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Study on the Effect of Ginaton on Reducing Cerebral Vasospasm and Early Brain Injury after Hemorrhagic Stroke by Inhibiting Inflammatory Response

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World Journal of Traditional Chinese Medicine 2024年第1期10卷 33-39页

作者： Xue-Bo Pang Xiao-Lin Zhang Mei-Rong Wang ying yuan Xiao Zhang Department of Neurology Xingtai Third HospitalXingtaiChina

Objective:The objective of this study was to investigate the effects and possible mechanisms of action of ginseng on cerebral vasospasm and early brain injury(EBI)following hemorrhagic *** and Methods:Sprague-Dawley(SD)rats(n=48)were randomly divided into sham operation(sham group),subarachnoid hemorrhage(SAH)model(SAH group),normal saline(NS group),and Ginaton(Extract of Ginkgo Biloba Leaves Drops)intervention(gin group)***-1 m RNA and tumor necrosis factor levels were detected using reverse transcription-polymerase chain *** relative expression of m RNA was detected by Western ***:(1)Compared with the sham group,the SAH,NS,and gin groups had different degrees of neurological *** with the SAH and NS groups,the neurological deficits in the gin group were significantly improved(P<0.05).(2)Compared with the sham group,the relative expression levels of MCP-1 m RNA in the SAH,NS,and gin groups were 5.1±0.9,3.4±0.6,and 2.5±0.4,respectively;the relative expression levels of m RNA were 13.3±2.4,11.2±1.8,and 3.8±0.6,respectively.(3)The apoptosis rates of brain tissue in the sham,SAH,NS,and gin groups were 4.8±0.7,54.2±10.3,50.1±7.4,and 28.4±4.5,respectively.(4)Western blot showed that the relative expression levels of toll-like receptor-4(TLR-4)protein in the sham,SAH,NS,and gin groups were 0.29±0.03,0.87±0.15,0.65±0.13,and 0.41±0.17,respectively;the relative expression levels of B protein were 0.21±0.04,0.96±0.14,0.73±0.18,and 0.30±0.05,*** treatment could inhibit TLR-4 and nuclear factor-κB(NF-κB)protein ***:Dona tablets may inhibit activation of the NF-κB signaling pathway,and SAH-induced inflammatory response,so as to reduce cerebral vasospasm and EBI.

关键词： Cerebral hemorrhage early brain injury ginaton neurological deficit nuclear factor-κB

Rare giant intradural epidural hemolymphangioma:A case report

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World Journal of Clinical Cases 2024年第25期12卷 5798-5804页

作者： Shou-Feng Sun Xue-Hua Wang ying-ying yuan yuan-Dong Shao Department of Spine Surgery Binzhou People’s HospitalBinzhou 256600Shandong ProvinceChina Department of Infectious Disease Binzhou People’s HospitalBinzhou 256600Shandong ProvinceChina

BACKGROUND Hemolymphangioma is a rare,noninvasive benign tumor that originates from vascular and lymphatic *** is usually congenital and can present with varying symptoms depending on its location and *** are very few reports of hemolymphangiomas within the spinal canal,and giant lesions are exceptionally *** SUMMARY In July 2023,a 64-year-old male with a giant intravertebral epidural hemolymphangioma from thoracic 11 to lumbar 2(T11-L2)was admitted to the Department of Spine Surgery at the People's Hospital of Binzhou City,*** patient experienced progressive lumbar and left lower limb pain,numbness,weakness in both lower limbs,and difficulty with urination and *** studies revealed a large cystic mass in the spinal canal at *** decompression was performed,and the pathology confirmed *** Complete resection of hemolymphangiomas has the best prognosis,and final diagnosis relies on pathologic *** this case,the mass was removed intact with a pedicle nail rod system,leading to adequate spinal decompression and restoration of spinal stability.

关键词： Hemolymphangioma Intradural epidural tumor Surgical treatment Vascular anomalies Vascular malformations Case report

Microstructure and properties of LZQT600-3 HCCDIBs for plunger pump cylinder

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China Foundry 2024年第2期21卷 197-204页

作者： Chun-jie Xu yuan-ying Jin Dong Ma Zhen Zhao Jia-wei Qi Shang Sui Xiang-quan Wu Can Guo Zhong-ming Zhang Yong-hui Liu Dan Shechtman School of Materials Science and Engineering Xi'an University of TechnologyXi'an 710048China Xi'an Shechtman Nobel Prize New Materials Institute Xi'an 710048China Tongchuan Huazhu Precision Technology Co. Ltd.Tongchuan 727100ShaanxiChina Faculty of Materials Science and Engineering Technion-Israel Insititue of TechnologyHaifa 3200003Israel

It is important to improve the comprehensive performance of the ductile iron bars(DIBs)for the cylinder block of the extra high pressure hydraulic plunger pump and accelerate the industrial *** this work,the LZQT600-3 DIBs with the diameter of 145 mm were prepared by the horizontal continuous casting(HCC)process,that is,LZQT600-3 *** microstructure and room temperature tensile properties of different sections[left-edge(surface layer),left-1/2R(left half of the radius),and the center of the HCCDIBs]were *** results show that the spheroidization of LZQT600-3 HCCDIBs matrix from the left-edge,left-1/2R to the center is at nodulizing grade II and *** the cooling rate gradually decreases from surface to the center of the HCCIBs,the number of spheroidized graphite is gradually reduced,the size is gradually increased,the shape factor is decreased,and the pearlite content and lamellate spacing are *** the horizontal direction of the section,the hardness of the material is distributed symmetrically around the center of the *** the vertical direction,the hardness distribution in the center of the HCCDIBs is asymmetrical due to the gravity during the solidification ***,the microstructure in the lower part of the section solidifies relatively *** left-edge has the best tensile mechanical properties,and the ultimate tensile strength,yield tensile strength and elongation are 597.3 MPa,418.5 MPa and 9.6%,*** tensile fracture belongs to the ductile-brittle hybrid *** comprehensive performances of LZQT600-3 HCCDIBs meet the actual application requirements of ultra-high pressure hydraulic plunger pump cylinder.

关键词： horizontal continuous casting(HCC) nodular cast iron ductile iron bars microstructure mechanical properties

Tislelizumab in previously treated,locally advanced unresectable/metastatic microsatellite instability-high/mismatch repair-deficient solid tumors

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Chinese Journal of Cancer Research 2024年第3期36卷 257-269页

作者： Jian Li Ye Xu Aimin Zang Yunong Gao Quanli Gao Yanqiao Zhang Dong Wang Jianming Xu ying yuan Haiping Jiang Jieer ying Chunmei Shi Yanhong Deng Jing Wang Tianshu Liu Yi Huang Xiaoping Qian Yueyin Pan ying Cheng Sheng Hu Jin Wang Mengyue Shi Ke Wang Han Hu Lin Shen State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers Beijing Key Laboratory of Carcinogenesis and Translational ResearchDepartment of Gastrointestinal OncologyPeking University Cancer Hospital&InstituteBeijing 100142China Department of Oncology Fudan University Shanghai Cancer CenterShanghai 200032China Department of Medical Oncology Affiliated Hospital of Hebei UniversityBaoding 071000China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of GynecologyPeking University Cancer Hospital&InstituteBeijing 100142China Department of Immunotherapy Henan Cancer HospitalZhengzhou 450001China Department of Gastrointestinal Oncology Affiliated Cancer Hospital of Harbin Medical UniversityHarbin 150086China Department of Gastrointestinal Oncology Chongqing University Cancer HospitalChongqing 400030China Department of Gastrointestinal Oncology the Fifth Medical CenterChinese PLA General HospitalBeijing 100048China Department of Medical Oncology the Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China Department of Medical Oncology the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Medical Oncology Cancer Hospital of the University of Chinese Academy of SciencesHangzhou 310022China Department of Medical Oncology Fujian Medical University Union HospitalFuzhou 350001China Department of Oncology the Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510655China Department of Medical Oncology Hunan Cancer HospitalChangsha 410013China Department of Medical Oncology Zhongshan HospitalFudan UniversityShanghai 200032China Department of Immunotherapy Hubei Cancer HospitalWuhan 430079China Department of Medical Oncology the Affiliated Hospital of Nanjing University Medical SchoolNanjing 210008China Department of Medical Oncology Anhui Provincial HospitalHefei 230001China Department of Medical Oncology Jilin Cancer Hospital

Objective:The open-label,phase II RATIONALE-209 study evaluated tislelizumab(anti-programmed cell death protein 1 antibody)as a tissue-agnostic monotherapy for microsatellite instability-high(MSI-H)/mismatch repair-deficient(dMMR)***:Adults with previously treated,locally advanced unresectable or metastatic MSI-H/dMMR solid tumors were *** received tislelizumab 200 mg intravenously every 3 *** response rate(ORR;primary endpoint),duration of response(DoR),and progression-free survival(PFS)were assessed by independent review committee(Response Evaluation Criteria in Solid Tumors v1.1).Results:Eighty patients were enrolled and treated;75(93.8%)patients had measurable disease at *** had metastatic disease and received at least one prior therapy for advanced/metastatic disease(n=79;98.8%).At primary analysis(data cutoff July 8,2021;median follow-up 15.2 months),overall ORR[46.7%;95%confidence interval(95%CI),35.1−58.6;one-sided P<0.0001]and ORR across tumor-specific subgroups[colorectal(n=46):39.1%(95%CI,25.1–54.6);gastric/gastroesophageal junction(n=9):55.6%(95%CI,21.2−86.3);others(n=20):60.0%(95%CI,36.1−80.9)]were significantly greater with tislelizumab vs.a prespecified historical control ORR of 10%;five(6.7%)patients had complete *** DoR,PFS,and overall survival were not reached with long-term follow-up(data cutoff December 5,2022;median follow-up 28.9 months).Tislelizumab was well tolerated with no unexpected safety ***-related adverse events(TRAEs)of grade≥3 occurred in 53.8%of patients;7.5%of patients discontinued treatment due to ***:Tislelizumab demonstrated a significant ORR improvement in patients with previously treated,locally advanced unresectable or metastatic MSI-H/dMMR tumors and was generally well tolerated.

关键词： Biomarkers DNA mismatch repair immune checkpoint inhibitors microsatellite instability phase II clinical trials programmed cell death 1 receptor

Shexiang Tongxin Dropping Pill Promotes Angiogenesis through VEGF/eNOS Signaling Pathway on Diabetic Coronary Microcirculation Dysfunction

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Chinese Journal of Integrative Medicine 2024年第10期30卷 886-895页

作者： CUI Xin-yu LIU Tian-hua BAI Ya-li ZHANG Meng-di LI Guo-dong ZHANG Yu-ting yuan Yue-ying ZHANG Ya-wen YU Li-shuang HAN Li-na WU Yan School of Traditional Chinese Medicine Beijing University of Chinese Medicine Key Laboratory of Traditional Chinese Medicine Syndrome and Formula Ministry of Education Beijing University of Chinese Medicine Beijing Research Institute of Chinese Medicine Beijing University of Chinese Medicine

Objective: To study the effect of Shexiang Tongxin Dropping Pill(STDP) on angiogenesis in diabetic cardiomyopathy mice with coronary microcirculation dysfunction(CMD). Methods: According to a random number table, 6 of 36 SPF male C57BL/6 mice were randomly selected as the control group, and the remaining 30 mice were injected with streptozotocin intraperitoneally to replicate the type 1 diabetes model. Mice successfully copied the diabetes model were randomly divided into the model group, STDP low-dose group [15 mg/(kg·d)], medium-dose group [30 mg/(kg·d)], high-dose group [60 mg/(kg·d)], and nicorandil group [15 mg/(kg·d)], 6 in each group. The drug was given by continuous gavage for 12 weeks. The cardiac function of mice in each group was detected at the end of the experiment, and coronary flow reserve(CFR) was detected by chest Doppler technique. Pathological changes of myocardium were observed by hematoxylin-eosin staining, collagen fiber deposition was detected by masson staining, the number of myocardial capillaries was detected by platelet endothelial cell adhesion molecule-1 staining, and the degree of myocardial hypertrophy was detected by wheat germ agglutinin staining. The expression of the vascular endothlial growth factor(VEGF)/endothelial nitric oxide synthase(eNOS) signaling pathway-related proteins in myocardial tissue was detected by Western blot. Results: Compared with the model group, medium-and high-dose STDP significantly increased the left ventricular ejection fraction and left ventricular fraction shortening(P<0.01), obviously repaired the disordered cardiac muscle structure, reduced myocardial fibrosis, reduced myocardial cell area, increased capillary density, and increased CFR level(all P<0.01). Western blot showed that high-dose STDP could significantly increase the expression of VEGF and promote the phosphorylation of vascular endothelial growth factor receptor 2, phosphoinositide 3-kinase, protein kinase B, and eNOS(P<0.05 or P<0.01). Co

关键词： Shexiang Tongxin Dropping Pill angiogenesis coronary microcirculation dysfunction diabetic cardiomyopathy type 1 diabetes

Prophylactic effects of Edible Lilium-Egg yolk compound powder on depression-like behaviors in rats exposed to chronic unpredictable mild stress: A role of gut-brain axis

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Food Science and Human Wellness 2024年

作者： Yu Huang Yu-xin Luo Sai-nan Tian Meng-zhou Xie Liang Li Ming-xing Jiang Zhi-ying yuan Hunan University of Chinese Medicine Key Laboratory of TCM Heart and Lung Syndrome Differentiation & Medicated Diet and Dietotherapy， Hunan University of Chinese Medicine TCM and Ethnomedicine Innovation & Development International Laboratory， School of Pharmacy， Hunan University of Chinese Medicine

The incidence rate and harmfulness of depression are increasing yearly， and the research on the antidepressant effect of regulating the intestinal microecology balance has attracted widespread attention. The purpose of this research was to study the preventive effects and the regulatory mechanism of edible Lilium-egg yolk compound powder(Chinese abbreviation， BHT) on gut-brain crosstalk in depressive rats induced by chronic unpredictable mild stress(CUMS) through the "microbiota-gut-brain" axis. Results showed that infusion of BHT for 21 days ameliorated the morphology of the hippocampus and colon， increased the rate of sucrose preference， reduced the immobility time of forced swimming， increased the expression level of anti-inflammatory cytokine Interleukin-10 (IL-10) in serum， up-regulate the expression level of plasma neurotransmitter 5-hydroxy tryptamine (5-HT)， down-regulate the expression of inflammatory factors tumor necrosis factor-α (TNF-α)， interleukin-6 (IL-6)， and interleukin-1β (IL-1β) and neurotransmitter glutamic acid (Glu) in serum， and decrease the expression levels of lipopolysaccharide (LPS)， diamine oxidase (DAO) and lactate dehydrogenase (LD) in plasma. The underlying mechanism may be to reduce the activation of microglia (lower levels of CD11b， IBa1 protein and gene expression)， regulate hippocampal GR/BDNF/NPY signal pathway (higher levels of GR， BDNF， NPY protein and gene expression)， enhance intestinal mucosal barrier function (higher levels of ZO-1， Occludin protein and gene expression)， regulate the composition and structure of intestinal flora(Analysis results of LEfSe combined with random forest showed that Prevotella and Paraprevotella might be biomarkers of BHT intervention in depression)， and it is related to the improvement of glutathione metabolism， and other metabolic pathways. Pearson correlation analysis found that 5-HT is strongly positively correlated with Prevotella，and Glu has a strong negative correlation with ***

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促进绿色生物制造高质量发展,培育新质生产力

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研究与发展管理 2024年第4期36卷 5-7页

作者：元英进天津大学天津300072

1绿色生物制造是新质生产力的重要源泉习近平总书记强调,必须继续做好创新这篇大文章,推动新质生产力加快发展。2024年全国政府工作报告明确提出,要积极打造生物制造等新增长引擎。生物制造是以合成生物学等前沿技术为基础的物质先进生... 详细信息

1绿色生物制造是新质生产力的重要源泉习近平总书记强调,必须继续做好创新这篇大文章,推动新质生产力加快发展。2024年全国政府工作报告明确提出,要积极打造生物制造等新增长引擎。生物制造是以合成生物学等前沿技术为基础的物质先进生产方式,利用微生物、细胞、酶等生命体的代谢机能或催化功能,结合化学工程技术或发酵技术实现目标产品的制造,以其原料的可再生性、生产过程的清洁与高效性的特点脱颖而出。这种新型的生产模式正在逐步减少对化石原料的依赖,特别是在化工、医药、能源和轻工等传统制造业中。展望未来,生物制造有望彻底革新物质加工和生产模式,引领产业走向更加绿色、可持续的发展道路。

关键词：传统制造业先进生产方式生物制造政府工作报告展望未来增长引擎代谢机能合成生物学

马克思早期人的解放思想的两条线索及其理论意义

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湖北大学学报（哲学社会科学版） 2024年第5期51卷 47-54页

作者：韩玲袁颖芳江西师范大学马克思主义学院江西南昌330022

人的解放是贯穿马克思一生理论思考的根本主题,这在马克思早期思想中有着充分的展现。马克思认为政治解放虽然消除了封建等级制度对人的束缚,但没有解决市民社会中人的异化;以黑格尔的自我意识以及青年黑格尔派主要分子鲍威尔和施蒂纳... 详细信息

人的解放是贯穿马克思一生理论思考的根本主题,这在马克思早期思想中有着充分的展现。马克思认为政治解放虽然消除了封建等级制度对人的束缚,但没有解决市民社会中人的异化;以黑格尔的自我意识以及青年黑格尔派主要分子鲍威尔和施蒂纳的“批判意识”解决市民社会矛盾的精神解放,也无法扬弃人的异化。通过对政治解放和唯心主义精神解放的批判,马克思提出无产阶级是人的解放的现实力量,无产阶级的劳动解放是人的解放的内在动力,这构成了马克思早期关于人的解放的两条重要线索,展现出马克思早期阐释人的解放的方向。虽然这一时期马克思关于人的解放的两条线索带有人本主义的色彩,但马克思以此批判地考察了当时流行的各种“虚假”共产主义学说,从而阐发了真正的共产主义内涵,这在科学社会主义发展史上具有重要的理论意义。

关键词：马克思人的解放政治解放精神解放无产阶级劳动解放

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“饰论一体”:西方辞格论辩观源流考

当代修辞学 2024年第5期 19-31页

作者：袁影方忆翎苏州大学外国语学院江苏苏州215006

修辞格的认知功能、解构功能等当代研究令人瞩目,但与之密切相关而渊源更为深厚的论辩功能却尚未引起关注。本文依据大量原始经典对西方辞格论辩观进行系统溯源,从古希腊、古罗马、中世纪、文艺复兴、启蒙各大时期的修辞学要著中,考辨... 详细信息

修辞格的认知功能、解构功能等当代研究令人瞩目,但与之密切相关而渊源更为深厚的论辩功能却尚未引起关注。本文依据大量原始经典对西方辞格论辩观进行系统溯源,从古希腊、古罗马、中世纪、文艺复兴、启蒙各大时期的修辞学要著中,考辨出隐喻、提喻、转喻等转义辞格与反复、对照、修辞问句等非转义辞格的诸多论辩功能:逻辑诉求、人格诉求、情感诉求、在场/凸显、丰裕等。本文着重揭示西方古典时期辞格论辩观中所蕴含的“饰”即“论”或“饰论一体”“饰论不二”的精辟思想。

关键词：修饰论辩辞格论辩功能西方修辞学