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Lattice-mismatch-induced formation of defect-rich Pd-Cu alloy nanocages for enhanced formic acid oxidation activity

SCIENCE CHINA-CHEMISTRY 2025年第2期68卷 481-491页

作者： Liu, Zhaojun Wang, Zhengyan Wang, Zhaoyu yuan, hao Bai, Yuke Wang, Xiaoxiao Mu, Zerui Wu, Chunxia Liu, Kai Hu, Zhun Gao, Chuanbo Xi An Jiao Tong Univ Frontier Inst Sci & Technol Sate Key Lab Multiphase Flow Power Engn Xian 710049 Peoples R China Xi An Jiao Tong Univ Inst Ind Catalysis Sch Chem Engn & Technol Xian 710049 Peoples R China

Crystallographic defects in noble metal nanocrystals are recognized as highly active catalytic sites, significantly enhancing activities in many important reactions. Despite their importance, synthesizing noble metal nanocrystals with a high density of defects poses a considerable synthetic challenge. Here, we present a novel lattice mismatch-induced formation mechanism to create high-density defects in noble metal nanocrystals. This approach takes advantage of lattice mismatch to enable non-epitaxial nucleation and growth of a noble metal on a foreign metal substrate, forming abundant noble metal crystallites with random lattice orientations not dictated by the substrate lattice. As these crystallites grow extensively, they merge, forming numerous grain boundaries and yielding defect-rich noble metal nanocrystals. Defect-rich alloy nanocrystals can also be synthesized through a subsequent vacancy-diffusion alloying process. We take defective PdCu alloy nanocages as an example and demonstrate the effectiveness of crystallographic defects in enhancing catalytic performance of noble metal nanocrystals. The nanocages exhibit superior activity in the electrocatalytic formic acid oxidation reaction, which is 1.6 times greater than their defect-free counterparts. Our strategy offers a new avenue for creating defect-rich noble metal nanocrystals as highly efficient catalysts for a wide array of catalytic applications.

关键词： noble metal nanocrystals defects non-epitaxial growth electrocatalysis formic acid oxidation reaction

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Bidirectional regulation of the cyclic guanosine monophosphateadenosine monophosphate synthase-stimulator of interferon gene pathway and its impact on hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2025年第2期17卷 246-261页

作者： Ai-Yu Nie Zhong-Hui Xiao Jia-Li Deng Na Li Li-yuan hao Sheng-hao Li Xiao-Yu Hu College of Clinical Medicine Chengdu University of Traditional Chinese MedicineChengdu 610075Sichuan ProvinceChina Department of Infection Affiliated Hospital of Chengdu University of Traditional Chinese MedicineChengdu 610072Sichuan ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC)ranks as the fourth leading cause of cancerrelated deaths in China,and the treatment options are *** cyclic guanosine monophosphate-adenosine monophosphate synthase(cGAS)activates the stimulator of interferon gene(STING)signaling pathway as a crucial immune response pathway in the cytoplasm,which detects cytoplasmic DNA to regulate innate and adaptive immune *** a potential therapeutic target,cGASSTING pathway markedly inhibits tumor cell proliferation and metastasis,with its activation being particularly relevant in ***,prolonged pathway activation may lead to an immunosuppressive tumor microenvironment,which fostering the invasion or metastasis of liver tumor *** To investigate the dual-regulation mechanism of cGAS-STING in *** This review was conducted according to the PRISMA *** study conducted a comprehensive search for articles related to HCC on PubMed and Web of Science *** rigorous screening and meticulous analysis of the retrieved literature,the research aimed to summarize and elucidate the impact of the cGAS-STING pathway on HCC *** All authors collaboratively selected studies for inclusion,extracted data,and the initial search of online databases yielded 1445 *** removing duplicates,remaining 964 records were ***,55 articles met the inclusion criteria and were included in this *** Acute inflammation can have a few inhibitory effects on cancer,while chronic inflammation generally promotes its *** cGAS-STING pathway activation will result in a suppressive tumor microenvironment.

关键词： Hepatocellular carcinoma Cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon gene Interferon genes The metastasis of a tumor Immunology

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Retrospective analysis of preoperative tumor marker levels in rectal cancer patients: Implications for diagnosis

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World Journal of Gastrointestinal Surgery 2025年第3期17卷 221-228页

作者： Ming Li Da-hao yuan Zhi Yang Teng-Xiang Lu Lei Zhang Clinical Laboratory Linquan County People’s HospitalLinquan 236400Anhui ProvinceChina Hemodialysis Center Linquan County People’s HospitalLinquan 236400Anhui ProvinceChina Department of Gastrointestinal Surgery Linquan County People’s HospitalLinquan 236400Anhui ProvinceChina

BACKGROUND Early detection of rectal cancer poses significant *** diagnostic methods,including colonoscopy,imaging techniques,and fecal tests,have limitations such as invasiveness,cost,and varying *** study evaluated the diagnostic value of preoperative serum tumor markers in rectal cancer *** To investigate the value of a multi-marker approach for the preoperative diagnosis of rectal *** A retrospective analysis of 250 patients diagnosed with rectal cancer between July 2022 and July 2024 was *** alpha-fetoprotein levels,carcinoembryonic antigen(CEA),cancer antigen 125(CA125),CA19-9,CA15-3,and CA72-4 were *** blood samples were collected under standardized conditions,including fasting status and proper storage methods,within two weeks before *** performance was assessed using receiver operating characteristic curve *** among clinicopathological features were also *** CEA demonstrated the highest diagnostic performance among individual tumor markers with an area under the curve(AUC)of 0.78[95%confidence interval(CI):0.73-0.83].However,a combination of CEA,CA19-9,and CA72-4 showed superior performance,achieving an AUC of 0.87(95%CI:0.83-0.91).Significant correlations were observed between CEA levels and several clinicopatho-logical features,including tumor stage(P<0.001),lymph node involvement(P=0.002),and distant metastasis(P<0.001).Furthermore,in a subgroup analysis of patients diagnosed after July 2022,the integration of fecal occult blood testing with the tumor marker panel(CEA+CA19-9+CA72-4)significantly improved diagnostic accuracy,increasing the AUC to 0.91(95%CI:0.86-0.96).CONCLUSION A multimarker approach combining CEA,CA19-9,and CA72-4 with fecal occult blood testing enhances the preoperative assessment of patients with rectal *** findings suggest potential improvements in risk stratification and management of patients with rect

关键词： Rectal cancer Tumor markers Carcinoembryonic antigen Cancer antigen 19-9 Cancer antigen 72-4 Fecal occult blood test Diagnosis

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高校思想政治理论课实践教学的现实困境与改革路径

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教育理论与实践 2025年第6期45卷 45-48页

作者：李昊远常州机电职业技术学院马克思主义学院江苏常州213164

高校开展思政课实践教学,是促进高校思想政治理论课高质量发展和顺应“受教育者在场”的高等教育发展趋势的时代因应。目前,高校思想政治理论课实践教学主要存在运行机制不健全、方式方法不新颖、课程体系不完善、指导教师能力不足的现... 详细信息

高校开展思政课实践教学,是促进高校思想政治理论课高质量发展和顺应“受教育者在场”的高等教育发展趋势的时代因应。目前,高校思想政治理论课实践教学主要存在运行机制不健全、方式方法不新颖、课程体系不完善、指导教师能力不足的现实问题。高校思想政治理论课实践教学改革路径是,构建多重机制保障教学运行,创新“互联网+”的教学方式方法,推进以教材建设为中心的课程化进程,运用“两种思维”提升教师的岗位胜任力。

关键词：高校思想政治理论课实践教学多重机制教材建设

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焦虑、抑郁、神经质与复发性流产的因果关系:一项孟德尔随机化研究

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陆军军医大学学报 2025年第4期47卷 378-384,F0003页

作者：袁昊李霄孙志玉卫爱武河南中医药大学第一附属医院生殖医学科郑州河南中医药大学第一临床医学院郑州

目的分别探究焦虑、抑郁、神经质等3种负面情绪与复发性流产之间的因果关系。方法利用全基因组关联研究数据提取与焦虑、抑郁、神经质密切相关的遗传位点作为工具变量,分别利用逆方差加权法、加权中位数法、加权众数法及MR-Egger回归法... 详细信息

目的分别探究焦虑、抑郁、神经质等3种负面情绪与复发性流产之间的因果关系。方法利用全基因组关联研究数据提取与焦虑、抑郁、神经质密切相关的遗传位点作为工具变量,分别利用逆方差加权法、加权中位数法、加权众数法及MR-Egger回归法进行孟德尔随机化分析,评价焦虑、抑郁、神经质与复发性流产之间的因果效应,并进行异质性、基因多效性与敏感性分析。结果从全基因组关联研究(genome-wide association study,GWAS)数据中提取共46个SNPs作为工具变量(焦虑数据5个,抑郁数据9个,神经质数据32个),经逆方差加权法、加权中位数法、加权众数法及MR-Egger回归法计算OR值与95%CI,焦虑数据结果分别为1.07(0.86~1.32)、1.10(0.85~1.43)、1.14(0.81~1.59)、1.18(0.53~2.61),抑郁数据结果分别为1.11(0.93~1.32)、1.05(0.83~1.32)、0.96(0.67~1.38)、0.57(0.25~1.31),神经质数据结果分别为1.01(0.75~1.36)、1.07(0.73~1.56)、1.02(0.49~2.12)、2.40(0.46~12.44),上述因果分析均无统计学意义(P均>0.05);经可靠性分析,异质性评价Cochran’sQ检验差异不具有显著性(P均>0.05),基因多效性评价MR-Egger回归截距均接近于0(P均>0.05),敏感性评价留一法检验后合并因果效应值相近。结论焦虑、抑郁、神经质与复发性流产之间不存在因果关联,可靠性检验提示结果相对稳健。

关键词：负面情绪复发性流产孟德尔随机化

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植物蛋白基玉米黄色素微胶囊的制备及性能评价

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食品科学 2025年第5期46卷 65-74页

作者：高莉杨俊燕赵英虎季海霞陈佳慧郝媛石英郝瑞中北大学化学与化工学院山西太原030051

为了改善玉米黄色素(maize yellow pigment,MYP)水溶性差、不稳定性和生物利用度低等问题,本实验以不同植物基蛋白(豌豆分离蛋白、火麻蛋白、大豆分离蛋白)和海藻酸钠两类材料结合作为复合壁材,以麦芽糊精为单一壁材分别制备MYP微胶囊,... 详细信息

为了改善玉米黄色素(maize yellow pigment,MYP)水溶性差、不稳定性和生物利用度低等问题,本实验以不同植物基蛋白(豌豆分离蛋白、火麻蛋白、大豆分离蛋白)和海藻酸钠两类材料结合作为复合壁材,以麦芽糊精为单一壁材分别制备MYP微胶囊,对微胶囊的包埋效果、理化性质、粒径、热稳定性、微观结构、体外消化特性以及抗氧化能力进行评价,并研究其对H_(2)O_(2)诱导的ARPE-19细胞氧化损伤模型的保护作用。结果表明,MYP的微胶囊化可以提高其溶解度、生物利用度和抗氧化活性;微胶囊(MYP质量浓度在375~1 125μg/mL范围内)不影响ARPE-19细胞活力,并且在H_(2)O_(2)诱发氧化损伤模型中显示出更好的细胞抗氧化作用;3种壁材展现出不同的功能特性。与其他壁材相比,豌豆蛋白-海藻酸钠壁材的微胶囊有较高的包埋率、较低的含水量、较小尺寸,同时具有良好的流动性和稳定性。

关键词：玉米黄色素植物蛋白基复凝聚法壁材微胶囊

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Phase changings in the surface layers of Td-WTe_(2) driven by alkali-metal deposition

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Chinese Physics B 2025年第1期34卷 172-178页

作者： Yu Zhu Zheng-Guo Wang Yu-Jing Ren Peng-hao yuan Jing-Zhi Chen Yi Ou Li-Li Meng Yan Zhang International Center for Quantum Materials School of PhysicsPeking UniversityBeijing 100871China Collaborative Innovation Center of Quantum Matter Beijing 100871China

The discovery of phase changings in two-dimensional(2D)materials driven by external stimuli not only helps to understand the various intriguing phases in 2D materials but also provides directions for constructing new functional ***,by combining angle-resolved photoemission spectroscopy(ARPES)and in-situ alkali-metal deposition,we studied how alkali-metal adatoms affect the electronic structure of T_(d)-WTe_(2)on two different cleaved *** found that depending on the polarization direction of the cleaved surface,the alkali-metal deposition triggered two successive phase transitions on one surface of WTe_(2),while on the other surface,no phase transition was *** attributed the observed phase transitions to a Td↑-1T′-Td↓structural transition driven by an alkali-metal induced sliding of *** comparing the band structure obtained in different structural phases of WTe_(2),we found that the evolution of band structure across different phases is characterized by an energy scale that could be related to the degree of orbital hybridization between two adjacent WTe_(2)*** results demonstrate a method that manipulates the surface structure of bulk 2D *** also builds a direct correlation between the electronic structure and the degree of interlayer misalignment in this intriguing 2D material.

关键词： angle-resolved photoemission spectroscopy transition metal dichalcogenides phase transition

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A Ruin Model with Compound Poisson Income and Dependence Between Claim Sizes and Claim Intervals

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Acta Mathematicae Applicatae Sinica 2015年第2期31卷 445-452页

作者： yuan-yuan hao Hu YANG Department of Statistics and Actuarial Science Chongqing University College of Mathematics Chongqing Normal University

We consider a ruin model with random income and dependence between claim sizes and claim intervals. In this paper, we extend the determinate premium income into a compound Poisson process and assume that the distribution of the time between two claim occurrences depends on the previous claim *** the premium size is exponentially distributed, the（Gerber-Shiu） discounted penalty functions is ***, we consider a similar model.

关键词： discounted penalty function laplace transform ruin model dependence

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A Ruin Model with Random Income and Dependence between Claim Sizes and Claim Intervals

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Acta Mathematicae Applicatae Sinica 2010年第4期26卷 625-632页

作者： Hu Yang yuan-yuan hao College of Mathematics and Statistics Chongqing UniversityChongqing400030China

In this paper,we consider a generalization of the classical ruin model,where the income is random and the distribution of the time between two claim occurrences depends on the previous claim *** model is more appropriate than the classical ruin *** expression for the generating function of the Gerber-Shiu expected discounted penalty function are derived.A similar model is ***,the result are showed by two examples.

关键词： Ruin model expected discounted penalty function dependence ruin probability

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An Improved RPL Algorithm for Low-Power and Lossy Networks

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China Communications 2023年第1期20卷 140-152页

作者： Yanan Cao hao yuan Tianjin Key Laboratory of Wireless Mobile Communications and Power Transmission Tianjin Normal UniversityTianjin 300387China Chinese People’s Liberation Army Unit 61846 Zhuozhou 07250China

The routing protocol for low-power and lossy networks(RPL),standardized by Internet Engineering Task Force(IETF),is mainly designed to use for Low-power and Lossy Networks(LLNs).To solve the problems of several important routing metrics are not evaluated,the optimal path may contain long single hop links,lack of scientific multi-routing metrics evaluation method and mechanism to balance the parent child number(especially the parent with one hop away from root),this paper proposes an improved RPL algorithm for LLN(I-RPL).First of all,we propose the evaluated routing metrics:child number of parent,candidate parent number,hop count,ETX and energy consumption ***,we improve the path ETX calculation method to avoid selecting optimal path containing long single hop *** we design a novel lexical method to synthetically evaluate candidate ***,based on the evaluation results of candidate parents,we design a novel objective function and a new calculation node rank method which can also be used for selecting the optimal ***,evaluation results show that I-RPL outperforms ETXOF and several other improvements in terms of packet delivery ratio,latency,etc.

关键词： routing protocol RPL routing metric lexical method objective function

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