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World Journal of Gastrointestinal Oncology 2024年第5期16卷 2219-2224页

作者： Wen-Tao Zhong yuan lv Qian-Yu Wang Ran An Gang Chen Jun-Feng Du The Second School of Clinical Medicine Southern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Department of General Surgery The 7^(th)Medical Center of PLA General HospitalBeijing 100700China Department of Pathology The 7^(th)Medical Center of PLA General HospitalBeijing 100700China

BACKGROUND According to the latest report,colorectal cancer is still one of the most prevalent cancers,with the third highest incidence and mortality *** of advanced rectal cancer with distant metastases is usually unsatisfactory,especially for mismatch repair proficient(pMMR)rectal cancer,which leads to poor prognosis and *** SUMMARY We report a case of a pMMR rectal adenocarcinoma with metastases of multiple lymph nodes,including the left supraclavicular lymph node,before treatment in a 70-year-old *** received full courses of chemoradiotherapy(CRT)followed by 4 cycles of programmed death 1 inhibitor Tislelizumab,and a pathologic complete response(pCR)was achieved,and the lesion of the left supraclavicular lymph node also *** pMMR advanced rectal cancer with preserved intact distant metastatic lymph nodes may benefit from full-course CRT combined with immunotherapy.

关键词： Rectal cancer Metastasis Chemoradiotherapy Immunotherapy Prognosis Case report

Overview of ectopic pancreas

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World Journal of Gastrointestinal Surgery 2024年第2期16卷 284-288页

作者： Chang-Fei Li Qiu-Ru Li Miao Bai yuan-Shi lv Yan Jiao Patient Service Center The Second Hospital of Jilin UniversityChangchun 130000Jilin ProvinceChina Department of Neurology The Second Hospital of Jilin UniversityChangchun 130000Jilin ProvinceChina Department of Fundus Disease The Second Hospital of Jilin UniversityChangchun 130000Jilin ProvinceChina Department of Thyroid Head and Neck Surgery Jilin Cancer HospitalChangchun 130000Jilin ProvinceChina Department of Hepatobiliary and Pancreatic Surgery General Surgery CenterThe First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina

This editorial discusses the article written by Zheng et al that was published in the latest edition of the World Journal of Gastrointestinal *** primary focus is on the causes,location,diagnosis,histological classification,and therapy of ectopic *** pancreas refers to the presence of pancreatic tissue that is situated in a location outside its usual anatomical placement,and is not connected to the normal pancreas in terms of blood supply or anatomical ***,the embryological origin of ectopic pancreas remains *** most prevalent form of ectopic pancreatic is gastric ectopic *** ultrasonography examination can visualize the morphological charac-teristics of the ectopic pancreatic lesion and pinpoint its anatomical *** histological categorization of ectopic pancreas *** treatment has been widely advocated in ectopic pancreas.

关键词： Pancreas Gastric ectopic pancreas Diagnosis Treatment Anatomy

Dapagliflozin and sacubitril on myocardial microperfusion in patients with post-acute myocardial infarction heart failure and type 2 diabetes

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World Journal of Clinical Cases 2024年第22期12卷 5008-5015页

作者： yuan lv Wei-Jun Luo Department of Cardiology Lishui People's HospitalLishui 323000Zhejiang ProvinceChina

BACKGROUND Coronary heart disease and type 2 diabetes mellitus(T2DM)frequently coexist,creating a complex and challenging clinical scenario,particularly when complicated with acute myocardial infarction(AMI).AIM To examine the effects of dapagliflozin combined with sakubactrovalsartan sodium tablets on myocardial *** In total,98 patients were categorized into control(n=47)and observation(n=51)*** control group received noxital,while the observation group was treated with dapagliflozin combined with noxital for 6 *** in myocardial microperfusion,blood glucose level,cardiac function,N-terminal prohormone of brain natriuretic peptide(NT-proBNP)level,growth differentiation factor-15(GDF-15)level,and other related factors were compared between the two ***,the incidence of major adverse cardiovascular events(MACE)and adverse reactions were *** After treatment,in the observation and control groups,the corrected thrombolysis in myocardial infarction frame counts were 37.12±5.02 and 48.23±4.66,*** NT-proBNP levels were 1502.65±255.87 and 2015.23±286.31 pg/mL,the N-terminal pro-atrial natriuretic peptide(NT-proANP)levels were 1415.69±213.05 and 1875.52±241.02 ng/mL,the GDF-15 levels were 0.87±0.43 and 1.21±0.56 g/L,and the high-sensitivity C-reactive protein(hs-CRP)levels were 6.54±1.56 and 8.77±1.94 mg/L,respectively,with statistically significant differences(P0.05).CONCLUSION Dapagliflozin combined with nocinto can improve myocardial microperfusion and left ventricular remodeling and reduce MACE incidence in patients with post-AMI heart failure and *** underlying mechanism may be related to the reduction i

关键词： Dagelin Nocinto Acute myocardial infarction Type 2 diabetes Heart failure Myocardial microperfusion

Multiple pulp stones emerge across all teeth during mixed dentition:A case report

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World Journal of Clinical Cases 2024年第22期12卷 5189-5195页

作者： yuan lv Jie Zhu Cheng-Tao Fu Le Liu Jing Wang Yan-Feng Li Department of Stomatology China Aerospace Science&Industry Corporation 731 HospitalBeijing 100074China School of Medicine Huzhou UniversityHuzhou 313204Zhejiang ProvinceChina Department of Stomatology The Fourth Medical CentreChinese People's Liberation Army General HospitalBeijing 100048China

BACKGROUND This paper reports a rare presentation of multiple pulp stones(PSs)emerging in all teeth during mixed *** offers valuable insights into the clinical diagnosis,treatment,and prognosis of multiple PSs,shedding light on their occurrence during the mixed dentition *** SUMMARY A 10-year-old girl presented with repeated pain in the mandibular right posterior *** examination revealed carious lesions,abnormal tooth shapes,and anomalies in tooth *** examinations showed multiple PSs with diverse shapes,sizes,and quantities in all teeth,alongside anomalies in tooth shape and *** canal therapy was initiated,but the patient initially lacked timely *** return for treatment completion,an extracted tooth revealed irregular calculus within the pulp *** This case underscores the importance of considering multiple PSs in mixed dentition,necessitating comprehensive evaluation and management strategies.

关键词： Mixed dentition Multiple pulp stones Pulp calcification Cone-beam computed tomography Case report

Gastrointestinal manifestations of critical ill heatstroke patients and their associations with outcomes:A multicentre,retrospective,observational study

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World Journal of Gastroenterology 2024年第4期30卷 346-366页

作者： Yu-Cong Wang Xin-Yang Jin Zheng Lei Xiao-Jiao Liu Yu Liu Bang-Guo Zhang Jian Gong Lie-Tao Wang lv-yuan Shi Ding-yuan Wan Xin Fu Lu-Ping Wang Ai-Jia Ma Yi-Song Cheng Jing Yang Min He Xiao-Dong Jin Yan Kang Bo Wang Zhong-Wei Zhang Qin Wu Department of Critical Care Medicine West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina School of Pharmacy Macao University of Science and TechnologyMacao 999078China Department of Critical Care Medicine The First People's Hospital of Ziyang CityZiyang 641399Sichuan ProvinceChina Department of Critical Care Medicine The First People's Hospital of Guanghan CityChengdu 618399Sichuan ProvinceChina Department of Critical Care Medicine Lezhi County Traditional Chinese Medicine HospitalChengdu 641599Sichuan ProvinceChina Department of Critical Care Medicine Chengdu Qingbaijiang District People's HospitalChengdu 610399Sichuan ProvinceChina Department of Critical Care Medicine Ziyang People's HospitalChengdu 641399Sichuan ProvinceChina

BACKGROUND Extreme heat exposure is a growing health problem,and the effects of heat on the gastrointestinal(GI)tract is *** study aimed to assess the incidence of GI symptoms associated with heatstroke and its impact on *** To assess the incidence of GI symptoms associated with heatstroke and its impact on *** Patients admitted to the intensive care unit(ICU)due to heatstroke were included from 83 *** history,laboratory results,and clinically relevant outcomes were recorded at ICU admission and daily until up to day 15,ICU discharge,or *** symptoms,including nausea/vomiting,diarrhoea,flatulence,and bloody stools,were *** characteristics of patients with heatstroke concomitant with GI symptoms were *** regression analyses were performed to determine significant predictors of GI *** A total of 713 patients were included in the final analysis,of whom 132(18.5%)patients had at least one GI symptom during their ICU stay,while 26(3.6%)suffered from more than one *** with GI symptoms had a significantly higher ICU stay compared with those *** mortality of patients who had two or more GI symptoms simultaneously was significantly higher than that in those with one GI *** logistic regression analysis revealed that older patients with a lower GCS score on admission were more likely to experience GI *** The GI manifestations of heatstroke are common and appear to impact clinically relevant hospitalization outcomes.

关键词： Extreme heat Flatulence Sunstroke Intensive care units Diarrhea

Physicochemical characterization of Dendrobium officinale polysaccharides and regulation of immunometabolic homeostasis in Sub-health mice based on the CD4-Th17/Treg immunity axis

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Food Science and Human Wellness 2024年

作者： Bo Li Ze-Hua Zhang Hao-Ru Guan Xing-Li-Shang He Ning Wang Ying-Jie Dong Mei Rong Jiu-Jie Jia Ting-Ting Chen Zhi-yuan Li Gui-yuan lv Lin-Nan Zhang Su-Hong Chen Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals， Zhejiang University of Technology Zhejiang Provincial Key Laboratory of TCM for Innovative R & D and Digital Intelligent Manufacturing of TCM Great Health Products.Huzhou College of Pharmaceutical Science， Zhejiang Chinese Medical University

The aim of this study was to investigate the role of DOPS and DOPS100 in attenuating immune dysfunction in subfertile mice. The results of the study revealed several noteworthy findings. First， DOPS and DOPS100 treatments led to significant improvement in weight gain and reversal of fatigue-related behaviors compared to the normal group. Second， both DOPS and DOPS100 showed effectiveness in reducing immune organ swelling， modulating immunoglobulin （IgA and IgM） levels， and restoring complement （C3c and C4） levels. In addition， they demonstrated a significant ability to enhance the integrity of the intestinal mechanical barrier by differentially upregulating the tight junction proteins Occludin and ZO-1. In addition， it was found that DOPS100 specifically enhanced the CD4+-Th17/Treg immune axis in the gut， as evidenced by increased expression of Foxp3 as well as decreased expression of RORγt， and further modulation of IL-10， IL-22， and IL-17A expression levels of inflammatory factors. These findings collectively suggest that DOPS100 holds significant potential in improving sub-healthy status by repairing the intestinal barrier， restoring local immune homeostasis， and activating the intestinal immune regulatory network. The study's outcomes provide valuable insights into the therapeutic implications of DOPS and DOPS100 in addressing immune dysfunction in sub-healthy conditions.

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青银高速公路旧关至太原段张靖村东滑坡特征及稳定性评价

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四川有色金属 2024年第1期 10-13,26页

作者：吕媛甘肃省地质矿产勘查开发局第二地质矿产勘查院甘肃兰州730030

张靖村东滑坡为一处古滑坡,后因前缘人类活动造成局部复活。本文在对场地工程地质条件和滑坡基本特征进行分析的基础上,判定该滑坡现状处于基本稳定状态,通过验算滑坡坡稳定性及滑动推力,该处斜坡稳定性稍差,增强坡体稳定性后予以通过... 详细信息

张靖村东滑坡为一处古滑坡,后因前缘人类活动造成局部复活。本文在对场地工程地质条件和滑坡基本特征进行分析的基础上,判定该滑坡现状处于基本稳定状态,通过验算滑坡坡稳定性及滑动推力,该处斜坡稳定性稍差,增强坡体稳定性后予以通过。研究结果为滑坡的防治、线路工程设计及防灾减灾提供重要地质依据。

关键词：高速公路工程地质张靖村东滑坡特征稳定性评价

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落叶松苗木抗旱性研究进展

辽宁林业科技 2024年第3期 58-60页

作者：吕媛清原满族自治县自然资源事务服务中心辽宁抚顺113300

干旱胁迫制约着林木的正常生长发育,林木在干旱条件下,主要生理活动进程改变,生长受限,表现出各种适应性机制,这也为林木的抗旱性评价和选育提供了基础。落叶松是我国重要的生态经济型树种,优质苗木需求较大,但在春天时易遭受干旱胁迫,... 详细信息

干旱胁迫制约着林木的正常生长发育,林木在干旱条件下,主要生理活动进程改变,生长受限,表现出各种适应性机制,这也为林木的抗旱性评价和选育提供了基础。落叶松是我国重要的生态经济型树种,优质苗木需求较大,但在春天时易遭受干旱胁迫,为揭示其苗木对干旱胁迫的调节和抵御策略,该文总结了落叶松苗木在干旱逆境下生长、解剖结构和生理特性的变化及外源物质对干旱的缓解作用等研究进展,以期为优良抗旱落叶松品系选育和苗木培育提供理论基础。

关键词：落叶松苗木干旱胁迫抗旱性

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人工智能创造力探究

现代教育技术 2024年第1期34卷 17-25页

作者：胡卫平张阳吕元婧徐晶晶陕西师范大学现代教学技术教育部重点实验室陕西西安710062

目前,国内外大语言模型如雨后春笋般涌现,加速了通用人工智能时代的到来。人工智能在科学、艺术等领域展现出的卓越创造力,大大推动了人类科技进步,但也给人类传统创造力带来了巨大挑战,需要对人工智能创造力的本质特征进行审视,并预测... 详细信息

目前,国内外大语言模型如雨后春笋般涌现,加速了通用人工智能时代的到来。人工智能在科学、艺术等领域展现出的卓越创造力,大大推动了人类科技进步,但也给人类传统创造力带来了巨大挑战,需要对人工智能创造力的本质特征进行审视,并预测其未来应用方向。基于此,文章聚焦于人工智能创造力,首先阐释了人工智能创造力的基本内涵;接着,文章从通用领域创造力表现和专业领域创造力表现两个维度,介绍了人工智能创造力的外在表现;然后,文章从产生机制和调控机制两个方面,深入剖析了人工智能创造力的内在机制,并结合人类创造力评价经验提出了人工智能创造力的评价原则和评价方法;最后,文章分析了人工智能创造力未来的应用模式、应用前景并给出应用建议。文章的研究既可促进人工智能创造力的发展和人工智能技术的进步,也能为人类创造力的培养和提升提供一定的借鉴。

关键词：人工智能创造力人机融合创造性成果

固化单宁纤维素基气凝胶吸附还原Ag(I)行为研究

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中国环境科学 2024年第4期44卷 2083-2092页

作者：陈颖林昱灵吕源财刘以凡林春香叶晓霞刘明华福州大学环境与安全工程学院福建福州350108

以纤维素为原料,在NaOH/尿素/H_(2)O溶解体系中通过交联作用将橡椀单宁固化在纤维素基体上,制得固化橡椀单宁纤维素基气凝胶(VTCA).通过SEM-EDS、FT-IR、XRD等对VTCA进行表征,并研究其对水溶液中Ag(I)的吸附行为.结果表明,VTCA具有明显... 详细信息

以纤维素为原料,在NaOH/尿素/H_(2)O溶解体系中通过交联作用将橡椀单宁固化在纤维素基体上,制得固化橡椀单宁纤维素基气凝胶(VTCA).通过SEM-EDS、FT-IR、XRD等对VTCA进行表征,并研究其对水溶液中Ag(I)的吸附行为.结果表明,VTCA具有明显的三维网格多孔结构,孔隙率达到97.95%,在较宽的pH范围内(1~8)对Ag(I)均保持较高的吸附效率(>75%).吸附过程符合拟二级动力学模型和Langmuir吸附等温线模型,温度升高有利于吸附,最高理论吸附量为147.2mg/g.吸附还原研究机理表明,VTCA主要通过静电吸引和螯合作用将Ag(I)吸附到其表面,并通过单宁结构上的酚羟基将其原位还原为Ag^(0),证明VTCA具有良好的吸附还原性能,能够实现对水体中Ag(I)的回收.

关键词：吸附还原纤维素基气凝胶橡椀单宁 Ag(I)

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