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Treatment and Clinical Management of Chronic Thromboembolic Pulmonary Hypertension:An Update of Literature Review

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Congenital Heart Disease 2024年第2期19卷 157-176页

作者： yuan ren Yingxian Sun Zhiguang Yang Yanli Chen The Department of Cardiology The First Affiliated Hospital of China Medical UniversityShenyang110000China The Radiology Department Shengjing Hospital of China Medical UniversityShenyang110020China

Chronic thromboembolic pulmonary hypertension(CTEPH)is a chronic,progressive,debilitating,and life-threa-tening complication of pulmonary embolism(PE).Recent technological advances have permitted various treat-ment options for the treatment of CTEPH,including surgery,angioplasty,and medical treatment,depending on the location and characteristics of *** endarterectomy(PEA)is the treatment of choice for CTEPH,as it offers excellent long-term outcomes and a high probability of ***,various medical and interventional therapies are currently being developed for patients with inoperable *** review mainly summarizes the current treatment approaches of CTEPH,offering more options for specialist physicians to,thus,better manage chronic thromboembolic syndromes.

关键词： Chronic thromboembolic pulmonary hypertension(CTEPH) chronic thromboembolic pulmonary disease(CTEPD) pulmonary endarterectomy(PEA) balloon pulmonary angioplasty(BPA) COVID-19

Asymmetric alkenylation reaction of benzoxazinones with diarylethylenes catalyzed by B(C_(6)F_(5))_(3)/chiral phosphoric acid

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Chinese Chemical Letters 2024年第5期35卷 135-140页

作者： Zhen Liu Zhi-yuan ren Chen Yang Xiangyi Shao Li Chen Xin Li State Key Laboratory of Elemento-Organic Chemistry Frontiers Science Center for New Organic MatterCollege of ChemistryNankai UniversityTianjin 300071China Haihe Laboratory of Sustainable Chemical Transformations Tianjin 300192China Zhenhai High School of Zhejiang Ningbo 315299China

Catalytic enantioselective alkenylation is an efficient method to construct chiral alkene molecules,but the asymmetric alkenylation of simple alkenes catalyzed by metal-free catalysts remains an elusive ***,we reported an asymmetric alkenylation of benzoxazinones with diarylethylenes by utilizing a B(C_(6)F_(5))_(3)/chiral phosphoric acid catalyst.A broad of benzoxazinones and diarylethylenes with electron-withdrawing and electron-donating groups were tolerated(up to 95%yield and 97.5:2.5 e.r.)in the methodology under mild reaction ***,the synthetic utility was confirmed by the scaled-up reaction and transformations of the *** mechanism was preliminarily explored by control reactions,nonlinear effect experiment and DFT calculations.

关键词： Asymmetric alkenylation Simple alkenes Benzoxazinones B(C_(6)F_(5))_(3)/chiral phosphoric acid Theoretical calculations

CD87-targeted BiT E and CAR-T cells potently inhibit invasive nonfunctional pituitary adenomas

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Science China Life Sciences 2024年

作者： yuan ren Xinjie Bao Ming Feng Bing Xing Wei Lian Yong Yao renzhi Wang Department of Neurosurgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College

Recently, bispecific T-cell engagers(BiTEs) and chimeric antigen receptor-modified T cells(CAR-Ts) have been shown to have high therapeutic efficacy in hematological tumors. CD87 is highly expressed in solid tumors with an oncogenic function. To assess their cytotoxic effects on invasive nonfunctioning pituitary adenomas(iNFPAs), we first examined CD87 expression and its effects on the metabolism of iNFPA cells. We generated CD87-specific BiTE and CAR/IL-12 T cells, and their cytotoxic effects on iNFPAs cells and in mouse models were determined. CD87 had high expression in i NFPA tissue and cell samples but was undetected in noncancerous brain samples. CD87×CD3BiTE and CD87 CAR/IL-12 T-cells showed antigenic specificity and exerted satisfactory cytotoxic effects, decreasing tumor cell proliferation in vitro and reducing existing tumors in experimental mice. Overall, the above findings suggest that CD87 is a promising target for the immunotherapeutic management of iNFPAs using anti-CD87 BiTE and CD87-specific CAR/IL-12 T cells.

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人口迁移流动与城镇化发展战略任务

北京行政学院学报 2024年第1期 107-117页

作者：任远复旦大学社会发展与公共政策学院上海200433

本世纪以来,特别是2010年以来,我国人口迁移流动和城镇化表现出的特点是:流动人口数量继续增长,人口流动向东部地区尤其是东南沿海地区转移,人口迁移流动存在“南强北弱”和“北人南迁”趋势,人口城镇化水平继续提高和中西部地区城镇化... 详细信息

本世纪以来,特别是2010年以来,我国人口迁移流动和城镇化表现出的特点是:流动人口数量继续增长,人口流动向东部地区尤其是东南沿海地区转移,人口迁移流动存在“南强北弱”和“北人南迁”趋势,人口城镇化水平继续提高和中西部地区城镇化增长更快,人口更明显地向特大城市和超大城市集聚,带来超大、特大城市数量增加,并在此基础上带动若干核心城市都市圈和城市群发展等。结合人口迁移流动态势,直面我国城镇化发展进程所面临的战略任务,提出应加快推进农业转移人口和流动人口的市民化,在城镇化过程中实现更加平衡的国家发展,以及在不同地区实践多样性和因地制宜的城镇化发展。

关键词：人口迁移流动城镇化市民化农业转移人口

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当代英国小说起源研究中的小说与罗曼司

国外文学 2024年第2期 21-31页

作者：任远上海工程技术大学外国语学院

伊安·瓦特的《小说的兴起》开启了20世纪后半叶英国小说起源研究的先河。该书的不少忽略之处得到了后来学者的补充,小说文体的多质性和小说史起源历史的复杂性也得以更充分证实。这一研究中的一大问题即是罗曼司的定位及其与小说的关... 详细信息

伊安·瓦特的《小说的兴起》开启了20世纪后半叶英国小说起源研究的先河。该书的不少忽略之处得到了后来学者的补充,小说文体的多质性和小说史起源历史的复杂性也得以更充分证实。这一研究中的一大问题即是罗曼司的定位及其与小说的关系。从单纯强调小说与罗曼司之间的断裂,到意识到小说与罗曼司之间的联系,这即是20世纪后半叶的小说起源史研究的大致走向。其中主要的研究视角包括新历史主义、女性主义、科技手段辅助与文本细读相结合、比较和全球视角等,同时也体现了将宏大叙事与对于异类、断续和转瞬即逝的潮流的关注相结合的趋势。

关键词：罗曼司小说英国小说的起源

Predicting short-term major postoperative complications in intestinal resection for Crohn’s disease:A machine learning-based study

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 717-730页

作者： Fang-Tao Wang Yin Lin Xiao-Qi yuan ren-yuan Gao Xiao-Cai Wu Wei-Wei Xu Tian-Qi Wu Kai Xia Yi-Ran Jiao Lu Yin Chun-Qiu Chen Diagnostic and Treatment Center for Refractory Diseases of Abdomen Surgery Shanghai Tenth People’s HospitalTongji University School of MedicineShanghai 200072China

BACKGROUND Due to the complexity and numerous comorbidities associated with Crohn’s disease(CD),the incidence of postoperative complications is high,significantly impacting the recovery and prognosis of ***,additional stu-dies are required to precisely predict short-term major complications following intestinal resection(IR),aiding surgical decision-making and optimizing patient *** To construct novel models based on machine learning(ML)to predict short-term major postoperative complications in patients with CD following *** A retrospective analysis was performed on clinical data derived from a patient cohort that underwent IR for CD from January 2017 to December *** study participants were randomly allocated to either a training cohort or a validation *** logistic regression and random forest(RF)were applied to construct models in the training cohort,with model discrimination evaluated using the area under the curves(AUC).The validation cohort assessed the performance of the constructed *** Out of the 259 patients encompassed in the study,5.0%encountered major postoperative complications(Clavien-Dindo≥III)within 30 d following IR for *** AUC for the logistic model was 0.916,significantly lower than the AUC of 0.965 for the RF *** logistic model incorporated a preoperative CD activity index(CDAI)of≥220,a diminished preoperative serum albumin level,conversion to laparotomy surgery,and an extended operation time.A nomogram for the logistic model was *** for the surgical approach,the other three variables ranked among the top four important variables in the novel ML *** Both the nomogram and RF exhibited good performance in predicting short-term major postoperative complic-ations in patients with CD,with the RF model showing more superiority.A preoperative CDAI of≥220,a di-minished preoperative serum albumin level,and an extended operation time might be the most crucial ***

关键词： Crohn’s disease Postoperative complications Nomogram Random forest Intestinal resection

“到民间去”:早期中国共产党人领导青年运动的“农村转向”及其历史贡献

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社会主义研究 2024年第3期 73-80页

作者：任园东华大学马克思主义学院上海市习近平新时代中国特色社会主义思想研究中心东华大学基地

“到民间去”是二十世纪一二十年代对青年影响深广的政治文化运动之一。从1924年开始,“到民间去”在社会主义青年团机关刊物《中国青年》上的话语重现及其实践力量,重塑了这一运动中青年与农村之间的结构性关联。中国共产党人领导青年... 详细信息

“到民间去”是二十世纪一二十年代对青年影响深广的政治文化运动之一。从1924年开始,“到民间去”在社会主义青年团机关刊物《中国青年》上的话语重现及其实践力量,重塑了这一运动中青年与农村之间的结构性关联。中国共产党人领导青年运动从“发现农村”到“组织农村”的理论指引和实践指导历程,充分显示了经过理论武装的革命力量对于革命实践的认识深化过程,为我们党探索中国革命新道路提供了理论准备和方法基础,也在一定程度上推动了马克思主义中国化时代化的历史进程。

关键词：到民间去青年运动中国青年

唤醒·互动·引领:出版直播营销策略的情感转向与实践路径

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编辑之友 2024年第7期 53-59页

作者：任媛媛王海涛山东大学新闻传播学院山东济南250100 山东大学文化传播学院山东威海264209

在数字化连接时代,用户的消费行为由量的阶段、质的阶段进化到感情阶段,出版行业相应地在制定营销策略时面临着用户由价格敏感型向情感流动型转变的新情况。文章基于费尔克拉夫的话语分析路径,运用量化内容分析与质化深度访谈方法,对出... 详细信息

在数字化连接时代,用户的消费行为由量的阶段、质的阶段进化到感情阶段,出版行业相应地在制定营销策略时面临着用户由价格敏感型向情感流动型转变的新情况。文章基于费尔克拉夫的话语分析路径,运用量化内容分析与质化深度访谈方法,对出版直播中使用的情感营销策略进行探析。研究表明,在生产层面,出版直播采用词汇、隐喻与认同的策略唤醒用户情感;在场景层面,出版直播通过情感互动,制定了植入式、定制式与沉浸式的出版营销策略;在消费层面,出版直播通过文本泛生活化的文化适应与主播IP化的商业选择,主动进行情感引领。

关键词：出版直播情感式营销话语分析

Programmed cell death 1 inhibitor sintilimab plus concurrent chemoradiotherapy for locally advanced pancreatic adenocarcinoma

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World Journal of Clinical Oncology 2024年第7期15卷 859-866页

作者： Shi-Qiong Zhou Peng Wan Sen Zhang yuan ren Hong-Tao Li Qing-Hua Ke Department of Chemoradiotherapy The First Affiliated Hospital of Yangtze UniversityJingzhou 434000Hubei ProvinceChina

BACKGROUND Pancreatic adenocarcinoma,a malignancy that arises in the cells of the pancreas,is a devastating disease with unclear etiology and often poor *** advanced pancreatic cancer,a stage where the tumor has grown significantly but has not yet spread to distant organs,presents unique challenges in *** article aims to discuss the current strategies,challenges,and future directions in the management of locally advanced pancreatic adenocarcinoma(LAPC).AIM To investigate the feasibility and efficacy of programmed cell death 1(PD-1)inhibitor sintilimab plus concurrent chemoradiotherapy for *** Eligible patients had LAPC,an Eastern cooperative oncology group performance status of 0 or 1,adequate organ and marrow functions,and no prior anticancer *** the observation group,participants received intravenous sintilimab 200 mg once every 3 wk,and received concurrent chemoradiotherapy(concurrent conventional fractionated radiotherapy with doses planning target volume 50.4 Gy and gross tumor volume 60 Gy in 28 fractions and oral S-140 mg/m2 twice daily on days 1-14 of a 21-d cycle and intravenous gemcitabine 1000 mg/m2 on days 1 and 8 of a 21-d cycle for eight cycles until disease progression,death,or unacceptable toxicity).In the control group,participants only received concurrent *** April 2020 to November 2021,64 participants were finally enrolled with 34 in the observation group and 30 in the control *** Thirty-four patients completed the scheduled course of chemoradiotherapy,while 32(94.1%)received sintilimab plus concurrent chemoradiotherapy with 2 patients discontinuing sintilimab in the observation *** patients completed the scheduled course of chemoradiotherapy in the control *** on the Response Evaluation Criteria in Solid Tumors guidelines,the analysis of the observation group revealed that a partial response was observed in 11 patients(32.4%),stable disease was evident in 19 pa

关键词： Immunotherapy Concurrent chemoradiotherapy Locally advanced pancreatic adenocarcinoma Programmed cell death 1 Sintilimab