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World Journal of Gastroenterology 2024年第38期30卷 4239-4241页

作者： Yao-qian yuan qian-qian Chen Department of Gastroenterology The First Medical Center of Chinese PLA General HospitalBeijing 100853China

This letter comments on the article that developed and tested a machine learning model that predicts lymphovascular invasion/perineural invasion status by combining clinical indications and spectral computed tomography characteristics *** review the research content,methodology,conclusions,strengths and weaknesses of the study,and introduce follow-up research to this work.

关键词： Gastric cancer Spectral computed tomography Perineural invasion Lympho-vascular invasion Machine learning

Signaling pathways of chronic kidney diseases,implications for therapeutics

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Signal Transduction and Targeted Therapy 2022年第7期7卷 2245-2271页

作者： qian yuan Ben Tang Chun Zhang Department of Nephrology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

Chronic kidney disease(CKD)is a chronic renal dysfunction syndrome that is characterized by nephron loss,inflammation,myofibroblasts activation,and extracellular matrix(ECM)*** and oxidative stress are the driving force for the loss of nephron including tubules,glomerulus,and ***3 inflammasome signaling,MAPK signaling,PI3K/Akt signaling,and RAAS signaling involves in *** upregulated Nox expression and the decreased Nrf2 expression result in oxidative stress *** injured renal resident cells release proinflammatory cytokines and chemokines to recruit immune cells such as macrophages from bone ***-κB signaling,NLRP3 inflammasome signaling,JAK-STAT signaling,Toll-like receptor signaling,and cGAS-STING signaling are major signaling pathways that mediate inflammation in inflammatory cells including immune cells and injured renal resident *** inflammatory cells produce and secret a great number of profibrotic cytokines such as TGF-β1,Wnt ligands,and angiotensin ***-βsignaling,Wnt signaling,RAAS signaling,and Notch signaling evoke the activation of myofibroblasts and promote the generation of *** potential therapies targeted to these signaling pathways are also introduced *** this review,we update the key signaling pathways of lipotoxicity,oxidative stress,inflammation,and myofibroblasts activation in kidneys with chronic injury,and the targeted drugs based on the latest *** these pathways and the targeted therapies will be instrumental to advance further basic and clinical investigation in CKD.

关键词： NLRP3 inflammation kidney

Single-atom Ag-loaded carbon nitride photocatalysts for efficient degradation of acetaminophen:The role of Ag-atom and O_(2)

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Journal of Environmental Sciences 2024年第5期139卷 12-22页

作者： Yi yuan Wen-Long Wang Zhi-Wei Wang Jin Wang qian-yuan Wu Key Laboratory of Microorganism Application and Risk Control of Shenzhen Guangdong Provincial Engineering Research Center for Urban Water Recycling and Environmental SafetyInstitute of Environment and EcologyShenzhen International Graduate SchoolTsinghua UniversityShenzhen 518055China Shenzhen Environmental Science and New Energy Technology Engineering Laboratory Tsinghua-Berkeley Shenzhen InstituteShenzhen 518055China College of Materials Science and Engineering Shenzhen UniversityShenzhen 518071China

Carbon nitride has been extensively used as a visible-light photocatalyst,but it has the disadvantages of a low specific surface area,rapid electron-hole recombination,and relatively low light *** this study,single-atom Ag was successfully anchored on ultrathin carbon nitride(UTCN)via thermal polymerization,the catalyst obtained is called *** Ag hardly changed the carbon nitride's layered and porous physical *** exhibited efficient visible-light photocatalytic performances in the degradation of various recalcitrant pollutants,eliminations of 85% were achieved by visible-light irradiation for *** with Ag improved the photocatalytic performance of UTCN by narrowing the forbidden band gap from 2.49 to 2.36 e V and suppressing electron-hole pair *** addition,Ag doping facilitated O_(2) adsorption on UTCN by decreasing the adsorption energy from -0.2 to -2.22 e V and favored the formation of O_(2)^(·-).Electron spin resonance and radical-quenching experiments showed that O_(2)^(·-)was the major reactive species in the degradation of Acetaminophen(paracetamol,APAP).

关键词： Ag single atom Carbon nitride Photocatalysis Visible light Adsorption energy Reactive species

Effect of Water Content on the Size and Membrane Thickness of Polystyrene-block-Poly(ethylene oxide) Vesicles

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Chinese Journal of Polymer Science 2015年第4期33卷 661-668页

作者： Chun-yan Wang qian yuan 杨曙光徐坚 State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Material Science and EngineeringDonghua University Laboratory of Polymer Physics and Chemistry Institute of ChemistryChinese Academy of Sciences

The asymmetric amphiphilic block copolymer polystyrene962-block-poly（ethylene oxide）227 （PS962-b-PEO227） eanforms mieelles with N, N-dimethylforrnamide （DMF） as co-solvent and water as selected solvent, and when the water content of the mixed solvent is higher than 4.5 wt%, the vesicle will be dominated. This work finds that once vesicles are formed in the DMF-water mixed solvent, the vesicle size and membrane thickness can be tuned by further increasing water content. As the water fraction elevated from 4.8 wt% to 13.0 wt%, the vesicle size dercreases from 246 nm to 150 nm, while the membrane thickness increases from 28 nm to 42 nm. In addition, the block copolymer packing and the free energy are analyzed as the vesicle size becomes small and the membrane becomes thick.

关键词： Vesicles Micelle Block copolymer Polymersomes.

Time-asymptotic stability of planar Navier-Stokes shocks with spatial oscillations

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Science China Mathematics 2024年

作者： qian yuan Institute of Applied Mathematics Academy of Mathematics and Systems ScienceChinese Academy of Sciences

Abstract This paper shows that for the three-dimensional compressible isentropic Navier-Stokes equations,the planar viscous shocks are time-asymptotically stable to suitably small initial perturbations with zero *** particular, the perturbations consist of not only H3-perturbations but also periodic ones that oscillate at spatial infinity. In the former case, the final shock locations can be predicted in terms of the initial conditions,while in the latter the locations are subject to the dynamics of the oscillations. The stability analysis is based on the L2-energy method. The key point is that the bad effect due to the compression of the shock waves can be removed by a combination of an anti-derivative technique and the use of the Poincar′e inequality in the normal and transversal directions, respectively.

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Contact Force Distribution and Static Load-carrying Capacity of Large Size Double Row Four-point Contact Ball Bearing

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Defence Technology（防务技术） 2013年第4期9卷 229-236页

作者： Yan-shuang WANG qian-qian yuan Henan University of Science and Technology

Clearance not only affects the startup torque,rotation precision and stiffness of bearing,but also affects the load distribution,load-carrying capacity and life of bearing.A computational model in which the clearance of bearing is first included is presented for determining the contact force distribution and static load-carrying capacity of a double row four-point contact ball bearing which is subjected to the combined radial,axial and overturning moment *** relation between the negative axial clearance and the contact force distribution is *** static load-carrying capacity curves are established,and the effects of the changes in negative axial clearance,curvature radius coefficient of raceway groove and initial contact angle on the static load-carrying capacity are *** results show that,with the increase in the absolute value of negative clearance,the maximum contact load decreases first and then *** clearance values in the range of 0.2 mme0 mm have little effect on the static load-carrying capacity of *** the increase in the curvature radius coefficient of raceway groove and the decrease in the initial contact angle,the static load capacity of bearing decreases.

关键词：四点接触球轴承承载能力接触力静态双排大尺寸轴向游隙轴向间隙

A comprehensive review of cavitation in valves:mechanical heart valves and control valves

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Bio-Design and Manufacturing 2019年第2期2卷 119-136页

作者： Jin-yuan qian Zhi-xin Gao Cong-wei Hou Zhi-jiang Jin Institute of Process Equipment College of Energy EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China State Key Laboratory of Fluid Power and Mechatronic Systems Zhejiang UniversityHangzhou 310027People’s Republic of China

Valves are widely used in various working conditions for their flow control functions,and the cavitation inside valves has been investigated owing to its harm to the valve itself and the connecting downstream *** paper presents a comprehensive review of the progress that has been achieved in the past years about cavitation in valves including both mechanical heart valves and control *** review is divided in the following parts,namely the location where there is a high possibility of the occurrence of cavitation,the parameters that affect cavitation intensity,and the methods to minimize cavitation *** should be noticed that although simulation has been widely used,advanced experiments are still needed in order to obtain accurate analysis of cavitation in valves and the cavitation model still needs to be improved.

关键词： Cavitation Mechanical heart valves Control valves

BIVARIATE FRACTAL INTERPOLATION FUNCTIONS ON RECTANGULAR DOMAINS

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Journal of Computational Mathematics 2002年第4期20卷 349-362页

作者： Xiao-yuan qian (Department of Applied Mathematics, Dalian University of Technology, Dalian 116024, China) Department of Applied Mathematics Dalian University of Technology Dalian 116024

Non-tensor product bivariate fractal interpolation functions defined on gridded rectangular domains are constructed. Linear spaces consisting of these functions are introduced. The relevant Lagrange interpolation problem is discussed. A negative result about the existence of affine fractal interpolation functions defined on such domains is obtained.

关键词： fractal bivariate functions interpolation

Self-initiated static-dynamic state transition behavior and triggering mechanism of strain rockburst using three-dimensional discrete element method

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Underground Space 2024年第3期16卷 143-163页

作者： yuan qian Cheng Zhao Rui Wei Rui Zhang Lin Huang Huiguan Chen Department of Geotechnical Engineering College of Civil EngineeringTongji UniversityShanghai 200092China Key Laboratory of Geotechnical and Underground Engineering of Ministry of Education Tongji UniversityShanghai 200092China School of Engineering Tibet UniversityLhasaTibet850000China

The accurate understanding of rockburst mechanism poses a global challenge in the field of rock *** for strain rockburst,achieving self-initiated static-dynamic state transition is a crucial step in the formation of catastrophic ***,the state transition behavior and its impact on rockburst have not received sufficient attention,and are still poorly ***,this study specifically focuses on the state transition behavior,aiming to investigate its abrupt transition process and formation mechanism,and triggering effects on *** facilitate the study,a novel burst rock-surrounding rock combined laboratory test model is proposed and its effectiveness is validated through experiment ***,corresponding numerical models are established using the three-dimensional(3D)discrete element method(DEM),enabling successful simulation of static brittle failure and rockbursts of varying intensities under quasi-static displacement loading ***,through secondary development,comprehensive recording of the mechanical and energy information pertaining to the combined specimen system and its subsystems is *** a result of numerical investigation studies,the elastic rebound dynamic behavior of the surrounding rock was discovered and identified as the key factor triggering rockburst and controlling its *** impact loading on the burst rock,induced by elastic rebound,directly initiates the dynamic processes of rockburst,serving as the direct ***,the transient work and energy convergence towards the burst rock resulting from elastic rebound are recognized as the inherent cause of ***,it has been observed that a larger extent of surrounding rock leads to a stronger elastic rebound,thereby directly contributing to a more intense *** findings can provide novel theoretical insights for the exploring of rockburst mechanism and the development of monitoring and

关键词： Strain rockburst Static-dynamic state transition Self-initiation Triggering mechanism Elastic rebound Discrete element method

基于GPT-4的专利权利要求书自动生成及其评估研究

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科技情报研究 2025年第1期7卷 95-108页

作者：李军华袁倩燕翔吕长红上海海事大学图书馆(档案馆) 上海201306

[目的/意义]本研究旨在利用GPT-4模型自动生成权利要求书,降低研发人员的撰写难度,提升专利审查的工作效率和质量。[方法/过程]文章构建了适合自动生成权利要求书的Prompt,并实施了Zero-Shot、Exact-Drafting、Stepwise-Claim和Exact-St... 详细信息

[目的/意义]本研究旨在利用GPT-4模型自动生成权利要求书,降低研发人员的撰写难度,提升专利审查的工作效率和质量。[方法/过程]文章构建了适合自动生成权利要求书的Prompt,并实施了Zero-Shot、Exact-Drafting、Stepwise-Claim和Exact-Step Claim 4种提示策略。将专利说明书和技术交底书输入GPT-4模型,使用Prompt指导其输出,实现权利要求书的自动化生成。同时,使用ROUGE和BERTScore评估指标来评价文本质量,并从权利要求数量、文本长度、高频词、中文关键词:和常用搭配等多个维度,分析生成文本与参考文本的异同。最后,请专家分别从清晰度、一致性、相关性、专业性和完整性5个方面,评估生成的权利要求书的质量。[结果/结论]实证研究结果显示,Exact-Step Claim提示策略能显著提升权利要求书的生成质量。此外,基于专利说明书生成的权利要求书,在权利要求数量和文本长度上与参考文本更为匹配,表明GPT-4模型在自然语言理解和生成领域的应用效果与输入文本质量密切相关。本研究提供了一种高效智能的辅助方法,有助于推动专利文本撰写和审查领域的发展,同时也存在挑战,需要进一步提升模型在理解复杂技术术语和遵循专利法规范中的精确度,并探索如何优化模型对权利要求数量和文本长度的判断能力。

关键词：权利要求书机器阅读理解 GPT-4 提示词专利