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The actin motor protein OsMYA1 associates with OsExo70H1 and contributes to rice secretory defense by modulating OsSyp121 distribution

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Journal of Integrative Plant Biology 2024年第9期66卷 2058-2075页

作者： yuan‐bao li Chengyu liu Ningning Shen Shuai Zhu Xianya Deng Zixuan liu li‐Bo Han Dingzhong Tang State Key Laboratory of Ecological Control of Fujian‐Taiwan Crop Pests Key Laboratory of Ministry of Education for GeneticsBreeding and Multiple Utilization of CropsPlant Immunity CenterFujian Agriculture and Forestry UniversityFuzhou 350002China College of Agriculture Fujian Agriculture and Forestry UniversityFuzhou 350002China College of life Sciences Fujian Agriculture and Forestry UniversityFuzhou 350002China School of Future Technology Fujian Agriculture and Forestry UniversityFuzhou 350002China

Magnaporthe oryzae(***)is a devastating hemibiotrophic *** biotrophic invasive hyphae(IH)are enclosed in the extrainvasive hyphal membrane produced by plant cells,thus generating a front line of the battlefield between the pathogen and the host *** plants,defense-related complexes such as proteins,callose-rich materials and vesicles,are directionally secreted to this interface to confer defense responses,but the underlying molecular mechanism is poorly *** this study,we found that a Myosin gene,Myosin A1(OsMYA1),contributed to rice *** OsMYA1 knockout mutant exhibited decreased resistance to *** ***1 localizes to the actin cytoskeleton and surrounds the IH of ***1 interacts with an exocyst subunit,OsExo70H1,and regulates its accumulation at the plasma membrane(PM)and pathogen–plant ***,OsExo70H1 interacted with the rice syntaxin of the plants121 protein(OsSyp121),and the distribution of OsSyp121 to the PM or the pathogen–plant interface was disrupted in both the OsMYA1 and OsExo70H1 ***,these results not only reveal a new function of OsMYA1 in rice blast resistance,but also uncover a molecular mechanism by which plants regulate defense against *** by OsMYA1-initiated vesicle secretory pathway,which originates from the actin cytoskeleton to the PM.

关键词： cytoskeleton plant defense mechanism rice blast vesicle delivery

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The actin motor protein OsMYA1 associates with OsExo70H1 and contributes to rice secretory defense by modulating OsSyp121 distribution

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Journal of Integrative Plant Biology 2024年第09期 2058-2075页

作者： yuan-bao li Chengyu liu Ningning Shen Shuai Zhu Xianya Deng Zixuan liu li-Bo Han Dingzhong Tang State Key Laboratory of Ecological Control of Fujian-Taiwan Crop Pests Key Laboratory of Ministry of Education for GeneticsBreeding and Multiple Utilization of Crops Plant Immunity Center Fujian Agriculture and Forestry University College of Agriculture Fujian Agriculture and Forestry University College of life Sciences Fujian Agriculture and Forestry University School of Future Technology Fujian Agriculture and Forestry University

Magnaporthe oryzae(M. oryzae) is a devastating hemibiotrophic pathogen. Its biotrophic invasive hyphae(IH) are enclosed in the extrainvasive hyphal membrane produced by plant cells, thus generating a front line of the battlefield between the pathogen and the host plants. In plants, defense-related complexes such as proteins, callose-rich materials and vesicles,are directionally secreted to this interface to confer defense responses, but the underlying molecular mechanism is poorly understood. In this study, we found that a Myosin gene, Myosin A1(Os MYA1),contributed to rice defense. The Os MYA1 knockout mutant exhibited decreased resistance to M. oryzae infection. Os MYA1 localizes to the actin cytoskeleton and surrounds the IH of M. oryzae. Os MYA1 interacts with an exocyst subunit, Os Exo70H1, and regulates its accumulation at the plasma membrane(PM) and pathogen–plant interface. Furthermore, Os Exo70H1interacted with the rice syntaxin of the plants121protein(Os Syp121), and the distribution of Os Syp121to the PM or the pathogen–plant interface was disrupted in both the Os MYA1 and Os Exo70H1 ***, these results not only reveal a new function of Os MYA1 in rice blast resistance, but also uncover a molecular mechanism by which plants regulate defense against M. oryzae by Os MYA1-initiated vesicle secretory pathway, which originates from the actin cytoskeleton to the PM.

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DG Hosting Capacity Assessment Considering Dependence Among Wind Speed,Solar Radiation,and Load Demands

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CSEE Journal of Power and Energy Systems 2024年第3期10卷 1011-1025页

作者： Junyi Yang Jiangmin bao Yuhan Hou Han Wu Qiang li Yue yuan Hohai University Nanjing 211100China State Grid Jiangsu Electric Power Co. Ltd.Suzhou Power Supply BranchSuzhou 215004China Nanjing Institute of Technology Nanjing 211167China Electric Power Research Institute of State Grid Jiangsu Electric Power Co.Ltd. Nanjing 211103China IEEE CSEE

Dependence of distributed generation(DG)outputs and load plays an essential role in renewable energy *** paper presents a novel DG hosting capacity(DGHC)evaluation method for distribution networks considering highdimensional dependence relations among solar radiation,wind speed,and various load types(i.e.,commercial,residential,and industrial).First,an advanced dependence modeling method called regular vine(R-vine)is applied to capture the complex dependence structure of solar radiation,wind speed,commercial loads,industrial loads,and residential ***,a chanceconstrained DGHC evaluation model is employed to figure out maximum hosting capacity of each DG and its optimal allocation plan with different operational ***,a Benders decomposition algorithm is also employed to reduce computational *** proposed approaches are validated using a set of historical data from *** show dependence among different DGs and loads has significant impact on hosting *** also suggest using the R-vine model to capture dependence among distributed energy resources(DERs)and *** finding provides useful advice for distribution networks in installing renewable energy generations.

关键词： Benders decomposition correlation DG hosting capacity regular vine

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CMSOF:a structured data organization framework for scanned Chinese medicine books in digital libraries

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Journal of Zhejiang University-Science C(Computers and Electronics) 2010年第11期11卷 882-892页

作者： Jie yuan bao-gang WEI li-dong WANG Wei-ming LU Yue-ting ZHUANG School of Computer Science and Technology Zhejiang University Hangzhou 310027 China

Organizing unstructured information from books into a well-defined structure is a significant challenge in digital *** digital libraries can provide only search services at the granularity of books and few libraries allow books to be accessed at the granularity of chapters,as manually constructing directory information for books is *** structured data from scanned books thus remains an urgent and important *** this paper,we propose a novel structured data organization framework called CMSOF to organize scanned data automatically,and apply it to a Chinese medicine digital library. In the framework,image blocks and text blocks on the scanned page of books are separated based on the gray histogram projection method or a hybrid method of region growth and the Ada-Boosting classifier at first,and then the text structure is obtained from text blocks by text size and font type ***,image blocks and structured OCRed text are correlated at the semantic *** integrating the structured data into a Chinese medicine information system(CMIS) ,we can organize the Chinese medicine books well and users can access the books with flexibility,which indicates that CMSOF is an efficient framework to organize books mixed with images and text.

关键词： Digital library Chinese medicine Structured data organization Cross media Image separation

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Thalidomide-based Regimens for Elderly and/or Transplant Ineligible Patients with Multiple Myeloma： A Meta-analysis

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Chinese Medical Journal 2016年第3期129卷 320-325页

作者： Wen-Wen Lyu Qing-Chun Zhao De-Hai Song Jin-Jie Zhang Zhao-Xing Ding bao-yuan li Chuan-Mei Wei Department of Pharmacy Binzhou Medical University Hospital Binzhou Shandong 256603 China School of Pharmacy Shenyang Pharmaceutical University Shenyang Liaoning 110016 China

Background： Thalidomide is an immunomodulatory and anti-angiogenic drug that has shown promise in patients with *** comparing efficacy of standard melphalan and prednisone （MP） therapy with MP plus thalidomide （MPT） in transplant-ineligible or elderly patients with multiple myeloma （MM） have provided conflicting *** meta-analysis aimed to determine the efficacy and toxicity of thalidomide in previously untreated elderly patients with ***： Medline, the Cochrane Controlled Trials register, conference proceedings of the American Society of Hematology （1995-2014）, the American Society of Clinical Oncology （1995-2014）, and CBM, VIP, and CNKI databases were searched for randomized control trials with the use of the medical subject headings ＆quot;MM＆quot; and ＆quot;thalidomide＆quot;.Trials were assessed by two reviewers for ***-analysis was conducted using a fixed effects *** analysis was performed to test the robustness of the ***： Overall, seven trials were identified, covering a total of 1821 *** summary hazard ratio （thalidomide ***） was 0.82 （95% confidence interval [CI]： 0.72-0.94） for overall survival （OS）, and 0.65 （95% CI： 0.58-0.73） for progression-free survival, in favor of thalidomide treated *** risk ratio of complete response with induction thalidomide was 3.48 （95% CI： 2.24-5.41）.A higher rate of Ⅲ/Ⅳ adverse events were observed in MPT arm compared with the MP ***, analysis of sub-groups administering anticoagulation as venous thromboembolism prophylaxis suggested no difference in relative risk of thrombotic events between two arms （RR =1.47, 95% CI： 0.43-5.07, P =0.54）.Further analysis of trials on the treatment effects of MPT versus MP on adverse events-related mortality showed no statistical difference between two arms （RR =1.24, 95% CI： [0.95-1.63], P =0.120）.Conclusion： Thalidomide appears to improve the OS of elderly and/or transplant-ineligible patie

关键词： Elderly Meta-analysis Multiple Myelolna Thalidomide

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A tectono-thermal perspective on the petroleum generation,accumulation and preservation in the southern Ordos Basin, North China

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Petroleum Science 2024年第3期21卷 1459-1473页

作者： Peng Yang Zhan-li Ren Jin-Hua Fu Hong-Ping bao Hui Xiao Zheng Shi Kun Wang yuan-yuan Zhang Wen-Hui liu Wen-Hou li State Key Laboratory of Continental Dynamics Department of GeologyNorthwest UniversityXi'an710069ShanxiChina National Engineering Laboratory for Exploration and Development of Low-Permeability Oil and Gas Fields Exploration and Development Research Institute of PetroChina Changqing Oilfield CompanyXi'an710018ShaanxiChina Shaanxi Key Lab of Petroleum Accumulation Geology School of Earth Science and EngineeringXi'an Shiyou UniversityXian710065ShaanxiChina Wuxi Research Institute of Petroleum Geology Petroleum Exploration and Production Research InstituteSINOPECWuxi214126JiangsuChina

The southern Ordos Basin has excellent petroleum exploration ***,the tectono-thermal history and the controls on petroleum generation,accumulation and preservation conditions in southern basin are *** this study,we analyzed the present geothermal field,paleo-geothermal gradient,maturity of the hydrocarbon source rocks,uplift and cooling process and tectono-thermal evolution *** the study area,for the Ordovician,Permain and the Triassic strata,the present temperature is low(3070℃)in the southeastern area but high(80140℃)in the northwestern *** paleogeothermal gradient varied from 24℃/km to 30℃/km with a heat flow of 58—69 m W/m^(2)(i.e.,a medium-temperature basin).The paleo-temperatures are higher than the present temperatures and the maximum paleo-temperatures controlled the thermal maturity of the source *** vitrinite reflectance(Ro)values of the Triassic strata are>0.7%and the thermal maturity reached the middlemature oil generation *** Rovalues of the Permian-Ordovician strata are>1.8%and the thermal maturity reached the over-mature gas generation *** southern Ordos Basin has experienced the multiple tectonic events at the Late Ordovician Caledonian(452 Ma),Late Triassic(215 Ma),Late Jurassic(165160 Ma),End-Early Cretaceous(110100 Ma)and Cenozoic(since 40 Ma).A large-scale tectonothermal event occurred at the End-Early Cretaceous(110100 Ma),which was controlled by lithospheric extension,destruction and *** event led to the highest paleo-temperatures and thermal maturities and coeval with the peak period of petroleum generation and *** southern Ordos Basin has undergone rapid and large-scale uplift since the Late Cretaceous due to expansion of the northeastern margin of the Tibetan Plateau,uplift of the Qinling orogenic belt and thrust faulting in the liupanshan tectonic *** southern Ordos Basin experienced tectonic overprinting that was strong in the south and weak in the *** str

关键词： Fission-track dating Vitrinitereflectance Geothermal field Tectono-thermal evolution Petroleum geology Ordos Basin

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Regulating Signal Pathway Triggers Circular Reactive Oxygen Species Production to Augment Oxidative Stress with Enzyme-Activated Nanoparticles

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CCS Chemistry 2024年第3期6卷 693-708页

作者： Benkai bao Qiong yuan Qian Feng ling li Meiqi li Yanli Tang Key Laboratory of Analytical Chemistry for life Science of Shaanxi Province Key Laboratory of Applied Surface and Colloid ChemistryMinistry of EducationSchool of Chemistry and Chemical EngineeringShaanxi Normal UniversityXi’anShaanxi Province 710119

Regulating antioxidative stress pathways to augment oxidative stress and enhance antitumor therapy is highly desirable but very ***,we initiated a multifunctional nanoparticle to regulate the Keap1-Nrf2 antioxidative stress pathway to promote cancer cell *** OPFV-SnMP@GE11 nanoparticles were assembled by enzyme-activated OPFV-TLQ,tin mesoporphyrin(SnMP),and ***-SnMP@GE11 accumulated at tumor sites through specific targeting with ***-TLQ was specifically reduced to a photosensitizer OPFVNH2 by endocellular NAD(P)H:quinone oxidoreductase 1(NQO1).Under irradiation,OPFV-NH2 greatly produced reactive oxygen species(ROS)through a type I mechanism,which activated the Keap1-Nrf2 signal pathway and enhanced the transcription of NQO1,resulting in a continuous and explosive generation of ***,SnMP inhibited the activity of heme oxygenase-1(HO-1),further depressing antioxidative *** strategy provides insight into the regulation of the signal pathway to amplify oxidative stress,paving the way to studying the molecular mechanisms of cellular activities to enhance cancer therapy.

关键词： Keap1-Nrf2 pathway enzyme-activated probe reactive oxygen species oxidative stress antitumor therapy

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Effect of Artificial Electric Field Surface by Wave-Driven Triboelectricity on Anti-Bioadhesion for Riser Protection

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China Ocean Engineering 2024年第3期38卷 483-490页

作者： YI Peng QIU Hong-yuan li Yong CAI bao-ping Javad MOSTAGHIMI ZHANGWen-jie XIAO Wen-sheng College of Mechanical and Electrical Engineering China University of PetroleumQingdao 266580China CNOOC EnerTech Equipment Technology Co. Ltd.Tianjin 300450China Department of Mechanical&Industrial Engineering University of TorontoToronto ONM5S3G8Canada

Biofouling has been a persistent problem in marine riser system, resulting in energy waste and equipment damage. Inthis study, a kind of water wave-driven contact-mode flexible triboelectric nanogeneration has been prepared byusing graphene-doped PDMS as dielectric friction material. When the graphene content is 2%, the average outputvoltage can reach 46 V under the contact frequency 10 Hz. The flexible triboelectric nanogeneration encapsulationmodule is impinged by water waves to generate alternating microelectric field on the riser surface and destroy theadhesion conditions of microorganisms during the biofilm stage. In the biofouling experiments at different stages, thebiofouling area of the platymonas subcordiformis has been reduced by 53%, 62% and 61%. It provides a new ideafor effective treatment of biofouling of mussels, oysters and barnacles attached to risers.

关键词： wave-drive triboelectric nanogeneration alternating microelectric field anti-biofouling

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Distributed phase-matching measurement for dynamic strain and temperature sensing based on stimulated Brillouin scattering enhanced four-wave mixing

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Photonics Research 2024年第1期12卷 141-153页

作者： yuan WANG PEDRO TOVAR JUNTONG YANG liANG CHEN XIAOYI bao Nexus for Quantum Technologies University of OttawaOttawaOntario K1N 6N5Canada

A Brillouin dynamic grating(BDG) can be used for distributed birefringence measurement in optical fibers,offering high sensitivity and spatial resolution for sensing ***,it is quite a challenge to simultaneously achieve dynamic measurements with both high accuracy and high spatial *** this work,we propose a sensing mechanism to achieve distributed phase-matching measurement using a chirped pulse as a probe *** BDG reflection,the peak reflection corresponds to the highest four-wave mixing(FWM) conversion efficiency,and it requires the Brillouin frequency in the fast and slow axes to be equal,which is called the phase-matching *** condition changes at different fiber positions,which requires a range of frequency injection for the probe *** proposed method uses a chirped pulse as a probe wave to cover this frequency range associated with distributed birefringence *** allows us to detect distributed phase matching for birefringence changes that are introduced by temperature and strain *** to the single shot and direct time delay measurement capability,the acquisition rate in our system is only limited by the fiber ***,unlike conventional BDG spectrum recovery-based systems,the spatial resolution here is determined by both the frequency chirping rate of the probe pulse and the birefringence profile of the *** the experiments,an acquisition rate of 1 k Hz(up to fiber length limits) and a spatial resolution of 10 cm using a 20 ns probe pulse width are *** minimum detectable temperature and strain variation are 5.6 mK and 0.37 με along a 2 km long polarization-maintaining fiber(PMF).

关键词： fiber scattering polarization

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Mechanical Modeling and Analysis of Stability Deterioration of Production Well During Marine Hydrate Depressurization Production

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China Ocean Engineering 2024年第2期38卷 338-351页

作者： SUN Huan-zhao CHANG yuan-jiang SUN bao-jiang WANG Kang CHEN Guo-ming li Hao DAI Yong-guo Centre for Offshore Engineering and Safety Technology China University of Petroleum(East China)Qingdao 266580China School of Petroleum Engineering China University of Petroleum(East China)Qingdao 266580China Jiangsu Shuguang Oil Tools Co. LtdTaizhou 225532China

Different from oil and gas production,hydrate reservoirs are shallow and unconsolidated,whose mechanical properties deteriorate with hydrate ***,the formations will undergo significant subsidence during depressurization,which will destroy the original force state of the production ***,existing research on the stability of oil and gas production wells assumes the formation to be stable,and lacks consideration of the force exerted on the hydrate production well by formation subsidence caused by hydrate decomposition during *** fill this gap,this paper proposes an analytical method for the dynamic evolution of the stability of hydrate production well considering the effects of hydrate *** on the mechanical model of the production well,the basis for stability analysis has been proposed.A multi-field coupling model of the force state of the production well considering the effect of hydrate decomposition and formation subsidence is established,and a solver is *** analytical approach is verified by its good agreement with the results from the numerical method.A case study found that the decomposition of hydrate will increase the pulling-down force and reduce the supporting force,which is the main reason for the stability *** higher the initial hydrate saturation,the larger the reservoir thickness,and the lower the production pressure,the worse the stability or even *** work can provide a theoretical reference for the stability maintaining of the production well.

关键词： natural gas hydrate production well depressurization production formation deformation stability deterioration

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