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International Journal of Biomathematics 2020年第3期13卷 37-54页

作者： Qiu lu Min Xiao Zunshui Cheng yurong Song Chengdai Huang Jinde Cao College of Automation Nanjing University of Posts and Telecommunications Nanjing 210003 China School of Mathematics and Physics Qingdao University of Science and Technology Qingdao 266061 China School of Mathematics and Statistics Xinyang Normal University Xinyang 464000China School of Mathematics Southeast University Nanjing 210096China

In this paper,we propose a novel fractional-order proportional-derivative(PD)strategy to achieve the control of bifurcation of a fractional-order gene regulatory model with *** stability theory of fractional differential equations proved that with delays,some explicit conditions for the local asymptotical stability and Hopf bifurcation are given for the controlled fractional-order genetic *** is demonstrated that the fractional-order gene regulatory model becomes controllable by adjusting the control gain *** addition,the effect of fractional-order parameter on the dynamical behaviors is ***,numerical simulations are carried out to testify the validity of the main results and the availability of the fractional-order PD controller.

关键词： Hopf bifurcation fractional-order single-genetic regulatory network fractional-order PD controller time delay

油菜根际内生真菌PI-020的分离鉴定和定殖促生作用

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扬州大学学报（农业与生命科学版） 2022年第5期43卷 129-135页

作者：徐彬刘琴李传明刘雪梅韩光杰夏杨黄立鑫陆玉荣祁建杭徐健江苏里下河地区农业科学研究所/国家农业微生物扬州观测实验站江苏扬州225007 扬州绿源生物化工有限公司江苏扬州225008

为挖掘农业微生物资源,分离筛选具有促进植物生长作用的内生菌,采用选择性培养基,通过组织分离法自油菜根系皮层组织分离共生真菌,再以无菌油菜苗根际定殖筛选、纯化,获得油菜根际内生真菌PI-020。通过培养形态学观察和转录延伸因子Tef-... 详细信息

为挖掘农业微生物资源,分离筛选具有促进植物生长作用的内生菌,采用选择性培养基,通过组织分离法自油菜根系皮层组织分离共生真菌,再以无菌油菜苗根际定殖筛选、纯化,获得油菜根际内生真菌PI-020。通过培养形态学观察和转录延伸因子Tef-1α基因序列分析,明确PI-020为梨形孢属(Piriformospora)真菌,与已鉴定种印度梨形孢(***)同源性达98.87%。分离菌株PI-020能在油菜、辣椒、西瓜、水稻等不同植物幼苗皮层细胞定殖,根际皮层附有典型的梨形厚垣孢子,用特异引物进行PCR扩增,获得梨形孢属特有的84 bp基因片段。PI-020在油菜苗根际定殖可显著促进油菜苗生长,表现出油菜株高增加,根系增长,叶面积增大,叶绿素含量显著提高。800、400倍不同浓度PI-020培养液处理15 d后,油菜苗生长量较对照分别提高70.1%和92.7%。这一研究表明分离的梨形孢PI-020是一株对油菜具有定殖促生功能的内生真菌。

关键词：油菜内生真菌印度梨形孢分离鉴定定殖

Physiological and Biochemical Characteristics and Response Patterns of Salinity Stress Responsive Genes (SSRGs) in Wild Quinoa (Chenopodium quinoa L.)

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Phyton-International Journal of Experimental Botany 2023年第2期92卷 399-410页

作者： yurong Jiang Muhammad Yasir Yuefen Cao Lejia Hu Tongli Yan Shuijin Zhu Guoquan lu The Key Laboratory for Quality Improvement of Agricultural Products of Zhejiang Province College of Advanced Agricultural SciencesZhejiang A&F UniversityHangzhou311300China College of Agriculture and Biotechnology Zhejiang UniversityHangzhou310058China

Cultivating salt-tolerant crops is a feasible way to effectively utilize saline-alkali land and solve the problem of underutilization of saline ***,a protein-comprehensive cereal in the plant kingdom,is an exceptional crop in terms of salt stress tolerance *** seems an excellent model for the exploration of salt-tolerance mechanisms and cultivation of salt-tolerant *** this study,the seeds and seedlings of the quinoa cultivar Shelly were treated with different concentrations of NaCl *** physiological,biochemical characteristics and agronomic traits were investigated,and the response patterns of three salt stress-responsive genes(SSRGs)in quinoa were determined by real-time *** optimum level of stress tolerance of quinoa cultivar Shelly was found in the range of 250–350 mM concentration of *** stress significantly induced expression of superoxide dismutase(SOD),peroxidase(POD),and particularly betaine aldehyde dehydrogenase(BADH).BADH was discovered to be more sensitive to salt stress and played an important role in the salt stress tolerance of quinoa seedlings,particularly at high NaCl concentrations,as it displayed upregulation until 24 h under 100 mM salt ***,it showed upregulation until 12 h under 250 mM salt *** together,these results suggest that BADH played an essential role in the salt-tolerance mechanism of *** on the expression level and prompt response induced by NaCl,we suggest that the BADH can be considered as a molecular marker for screening salt-tolerant quinoa germplasm at the early stages of crop *** treatment at different plant ontogeny or at different concentrations had a significant impact on quinoa ***,an appropriate treatment approach needs to be chosen rationally in the process of screening salt-tolerant quinoa germplasm,which is useful to the utilization of saline *** study provides a fundamental information to deepen knowledge of the s

关键词： Salt tolerant NaCl stress stress-responsive genes

Speeding up the prediction of C-O cleavage through bond valence and charge on iron carbides

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International Journal of Minerals,Metallurgy and Materials 2023年第10期30卷 2014-2024页

作者： yurong He Kuan lu Jinjia Liu Xinhua Gao Xiaotong Liu Yongwang Li Chunfang Huo James P.Lewis Xiaodong Wen Ning Li Beijing Advanced Innovation Center for Materials Genome Engineering Beijing Information Science&Technology UniversityBeijing 101400China State Key Laboratory of High-efficiency Utilization of Coal and Green Chemical Engineering College of Chemistry and Chemical EngineeringNingxia UniversityYinchuan 750021China State Key Laboratory of Coal Conversion Institute of Coal ChemistryChinese Academy of SciencesTaiyuan 030001China National Energy Center for Coal to Liquids Synfuels China Co.Ltd.Beijing 101400China Hong Kong Quantum AI Laboratory Ltd.University of Hong KongHong Kong 999077China

The activation of CO on iron-based materials is a key elementary reaction for many chemical *** investigate CO adsorption and dissociation on a series of Fe,Fe_(3)C,Fe_(5)C_(2),and Fe_(2)C catalysts through density functional theory *** detect dramatically different performances for CO adsorption and activation on diverse surfaces and *** activation of CO is dependent on the local coordination of the molecule to the surface and on the bulk phase of the underlying *** bulk properties and the different local bonding environments lead to varying interactions between the adsorbed CO and the surface and thus yielding different activation levels of the C-O *** also examine the prediction of CO adsorption on different types of Fe-based catalysts by machine learning through linear regression *** combine the features originating from surfaces and bulk phases to enhance the prediction of the activation energies and perform eight different linear regressions utilizing the feature engineering of polynomial *** them,a ridge linear regression model with2nd-degree polynomial feature generation predicted the best CO activation energy with a mean absolute error of 0.269 eV.

关键词： adsorption CO activation iron carbides density functional theory

Self‑Assembly of Binderless MXene Aerogel for Multiple‑Scenario and Responsive Phase Change Composites with Ultrahigh Thermal Energy Storage Density and Exceptional Electromagnetic Interference Shielding

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Nano-Micro Letters 2024年第3期16卷 367-382页

作者： Chuanbiao Zhu yurong Hao Hao Wu Mengni Chen Bingqing Quan Shuang Liu Xinpeng Hu Shilong Liu Qinghong Ji Xiang lu Jinping Qu Key Laboratory of Material Chemistry for Energy Conversion and Storage of Ministry of Education School of Chemistry and Chemical EngineeringHuazhong University of Science and TechnologyWuhan 430074People’s Republic of China Qingdao Mental Health Center Qingdao 266034People’s Republic of China Hubei Engineering Research Center for Biomaterials and Medical Protective Materials Huazhong University of Science and TechnologyWuhan 430074People’s Republic of China Hubei Key Laboratory of Material Chemistry and Service Failure School of Chemistry and Chemical EngineeringHuazhong University of Science and TechnologyWuhan 430074People’s Republic of China National Engineering Research Center of Novel Equipment for Polymer Processing Key Laboratory of Polymer Processing Engineering(South China University of Technology)Ministry of EducationGuangdong Provincial Key Laboratory of Technique and Equipment for Macromolecular Advanced ManufacturingSchool of Mechanical and Automotive EngineeringSouth China University of TechnologyGuangzhou 510641People’s Republic of China

The severe dependence of traditional phase change materials(PCMs)on the temperature-response and lattice deficiencies in versatility cannot satisfy demand for using such materials in complex application ***,we introduced metal ions to induce the self-assembly of MXene nanosheets and achieve their ordered arrangement by combining suction filtration and rapid ***,a series of MXene/K^(+)/paraffin wax(PW)phase change composites(PCCs)were obtained via vacuum impregnation in molten *** prepared MXene-based PCCs showed versatile applications from macroscale technologies,successfully transforming solar,electric,and magnetic energy into thermal energy stored as latent heat in the ***,due to the absence of binder in the MXene-based aerogel,MK3@PW exhibits a prime solar-thermal conversion efficiency(98.4%).Notably,MK3@PW can further convert the collected heat energy into electric energy through thermoelectric equipment and realize favorable solar-thermal-electric conversion(producing 206 mV of voltage with light radiation intensity of 200 mw cm^(−2)).An excellent Joule heat performance(reaching 105℃with an input voltage of 2.5 V)and responsive magnetic-thermal conversion behavior(a charging time of 11.8 s can achieve a thermal insulation effect of 285 s)for contactless thermotherapy were also demonstrated by the MK3@***,as a result of the ordered arrangement of MXene nanosheet self-assembly induced by potassium ions,MK3@PW PCC exhibits a higher electromagnetic shielding efficiency value(57.7 dB)than pure MXene aerogel/PW PCC(29.8 dB)with the same MXene *** work presents an opportunity for the multi-scene response and practical application of PCMs that satisfy demand of next-generation multifunctional PCCs.

关键词： Self-assembly Multiple-scenario Phase change composites Thermal energy storage Electromagnetic interference shielding

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45%戊唑·咪鲜胺WP防治小麦赤霉病试验

天津农业科学 2018年第9期24卷 70-72,84页

作者：张春梅邵统响卫甜吕敏刘怀阿陆玉荣刘建凤江苏里下河地区农业科学研究所江苏扬州225007 睢宁县植保站江苏睢宁221200

以45%戊唑·咪鲜胺可湿性粉剂(WP)对小麦赤霉病进行田间防治。结果表明,在江苏睢宁试验点,900 g·hm^(-2)和1 050 g·hm^(-2)的45%戊唑·咪鲜胺WP对小麦赤霉病的防效分别为87.62%和91.36%,显著高于对照组(80%戊唑醇WP 120 g·hm^(-2)和... 详细信息

以45%戊唑·咪鲜胺可湿性粉剂(WP)对小麦赤霉病进行田间防治。结果表明,在江苏睢宁试验点,900 g·hm^(-2)和1 050 g·hm^(-2)的45%戊唑·咪鲜胺WP对小麦赤霉病的防效分别为87.62%和91.36%,显著高于对照组(80%戊唑醇WP 120 g·hm^(-2)和25%咪鲜胺EC 900 mL·hm^(-2));在江苏里下河地区农业科学研究所试验点,900 g·hm^(-2)和1 050 g·hm^(-2)的45%戊唑·咪鲜胺WP施用后14 d对小麦赤霉病的防效分别为87.4%和91.4%,药后26 d分别为77.2%和81.2%,两种剂量处理的防效均显著高于对照药剂(430 g·L^(-1)戊唑醇SC 300 mL·hm^(-2)和50%咪鲜胺WP 600 g·hm^(-2)),但显著低于对照药剂(48%氰烯菌酯·戊唑醇SC 360 m L·hm^(-2))。综上所述,45%戊唑·咪鲜胺WP防治小麦赤霉病具有较好的效果,生产上建议使用剂量为1 050 g·hm^(-2),于小麦杨花期第1次施药,如药后7 d遇阴雨天气,必须进行第2次用药防治。

关键词：戊唑醇咪鲜胺赤霉病防效

The role of aromatic residues in controlling the supramolecular chirality of short amphiphilic peptides

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Nano Research 2023年第10期16卷 12230-12237页

作者： Hao Qi Kai Qi Jie Li Chunyong He Mingrui Liao Xuzhi Hu yurong Zhao Yubin Ke Chunqiu Zhang Jun Zhang Jiqian Wang Jian R.lu Hai Xu Department of Biological and Energy Chemical Engineering China University of Petroleum(East China)Qingdao 266580China College of Life Science Nankai UniversityTianjin 300071China Spallation Neutron Source Science Center Chinese Academy of Sciences(CAS)Dongguan 523803China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Biological Physics Group Department of Physics and AstronomyThe University of ManchesterManchester M139PLUK School of Material Science and Engineering China University of Petroleum(East China)Qingdao 266580China

Although the relationship between molecular and supramolecular chirality remains elusive,the existing results have demonstrated the vital role of hydrophilic motifs in controlling the supramolecular handedness of peptide nanofibrils compared with hydrophobic ***,unlike conventional hydrophobic residues,we speculate that aromatic hydrophobic residues are mostly likely to play a unique role in regulating the supramolecular handedness because theπ–πstacking interactions of their side chains are directional like hydrogen bonding and can direct high levels of self-assembly due to the geometric confining of aromatic *** confirm this hypothesis,we here design a series of amphiphilic short peptides,with their hydrophobic motifs being composed of aromatic *** short lengths not only favor their structural stability,synthesis,and sequence variation but also enable us to readily link their molecular and supramolecular *** the combination of experiments and theoretical simulations,we demonstrate that the peptides containing L-form aromatic residues form left-handed nanofibrils while those containing D-form aromatic residues assemble into right-handed ones,irrespective of the chirality of their C-terminal hydrophilic *** calculations revealed that the stacking of aromatic side chains betweenβ-strands directed the twisting direction of theβ-sheets formed,with L-and D-form phenylalanine side chains stacking in a clockwise and anti-clockwise way,and more ordered and stronger aromatic stacking for homochiral peptides facilitated the formation of nanofibrils with a marked tubular *** study has bridged the knowledge gap in our understanding of how aromatic residues affect the supramolecular chirality of short peptides.

关键词： amphiphilic short peptide molecular chirality supramolecular handedness aromatic residue π–πstacking

Recent advances in the translation of drug metabolism and pharmacokinetics science for drug discovery and development

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Acta Pharmaceutica Sinica B 2022年第6期12卷 2751-2777页

作者： yurong Lai Xiaoyan Chu Li Di Wei Gao Yingying Guo Xingrong Liu Chuang lu Jialin Mao Hong Shen Huaping Tang Cindy Q.Xia Lei Zhang Xinxin Ding Drug Metabolism Gilead Sciences Inc.Foster CityCA 94404USA Department of Pharmacokinetics Pharmacodynamics and Drug MetabolismMerck&Co.Inc.KenilworthNJ 07033USA Pharmacokinetics Dynamics and MetabolismPﬁzer Worldwide Research and DevelopmentGrotonCT 06340USA Eli Lilly and Company IndianapolisIN 46221USA Drug Metabolism and Pharmacokinetics BiogenCambridgeMA 02142USA Drug Metabolism and Pharmacokinetics Accent TherapeuticsInc.LexingtonMA 02421USA Department of Drug Metabolism and Pharmacokinetics GenentechA Member of the Roche GroupSouth San FranciscoCA 94080USA Drug Metabolism and Pharmacokinetics Department Bristol-Myers Squibb CompanyPrincetonNJ 08540USA Bioanalysis and Biomarkers Glaxo Smith KlineKing of the PrussiaPA 19406USA Department of Drug Metabolism and Pharmacokinetics Takeda Pharmaceuticals International Co.CambridgeMA 02139USA Ofﬁce of Research and Standards Ofﬁce of Generic DrugsCDERFDASilver SpringMD 20993USA Department of Pharmacology and Toxicology College of PharmacyUniversity of ArizonaTucsonAZ 85721USA Current afﬁliation:Translational Medicine EMD Serono Research&Development InstituteInc.BillericaMA 01821USA Current afﬁliation:Drug Metabolism Gilead Sciences Inc.Foster CityCA 94404USA

Drug metabolism and pharmacokinetics(DMPK) is an important branch of pharmaceutical *** nature of ADME(absorption,distribution,metabolism,excretion) and PK(pharmacokinetics) inquiries during drug discovery and development has evolved in recent years from being largely descriptive to seeking a more quantitative and mechanistic understanding of the fate of drug candidates in biological *** progress has been made in the past decade,not only in the characterization of physiochemical properties of drugs that influence their ADME,target organ exposure,and toxicity,but also in the identification of design principles that can minimize drug-drug interaction(DDI) potentials and reduce the *** importance of membrane transporters in drug disposition,efficacy,and safety,as well as the interplay with metabolic processes,has been increasingly *** increases in investments on new modalities beyond traditional small and large molecule drugs,such as peptides,oligonucleotides,and antibody-drug conjugates,necessitated further innovations in bioanalytical and experimental tools for the characterization of their ADME *** this review,we highlight some of the most notable advances in the last decade,and provide future perspectives on potential major breakthroughs and innovations in the translation of DMPK science in various stages of drug discovery and development.

关键词： Drug discovery and development New drug application Biologics license application Pharmacokinetics ADME New modalities Model-informed drug development Micro-physiological systems

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中国水稻生产“双减”的目的意义与途径方法

中国农学通报 2018年第23期34卷 12-18页

作者：剧成欣季红娟张春梅陆玉荣刘建凤吕敏卫甜赵步洪王志琴杨建昌江苏里下河地区农业科学研究所/江苏省生态农业工程技术研究中心江苏扬州225007 扬州大学江苏省作物遗传生理国家重点实验室培育点/粮食作物现代产业技术协同创新中心江苏扬州225009

实现化肥和农药"双减"是中国当前水稻生产的迫切需求。为了对水稻生产"双减"提供理论参考,本研究概述了世界与中国化肥农药的使用现状,总结了水稻生产"双减"的技术措施与实施途径,介绍了水稻生产"双减"的政策措施,探讨了实施水稻生产"双... 详细信息

实现化肥和农药"双减"是中国当前水稻生产的迫切需求。为了对水稻生产"双减"提供理论参考,本研究概述了世界与中国化肥农药的使用现状,总结了水稻生产"双减"的技术措施与实施途径,介绍了水稻生产"双减"的政策措施,探讨了实施水稻生产"双减"后对粮食安全和生态安全的影响,并展望了水稻生产"双减"的发展趋势与方向。

关键词：水稻化肥农药双减高产高效植物保护

Diagnosis and therapy of primary undifferentiated embryonal sarcoma of the liver

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Chinese Medical Journal 2014年第8期127卷 1585-1587页

作者： Lyu Shaocheng Shi Xianjie Liang yurong Gu Wanqing Ji Wenbin luo Ying lu Fang Xu Mingyue Department of Hepatobiliary Surgery People's Liberation Army General Hospital Beijing 100853 China

Primary undifferentiated embryonal sarcoma （UES） of the liver, also called malignant mesenchymoma of the liver, is a rare hepatic malignancy. It arises from the mesoderm and comprises more than two types of sarcomas. UES can occur at any site of the body; common sites include the retroperitoneum and the lower extremities. Only a few cases of UES have been reported worldwide.1 In this study, we retrospectively examined the clinical data of 11 patients with UES between January 2000 and November 2011 at the People＇s Liberation Army General Hospital.

关键词： liver undifferentiated embryonal sarcoma diagnosis therapy