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Intricacies in the cross talk between metabolic enzymes,RNA,and protein translation

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Journal of Molecular Cell Biology 2019年第10期11卷 813-815页

作者： yuan lv Muqddas Tariq Xiangpeng Guo Shahzina Kanwal Miguel AEsteban Joint School of Life Sciences Guangzhou Institutes of Biomedicine and Health and Guangzhou Medical UniversityGuangzhou 511436China Key Laboratory of Regenerative Biology and Guangdong Provincial Key Laboratory of Stem Cells and Regenerative Medicine Guangzhou Institutes of Biomedicine and HealthChinese Academy of SciencesGuangzhou 510530China Laboratory of RNA Chromatinand Human DiseaseGuangzhou Institutes of Biomedicine and HealthChinese Academy of SciencesGuangzhou 510530China Guangzhou Regenerative Medicine and Health Guangdong Laboratory Guangzhou 510005China University of Chinese Academy of Sciences Beijing 100049China Institute for Stem Cells and Regeneration Chinese Academy of SciencesBeijing 100101China

The development of tech niq ues allowing the systematic capture of the RNA-bound proteome has yielded many *** these,metabolic enzymes have been frequently detected as RNA-binding proteins(RBPs)by different profiling methodologies in various cell types(Hentze et al.,2018).Compared to previous-more simplistic-views,it is now known that cellular metabolism(not only limited to the tricarboxylic acid,TCA,cycle)is *** fact,metabolic enzymes translocate to the nucleus and are enriched at actively transcribed loci,where they sustain epigenetic/epitranscriptomic marks through localized metabolite production(Mews et al.,2017).It has been proposed that the in teraction with nascent RNAs facilitates the anchorage of metabolic enzymes at target loci(Bao et al.,2018),and it is plausible that mature RNAs work in the same way to assist metabolic reactions in the cytoplasm.

关键词： al. metabolism metabolic

Studies on sulfinatodehalogenation——ⅩⅩ.Sodium dithionite-initiated addition of per-and polyfluoroalkyl iodides to cyclic enol ethers and chemical conversions of the products

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Chinese Journal of Chemistry 1991年第2期9卷 167-173页

作者： HUANG Wei-yuan XIE yuan-lv Long Shanghai Institute of Organic Chemistry The Chinese Academy of SciencesShanghai 200032

Per-and polyfluoroalkyl iodides[R_FI,R_F=Cl(CF_2)_4,1a;Cl(CF_2)_6,1b;Cl(CF_2)_8,1c;n- C_6F_(13),1d;n-C_8F_(17),1e]reacted with cyclic enol ethers such as 2,3-dihydrofuran(2)and 3,4-dihydro- 2H-pyran(3)in aqueous acetonitrile in the presence of sodium dithionite and sodium bicarbonate at room temperature(10—15℃)to give the corresponding 2-(F-alkyl)hemiacetals in high *** adducts were oxidized with Ce(NH_4)_2(NO_3)_6 in acetonitrile or reduced with LiAlH_4 in ether to form the corresponding 2-(F-alkyl)lactones or diols respectively in good *** the presence of p- toluenesulfonic acid,the adducts were refluxed in benzene and CH_3CN to produce the corresponding 2,3-dihydro-4-(F-alkyl)furan and 3,4-dihydro-5-(F-alkyl)-*** is a new and effective method for preparing these useful organofluorine compounds.

关键词： Studies on sulfinatodehalogenation CF Sodium dithionite-initiated addition of per-and polyfluoroalkyl iodides to cyclic enol ethers and chemical conversions of the products

Cloning and structural characterization of juvenile hormone diol kinase in Spodoptera litura

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Insect Science 2016年第6期23卷 819-828页

作者： Bao-Juan Zeng yuan lv Li-Li Zhang Li-Hua Huang Qi-Li Feng Guangzhou Key Laboratory of Insect Development Regulation and Application Research School of Life Sciences South China Normal University Guangzhou 510631 China

Juvenile hormone （JH） is one of the key insect hormones that regulate metamorphosis. Juvenile hormone diol kinase （JHDK） is an enzyme involved in JH metabolism and catalyzes JH diol to form a polar end product, JH diol phosphate that has no JH activity. In this study, a JHDK complementary DNA （cDNA） was cloned from Spodoptera litura and the structure and expression of the gene was characterized. The cDNA was 714 base pairs in length and encoded a protein of 183 amino acids with a molecular mass of 21 kDa and an isoelectric point of 4.55. Based on the structure, three putative calcium binding motifs and guanosine triphosphate-binding motifs were predicted in the protein. Modeling of the 3-D structure showed that the protein consisted of eight α-helixes linked with loops, with no β-sheets. The gene was expressed in the epidermis, fat body and midgut of fifth and sixth instar larvae. The expression level in the epidermis was lower than in the fat body and midgut. The gene was expressed at higher levels at the early stages than in the later stages of fifth and sixth instar midgut and fat body. The results suggest that this gene may be involved in the regulation of the JH titer in larvae ofS. litura.

关键词： juvenile hormone juvenile hormone diol kinase metabolism Spodoptera litura

Chemoradiotherapy plus tislelizumab for mismatch repair proficient rectal cancer with supraclavicular lymph node metastasis:A case report

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 2219-2224页

作者： Wen-Tao Zhong yuan lv Qian-Yu Wang Ran An Gang Chen Jun-Feng Du The Second School of Clinical Medicine Southern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Department of General Surgery The 7^(th)Medical Center of PLA General HospitalBeijing 100700China Department of Pathology The 7^(th)Medical Center of PLA General HospitalBeijing 100700China

BACKGROUND According to the latest report,colorectal cancer is still one of the most prevalent cancers,with the third highest incidence and mortality *** of advanced rectal cancer with distant metastases is usually unsatisfactory,especially for mismatch repair proficient(pMMR)rectal cancer,which leads to poor prognosis and *** SUMMARY We report a case of a pMMR rectal adenocarcinoma with metastases of multiple lymph nodes,including the left supraclavicular lymph node,before treatment in a 70-year-old *** received full courses of chemoradiotherapy(CRT)followed by 4 cycles of programmed death 1 inhibitor Tislelizumab,and a pathologic complete response(pCR)was achieved,and the lesion of the left supraclavicular lymph node also *** pMMR advanced rectal cancer with preserved intact distant metastatic lymph nodes may benefit from full-course CRT combined with immunotherapy.

关键词： Rectal cancer Metastasis Chemoradiotherapy Immunotherapy Prognosis Case report

Abrupt onset of type 1 diabetes mellitus during recombinant interferon-alpha 2b therapy in a patient with chronic hepatitis B

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World Journal of Gastroenterology 2008年第29期14卷 4713-4715页

作者： yuan-yuan lv Bing-Yin Shi Hui Guo Department of Endocrinology First Affiliated Hospital Medical School of Xi'an Jiaotong University Xi'an 710061 Shaanxi Province China

We describe a case of a 33-year-old female patient with chronic hepatitis B who developed type 1 diabetes mellitus (DM) after a 13-mo period of treatment with recombinant human interferon-alpha (IFN-α) 2b. The patient presented with polydipsia, polyuria, hypergly-cemia, diabetic ketoacidosis, combined with C-peptide secretion defi ciency and positive islet cell autoantibody (ICAb). IFN-α 2b treatment was terminated and in-stead insulin treatment was initiated. Five months after cessation of the recombinant human IFN-α 2b therapy, the patient remained insulin-dependent. Her serum HBV DNA became negative and serum transaminase returned to the normal level after a 10-mo period of IFN therapy. Type 1 DM induced by IFN-α is relatively rare in patients with chronic hepatitis B. We should pay more attention to patients on IFN-α therapy to avoid destruction of pancreatic beta cells. This is the first case report from China.

关键词： Interferon-alpha Islet cell autoantibody Type 1 diabetes mellitus Autoimmune disease Chronichepatitis B

High-pressure capacity expansion and water injection mechanism and indicator curve model for fractured-vuggy carbonate reservoirs

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Petroleum 2024年第3期10卷 511-519页

作者： Lixin Chen Chengzao Jia Rujie Zhang Ping Yue Xujian Jiang Junfang Wang Zhou Su Yun Xiao yuan lv Institute of Unconventional Oil and Gas Science and Technology China University of Petroleum(Beijing)Beijing102249China State Key Laboratory of Reservoir Geology and Development Southwest Petroleum UniversityChengdu610500China Tarim Oilfield Company PetroChinaKorla841000China

Water injection for oil displacement is one of the most effective ways to develop fractured-vuggy carbonate *** the increase in the number of rounds of water injection,the development effect gradually *** emergence of high-pressure capacity expansion and water injection technology allows increased production from old *** high-pressure capacity expansion and water injection technology has been implemented in practice for nearly 10 years in fractured-vuggy reservoirs,its mechanism remains unclear,and the water injection curve is not *** the past,evaluating its effect could only be done by measuring the injection-production *** this study,we analyze the mechanism of high-pressure capacity expansion and water *** propose a fluid exchange index for high-pressure capacity expansion and water injection and establish a discrete model suitable for high-pressure capacity expansion and water injection curves in fractured-vuggy *** propose the following mechanisms:replenishing energy,increasing energy,replacing energy,and releasing *** above mechanisms can be identified by the high-pressure capacity expansion and water injection curve of the well HA6X in the Halahatang Oilfield in the Tarim *** solving the basic model,the relative errors of Reservoirs I and II are found to be 1.9%and 1.5%,respectively,and the application of field examples demonstrates that our proposed high-pressure capacity expansion and water injection indicator curve is reasonable and *** research can provide theoretical support for high-pressure capacity expansion and water injection technology in fracture-vuggy carbonate reservoirs.

关键词： Fractured-vuggy carbonate reservoirs High-pressure capacity expansion and water injection Mechanism Water injection indicator curve

Compound heterozygous mutation of MUSK causing fetal akinesia deformation sequence syndrome: A case report

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World Journal of Clinical Cases 2019年第21期7卷 3655-3661页

作者： Na Li Chong Qiao yuan lv Tian Yang Hao Liu Wen-Qian Yu Cai-Xia Liu Department of Obstetrics and Gynecology Shengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina Key Laboratory of Maternal-Fetal Medicine of Liaoning Province Key Laboratory of Obstetrics and Gynecology of Higher Education of Liaoning ProvinceShenyang 110004Liaoning ProvinceChina

BACKGROUND Fetal akinesia deformation sequence(FADS)is a broad spectrum disorder with absent fetal movements as the unifying *** etiology of FADS is heterogeneous and mostly still unknown.A prenatal diagnosis of FADS relies on clinical features obtained by ultrasound and fetal muscle ***,the recent advances of next-generation sequencing(NGS)can effectively provide a definitive molecular *** SUMMARY A fetus presented after 24 wk and 6 d of gestation with absent fetal movements and multiple abnormal ultrasonographic *** mother had had a previous abortion due to a similarly affected fetus a year before.A clinical diagnosis of FADS was *** parents refused cord blood examination and chose abortion.A molecular diagnosis of fetal muscle using NGS of genes found a compound heterozygous mutation in the MUSK gene:c.220C>T(chr9:113449410 p.R74W)and c.421delC(chr9:113457745 p.P141fs).CONCLUSION To our knowledge,this is the first report in China showing that a mutation in MUSK is associated with *** supports previous finding that a lethal mutation of MUSK will cause FADS.A precise molecular diagnosis for genetic counseling and options for a prenatal diagnosis of FADS are very important,especially for recurrent FADS;this may also provide evidence for both prenatal and preimplantation genetic diagnoses.

关键词： MUSK gene Fetal akinesia deformation sequence Joint contractures Casereport

Overview of ectopic pancreas

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World Journal of Gastrointestinal Surgery 2024年第2期16卷 284-288页

作者： Chang-Fei Li Qiu-Ru Li Miao Bai yuan-Shi lv Yan Jiao Patient Service Center The Second Hospital of Jilin UniversityChangchun 130000Jilin ProvinceChina Department of Neurology The Second Hospital of Jilin UniversityChangchun 130000Jilin ProvinceChina Department of Fundus Disease The Second Hospital of Jilin UniversityChangchun 130000Jilin ProvinceChina Department of Thyroid Head and Neck Surgery Jilin Cancer HospitalChangchun 130000Jilin ProvinceChina Department of Hepatobiliary and Pancreatic Surgery General Surgery CenterThe First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina

This editorial discusses the article written by Zheng et al that was published in the latest edition of the World Journal of Gastrointestinal *** primary focus is on the causes,location,diagnosis,histological classification,and therapy of ectopic *** pancreas refers to the presence of pancreatic tissue that is situated in a location outside its usual anatomical placement,and is not connected to the normal pancreas in terms of blood supply or anatomical ***,the embryological origin of ectopic pancreas remains *** most prevalent form of ectopic pancreatic is gastric ectopic *** ultrasonography examination can visualize the morphological charac-teristics of the ectopic pancreatic lesion and pinpoint its anatomical *** histological categorization of ectopic pancreas *** treatment has been widely advocated in ectopic pancreas.

关键词： Pancreas Gastric ectopic pancreas Diagnosis Treatment Anatomy

Dapagliflozin and sacubitril on myocardial microperfusion in patients with post-acute myocardial infarction heart failure and type 2 diabetes

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World Journal of Clinical Cases 2024年第22期12卷 5008-5015页

作者： yuan lv Wei-Jun Luo Department of Cardiology Lishui People's HospitalLishui 323000Zhejiang ProvinceChina

BACKGROUND Coronary heart disease and type 2 diabetes mellitus(T2DM)frequently coexist,creating a complex and challenging clinical scenario,particularly when complicated with acute myocardial infarction(AMI).AIM To examine the effects of dapagliflozin combined with sakubactrovalsartan sodium tablets on myocardial *** In total,98 patients were categorized into control(n=47)and observation(n=51)*** control group received noxital,while the observation group was treated with dapagliflozin combined with noxital for 6 *** in myocardial microperfusion,blood glucose level,cardiac function,N-terminal prohormone of brain natriuretic peptide(NT-proBNP)level,growth differentiation factor-15(GDF-15)level,and other related factors were compared between the two ***,the incidence of major adverse cardiovascular events(MACE)and adverse reactions were *** After treatment,in the observation and control groups,the corrected thrombolysis in myocardial infarction frame counts were 37.12±5.02 and 48.23±4.66,*** NT-proBNP levels were 1502.65±255.87 and 2015.23±286.31 pg/mL,the N-terminal pro-atrial natriuretic peptide(NT-proANP)levels were 1415.69±213.05 and 1875.52±241.02 ng/mL,the GDF-15 levels were 0.87±0.43 and 1.21±0.56 g/L,and the high-sensitivity C-reactive protein(hs-CRP)levels were 6.54±1.56 and 8.77±1.94 mg/L,respectively,with statistically significant differences(P0.05).CONCLUSION Dapagliflozin combined with nocinto can improve myocardial microperfusion and left ventricular remodeling and reduce MACE incidence in patients with post-AMI heart failure and *** underlying mechanism may be related to the reduction i

关键词： Dagelin Nocinto Acute myocardial infarction Type 2 diabetes Heart failure Myocardial microperfusion