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Efficacy of Shenlingbaizhu formula on irritable bowel syndrome:a systematic review

Journal of Traditional Chinese Medicine 2020年第6期40卷 897-907页

作者： wang yuxian Zhang Shengsheng Zhou Qiang Meng Meng Chen Wenwen Beijing Hospital of Traditional Chinese Medicine Capital Medical UniversityBeijing 100010China

OBJECTIVE:To evaluate the effectiveness and safety of a Shenlingbaizhu(SLBZ)formula in the treatment of irritable bowel syndrome(IBS).The effectiveness of SLBZ with or without conventional treatment was compared to that of conventional treatment ***:A comprehensive literature search of four Chinese electronic databases,three English language databases,and two English language trial registries from inception to June 2019 was *** authors independently screened the citations and retrieved full publications of randomized trials on the use of SLBZ with or without conventional treatment for *** methodological quality of the trials was assessed with the Cochrane Collaboration’s tool for assessing the risk of *** were extracted and subjected to Meta-analysis to compare the efficacy of the SLBZ formula with or without conventional treatment to conventional treatment ***:Thirteen trials(comprising a total of 868 patients with IBS)were included in this *** risk of bias of all 13 included trials was assessed as *** SLBZ formula was associated with significant improvements in cure rate[relative risk(RR)score of 2.38,95%confidence interval(CI)1.43 to 3.95,I2=0%;8 trials,n=487,fixed-effects model(FEM)],diarrhea severity score[mean difference(MD)score of-0.62,95%CI-1.05 to-0.20,I2=88%;4 trials,n=286,random effects model(REM)],abdominal pain severity score(MD score of-0.61,95%CI-0.70 to-0.52,I2=63%;4 trials,n=286,FEM),and abdominal distention severity score(MD score of-0.88,95%CI-1.54 to-0.21,I2=91%;3 trials,n=226,REM)compared to the conventional treatment *** events were reported in five trials but only one of these indicated any adverse events associated with ***:Based on the 13 trials reviewed here,the SLBZ formula with or without conventional treatment appeared to be safe and more effective in improving the cure rate and reducing the severity of diarrhea,abdominal pain,and abdominal distention compared

关键词： Irritable bowel syndrome Shenlingbaizhu formula Review

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Multiple satellites observation evidence:High-m Poloidal ULF waves with time-varying polarization states

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Earth and Planetary Physics 2019年第3期3卷 190-203页

作者： Chao Wei Lei Dai SuPing Duan Chi wang yuxian wang State Key Laboratory of Space Weather National Space Science Center Chinese Academy of Sciences College of Earth and Planetary Sciences University of Chinese Academy of Sciences

We report multi-spacecraft observations of ULF waves from Van Allen Probes(RBSP), Magnetospheric Multiscale(MMS), Time History of Events and Macroscale Interactions during Substorm(THEMIS), and Geostationary Operational Environmental Satellites(GOES).On August 31, 2015, global-scale poloidal waves were observed in data from RBSP-B, GOES and THEMIS from L=4 to L=8 over a wide range of magnetic local time(MLT). The polarization states varied towards purely poloidal polarity. In two consecutive orbits over 18 hours, RBSP-A and RBSP-B recorded gradual variation of the polarization states of the poloidal waves; the ratio(|B_a|/|B_r|) decreased from 0.82 to 0.13. After the variation of polarization states, the poloidal ULF waves became very purely poloidal waves, localized in both L and MLT. We identify the poloidal wave as second harmonic mode with a large azimuthal wave number(m) of –232. From RBSP particle measurements we find evidence that the high-m poloidal waves during the polarization variations were powered by inward radial gradients and bump-on-tail ion distributions through the N=1 drift-bounce resonance. Most of the time, the dominant free energy source was inward radial gradients, compared with the positive gradient in the energy distribution of the bump-on-tail ion distributions.

关键词： poloidal waves polarization rotation bump-on-tail inward gradient

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Electron transfer to direct oxidation of aqueous organics by perovskites

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Nano Research 2023年第5期16卷 6316-6325页

作者： Tao Kong yuxian wang Shenning Liu Ya Liu Menghan Zhou Bofeng Li Xiaoguang Duan Chunmao Chen Shaobin wang State Key Laboratory of Heavy Oil Processing State Key Laboratory of Petroleum Pollution ControlChina University of Petroleum(Beijing)Beijing 102249China School of Chemical Engineering and Advanced Materials The University of AdelaideAdelaideSA 5005Australia

The residual of oxidant chemicals in advanced oxidation processes(AOPs)resulted in both economic cost and secondary ***,we report a direct oxidation of phenolic pollutants induced by Ca-Mn-O perovskites without using an *** by one-electron transfer process(ETP)from the phenolics to the Ca-Mn-O perovskites,this direct oxidation proceeds in fast reaction kinetics with activation energy of 51.4 kJ/mol,which was comparable with those AOPs-based catalytic ***,mineralization and polymerization reactions occurred on the Ca-Mn-O surface and ensured the complete removal of *** high spin state Mn(III)within Ca-Mn-O structure was the dominant active site for this *** elongated axial Mn(III)–O bonds within the[MnO_(6)]octahedron facilitated the acceptance of the electrons from the phenolics and thus promoted the initiation of the direct oxidation ***(III)in the high spin state can also activate dissolved O_(2)to produce singlet oxygen(^(1)O_(2))for a fast removal of *** mixed Mn(III)/Mn(IV)within Ca-Mn-O accelerated the ETP by enhancing the electrical *** efficient Ca-Mn-O-induced ETP for removal of organic contaminants casts off the dependence on external chemical and energy inputs and provides a sustainable approach for transforming the toxic organic pollutants into value-added polymers.

关键词： Ca-Mn-O perovskites surface direct oxidation electron transfer process spin state regulation

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In-situ synthesis of N, S co-doped hollow carbon microspheres for efficient catalytic oxidation of organic contaminants

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Chinese Chemical Letters 2022年第3期33卷 1298-1302页

作者： Yongbing Xie Ya Liu Yujie Yao Yanchun Shi Binran Zhao yuxian wang State Key Laboratory of Vanadium and Titanium Resources Comprehensive Utilization Panzhihua 617000China CAS Key Laboratory of Green Process&Engineering Beijing Engineering Research Center of Process Pollution ControlInstitute of Process EngineeringChinese Academy of SciencesBeijing 100190China State Key Laboratory of Heavy Oil Processing State Key Laboratory of Petroleum Pollution ControlChina University of Petroleum-BeijingBeijing 102249China School of Chemical Engineering and Advanced Materials The University of AdelaideAdelaideSA 5005Australia School of Chemical Engineering Northwest UniversityXi'an 710069China

Metal-free heteroatom doped nanocarbons are promising alternatives to the metal-based materials in catalytic ozonation for destruction of aqueous organic contaminants. In this study, N, S co-doped hollow carbon microspheres (NSCs) were synthesized from the polymerization products during persulfate wet air oxidation of benzothiazole. The contents of doped N and S as well as the structural stability were maneuvered by adjusting the subsequent N_(2)-annealing temperature. Compared with the prevailing single-walled carbon nanotubes, the N_(2)-annealed NSCs demonstrated a higher catalytic ozonation activity for benzimidazole degradation. According to the quantitative structure-activity relationship (QSAR) analysis, the synergistic effect between the graphitic N and the thiophene-S which redistributed the charge distribution of the carbon basal plane contributed to the activity enhancement of the N_(2)-annealed NSCs. Additionally, the hollow structure within the microspheres served as the microreactor to boost the mass transfer and reaction kinetics via the nanoconfinement effects. Quenching and electron paramagnetic resonance (EPR) tests revealed that benzimidazole degradation was dominated by the produced singlet oxygen (^(1)O_(2)) species, while hydroxyl radicals (^(·)OH) were also generated and participated. This study puts forward a novel strategy for synthesis of heteroatom-doped nanocarbons and sheds a light on the relationship between the active sites on the doped nanocarbons and the catalytic performance.

关键词： Metal-free catalysis Hollow carbon microspheres N,S co-doping Catalytic ozonation Singlet oxygen(1O_(2))

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Modeling the Jovian magnetosphere under an antiparallel interplanetary magnetic field from a global MHD simulation

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Earth and Planetary Physics 2018年第4期2卷 303-309页

作者： yuxian wang XiaoCheng Guo BinBin Tang WenYa Li Chi wang State Key Laboratory of Space Weather National Space Science Center Chinese Academy of Sciences College of Earth and Planetary Sciences University of Chinese Academy of Sciences

We present preliminary results of a new global Magnetohydrodynamics(MHD) simulation model of the Jovian *** model incorporates mass loading from Jupiter's satellite Io, the planet's fast corotation, and electrostatic coupling between its magnetosphere and ionosphere(M-I coupling). The basic configuration of the Jovian magnetosphere including the equatorial plasma flow pattern, the corotation enforcement current system, and the field aligned currents(FACs) in the ionosphere are presented under an antiparallel interplanetary magnetic field(IMF) condition. The simulation model results for equatorial density and pressure profiles are consistent with results from data-based empirical models. It is also found that there are similarities between the FACs distribution in the ionosphere and the observed aurora features, showing the potential application of the simple ionospheric model to the complicated M-I coupling. This model will help deepen our understanding of the global dynamics of the Jovian magnetosphere.

关键词： Jupiter magnetosphere magnetohydrodynamic(MHD)simulation

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DeepRisk:A deep learning approach for genome-wide assessment of common disease risk

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Fundamental Research 2024年第4期4卷 752-760页

作者： Jiajie Peng Zhijie Bao Jingyi Lia Ruijiang Han yuxian wang Lu Han Jinghao Peng Tao wang Jianye Hao Zhongyu Wei Xuequn Shang AI for Science Interdisciplinary Research Center Schoolof Computer ScienceNorthwestern Polyechnical UniversityXi'an 129China Key Laboratoryof Bg Data Sorage and Management Northwestern Polytechnical UniversityMinisty of Industy and Information TechnologyX'an 129Chin College of Intelligence and Computing Tianjin UniversityTianjin 300072China School of Data Science Fudan UniversityShanghai 200433China Research and Development Institute of Northwestern Polytechnical University in Shenzhen Shenzhen 518000China

The potential for being able to identify individuals at high disease risk solely based on genotype data has garnered significant *** widely applied,traditional polygenic risk scoring methods fall short,as they are built on additive models that fail to capture the intricate associations among single nucleotide polymorphisms(SNPs).This presents a limitation,as genetic diseases often arise from complex interactions between multiple *** address this challenge,we developed DeepRisk,a biological knowledge-driven deep learning method for modeling these complex,nonlinear associations among SNPs,to provide a more effective method for scoring the risk of common diseases with genome-wide genotype *** demonstrated that DeepRisk outperforms existing PRs-based methods in identifying individuals at high risk for four common diseases:Alzheimer's disease,inflammatory bowel disease,type 2diabetes,and breast cancer.

关键词： Disease risk prediction Deep learning Polygenic risk score Common disease risk Disease prevention

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PREECLAMPSIA AND CALCIUM METABOLISM

PREECLAMPSIA AND CALCIUM METABOLISM

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1st International Conference on Bone and Mineral Research

作者： wang yuxian Guo Shuzhen The First Clinical Hospital of Shanxi Medical University

＜正＞Preeclampsia is a hypertensive disorder unique to pregnacy and is of unknown *** main clinical features of the disorder are maternal hypertension,proteinuria,*** abnormal renal, hepatic and central nervous syste...

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电阻抗断层成像技术监测肺血流的临床应用

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中华医学杂志 2022年第36期102卷 2828-2833页

作者：王禹娴钟鸣复旦大学附属中山医院重症医学科上海200032

作为一种非有创、无辐射的床旁成像手段,目前电阻抗断层成像技术(EIT)可对患者进行实时的肺通气评估和肺血流监测,从而实现床旁通气血流比的可视化,有效指导低氧血症的病理生理机制研判,同时也为肺血流生理学的研究提供新方法。在新型... 详细信息

作为一种非有创、无辐射的床旁成像手段,目前电阻抗断层成像技术(EIT)可对患者进行实时的肺通气评估和肺血流监测,从而实现床旁通气血流比的可视化,有效指导低氧血症的病理生理机制研判,同时也为肺血流生理学的研究提供新方法。在新型冠状病毒肺炎的研究及治疗中EIT也发挥了其独特、不可替代的作用。同时作为功能性成像,该技术的操作细节和图像重建算法仍需要更多的研究去进一步优化,在临床应用中提供更稳健的评估。本文从EIT肺血流监测的方法介绍、操作实施与监测指标、应用及相关研究进展三个方面进行了阐述。

关键词：通气与血流灌注比值肺血流电阻抗断层成像技术高渗盐水造影

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葡萄牙社会党的理论发展与执政实践

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当代世界 2022年第8期 56-60页

作者：王禹宪中共中央对外联络部八局

葡萄牙社会党(以下简称社会党)创建于1875年,是欧洲历史最悠久的政党之一。1926年葡萄牙法西斯独裁政权上台后,该党被当局宣布为非法组织并暴力镇压,大批社会党人流亡海外坚持斗争,直至苏亚雷斯1973年重建社会党。1974年葡萄牙“四·二... 详细信息

葡萄牙社会党(以下简称社会党)创建于1875年,是欧洲历史最悠久的政党之一。1926年葡萄牙法西斯独裁政权上台后,该党被当局宣布为非法组织并暴力镇压,大批社会党人流亡海外坚持斗争,直至苏亚雷斯1973年重建社会党。1974年葡萄牙“四·二五”民主革命后,社会党恢复合法地位,并成为政坛举足轻重的政党,曾多次单独或联合执政。该党奉行民主社会主义价值观,宣称是“代表不同阶级、群众性、民主的政党”,主张探索适合葡萄牙国情的社会主义道路,对内主张建立公有制、私有制和合作制等经济形式共存的混合经济制度,对外则主张建立以和平、安全、民主和尊重人权为基础的国际秩序。自重建以来,社会党近50年的历史大致可根据其执政周期和代表人物划分为四个重要阶段,分别是苏亚雷斯时期(1973—1985年)、古特雷斯时期(1992—2001年)、索克拉特斯时期(2004—2011年)和科斯塔时期(2014年至今)。

关键词：葡萄牙社会党联合执政社会主义价值观流亡海外苏亚雷斯合作制特雷斯科斯塔

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葡萄牙共产党的发展历程、经验与挑战

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当代世界 2024年第4期 70-75页

作者：王禹宪中共中央对外联络部八局

葡萄牙共产党是目前西欧地区党员人数最多的共产党。作为一个拥有百年历史的老党,葡共经历过法西斯政权围剿的至暗时刻,也享有推翻独裁统治入阁参政的高光场面。在库尼亚尔、卡瓦略斯、德索萨、雷蒙多等几代领导人的带领下,葡共始终坚... 详细信息

葡萄牙共产党是目前西欧地区党员人数最多的共产党。作为一个拥有百年历史的老党,葡共经历过法西斯政权围剿的至暗时刻,也享有推翻独裁统治入阁参政的高光场面。在库尼亚尔、卡瓦略斯、德索萨、雷蒙多等几代领导人的带领下,葡共始终坚持共产主义理想信念、重视理论创新,不断加强党的组织建设、作风建设,努力扩大社会影响。在欧洲政治环境变迁和葡萄牙国内经济社会结构变化之下,葡共面临阶级基础有所削弱、理论创新遭遇瓶颈、政策主张吸引力下降、政治生存空间受到挤压、左翼力量协调欠佳等多重挑战,亟须采取创新性举措加以应对和化解。

关键词：葡萄牙共产党左翼政党理论创新实践探索

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