Hospital of Harbin Medical University Harbin Heilongjiang 150001 China Department of Nephrology First Afftiated Hospital of China Medical University Shenyang Liaoning 110001 China Department of Nephrology Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200025 China Department of Nephrology Second Xiangya Hospital Central South University Changsha Hunan 410000 China Department of Nephrology First Affiliated Hospital of Medical College Xi'an Jiaotong University Xi'an Shaanxi 710061 China Department of Nephrology First Affiliated Hospital of Nanjing Medical University (Jiangsu Province Hospital) Nanjing Jiangsu 210029 China Department of Nephrology Sichuan Provincial People's Hospital Chengdu Sichuan 610072 China Department of Nephrology Guangdong Provincial People's Hospital Guangzhou Guangdong 510030 China Department of Nephrology Affliated Xiehe Hospital Tongji Medical College Huazhong Science and Technology University Wuhan Hubei 430022 China Department of Nephrology Daping Hospital Third Military Medi

Background Data on the epidemiology of hypertension in Chinese non-dialysis chronic kidney disease （CKD） patients are *** aim of the present study was to investigate the prevalence,awareness,treatment,and control of hypertension in the non-dialysis CKD patients through a nationwide,multicenter study in *** The survey was performed in 61 tertiary hospitals in 31 provinces,municipalities,and autonomous regions in China （except Hong Kong,Macao,and Taiwan）.Trained physicians collected demographic and c{2.ical data and measured blood pressure （BP） using a standardized *** was defned as systolic BP ≥140 mmHg and/or diastolic BP ≥90 mmHg,and/or use of antihypertensive *** 〈140/90 mmHg and 〈130/80 mmHg were used as the 2.thresholds of hypertension *** multivariate logistic regression with adjustment for sex and age,we analyzed the association between CKD stages and uncontrolled hypertension in non-dialysis CKD *** The analysis included 892. non-dialysis CKD *** prevalence,awareness,and treatment of hypertension in non-dialysis CKD patients were 67.3%,85.8%,and 81.0%,*** hypertensive CKD patients,33.1% and 14.1% had controlled BP to 〈140/90 mmHg and 〈130/80 mmHg,*** successive CKD stages,the prevalence of hypertension in non-dialysis CKD patients increased,but the control of hypertension decreased （P〈0.001）.When the threshold of BP 〈130/80 mmHg was considered,the risk of uncontrolled hypertension in CKD 2.3a,3b,4,and 5 stages increased 1.3,1.4,1.4,2.5,and 4.0 times compared with CKD 1 stage,respectively （P〈0.05）.Using the threshold of 〈140/90 mmHg,the risk of uncontrolled hypertension increased in advanced stages （P〈0.05）.Conclusions The prevalence of hypertension Chinese non-dialysis CKD patients was high,and the hypertension control was *** successive CKD stages,the risk of uncontrolled hypertension increased.

关键词： non-dialysis chronic kidney disease chronic kidney disease stages hypertension epidemiology

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Consensus statement on layout and delivery of automatic external defibrillator in China

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Journal of Hainan Medical University 2020年第15期26卷 18-23页

作者： yu Cao Song Chen Yan-Fen Chai Xiao-hui Chen yu-guo Chen Shao-Wen Cheng Wen-Wei Cheng Bang-Han Ding Yang Deng Jie Fu Bang-jiang Fang Mai-Ying Fan Li Gui Ping Gong Wei guo Shu-Bin guo Liang Huang Ji-yuan Han Zhong Ji Xian-Fei Ji Xin-Cai Ji Hong-Xu Jin Xin-Jun jiang Wang-Xiang jiang Jia-Liang Liu Xiao-Ran Liu Zhi Liu Chuan-Zhu Lv Feng Lu Tan-Shi Li Xin Li Yong Li Shang-Lun Li Shuang-Ming Li Xiao-Gang Li Bao-Jun Li Pei-Wu Li Chun-Sheng Li Zhi-Jun Li Chang-Luo Li Xiang-Min Li Yin-Ping Li Zong-Jun Lu Zu-Xun Lu Zhong-Qiu Lu Zhi-Qian Luo Xiao-Xing Liao jian-Bo Lei Tao Ma yu Ma yue-Feng Ma Qing-Bian Ma lin-Hao Ma Jun-Qi Ma Shi-Nan Nie Jie-Miao Ou-Yang Peng Peng Qiao Pei Shu-Ming Pan guo-Zhong Qing Li-Jie Qin Wu-Ying Qiao Fei Shao Wei Song Xing-yue Song Zhen-Ju Song Rong-Ju Sun De-Ya Shang Du-Juan Sha Gui-Lan Tao guo-Gang tian Ying-Ping tian jian-guang tian Chao-Yang Tong Zi-Ren Tang Meng-Xiong Tang guo-Ping Wu Zhi Wan Tao Wang Xin Wang Peng Wang Zhong Wang Tong Wang Ri-Xing Wang Yi-Xin Wang Xiao-Dan Wang ling Wu Wei Wei Hua Xiang Feng Xu Jun Xu Jie Xu Miao-Rong Xie Shuo-Gui Xu Tie Xu Feng yu Wen Yi Li-Shan Yang Shi-Jiao Yan Jin-jian Yao Shou-Chun Yan xue-Zhong yu Xian-Zhi Ye Xian-Liang Yan Fu-Bing Zhou Rong-Bin Zhou Ming Zhou Qiang Zhou Jin Zhou Ping Zhou Chang-Ju Zhu Hua-Dong Zhu Ji-Hong Zhu Hong zhang mao zhang Hua zhang Na zhang guo-Qiang zhang guo-Xiu zhang Jin-Song zhang Wen-Wu zhang Wen-Zhong zhang jian-Feng zhang Yi-Min Zhu Jun Zeng yuan Zheng Zhi-Jie Zheng Shen Zhao Yan Zhao Min Zhao Bin Zhao Xiao-Dong Zhao Xiao-Jing Zhao Hong-Ke Zeng Sheng-Qiang Zou The Chinese Society of Emergency Medicine Research Unit of Island Emergency Medicine Chinese Academy of Medical SciencesHainan Medical University key laboratory of Emergency and Trauma of {2. Hainan Medical UniversityHaikouHainanChina Emergency and Trauma College Hainan Medical UniversityHaikouHainanChina Department of Emergency Hainan Clinical Research Center for Acute and Critical DiseasesThe Second Affiliated Hospital of Hainan Medical UniversityHaikouHainanChina key laboratory of Hainan Trauma and Disaster Rescue key laboratory of Trauma of Hainan Medical University

*** Sudden cardiac death(SCD)refers to sudden death due to a variety of cardiac *** is manifested as a sudden loss of consciousness,cardiac arrest,and respiratory arrest and generally shows early symptoms that are atypical and not easily detected[1].According to a recent study,nearly 544000 patients suffer from SCD every year in China[2..

关键词： cardiac death respiratory

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Advances in nuclear detection and readout techniques

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Nuclear Science and Techniques 2023年第12期34卷 281-358页

作者： Rui He Xiao‑Yang Niu Yi Wang Hong‑Wei Liang Hong‑Bang Liu Ye tian Hong‑lin {2. Chao‑Jie Zou Zhi‑Yi Liu yun‑Long {2. Hai‑Bo Yang Ju Huang Hong‑Kai Wang Wei‑Jia Han Bei Cao Gang Chen Cong Dai Li‑Min Duan Rui‑Rui Fan Fang‑Fa Fu jian‑Hua guo Dong Han Wei jiang Xian‑Qin Li Xin Li Zhuo‑Dai Li yu‑Tie Liang Shun Liao De‑Xu lin Cheng‑Ming Liu guo‑Rui Liu Jun‑Tao Liu Ze Long Meng‑Chen Niu Hao Qiu Hu Ran Xiang‑Ming Sun Bo‑Tan Wang Jia Wang Jin‑Xiang Wang Qi‑lin Wang Yong‑Sheng Wang Xiao‑Chuan Xia Hao‑Qing Xie He‑Run Yang Hong Yin Hong {12. Chun‑hui {2. Rui‑guang Zhao Ran Zheng Cheng‑Xin Zhao Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China Advanced Energy Science and Technology guangdong laboratory Huizhou 516000China key laboratory of Particle and Radiation Imaging Department of Engineering PhysicsTsinghua UniversityBeijing 100084China School of Integrated Circuits Dalian University of TechnologyDalian 116020China guangxi key {2. for Relativistic Astrophysics School of Physical Science and TechnologyGuangxi UniversityNanning 530004China School of Nuclear Science and Technology Lanzhou UniversityLanzhou 730000China State key laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Department of Radiation Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Electronic Engineering School Heilongjiang UniversityHarbin 150080China Spallation Neutron Source Science Center Dongguan 523803China Micro‑electronic Department Harbin Institute of TechnologyHarbin 150001China Purple Mountain Observatory Chinese Academy of SciencesNanjing 210034China Liaoning Academy of Materials Shenyang 110167China Istituto Nazionale di Fisica Nucleare Sezione di PerugiaPerugiaItaly School of Mathematics and Physics Chengdu University of TechnologyChengdu 620035China PLAC Key Laboratory of Quark and Lepton Physics(MOE)Central China Normal UniversityWuhan 430079China School of Electronics and Information Northwestern Polytechnical UniversityXi’an 710129China State key Lab of Superhard Materials College of PhysicsJilin UniversityChangchun 130012China School of Computer Science Northwestern Polytechnical UniversityXi’an 710129China

“A Craftsman Must Sharpen His Tools to Do His Job,”said *** detection and readout techniques are the foundation of particle physics,nuclear physics,and particle astrophysics to reveal the nature of the ***,they are being increasingly used in other disciplines like nuclear power generation,life sciences,environmental sciences,medical sciences,*** article reviews the short history,recent development,and trend of nuclear detection and readout techniques,covering Semiconductor Detector,Gaseous Detector,Scintillation Detector,Cherenkov Detector,Transition Radiation Detector,and Readout *** explaining the principle and using examples,we hope to help the interested reader underst and this research field and bring exciting information to the community.

关键词： Silicon detector Wide bandgap detector Time projection chamber(TPC) Multigap resistive plate chamber detector(MRPC) Scintillation detector Calorimeters Cherenkov detector Transition radiation detector Artificial intelligence Trigger-less readout

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Fungal diversity notes 1387-1511:taxonomic and phylogenetic contributions on genera and species of fungal taxa

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Fungal Diversity 2021年第6期111卷 1-335页

作者： Saranyaphat Boonmee Dhanushka N.Wanasinghe Mark S.Calabon Naruemon Huanraluek Sajini K.U.Chandrasiri Gareth E.B.Jones Walter Rossi Marco Leonardi Sanjay K.Singh Shiwali Rana Paras N.Singh Deepak K.Maurya Ajay C.Lagashetti Deepika Choudhary yu-Cheng Dai Chang-lin Zhao Yan-Hong Mu Hai-Sheng {2. Shuang-hui He Rungtiwa Phookamsak Hong-Bo jiang María P.Martín Margarita Dueñas MTeresa Telleria Izabela L.Kałucka Andrzej M.Jagodziński Kare Liimatainen Diana S.Pereira Alan J.L.Phillips Nakarin Suwannarach Jaturong Kumla Surapong Khuna Saisamorn Lumyong Tarynn B.Potter Roger G.Shivas Adam H.Sparks Niloofar Vaghefi Mohamed A.Abdel-Wahab Faten A.Abdel-Aziz guo-Jie Li Wen-Fei lin Upendra Singh Rajendra P.Bhatt Hyang Burm Lee Thuong T.T.Nguyen Paul M.Kirk Arun Kumar Dutta Krishnendu Acharya VVenkateswara Sarma M.Niranjan Kunhiraman C.Rajeshkumar Nikhil Ashtekar Sneha Lad Nalin N.Wijayawardene Darbe J.Bhat Rong-Ju Xu Subodini N.Wijesinghe Hong-Wei Shen Zong-Long Luo Jing-Yi zhang Phongeun Sysouphanthong Naritsada Thongklang Dan-Feng Bao Janith V.S.Aluthmuhandiram Jafar Abdollahzadeh Alireza Javadi Francesco Dovana Muhammad Usman Abdul Nasir Khalid Asha J.Dissanayake Anusha Telagathoti Maraike Probst Ursula Peintner Isaac Garrido-Benavent Lilla Bóna Zsolt Merényi Lajos Boros Bratek Zoltán JBenjamin Stielow Ning jiang Cheng-Ming tian Esmaeil Shams Farzaneh Dehghanizadeh Adel Pordel Mohammad Javan-Nikkhah Teodor T.Denchev Cvetomir M.Denchev Martin Kemler Dominik Begerow Chun-Ying Deng Emma Harrower Tohir Bozorov Tutigul Kholmuradova yusufjon Gafforov Aziz Abdurazakov jian-Chu Xu Peter E.Mortimer guang-Cong Ren Rajesh Jeewon Sajeewa S.N.Maharachchikumbura Chayanard Phukhamsakda Ausana Mapook Kevin D.Hyde Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand CAS key laboratory for Plant Biodiversity and Biogeography of East Asia(KLPB) Kunming Institute of BotanyChinese Academy of ScienceKunming 650201YunnanPeople’s Republic of China CIFOR-ICRAF China Program World Agroforestry(ICRAF)Kunming 650201YunnanPeople’s Republic of China Honghe Center for Mountain Futures Kunming Institute of BotanyHonghe CountyKunming 654400YunnanPeople’s Republic of China Department of Botany and Microbiology College of ScienceKing Saud UniversityP.O.Box 2455Riyadh 11451Saudi Arabia Section Environmental Sciences Department MeSVAUniversity of L’Aquila67100 CoppitoAQItaly National Fungal Culture Collection of India(NFCCI) Biodiversity and Palaeobiology GroupMACS Agharkar Research InstituteG.G.Agarkar RoadPune 411004India Institute of Microbiology School of Ecology and Nature ConservationBeijing Forestry UniversityBeijing 100083People’s Republic of China College of Biodiversity Conservation Southwest Forestry UniversityKunming 650224People’s Republic of China CAS key laboratory of Forest Ecology and Management Institute of Applied EcologyChinese Academy of SciencesShenyang 110164People’s Republic of China University of the Chinese Academy of Sciences Beijing 100049People’s Republic of China Centre for Mountain Futures(CMF) Kunming Institute of BotanyKunming 650201YunnanPeople’s Republic of China Department of Mycology Real Jardín Botánico-CSICPlaza de Murillo 228014 MadridSpain Department of Algology and Mycology Faculty of Biology and Environmental ProtectionUniversity of LodzBanacha 12/1690-237ŁódźPoland Institute of Dendrology Polish Academy of SciencesParkowa 562-035 KórnikPoland Jodrell laboratory Royal Botanic GardensKewRichmond TW93DSSurreyUK Faculdade de Ciências Biosystems and Integrative Sciences Institute(BioISI)Universidade de LisboaCampo Grande1749-016 LisbonPortugal Dep

This article is the 13th contribution in the Fungal Diversity Notes series,wherein 12. taxa from four phyla,ten classes,31 orders,69 families,92.genera and three genera incertae sedis are treated,demonstrating worldwide and geographic *** taxa described and illustrated in the present study include three new genera,69 new species,one new com-bination,one reference specimen and 51 new records on new hosts and new geographical *** new genera,Cylindrotorula(Torulaceae),Scolecoleotia(Leotiales genus incertae sedis)and Xenovaginatispora(lindomycetaceae)are introduced based on distinct phylogenetic lineages and unique *** described species are Aspergillus lan-naensis,Cercophora dulciaquae,Cladophialophora aquatica,Coprinellus punjabensis,Cortinarius alutarius,***-latus,***,Coryneum fagi,Cruentomycena uttarakhandina,Cryptocoryneum rosae,Cyathus uniperidiolus,Cylindrotorula indica,Diaporthe chamaeropicola,Didymella azollae,Diplodia alanphillipsii,Dothiora coronicola,Efibula rodriguezarmasiae,Erysiphe salicicola,Fusarium queenslandicum,Geastrum gorgonicum,***,Helicosporium sexualis,Helminthosporium chiangraiensis,Hongkongmyces kokensis,Hydrophilomyces hydraenae,Hygrocybe boertmannii,Hyphoderma australosetigerum,Hyphodontia yunnanensis,Khaleijomyces umikazeana,Laboulbenia divisa,Laboulbenia triarthronis,Laccaria populina,Lactarius pallidozonarius,Lepidosphaeria strobelii,Longipedicellata megafusiformis,Lophiotrema lincangensis,Marasmius benghalensis,***,***,Mariannaea camelliae,Mel-anographium smilaxii,Microbotryum polycnemoides,Mimeomyces digitatus,Minutisphaera thailandensis,Mortierella solitaria,Mucor harpali,Nigrograna jinghongensis,Odontia huanrenensis,***,Paraconiothyrium ajrekarii,Par-afuscosporella niloticus,Phaeocytostroma yomensis,Phaeoisaria synnematicus,Phanerochaete hainanensis,Pleopunctum thailandicum,Pleurotheciella dimorphospora,Pseudochaetosphaeronema

关键词： 72.new taxa One new combination One reference specimen 51 new records Agaricomycetes Ascomycota Bartheletiomycetes Basidiomycota Dothideomycetes Eurotiomycetes Exobasidiomycetes Laboulbeniomycetes Leotiomycetes Mortierellomycetes Mortierellomycota Mucoromycetes Mucoromycota Phylogeny Sordariomycetes Taxonomy

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