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Based on non-targeted metabolomics for differential components screening of Rosae Chinensis Flos and Rosae Rugosae Flos and their quality evaluation

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Traditional Medicine Research 2025年第2期10卷 1-15页

作者： Xu Liang Ni-Hui Zhang Zhi-Lai Zhan Guang-Lu Chang Yan gao Xia Li Wen-yuan gao School of Pharmaceutical Science and Technology Faculty of MedicineTianjin UniversityTianjin 300193China State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs China Academy of Chinese Medical SciencesBeijing 100700China Key Laboratory of Modern Chinese Medicine Resources Research Enterprises Tianjin 300402China

Background:Rosa chinensis *** Rosa rugosa *** not only of ornamental value,but also edible flowers and the flower buds have been listed in the Chinese Pharmacopoeia as traditional *** two plants have some differences in efficacy,but the flower buds are easily confused for similar *** addition,large-scale cultivation of ornamental rose flowers may lead to a decrease in the effective components of medicinal ***,it is necessary to study the chemical composition and make quality evaluation of Rosae Chinensis Flos(Yueji)and Rosae Rugosae Flos(Meigui).Methods:In this study,40 batches of samples including Meigui and Yueji from different regions in China were collected to establish high-performance liquid chromatography ***,the fingerprints data was analyzed using principal component analysis,hierarchical cluster analysis,and partial least squares discriminant analysis analysis chemometrics to obtain information on intergroup differences,and non-targeted metabolomic techniques were applied to identify and compare chemical compositions of samples which were chosen from groups with large *** compounds were screened by orthogonal partial least-squares discriminant analysis and S-plot,and finally multi-component quantification was performed to comprehensively evaluate the quality of Yueji and ***:The similarity between the fingerprints of 40 batches roses and the reference print R was 0.73 to 0.93,indicating that there were similarities and differences between the *** principal component analysis and hierarchical cluster analysis of fingerprints data,the samples from different origins and varieties were intuitively divided into four *** least-squares discriminant analysis analysis showed that Meigui and Yueji cluster into two categories and the model was reliable.A total of 89 compounds were identified by high resolution mass spectrometry,mainly were flavonoids and flavon

关键词： Rosa chinensis Jacq. Rosa rugosa Thunb. metabolomics chemometrics multiple component quantification quality evaluation

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Mizagliflozin ameliorates diabetes induced kidney injury by inhibitor inhibit inflammation and oxidative stress

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World Journal of Diabetes 2025年第1期16卷 91-103页

作者： Zhi-Min Lin Han-yuan gao Shu-Han Shi Yue-Ting Li Department of Nephrology The Second Affiliated Hospital of Fujian Medical UniversityQuanzhou 362000Fujian ProvinceChina

BACKGROUND Mizagliflozin(MIZ)is a specific inhibitor of sodium-glucose cotransport protein 1(SGLT1)originally developed as a medication for *** To explore the impact of MIZ on diabetic nephropathy(DN).METHODS Diabetic mice were created using db/db *** were administered either a low dose(0.5 mg/kg)or a high dose(1.0 mg/kg)of the SGLT1 inhibitor MIZ via stomach gavage for 8 ***,mesangial cells(MCs)were isolated and subjected to high glucose conditions in culture to assess the effects of MIZ on *** The results showed that low doses of MIZ significantly reduced albuminuria to a level comparable to that achieved with high doses in db/db *** doses of MIZ led to a substantial increase in body weight in mice,along with decreased blood glucose levels and food ***,the intervention with high-dose MIZ notably decreased the expression of extracellular matrix genes,such as collagen type 1 alpha 1 mRNA *** the expression of SGLT1 increased after exposure to high glucose,it decreased following treatment with ***,MIZ intervention was more effective in improving lactate dehydrogenase levels in MCs induced by high glucose compared to *** also significantly elevated levels of antioxidant enzymes superoxide dismutase,catalase,and glutathione,while reducing malondialdehyde *** These findings indicate that MIZ can ameliorate DN by inhibiting SGLT1,inflammation,and oxidative stress.

关键词： Mizagliflozin Sodium-glucose cotransport protein 1 Diabetic nephropathy Mesangial cells

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骨科学领域组织透明化技术的应用与展望

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中国组织工程研究 2025年第15期29卷 3227-3234页

作者：高阳高原马炳江岳辉石永新牡丹江医学院黑龙江省牡丹江市157011 深圳大学附属华南医院广东省深圳市518111 深圳市光明区人民医院广东省深圳市518106

背景:骨组织作为高度矿化且结构复杂的结缔组织,在维持生物体形态和功能中扮演关键角色,传统的成像技术难以满足对其深入观察的需求。组织透明化技术的出现使得研究者能够更加清晰地观察到骨内的细微结构,如骨小梁、骨髓腔以及与骨组织... 详细信息

背景:骨组织作为高度矿化且结构复杂的结缔组织,在维持生物体形态和功能中扮演关键角色,传统的成像技术难以满足对其深入观察的需求。组织透明化技术的出现使得研究者能够更加清晰地观察到骨内的细微结构,如骨小梁、骨髓腔以及与骨组织相互作用的神经和血管网络,为骨科学的研究和临床应用开辟了新的视角。目的:旨在全面梳理组织透明化技术在骨科学领域的应用,并探讨其在骨组织结构与功能研究、疾病机制解析以及治疗策略创新中的潜力,同时对其创新点进行展望。方法:检索覆盖中国知网和PubMed数据库,英文检索词为“tissue clearing,tissue optical,bone”等,中文检索词为“组织透明化、骨、骨缺损”等,结合布尔逻辑以优化检索策略。纳入与组织透明化技术和骨科学研究直接相关的期刊论文和学位论文,排除关联性不强、重复或数据不完整的文献。最终纳入82篇文献进行分析,关注点包括透明化技术的效能、应用范围及对骨科学研究的贡献。结果与结论:①组织透明化技术在骨结构分析、骨代谢研究、骨肿瘤的病理学特征、骨折愈合过程、骨感染的机制研究以及骨移植和植入物材料的生物相容性评价等多个领域均展现出其独特的应用优势;②该技术的应用不仅加速了骨科学领域的基础研究进展,也为临床治疗提供了新的策略和方法,其在骨科学研究领域具有广阔的应用前景。

关键词：组织透明化技术骨科学三维成像骨组织生物医学成像

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An approach for choosing discretization schemes and grid size based on the convection-diffusion equation

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Applied Mathematics and Mechanics(English Edition) 2018年第6期39卷 877-890页

作者： Lin ZHOU Zhenghong gao yuan gao School of Aeronautics Northwestern Polytechnical University

A new approach for selecting proper discretization schemes and grid size is presented. This method is based on the convection-diffusion equation and can provide insight for the Navier-Stokes equation. The approach mainly addresses two aspects, i.e., the practical accuracy of diffusion term discretization and the behavior of high wavenum- ber disturbances. Two criteria are included in this approach. First, numerical diffusion should not affect the theoretical diffusion accuracy near the length scales of interest. This is achieved by requiring numerical diffusion to be smaller than the diffusion discretization error. Second, high wavenumber modes that *** smaller than the length scales of interest should not be amplified. These two criteria provide a range of suitable scheme combinations for convective flux and diffusive flux and an ideal interval for grid spacing. The effects of time discretization on these criteria are briefly discussed.

关键词： convection-diffusion equation cell ReynOlds number diffusion term accu-racy high wavenumber mode scheme selection

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Insights into properties of activated carbons prepared from different raw precursors by pyrophosphoric acid activation

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Journal of Environmental Sciences 2016年第3期28卷 235-243页

作者： yuan gao Qinyan Yue Baoyu gao Shandong Provincial Key Laboratory of Water Pollution Control and Resource Reuse School of Environmental Science and EngineeringShandong University

Low-cost activated carbons（ACs） were prepared from four kinds of solid wastes：petroleum coke,Enteromorpha prolifera,lignin from papermaking black liquid and hair,by pyrophosphoric acid（H_4P_2O_7） ***-gravimetric analysis of the pyrolysis of H_4P_2O_7-precursor mixtures implied that H_4P_2O_7 had different influences on the pyrolysis behavior of the four raw materials.N_2 adsorption/desorption isotherms,scanning electron microscopy,Fourier transform infrared spectroscopy and adsorption capacities for dyes were used to characterize the prepared activated *** derived from *** exhibited the highest surface area（1094 m^2/g） and maximum monolayer adsorption capacity for malachite green（1250 mg/g）.Kinetic studies showed that the experimental data were in agreement with the pseudo-second-order *** adsorption isotherms were well described by the Langmuir isotherm model,indicating the adsorption of dye onto the ACs proceeded by monolayers.

关键词： Solid waste Pyrophosphoric acid Low-cost adsorbent Dye Adsorption

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Segmental nature of the Red River fault revealed by seismic anisotropy and geological structures

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Science China Earth Sciences 2024年第8期67卷 2423-2443页

作者： Ying LI yuan gao School of Earth and Space Sciences University of Science and Technology of ChinaHefei 230026China Key Laboratory of Earthquake Prediction Institute of Earthquake ForecastingChina Earthquake AdministrationBeijing 100036China

As the western boundary of the Sichuan-Yunnan block(SYB),the Red River fault(RRF)is a major fault that controls deep crustal movement and deformation in the southeast margin of the Tibetan Plateau and regulates middle-lower crustal *** data suggest that the RRF is segmented and exhibits distinct variations in seismicity,velocity structure and crustal deformation from north to *** anisotropy reveals a complex pattern of lateral spatial and vertical stratified distributions.(1)From the perspective of crustal stratification,in the upper crust,the fast wave polarization in the north segment of the RRF is complex and possibly influenced by the Sanjiang lateral collision zone and adjacent faults with varying *** fast wave polarization in the middle segment is in the NW-SE direction,indicating a localized area of closed down or locked up with consistent *** in the south segment,it presents a disordered pattern,signifying complex deep tectonics and stress conditions at the wedged intersection *** the middle-lower crust in the north and south segments of the RRF,the azimuthal anisotropy is strong and consistent with the spatial strike of the weak zone characterized by low-velocity and *** suggests a connection between the anisotropy and the material migration.(2)In the whole crustal scale,the fast wave directions in two sides of the RRF are consistent with the NW-SE tectonic *** indicates that the RRF,as a large fault potentially cutting through the whole crust,strongly controls the surrounding media.(3)In the lithospheric scale,the fast wave polarizations are oriented nearly E-W and independent of the fault strike,consistent with the low P-and S-wave velocity structures and positive radial anisotropy in the upper *** fast wave directions could be related to lithospheric olivine deformation and asthenospheric *** paper suggests a decoupling of deformation between the crust and the lithospheri

关键词： Red River fault Seismic anisotropy Geological structures Lithosphere Fault segmentation

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Editors' selection of papers from China's academic journals

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National Science Review 2018年第5期5卷 123-125页

作者： gao, yuan

PHYSICS Photonic spin-Hall effect in single catenary nanoholes The photonic spin-Hall effect is an important but intrinsically weak effect at the *** Luo and co-workers from the Institute of Optics and Electronics,Chi... 详细信息

关键词： Editors selection of papers from China’s academic journals CAS

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Facile one-step synthesis of functionalized biochar from sustainable prolifera-green-tide source for enhanced adsorption of copper ions

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Journal of Environmental Sciences 2018年第11期30卷 185-194页

作者： yuan gao Xiuzhen Zhu Qinyan Yue Baoyu gao Shandong Provincial Key Laboratory of Water Pollution Control and Resource Reuse School of Environmental Science and Engineering Shandong University Jinan 250100 China Key Laboratory of Industrial Ecology and Environmental Engineering (Ministry of Education) School of Environmental Science and Technology Dalian University of Technology Linggong Road 2 Dalian 116024 China

The use of biochars formed by hydrothermal carbonization for the treatment of contaminated water has been greatly limited, due to their poorly developed porosity and low content of surface functional groups. Also, the most common modification routes inevitably require post-treatment processes, which are time-consuming and energy-wasting. Hence, the objective of this research was to produce a cost-effective biochar with improved performance for the treatment of heavy metal pollution through a facile one-step hydrothermal carbonization process coupled with ammonium phosphate, thiocarbamide, ammonium chloride or urea, without any posttreatment. The effects of various operational parameters, including type of modification reagent, time and temperature of hydrothermal treatment, and ratio of modification reagent to precursor during impregnation, on the copper ion adsorption were examined. The adsorption data fit the Langmuir adsorption isotherm model quite well. The maximum adsorption capacities （mg/g） of the biochars towards copper ions followed the order of 40-8h-1.0-APBC （95.24）〉 140-Sh-O-BC （12.52）〉 140-8h-1.0-TUBC （12.08）〉 140-Sh-1.0-ACBC （7.440）〉 140-Sh-1.0-URBC （5.277）. The results indicated that biochars modified with ammonium phosphate displayed excellent adsorption performance toward copper ions, which was 7.6-fold higher than that of the pristine biochar. EDX and FT-IR analyses before and after adsorption demonstrated that the main removal mechanism involved complexation between the phosphate groups on the surface of the modified biochars and copper ions.

关键词： Hydrothermal carbonization Functionalized biochar Adsorption Heavy metal

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Air-sea carbon fluxes and their controlling factors in the Prydz Bay in the Antarctic

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Acta Oceanologica Sinica 2008年第3期27卷 136-146页

作者： gao Zhongyong CHEN Liqi gao yuan Key Laboratory of Global Change and Marine Atmospheric Chemistry of State Oceanic Administration Third Institute of Ocea- nography State Oceanic Administration Xiamen 361005 China Third Institute of Oceanography State Oceanic Administration Xiamen 361005 China Chinese Arctic and Antarctic Administration Beijing 100860 China Department of Earth and Environmental Sciences Rutgers University Newark NJ USA

The Prydz Bay in the Antarctic is an important area in the Southern Ocean due to its unique geographic feature. It plays an important role in the carbon cycle in the Southern Ocean. To investigate the distributions of carbon dioxide in the atmosphere and surface seawater and its air-sea exchange rates in this region, the Chinese National Antarctic Research Expedition （CHINARE） had set up several sections in the Prydz Bay. Here we present the results from the CHINARE-XVI cruises were presented onboard R/V Xue/ong from November 1999 to April 2000 and the main driving forces were discussed controlling the distributions of partial pressure of carbon dioxide. According to the partial pressure of carbon dioxide distributions, the Prydz Bay can be divided into the inside and outside regions. The partial pressure of carbon dioxide was low in the inside region but higher in the outside region during the measurement period. This distribution had a good negative correlation with the concentrations of ehlorophyll-a in general, suggesting that the partial pressure of carbon dioxide was substantially affected by biological production. The results also indicate that the biological produetion is most likely the main driving force in the marginal ice zone in the Southern Ocean in summer. However, in the Antarctic divergence sector of the Prydz Bay （about 64°S）, the hydrological processes become the controlling factor as the sea surface partial pressure of carbon dioxide is much higher than the atmospheric one due to the upwelling of the high DIC CDW, and this made the outside of Prydz Bay a source of carbon dioxide. On the basis of the calculations, the CO2 flux in January （austral summer） was -3.23 mmol/（m^2 · d） in the inner part of Prydz Bay, i.e. , a sink of atmospheric CO2, and was 0.62 mmol/（m^2 · d） in the outside part of the bay, a weak source of atmospheric CO2. The average air-sea flux of CO2 in the Prydz Bay was 2.50 mmol/（m^2 · d）.

关键词： Prydz Bay carbon flux carbon dioxide controlling factors

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Inverse design of mission success space for combat aircraft contribution evaluation

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Chinese Journal of Aeronautics 2020年第8期33卷 2189-2203页

作者： yuan gao Hu LIU Yongliang TIAN School of Aeronautic Science and Engineering Beihang UniversityBeijing 100083China

This paper presents a novel design method of the Mission Success Space(MSS) for the evaluation on aircraft contribution effectiveness. MSS concept was proposed for giving success criterion of a mission and judging the success by conventional mission effectiveness with regards to the aircraft capabilities. This space is created by the Mission Success Function(MSF) and the original Effectiveness Index Space(EIS) where empirical equations are usually assumed to be MSFs. Based on this MSS concept, this paper firstly defines the MSS-based evaluation, then further summarizes the evaluation process of the Contribution to System-of-Systems(CSS). More importantly, based on the thought of Inverse Design(ID), a new design method of MSF is presented comprehensively analyzing aircraft's CSS in a combat mission without using any empirical MSF. The definition of MSS based ID is given and the design procedure is sequentially introduced. Two different confrontation cases are depicted with many details as the simulation validation: Air-to-ground and Penetration. There are two design variables considered for designing MSS in the latter case while only one for the former. However, in both cases, the best design is given by evaluating the Gaussian fitting performance of CSS.

关键词： Contribution effectiveness Effectiveness evaluation Gaussian fitting Inverse design Military missions Modelling and simulation Success rate System of systems

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