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World Journal of Gastroenterology 2000年第2期6卷 287-289页

作者： Chen QK yuan sz Zeng ZY Huang ZQ Sun Yat Sen Univ Med Sci Sun Yat Sen Mem Hosp Dept Gastroenterol Guangzhou 510120 Guangdong Peoples R China

INTRODUCTIONMacrophages play an important role in tumor lysisand growth *** can be activated to atumoricidal state by a variety of agents such asIFNr,TNFα or *** killing machanisms ofactivated macrophages have been ***,it has been proved thatantibody dependent cellular cytotoxicity (ADCC) isone of the potent arms to lyse tumor cells

关键词： pancreatic neoplasms/therapy antibody monoclonal/therapeutic use macrophages lymphokine cytotoxicity immunologic interleukin-2

整合素β4结合蛋白与P311在人胚肾293细胞中的表达及共定位

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中国组织工程研究与临床康复 2007年第36期11卷 7211-7214页

作者：易绍萱袁顺宗马兵贺伟峰陈希炜胡晓红张小容彭旭周丽娜罗高兴吴军成都医学院第一附属医院实验研究中心四川省成都市610500 解放军第三军医大学西南医院全军烧伤研究所创伤烧伤与复合伤国家重点实验室疾病蛋白质组重庆市市级重点实验室重庆市400038

目的:利用激光共聚焦显微镜共定位检测整合素β4结合蛋白与P311蛋白在细胞内的分布,进一步证实它们在细胞内产生相互作用的可能性。方法:实验于2006-03/12在解放军第三军医大学西南医院全军烧伤研究所,创伤、烧伤与复合伤国家重点实验... 详细信息

目的:利用激光共聚焦显微镜共定位检测整合素β4结合蛋白与P311蛋白在细胞内的分布,进一步证实它们在细胞内产生相互作用的可能性。方法:实验于2006-03/12在解放军第三军医大学西南医院全军烧伤研究所,创伤、烧伤与复合伤国家重点实验室完成。先分别构建能在哺乳动物细胞中表达整合素β4结合蛋白的绿色荧光融合蛋白和表达P311的红色荧光融合蛋白的重组载体,经酶切鉴定正确后,利用脂质体介导法共转染人胚肾293细胞后,激光共聚焦显微镜进行共定位观察。结果:表达整合素β4结合蛋白的绿色荧光融合蛋白和表达P311的红色荧光融合蛋白的重组载体经双酶切鉴定正确,转染293细胞后,荧光显微镜下能观察到绿色和红色荧光。激光共聚焦显微镜下观察两者主要分布在293细胞的胞浆和胞核中,并且存在着共定位现象。结论:表达整合素β4结合蛋白的绿色荧光融合蛋白和表达P311的红色荧光融合蛋白的重组载体在空间分布上两者存在相互作用的物质基础。

关键词：整合素β4结合蛋白 P311 激光共聚焦基因表达共转染组织构建

Soil erosion calculation in the hydro-fluctuation belt by adding water erosivity factor in the USLE model

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Journal of Mountain Science 2020年第9期17卷 2123-2135页

作者： XIN Zhi-yuan XIA Jian-guo College of Resources Sichuan Agricultural UniversityChengdu 611130China

Soils in the hydro-fluctuation belts of the reservoirs are most highly influenced by the special hydro-conditions and reservoir operation,leading to unique soil erosion process and largely accelerate soil erosion *** present study aimed to estimate soil erosion rate in the hydro-fluctuation belt of the Pubugou Reservoir,Southwest China,based on the framework of Universal Soil Loss Equation(USLE).An attempt has been made to modify the original USLE by including the reservoir water erosivity(W),a new factor into the *** erosion rate from different land use types were quantitatively estimated,using the USLE and the modified USLE *** observation showed that soil erosion rate in dry farmland,bare land and grassland was 4700,44600 and 5050 t/km2,*** erosion rate assessed by the modified USLE was closely related to that recorded from the field monitoring *** findings of this study clearly highlight the importance of inclusion of the W factor to the original USLE model while assessing soil erosion in the reservoir hydro-fluctuation belt.

关键词： Modified USLE Water erosivity Soil erosion Hydro-fluctuation belt Reservoir

Benthodytes occidentpalauta ***.,a new species of deep-sea holothuroid(Elasipodida:Psychropotidae)from the west of Kyushu-Palau Ridge in the Western Pacific Ocean

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Journal of Oceanology and Limnology 2024年第1期42卷 252-262页

作者： Chongzhen yuan Chunsheng WANG Dongsheng ZHANG Key Laboratory of Marine Ecosystem Dynamics Second Institute of OceanographyMinistry of Natural ResourcesHangzhou 310012China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai 519082China School of Oceanography Shanghai Jiao Tong UniversityShanghai 200030China

Benthodytes occidentpalauta *** collected from the Kyushu-Palau Ridge at a depth of 5481 m in *** new species is characterized by a gelatinous body wall,violet skin,six pairs of dorsal papillae,and a rough mid-ventral surface without tube *** dorsal deposits are rod-shaped and *** types of papillae deposits as crosses with four arms with central bipartite *** deposits are *** ossicles are rod-shaped with end *** deposits are rodshaped,tripartite,and *** phylogenetic analyses based on cytochrome oxidase subunit 1(COI)and 16S individually and a concatenated dataset of COI and 16S genes of this species support that *** *** to Benthodytes.

关键词： Holothuroidea Benthodytes cytochrome oxidase subunit 1(COI) 16S phylogenetic analysis

Efficacy and Safety of Second-line Treatments in Patients with Advanced Hepatocellular Carcinoma after Sorafenib Failure:A Meta-analysis

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Journal of Clinical and Translational Hepatology 2021年第6期9卷 868-877页

作者： Limin An Haotian Liao Kefei yuan Department of Liver Surgery&Liver Transplantation State Key Laboratory of Biotherapy and Cancer CenterWest China HospitalSichuan University and Collaborative Innovation Center of BiotherapyChengduSichuanChina Laboratory of Liver Surgery West China HospitalSichuan UniversityChengduSichuanChina

Background and Aims:In the last decade,several second-line therapies followed by sorafenib in patients with advanced hepatocellular carcinoma(HCC)have been *** the outcomes were different from each *** meta-analysis aimed to evaluate the efficacy and safety of the second-line therapies followed by sorafenib in patients with advanced ***:Embase(1974 to October 2019)and Ovid MEDLINE(1946 to October 2019)were searched for randomized clinical trials on second-line therapies followed by sorafenib in patients with advanced *** quality of each study was assessed by the modified Jadad *** analysis was carried out by RevMan5.3 *** and safety were *** included overall survival(OS),disease control rate,time to progression,and progression-free ***:Eight studies involving 3,173 patients were *** difference in OS was found between the second-line treatment group and the control group(HR=0.87,95%CI:0.74-1.01,p=0.06).Disease control rate(relative risk(RR)=1.36,95%CI:1.16-1.60,p=0.0002),time to progression(HR=0.64,95%CI:0.51-0.81,p=0.0002)and progression-free survival(HR=0.60,95%CI:0.46-0.77,p<0.0001)were significantly improved by the second-line *** was a slight difference in adverse events of any grade(RR=1.07,95%CI:1.00-1.14,p=0.03)between the two ***:These second-line therapies followed by sorafenib may potentially improve the prognosis in patients with advanced *** with other second-line therapies,regorafenib seemed to be more effective.

关键词： Hepatocellular carcinoma Therapeutics Sorafenib Systematic review Meta-analysis

Synthesis and Characterization of Iron-X(X:Ni,Cu) Nanowires

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Synthesis and Characterization of Iron-X(X:Ni,Cu) Nanowires

身体活动水平对2型糖尿病患者颈动脉内膜中层厚度增厚的影响研究

第十一届海峡两岸超微颗粒学术研讨会暨中国颗粒学会超微颗粒专委会2019年会

作者： Xu-Xiang Cai Mao-yuan Chen Yuh-Jing Chiou Hong-Ming Lin Yeukuang Hwu sz-Chian Liou Wen-An Chiou Chung-Kwei Lin Department of Materials Engineering Tatung University Department of Chemical Engineering Tatung University "Institute of Physics Academia Sinica" AIM Lab NanoCenterUniversity of Maryland School of Dental Technology College of Oral MedicineTaipei Medical University

Nano magnetic materials,have been applied to the drug delivery system,nano-bioprobe,biomarker,targeted therapy for cancer,and electromagnetic interference shielding *** of these different applications,the surfaces or compositions of the materials need to have different ***/transition metal nanowires(***/Ni,and Fe/Cunanowires)towards high oxidation resistance and good magnetization properties are examined in this *** mixed precursors of iron and copper or nickel to prepare the solid solution or alloy of Fe/Cu or Fe/Ni nanowires in an external magnetic *** nanowires can be prepared in diameter less than 100 nm with micrometer length.X-ray diffraction,field emission scanning electron microscope,inductively coupled plasma and vibrating sample magnetometer are used to examine the properties of these nanowires.

关键词： iron nanowires Nickel Copper External magnetic field Oxidation resistance Magnetic properties

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中国全科医学 2025年第6期28卷 697-704页

作者：孙珍珍崔茜楼青青陈晓栋方丹姚平袁晓丹南京中医药大学附属医院内分泌科江苏省南京市210004 南京医科大学附属常州第二人民医院内分泌科江苏省常州市213000 海南医学院第一附属医院代谢性疾病临床医学研究中心海南省海口市570102 南京中医药大学附属中西医结合医院心血管内科江苏省南京市210028 南京中医药大学护理学院江苏省南京市210023 南京中医药大学附属中西医结合医院内分泌科江苏省南京市210028 南京中医药大学附属中西医结合医院公共卫生科江苏省南京市210028

背景心血管疾病是2型糖尿病(T2DM)患者的主要死亡原因,颈动脉内膜中层厚度(CIMT)增厚可预测心血管疾病的发生。中高水平的身体活动(PA)可改善患者的血糖水平并降低心血管疾病的发生率和死亡风险。探讨这一可改变的生活方式与CIMT的关系... 详细信息

背景心血管疾病是2型糖尿病(T2DM)患者的主要死亡原因,颈动脉内膜中层厚度(CIMT)增厚可预测心血管疾病的发生。中高水平的身体活动(PA)可改善患者的血糖水平并降低心血管疾病的发生率和死亡风险。探讨这一可改变的生活方式与CIMT的关系可能是预防心血管疾病的有效策略。目的分析不同PA水平与T2DM患者CIMT增厚的关系,为患者推荐个性化活动方案提供科学依据。方法本研究为横断面研究,选取2019年1月—2022年2月于江苏省两家三级甲等医院内分泌门诊就诊的3099例T2DM患者为研究对象,采用国际身体活动量表(IPAQ)短问卷评估患者的PA水平,将患者分为轻度及以下PA组、中度PA组和高强度PA组。通过二元Logistic回归分析探讨PA与CIMT增厚的关系,并按照不同肥胖程度和血压、血脂及糖化达标状况进行分层分析。将PA水平作为连续变量绘制限制性立方样条评价PA与CIMT增厚的剂量反应关系。结果与轻度及以下PA患者(n=981)相比,中度(n=1389)和高强度(n=729)PA患者的年龄较小,糖化血红蛋白(HbA_(1c))和低密度脂蛋白胆固醇(LDL-C)水平较高(P0.05);而在肥胖患者(n=708)中仅中度PA与CIMT增厚相关(OR=0.614,95%CI=0.382~0.987,P<0.05);血压、血脂及糖化3项指标均不达标(n=324)和仅1项指标达标(n=1416)的患者,中度PA与发生CIMT增厚呈负相关(P<0.05)。结论PA水平与CIMT增厚存在剂量反应关系,中度PA与CIMT增厚呈负相关,尤其是在肥胖、血压、血脂及糖化控制较差的人群中,而高强度PA对CIMT的影响不显著。

关键词：糖尿病,2型身体活动颈动脉内膜中膜厚度横断面研究江苏省

Bisphosphonate-based nanocomposite hydrogels for biomedical applications

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Bioactive Materials 2020年第4期5卷 819-831页

作者： Weihao yuan Zhuo Li Xian Xie Zhi-Yong Zhang Liming Bian Department of Biomedical Engineering The Chinese University of Hong KongShatinHong Kong999077PR China Shenzhen Research Institute The Chinese University of Hong KongShenzhen518172PR China Translational Research Centre of Regenerative Medicine and 3D Printing of Guangzhou Medical University Guangdong Province Engineering Research Center for Biomedical EngineeringState Key Laboratory of Respiratory DiseaseThe Third Affiliated Hospital of Guangzhou Medical UniversityNo.63 Duobao RoadLiwan DistrictGuangzhou CityGuangdong Province510150PR China China Orthopedic Regenerative Medicine Group(CORMed) HangzhouZhejiang310058PR China

Nanocomposite hydrogels consist of polymeric network embedded with functional nanoparticles or nanostructures,which not only contribute to the enhanced mechanical properties but also exhibit the bioactivities for regulating cell ***(BPs)are capable of coordinating with various metal ions and modulating bone *** to the inherent dynamic properties of metal–ligand coordination bonds,BPbased nanocomposite hydrogels possess tunable mechanical properties,highly dynamic structures,and the capability to mediate controlled release of encapsulated therapeutic agents,thereby making them highly versatile for various biomedical *** review presents the comprehensive overview of recent developments in BP-based nanocomposite hydrogels with an emphasis on the properties of embedded nanoparticles(NPs)and interactions between hydrogel network and ***,various challenges in the biomedical applications of these hydrogels are discussed to provide an outlook of potential clinical translation.

关键词： Bisphosphonates Metal-ligand coordination Nanocomposite hydrogels

Efficacy and Duration of Electro-Acupuncture Combined with Conventional Antipsychotics for Schizophrenia:A Meta-Analysis

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World Journal of Traditional Chinese Medicine 2023年第2期9卷 212-223页

作者： Zhao-Han Huang yuan Fang Qi Yu Tong Wang College of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijingChina Shanghai Center for Women and Children's Health ShanghaiChina

Introduction:This study aimed to evaluate the effectiveness and optimal course time of electro-acupuncture(EA)combined with conventional antipsychotics in the treatment of schizophrenia(sz)and to provide a basis for its clinical ***:Relevant databases and authoritative websites were retrieved,and references were screened up to May *** quality evaluation and data extraction were carried out according to the requirements of Cochrane version 5.1.0,and meta-analysis was conducted using Rav Man5.4 ***:In total,16 randomized controlled trails comprising 1352 patients were ***-analysis revealed that the observation group showed greater improvements than the control group in total clinical efficacy(P0.05).In the 4-6 weeks following treatment,a significant improvement in all the four components of the PANSS scores was observed in the observation ***:The efficacy of EA combined with conventional antipsychotics for sz is better than that of psychiatric drugs *** addition,the effect of a 4-to 6-week treatment course on each outcome index is more significant,and the efficacy is higher.

关键词： Electro-acupuncture meta-analysis schizophrenia

Multitemporal UAV-based photogrammetry for landslide detection and monitoring in a large area:a case study in the Heifangtai terrace in the Loess Plateau of China

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Journal of Mountain Science 2020年第8期17卷 1826-1839页

作者： XU Qiang LI Wei-le JU yuan-zhen DONG Xiu-jun PENG Da-lei State Key Laboratory of Geohazard Prevention and Geoenvironment Protection Chengdu University of TechnologyChengdu 610059China

With high spatial resolution,on-demand-flying ability,and the capacity for obtaining threedimensional measurements,unmanned aerial vehicle(UAV)photogrammetry is widely used for detailed investigations of single landslides,but its effectiveness for landslide detection and monitoring in a large area needs to be *** Heifangtai terrace in the Loess Plateau of China is a loess terrace that is extremely susceptible to irrigation-induced loess *** paper used UAV-based photogrammetry for a series of highresolution images spanning over 30 months for landslide detection and monitoring of the terrace with an area of 32 km^*** and evenly distributed ground control points were established and measured to ensure the high accuracy of the photogrammetry *** structure-from-motion(Sf M)technique was used to convert overlapping images into orthographic images,3D point clouds,digital surface models(DSMs)and mesh *** multitemporal differential mesh models,landslide vertical movements and potential landslides were detected and *** results indicate that a combination of UAV-based orthophotos and differential mesh models can be used for flexible and accurate detection and monitoring of potential loess landslides in a large area.

关键词： Unmanned Aerial Vehicle Loess Plateau Landslide detection Landslide monitoring Differential mesh model Vertical movement