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Tetraphenylethylene-derived organic cages with persistent photogenic radicaloids and efficient photothermal conversion

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Science China Chemistry 2025年第2期68卷 661-669页

作者： Suqiong Yan Bo Yang Fanda Feng yuan zhang Shirong Ban Hui Ma Wei Huang State Key Laboratory of Coordination Chemistry School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210093China Shenzhen Research Institute of Nanjing University Shenzhen 518057China

Transformation of the electronic spin states has received significant interest in recent years because of its applications in the magnetic information storage materials and optical response ***,it can be formidably challenging to use ultraviolet(UV)light as a contactless stimulus to alter the electronic spin states of the supramolecular *** by the approach on the radical cation mechanism of the Scholl reaction and the photocyclization reactivity of tetraphenylethylene(TPE)derivatives,we report two photochromic cages(cage-TPE-1 and cage-TPE-2)that can be photochemically transformed from electron paramagnetic resonance(EPR)-silent to EPR-active form via UV irradiation due to the photo-induced electron transfer process at the TPE *** provided a strong single-electron signal with a g value of 2.003 in cage-TPE-1 and cage-TPE-2 but no signal was detected for the pristine samples without the *** transformation can be monitored by ultraviolet–visible–near-infrared(UV–vis–NIR)and photoluminescence(PL)*** photogenic radical cage intermediate was unstable in solution resulting in the degradation and intramolecular cyclization of the reactive species,while the radicals were found to be stable and persistent in the solid state due to the spin delocalization,the steric protection of confined cavities,and the oxygen *** theoretical calculations and spectral measurements suggest that the photogenic radical cage-TPE-2(•+)experiences photocyclization on the TPE *** with the close-shell cage,the radical cage-TPE-1(•+)and cage-TPE-2(•+)exhibit better photothermal conversion performance due to the incubated infrared absorption from open-shell electron feature and reduced band gap.

关键词： supramolecular cage photogenic radical photocyclization photothermal conversion

In vivo self-assembled bispecific fluorescence probe for early detection of bladder cancer and metastasis

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Science Bulletin 2025年第3期70卷 407-418页

作者： Da-Yong Hou Ni-yuan zhang Peng zhang Xiang-Peng Li Jiong-Cheng Wu Mei-Yu Lv Zhi-Jia Wang Xing-Jie Hu Jian-Xiao Liang Hong-Lei Wang Yue-Ze Wang Hui-Hui You Hong-Wei An Hao Wang Wanhai Xu NHC Key Laboratory of Molecular Probe and Targeted Theranostics Heilongjiang Key Laboratory of Scientific Research in UrologyHarbin Medical UniversityHarbin 150001China Department of PET-CT/MRI Harbin Medical University Cancer HospitalHarbin 150001China CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and Technology(NCNST)Beijing 100190China

Tumor metastasis accounts for over 90%of tumor-related deaths,prompting the development of fluorescently labeled tumor-specific molecular imaging agents for differentiating tumors from normal ***,early detection of metastasis lesions by tracking tumor markers alone has proven to be ***,we reported a glycopeptide-based bispecific fluorescence probe(bsProbe)for earlier detection of bladder cancer and *** simultaneously recognition(tumor&tumor microenvironment)and in vivo self-assembly,the tumor accumulation of bsProbe(12.3%ID/g)was obviously increased by∼6 fold compared with that in CXCR4 specific fluorescence probe(sProbe),indicating the obvious advantages of bsProbe over existing tumor metastasis detection ***,bsProbe substantially broadens the tumor diagnosis window and enhances the detection signal to noise ratio(SNR:approximately 9.5),permitting early diagnosis of lung micro-metastasis(∼1 mm),precise identifying of tumor boundaries and micro-tumors in orthotopic tumor *** importantly,bsProbe was demonstrated to distinguish malignant from benign specimen with a specificity of 90.48%and sensitivity of 92.22%in 195 clinical specimens of bladder cancer *** together,this novel synergetic targeting(CD206×CXCR4)strategy provides an attractive method for earlier detection of bladder cancer and metastasis,which might be further extended to the imaging-guided surgery of clinical invisible tumors.

关键词： Self-assembly Peptide Nanomaterial Fluorescence imaging Bladder cancer

Denosumab combined with immunotherapy,radiotherapy,and granulocyte-macrophage colony-stimulating factor for the treatment of metastatic nasopharyngeal carcinoma:A case report

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World Journal of Clinical Oncology 2025年第2期16卷 130-143页

作者： Wei-Wu Chen Yue-Hong Kong Li-yuan zhang Center for Cancer Diagnosis and Treatment The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina

BACKGROUND Bone is a major site of metastasis in nasopharyngeal carcinoma(NPC).Recently,nuclear factor kappa-beta ligand(RANKL)inhibitors have garnered attention for their ability to inhibit osteoclast formation and bone resorption,as well as their potential to modulate immune functions and thereby enhance the efficacy of programmed cell death protein 1(PD-1)inhibitor *** SUMMARY We present a case of a patient with NPC who developed sternal stalk metastasis and multiple bone metastases with soft tissue invasion following radical chemoradiotherapy and targeted *** to chemotherapy,the patient experienced severe bone marrow suppression and opted out of further chemotherapy ***,the patient received combination therapy,including RANKL inhibitors(denosumab)alongside PD-1,radiotherapy,and granulocyte-macrophage colonystimulating factor(PRaG)therapy(NCT05435768),and achieved 16 months of progression-free survival and more than 35 months of overall survival,without encountering any grade 2 or higher treatment-related adverse *** Denosumab combined with PRaG therapy could be a new therapeutic approach for the second-line treatment in patients with bone metastases.

关键词： Nasopharyngeal carcinoma Bone metastasis Radiotherapy Programmed cell death protein 1 inhibitors Denosumab Case report

Locally Enhanced Flow and Electric Fields Through a Tip Effect for Efficient Flow‑Electrode Capacitive Deionization

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Nano-Micro Letters 2025年第2期17卷 1-17页

作者： Ziquan Wang Xiangfeng Chen yuan zhang Jie Ma Zhiqun Lin Amor Abdelkader Maria‑Magdalena Titirici Libo Deng College of Chemistry and Environmental Engineering Shenzhen UniversityShenzhen 518060People’s Republic of China Research Center for Environmental Functional Materials College of Environmental Science and EngineeringTongji University1239 Siping RoadShanghai 200092People’s Republic of China Department of Chemical and Biomolecular Engineering National University of SingaporeSingapore 117585Singapore Department of Engineering Faculty of Science and TechnologyBournemouth UniversityTalbot CampusFern BarrowPooleEngland BH125BBUK Institut de Chimie de Nice UniversitéCôte d’AzurUMR CNRS 727228 Av.Valrose06108 NiceFrance Department of Chemical Engineering Imperial College LondonSouth Kensington CampusExhibition RdLondon SW72AZUK

Low-electrode capacitive deionization(FCDI)is an emerging desalination technology with great potential for removal and/or recycling ions from a range of ***,it still suffers from inefficient charge transfer and ion transport kinetics due to weak turbulence and low electric intensity in flow electrodes,both restricted by the current ***,a new tip-array current collector(designated as T-CC)was developed to replace the conventional planar current collectors,which intensifies both the charge transfer and ion transport *** effects of tip arrays on flow and electric fields were studied by both computational simulations and electrochemical impedance spectroscopy,which revealed the reduction of ion transport barrier,charge transport barrier and internal *** the voltage increased from 1.0 to 1.5 and 2.0 V,the T-CC-based FCDI system(T-FCDI)exhibited average salt removal rates(ASRR)of 0.18,0.50,and 0.89μmol cm^(-2) min^(-1),respectively,which are 1.82,2.65,and 2.48 folds higher than that of the conventional serpentine current collectors,and 1.48,1.67,and 1.49 folds higher than that of the planar current ***,with the solid content in flow electrodes increased from 1 to 5 wt%,the ASRR for T-FCDI increased from 0.29 to 0.50μmol cm^(-2) min^(-1),which are 1.70 and 1.67 folds higher than that of the planar current ***,a salt removal efficiency of 99.89%was achieved with T-FCDI and the charge efficiency remained above 95%after 24 h of operation,thus showing its superior long-term stability.

关键词： Flow-electrode Capacitive deionization Current collector Tip effect Desalination

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从合邑造像遗存看北朝道教义邑

考古与文物 2025年第1期 101-108页

作者：张媛刘睿中国社会科学院考古研究所四川省文物考古研究院

本文对近几十年来陆续发现、出土于陕西及周边一带的合邑造像遗存进行了系统搜集,共计32件;从中明晰了北朝道教义邑的整体概况,包括时空分布、性质、规模、活动内容、结邑范围等。在此基础上,采取统计分析结合实物例证、整体考察结合个... 详细信息

本文对近几十年来陆续发现、出土于陕西及周边一带的合邑造像遗存进行了系统搜集,共计32件;从中明晰了北朝道教义邑的整体概况,包括时空分布、性质、规模、活动内容、结邑范围等。在此基础上,采取统计分析结合实物例证、整体考察结合个案研究的方法,探讨了影响合邑造像的5个主要因素——神缘、亲缘、地缘及经济、政治关系;认为神缘是结邑的内在基础,亲缘、地缘是结邑的核心纽带,经济、政治关系是其有效补充形式。

关键词：合邑造像道教义邑北朝

第六届全国画学文献学术研讨会暨纪念俞剑华先生诞辰130周年会议综述

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南京艺术学院学报(美术与设计) 2025年第1期 118-120页

作者：张媛张书宁池州学院艺术与教育学院安徽池州247100 南京艺术学院美术与书法学院江苏南京210013

自2017年以来,陕西师范大学美术学院、四川大学艺术学院、河南大学美术学院、四川大学哲学系成功举办了前五届全国画学文献学术研讨会。为纪念南京艺术学院美术史论学科奠基人俞剑华先生诞辰130周年,推动画学文献的发掘与深入研究,促进... 详细信息

自2017年以来,陕西师范大学美术学院、四川大学艺术学院、河南大学美术学院、四川大学哲学系成功举办了前五届全国画学文献学术研讨会。为纪念南京艺术学院美术史论学科奠基人俞剑华先生诞辰130周年,推动画学文献的发掘与深入研究,促进学术交流,继承和弘扬他的学术精神与学术成就,继而推动美术学学科进一步发展,“第六届全国画学文献学术研讨会暨纪念俞剑华先生诞辰130周年”于2024年10月在南京艺术学院举办。

关键词：南京艺术学院俞剑华美术史论画学文献美术学院陕西师范大学河南大学学术成就

中成药治疗慢性阻塞性肺疾病稳定期的网状Meta分析

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中国中药杂志 2025年第1期50卷 248-266页

作者：张媛媛张梦真马千千周继红广州中医药大学广东广州510000 广州中医药大学第七临床医学院广东深圳518000

基于网状Meta分析,比较不同中成药治疗慢性阻塞性肺疾病稳定期的临床疗效及安全性。计算机检索中国知网(CNKI)、万方(Wanfang)、维普(VIP)、中国生物医学文献服务系统(SinoMed)、PubMed、Web of Science、EMbase、Cochrane Library数据... 详细信息

基于网状Meta分析,比较不同中成药治疗慢性阻塞性肺疾病稳定期的临床疗效及安全性。计算机检索中国知网(CNKI)、万方(Wanfang)、维普(VIP)、中国生物医学文献服务系统(SinoMed)、PubMed、Web of Science、EMbase、Cochrane Library数据库收录的中成药治疗慢性阻塞性肺疾病稳定期的随机对照试验(RCT)。检索时间为建库至2024年2月。根据Cochrane偏倚风险评估工具对纳入文献进行质量评价,采用RevMan 5.4、State 16.0软件绘制偏倚风险,并进行网状Meta分析。最终纳入113篇RCTs,总样本量8265例,涉及14种中成药。网状Meta分析显示,(1)改善肺功能第1秒用力呼气量占用力肺活量百分比(FEV1/FVC)方面,累计概率排名曲线下面积(SUCRA)排名前3的干预措施为金水宝胶囊+常规西医、玉屏风散+常规西医、三子止咳胶囊+常规西医;(2)提高临床疗效方面,SUCRA排名前3的干预措施为益肺胶囊+常规西医、玉屏风颗粒+常规西医、补肺活血胶囊+常规西医;(3)改善肺功能第1秒用力呼气量占预计值百分比(FEV1%pred)方面,SUCRA排名前3的干预措施为金水宝胶囊+常规西医、补肺颗粒+常规西医、百令胶囊+常规西医;(4)提高6 min步行试验(6MWT)方面,SUCRA排名前3的干预措施为金水宝胶囊+常规西医、百令胶囊+常规西医、健脾益肺口服液+常规西医;(5)降低慢性阻塞性肺疾病评估测试评分(CAT)方面,SUCRA排名前3的干预措施为补肺颗粒+常规西医、益肺胶囊+常规西医、益肺活血颗粒+常规西医;(6)减少慢性阻塞性肺疾病急性加重期(AECOPD)1年内发作次数方面,SUCRA排名前3的干预措施为玉屏风胶囊+常规西医、玉屏风散+常规西医、健脾益肺口服液+常规西医;(7)安全性方面,28篇报告了不良反应,主要涉及消化系统、循环系统和神经系统。结果表明,不同中成药联合常医西医治疗可有效改善FEV1/FVC、FEV1%pred,提高临床疗效和6MWT,降低CAT,减少AECOPD 1年内发作次数。但由于纳入文献的局限性,缺乏不同干预措施之间的直接比较,结果还需进一步验证。

关键词：中成药慢性阻塞性肺疾病稳定期随机对照试验网状Meta分析

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场域视阈下高校辅导员自我认同的反身性重构

江苏高教 2025年第1期 57-64页

作者：张媛刘爱莲河海大学马克思主义学院南京211100 南京审计大学马克思主义学院南京211815

辅导员群体自我认同度的高低关系高校学生教育管理工作质量的优劣。在场域视阈下,高校是学术场域与行政场域的结合体,兼具学术与行政的双重属性,辅导员在其中难以获取专家角色、享受权力话语和求得生存空间。为此,在对高校辅导员自我认... 详细信息

辅导员群体自我认同度的高低关系高校学生教育管理工作质量的优劣。在场域视阈下,高校是学术场域与行政场域的结合体,兼具学术与行政的双重属性,辅导员在其中难以获取专家角色、享受权力话语和求得生存空间。为此,在对高校辅导员自我认同反身性概念剖析的基础上,结合现代性制度对自我认同的深刻影响,提出在场域交互实践中克服自我认同危机的三条路径,具体包括与环境互动获得本体性安全、与他者互动克服自我无意义感和与制度互动形成自我认同的动力。

关键词：场域辅导员自我认同反身性重构现代性

生物可降解聚乳酸共衣康酸丁二醇酯/纳米二氧化硅包装材料对发酵酸奶贮藏品质及活菌数的影响

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食品与发酵工业 2025年第1期51卷 108-115页

作者：蒋伟陈钟生张元董同力嘎内蒙古农业大学食品科学与工程学院内蒙古呼和浩特010018

探讨不同阻隔性的聚乳酸共衣康酸丁二醇酯/纳米二氧化硅共聚物薄膜[poly(L-lactic-co-butanediol itaconate)nano-silica copolymer films,PLBI-SiO_(2)]包装对发酵酸奶贮藏效果,并对贮藏期间酸奶的理化指标和活菌数进行测定。结果表明:... 详细信息

探讨不同阻隔性的聚乳酸共衣康酸丁二醇酯/纳米二氧化硅共聚物薄膜[poly(L-lactic-co-butanediol itaconate)nano-silica copolymer films,PLBI-SiO_(2)]包装对发酵酸奶贮藏效果,并对贮藏期间酸奶的理化指标和活菌数进行测定。结果表明:在4℃贮藏0~21 d期间,所有包装组的pH都呈现下降趋势,PLBI-SiO_(2)0.5%包装组与对照(市售)组在贮藏后期pH下降得到减缓;在贮藏期间,PLBI-SiO_(2)0.5%包装组与对照(市售)组能有效维持酸奶的质构特性与持水能力,同时也保持良好的感官评价与表观黏度;所有包装组的活菌数在整个贮藏期间都呈现逐渐降低的趋势,但随包装阻隔性的提高,下降幅度得到减缓,PLBI-SiO_(2)0.5%包装组与对照组在贮藏21 d时,保加利亚乳杆菌与嗜热链球菌都保持在10~7 CFU/mL以上。综合各项指标,PLBI-SiO_(2)0.5%包装组在贮藏21 d可以维持酸奶贮藏品质并几近于市售包装组,这为酸奶及其他发酵乳替代包装材料提供了一定的理论基础。

关键词：酸奶贮藏纳米二氧化硅聚乳酸共衣康酸丁二醇酯纳米二氧化硅共聚物阻隔性