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第43届中国控制会议

作者： Liang Zhang Le Chen yuan-yuan lv College of Automation & College Of Artificial Intelligence Nanjing University of Posts and Telecommunications College of Coal Engineering Shanxi Datong University

Energy scheduling is the key to achieve energy optimization and efficiency improvement. This study focuses on residential areas, focusing on dispatch able loads(e.g., smart air conditioners, lighting systems) and non-dispatch able loads(e.g., refrigerators, washing machines), and realizes energy management in residential areas by regulating power prices with the help of energy dispatch centers(EDC). First, based on the a priori information, the power demand of the residential area and the price of purchasing power from the grid are obtained, and the hierarchical power market power supply problem is modeled as a discrete-finite Markov decision process. Second, under the premise of satisfying the residential area's electricity demand, taking into account the residential area's dissatisfaction and the profitability of the EDC, the Q-learning algorithm is applied to obtain the electricity sales prices at different moments and complete the electricity transaction. Finally, through the actual electricity consumption behavior of the residential area, the profitability of the energy dispatching center is calculated, and the carbon footprint of the residential area and its contribution to the reduction of carbon emissions are analyzed. The experimental results show that under different electricity curtailment elasticity coefficients(ECEC), the reinforcement learning-based electricity price regulation strategy for residential areas can reduce electricity consumption by 7.1%～20.1%, and reduce the cost of purchasing electricity by 1.2 million～3.64 million. At the same time, it reduces carbon emissions by about 33.99 tons to 96.31 tons. The proposed electricity price regulation strategy effectively reduces energy costs and carbon emissions.

关键词： Reinforcement learning Dynamic price Energy management Carbon emissions Carbon footprint

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Global Profiling of the Lysine Crotonylome in Different Pluripotent States

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Genomics, Proteomics & Bioinformatics 2021年第1期19卷 80-93页

作者： yuan lv Chen Bu Jin Meng Carl Ward Giacomo Volpe Jieyi Hu Mengling Jiang Lin Guo Jiekai Chen Miguel A.Esteban Xichen Bao Zhongyi Cheng Laboratory of Integrative Biology Guangzhou Institutes of Biomedicine and HealthChinese Academy of SciencesGuangzhou 510530China CAS Key Laboratory of Regenerative Biology and Guangdong Provincial Key Laboratory of Stem Cells and Regenerative Medicine Guangzhou Institutes of Biomedicine and HealthChinese Academy of SciencesGuangzhou 510530China University of Chinese Academy of Sciences Beijing 100049China Jingjie PTM BioLab(Hangzhou)Co.Ltd Hangzhou 310018China Joint School of Life Sciences Guangzhou Institutes of Biomedicine and Health and Guangzhou Medical UniversityGuangzhou 511436China Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory) Guangzhou 510005China Institute of Stem Cells and Regeneration Chinese Academy of SciencesBeijing 100101China Laboratory of RNA Molecular Biology Guangzhou Institutes of Biomedicine and HealthChinese Academy of SciencesGuangzhou 510530China

Pluripotent stem cells(PSCs)can be expanded in vitro in different culture conditions,resulting in a spectrum of cell states with distinct *** how PSCs transition from one state to another,ultimately leading to lineage-specific differentiation,is important for developmental biology and regenerative *** there is significant information regarding gene expression changes controlling these transitions,less is known about post-translational modifications of *** crotonylation is a newly discovered post-translational modification where lysine residues are modified with a crotonyl ***,we employed affinity purification of crotonylated(LC–MS/MS)to systematically profile protein crotonylation in mouse PSCs in different states including ground,metastable,and primed states,as well as metastable PSCs undergoing early pluripotency *** successfully identified 3628 high-confidence crotonylated sites in 1426 *** crotonylated proteins are enriched for factors involved in functions/processes related to pluripotency such as RNA biogenesis,central carbon metabolism,and proteasome ***,we found that increasing the cellular levels of crotonyl-coenzyme A(crotonyl-CoA)through crotonic acid treatment promotes proteasome activity in metastable PSCs and delays their differentiation,consistent with previous observations showing that enhanced proteasome activity helps to sustain *** atlas of protein crotonylation will be valuable for further studies of pluripotency regulation and may also provide insights into the role of metabolism in other cell fate transitions.

关键词： Metabolism Crotonylation Pluripotency RNA-binding proteins Proteasome

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Surfactant-assisted hydrothermal synthesis of MoS_(2) micro-pompon structure with enhanced photocatalytic performance under visible light

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Tungsten 2020年第2期2卷 203-213页

作者： Man‑Zhang Xu Qiang Li yuan‑yuan lv Zhi‑Ming yuan Yu‑Xi Guo Han‑Jun Jiang Jiu‑Wei Gao Jun Di Pin Song Li‑Xing Kang Lu Zheng Zhi‑Yong Zhang Wu Zhao Xue‑Wen Wang Zheng Liu Frontiers Science Center for Flexible Electronics Xi’an Institute of Flexible Electronics(IFE)and Xi’an Institute of Biomedical Materials&EngineeringNorthwestern Polytechnical UniversityXi’an 710072China School of Information Science and Technology Northwest UniversityXi’an 710127China School of Materials Science and Engineering Nanyang Technological UniversitySingapore 639798Singapore MIIT Key Laboratory of Flexible Electronics(KLoFE) Northwestern Polytechnical UniversityXi’an 710072China Centre for Micro‑/Nano‑Electronics(NOVITAS) School of Electrical and Electronic EngineeringNanyang Technological UniversitySingapore 639798Singapore CINTRA CNRS/NTU/THALES and UMI 3288Research Techno PlazaSingapore 637553Singapore

MoS_(2) nanomaterial with the micro-pompon structure was synthesized by a surfactant-assisted hydrothermal *** morphologies and structures of as-prepared MoS_(2) micro-pompon were investigated by adding different types of surfactants such as cetyltrimethyl ammonium bromide(CTAB),sodium dodecylbenzene sulphonate(SDBS),and polyvinyl pyrrolidone(PVP).The results indicated that the morphology of MoS_(2) could be controlled and changed effectively by the cationic sur-factant of CTAB.A reasonable growth mechanism for hollow structured MoS_(2) micro-pompon by hydrothermal processes was ***,photocatalytic degradation properties of MoS_(2) micro-pompon under visible light were evaluated by degradation of common organic dyes,which include rhodamine B(RhB),congo red,methyl orange,and methylene *** results indicated that MoS_(2) micro-pompon owned the highly selective catalytic ability to RhB with degradation efficiency of 95%in 60 min and 68%in 30 *** the additive of the surfactant,the MoS_(2)-CTAB sample exhibited an enhanced ability of photocatalytic activity where degradation efficiency was improved to 92%in 30 *** method employed in this work could be expanded to fabricate other sulfides with the controllable morphology and structure to further regulate the photocatalytic performance.

关键词： Hydrothermal method MoS_(2)micro-pompon Surfactant-assistant Visible light photocatalytic Rhodamine B

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电影影像的暗部呈现研究

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当代电影 2022年第8期 61-67页

作者：吕远北京电影学院摄影系

暗部体现着电影影像的独特魅力,是电影摄影师的兵家必争之地。数字时代,暗部呈现出更为丰富的层次和细节,成为展现质感和生成气氛的绝佳契机。本文阐述了光线结构对于暗部生成的意义,从照度控制、光比控制、合理化光源的角度分析暗部技... 详细信息

暗部体现着电影影像的独特魅力,是电影摄影师的兵家必争之地。数字时代,暗部呈现出更为丰富的层次和细节,成为展现质感和生成气氛的绝佳契机。本文阐述了光线结构对于暗部生成的意义,从照度控制、光比控制、合理化光源的角度分析暗部技术控制要点,并描述了动态光线、棋盘格布光法等使暗部生动的具体技巧。

关键词：暗部照度控制光比控制合理化光源暗部生动技巧

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陕西省民办高校发展评价与分析研究

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统计与信息论坛 2015年第3期30卷 108-112页

作者：吕元西安理工大学思政部陕西西安710054

借鉴现有高校排行榜的指标体系,结合民办高校的特点,设计了较科学的民办高校综合评价指标体系,并对陕西省民办高校进行了问卷调查。聚类分析的结果表明,陕西省民办高校之间具有比较显著的差异,而这种差异并不是传统的民办高校分类所反... 详细信息

借鉴现有高校排行榜的指标体系,结合民办高校的特点,设计了较科学的民办高校综合评价指标体系,并对陕西省民办高校进行了问卷调查。聚类分析的结果表明,陕西省民办高校之间具有比较显著的差异,而这种差异并不是传统的民办高校分类所反映的。因此,在制定民办高校分类管理政策时,不能按照传统的民办高校分类方法,而要考虑不同民办高校的办学条件、发展能力等方面的因素,制定相应的政策。

关键词：民办高校指标体系聚类分析分类管理

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胰岛素类似物——Aspart30

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中国临床药理学杂志 2005年第3期21卷 233-236页

作者：吕媛北京大学第一医院临床药理研究所北京100083

未修饰的人胰岛素分子之间由于自我联合形成六聚体,导致胰岛素从皮下注射部位吸收进入血循环的时间延迟。速效胰岛素类似物Aspart,因其β链的28位上的氨基酸被天门冬氨酸所取代,至使胰岛素分子彼此排斥,而降低了胰岛素分子的耦联生成6聚... 详细信息

未修饰的人胰岛素分子之间由于自我联合形成六聚体,导致胰岛素从皮下注射部位吸收进入血循环的时间延迟。速效胰岛素类似物Aspart,因其β链的28位上的氨基酸被天门冬氨酸所取代,至使胰岛素分子彼此排斥,而降低了胰岛素分子的耦联生成6聚体,从而使之经皮快速吸收。Aspart30是由30%可溶性门冬氨酸胰岛素和70%鱼精蛋白结晶体门冬氨酸胰岛素组成。因此本文对Aspart30药代动力学及临床研究做一综述。

关键词： Aspart30 胰岛素类似物糖尿病

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DL-3-n-butylphthalide protects the blood-brain barrier against ischemia/hypoxia injury via upregulation of tight junction proteins

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Chinese Medical Journal 2019年第11期132卷 1344-1353页

作者： Zhan-Ying Ye Han-Ying Xing Bei Wang Min Liu Pei-yuan lv Department of Neurology Hebei Medical University Shijiazhuang Hebei 050017 China Department of Neurosurgery Hebei General Hospital Shijiazhuang Hebei 050051 China Clinical Medical Research Center Hebei General Hospital Shijiazhuang Hebei 050051 China Department of Neurology Hebei General Hospital Shijiazhuang Hebei 050051 China

Background:The increased permeability of the blood-brain barrier (BBB) induced by ischemia/hypoxia is generally correlated with alteration of tight junctions (TJs). DL-3-n-butylphthalide (NBP) has been shown to exert neuroprotective effects after ischemic injury. However, few studies have assessed the correlation between NBP and TJs. This study aimed to investigate the potential effect of NBP on the TJ proteins claudin-5, zonula occludens-1 (ZO-1), and occludin during brain ischemia. Methods: A chronic cerebral hypoperfusion (CCH) Sprague-Dawley rat model was established, and NBP (20, 40, or 80 mg/kg, gavage, once a day) treatment was performed for 14 days. NBP (0.1 or 1.0μmol/L) pre-treatment was applied to an in vitro hypoxia microvascular endothelial cell model (1%〇2, 24 h). BBB permeability was assessed by performing the Evans blue assay. The expressions and localization of claudin-5, ZO-1, occludin, phosphorylated/total protein kinase B (p-Akt/Akt), phosphorylated/total glycogen synthase kinase 3p (GSK-3(3)/GSK-3p, and (3-catenin/p-actin were evaluated by Western blotting or immunofluorescence. Reactive oxygen species (ROS) generation was measured by flow cytometry analysis. TJ ultrastructure was observed by transmission electron microscopy. Results: In CCH rats, treatment with 40 and 80 mg/kg NBP decreased the Evans blue content in brain tissue (9.0 ± 0.9 (μg/g vs. 12.3 ± 1.9 (μg/g, P = 0.005;6.7 ± 0.6 μg/g vs. 12.3 ± 1.9μg/g, P 0.05). In the hypoxia cell model, NBP pre-treatment improved TJ ultrastructure, decreased intracellular ROS level, and increased the expression of claudin-5 (P < 0.01) and Z

关键词： DL-3-n-butylphthalide Blood-brain barrier Tight junctions Ischemia Claudin-5

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7-difluoromethoxyl-5,4'-di-n-octylgenistein inhibits growth of gastric cancer cells through downregulating forkhead box M1

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World Journal of Gastroenterology 2012年第33期18卷 4618-4626页

作者： Hong-Lin Xiang Fei Liu Mei-Fang Quan Jian-Guo Cao yuan lv Laboratory of Medical Engineering Medical College Hunan Normal University Changsha 410013 Hunan Province China

AIM: To investigate whether the 7-difluoromethoxyl-5, 4'-di-n-octylgenistein (DFOG), a novel synthetic genistein analogue, affects the growth of gastric cancer cells and its mechanisms. METHODS: A series of genistein analogues were prepared by difluoromethylation and alkylation, and human gastric cancer cell lines AGS and SGC-7901 cultured in vitro were treated with various concentrations of genistein and genistein analogues. The cell viability was measured by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The cells were incubated by DFOG at different concentrations. The growth inhibitory effects were evaluated using MTT and clonogenic assay. The distribution of the phase in cell cycle was analyzed using flow cytometric analysis with propidium iodide staining. The expression of the transcription factor forkhead box M1 (FOXM1) was analyzed by reverse transcription-polymerase chain reaction and Western blotting. The expression levelsof CDK1, Cdc25B, cyclin B and p27KIP1 protein were detected using Western blotting. RESULTS: Nine of the genistein analogues had more effective antitumor activity than genistein. Among the tested analogues, DFOG possessed the strongest activity against AGS and SGC-7901 cells in vitro. DFOG significantly inhibited the cell viability and colony formation of AGS and SGC-7901 cells. Moreover, DFOG efficaciously arrested the cell cycle in G2/M phase. DFOG decreased the expression of FOXM1 and its downstream genes, such as CDK1, Cdc25B, cyclin B, and increased p27KIP1 at protein levels. Knockdown of FOXM1 by small interfering RNA before DFOG treatment resulted in enhanced cell growth inhibition in AGS cells. Up-regulation of FOXM1 by cDNA transfection attenuated DFOG-induced cell growth inhibition in AGS cells. CONCLUSION: DFOG inhibits the growth of human gastric cancer cells by down-regulating the FOXM1 expression.

关键词： Gastric cancer 7-difluoromethoxyl-5 4'-din-octylgenistein Genistein Forkhead box M1 Therapeutic action

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Gastric adenosquamous carcinoma with an elevated serum level of alpha-fetoprotein:A case report

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World Journal of Gastrointestinal Surgery 2023年第10期15卷 2357-2361页

作者： Liang Sun Juan-Juan Wei Ran An Hui-Yun Cai yuan lv Tao Li Xiao-Fei Shen Jun-Feng Du Gang Chen Department of General Surgery The 7th Medical Center of PLA General HospitalBeijing 100700China Operating Room Department of AnesthesiologyThe 7th Medical Center of PLA General HospitalBeijing 100700China Department of Pathology The 7th Medical Center of PLA General HospitalBeijing 100700China

BACKGROUND Gastric adenosquamous carcinoma(ASC)is rare and characterized by coexisting of adenocarcinoma andsquamous carcinoma within the same *** present a female patient with gastric ASC who had an elevated serum level of alpha-fetopro-tein(AFP),which decreased to normal levels after a laparoscopic distant radical gastrectomy in a short *** clinicopathological features in AFP-producing gastric cancer(GC)are discussed,as well as potentially available prognostic *** SUMMARY A 50-year-old woman presented to our department with a chief complain of a 6-mo history of *** had no basic diseases including heart diseases and respiratory diseases,and she also denied any prior history of dysphagia,hematemesis,melena,rectal bleeding,hematochezia,or unintentional weight *** on her symptoms,an esophagogastroduodenoscopy was performed,showing an annular cavity lesion 3 cm from the pylorus with a diameter of 6 cm.A biopsy of the lesion showed gastric ASC,whereas the pylorus biopsy showed normal *** patient further received an enhanced computed tomography scan which demonstrated an invasive lesion close to the pylorus with a still clear margin of the tumor to peripheral organs such as the pancreas and *** lymph nodes were visible around,whereas no sign of liver metastasis was *** tumor markers including carcinoembryonic antigen(CEA),cancer antigen 199(CA199),CA724,CA125,and CA242 were all normal,while the level of serum AFP increased to 172 ng/mL.A laparoscopic distant radical gastrectomy was performed after exclusion of surgical *** pathology results showed that the tumor displayed an ulcerated ASC phenotype(90%of medium to highly-differentiated squamous cell carcinoma,10%of poorly differentiated ***,the serum level of AFP decreased to normal level on post operation day *** tumor cells were positive for CK5/6,p63,and CEA,and negative for AFP and Epstein-Ba

关键词： Gastric cancer Gastric adenosquamous carcinoma Alpha-fetoprotein Case report

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Mobility Management in Internet of Things

Mobility Management in Internet of Things

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作者： QIAN Linglong SU Cui lv yuan CHAI Rong Key Lab of Mobile Communication Technology Chongqing University of Posts and Telecommunications

Internet of Things（IoT） has received considerable attention in recent *** some typical IoT application scenarios,mobile terminals（MTs） may move individually or inside a *** support seamless communication during the moving process,efficient mobility management technologies have to be *** paper gives an overview of mobility management technologies in *** research works on system architectures,protocols and control mechanisms of mobility management in IoT are reviewed,and the challenges and future research directions are discussed.

关键词： Internet of Things(IoT) mobility management architecture protocol mechanism

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