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老年高血压患者疾病感知与焦虑抑郁症状相关关系研究

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中国慢性病预防与控制 2024年第3期32卷 188-192,197页

作者：武玉姣徐佳赵琦顾海雁施建华复旦大学公共卫生学院上海200032 上海市徐汇区疾病预防控制中心上海200237 上海市徐汇区田林街道社区卫生服务中心上海200030

目的分析社区老年高血压患者疾病感知与焦虑和抑郁症状的关系,为改善其心理健康状况提供科学依据。方法于2023年4月采用多阶段分层随机抽样方法从上海市徐汇区疾病预防控制中心慢性病信息化管理平台中的老年高血压患者中抽取848名作为... 详细信息

目的分析社区老年高血压患者疾病感知与焦虑和抑郁症状的关系,为改善其心理健康状况提供科学依据。方法于2023年4月采用多阶段分层随机抽样方法从上海市徐汇区疾病预防控制中心慢性病信息化管理平台中的老年高血压患者中抽取848名作为研究对象。分别采用病人健康问卷抑郁量表(PHQ-9)、广泛性焦虑障碍量表(GAD-7)、疾病感知问卷简化版(BIPQ)评估高血压患者疾病感知现状、焦虑症状和抑郁症状。使用SPSS 26.0软件进行χ^(2)检验,采用多因素logistic回归分析疾病感知对焦虑、抑郁症状的影响。结果848名调查对象中有焦虑症状、抑郁症状者分别占17.7%和23.2%,BIPQ总分为(35.18±8.58)分。多因素logistic回归分析结果显示,疾病感知总分(OR=1.069,95%CI:1.041~1.098)、疾病影响(OR=1.190,95%CI:1.046~1.353)、疾病可理解性(OR=1.276,95%CI:1.067~1.527)和疾病情绪(OR=1.178,95%CI:1.015~1.368)得分增加与高血压患者焦虑症状高风险相关;疾病感知总分(OR=1.051,95%CI:1.027~1.075)、疾病影响(OR=1.265,95%CI:1.126~1.420)、疾病关心(OR=1.158,95%CI:1.002~1.339)和疾病可理解性(OR=1.301,95%CI:1.102~1.535)得分增加与高血压患者抑郁症状高风险相关,症状识别(OR=0.852,95%CI:0.732~0.990)得分增加与高血压患者抑郁症状低风险相关。结论老年高血压患者对疾病的负性感知与焦虑抑郁症状的发生相关,帮助患者树立正确疾病认知可改善其心理健康状况。

关键词：高血压老年患者疾病感知焦虑抑郁

全球主要开源数据库强震动记录的基本分布特征

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地震研究 2024年第4期47卷 553-562页

作者：肖裴渊任叶飞吴玉娇周宝峰张亚军吴华灯温瑞智中国地震局工程力学研究所地震工程与工程振动重点实验室黑龙江哈尔滨150000 地震灾害防治应急管理部重点实验室黑龙江哈尔滨150000 宁夏交通建设股份有限公司宁夏银川750021 广东省地震局广东广州510070

强震动数据是地震工程和工程地震领域研究的基础,为了便于高效选取强震动记录,基于以下全球强震动开源数据库:美国USGS、欧洲ESM、日本K-NET和KiK-net、墨西哥RAII-UNAM和新西兰GeoNet,收集整理5.0级以上地震的强震动记录40余万组,约15... 详细信息

强震动数据是地震工程和工程地震领域研究的基础,为了便于高效选取强震动记录,基于以下全球强震动开源数据库:美国USGS、欧洲ESM、日本K-NET和KiK-net、墨西哥RAII-UNAM和新西兰GeoNet,收集整理5.0级以上地震的强震动记录40余万组,约150万条,通过震级、台站分布、场地条件、反应谱谱型等强震动基本信息对强震动记录进行筛选并分类,采用两套标准对场地进行了分类,对绝对加速度反应谱进行归一化,对比分析5个国家和地区的平均反应谱谱型的相似性与特殊性,结果表明:①美国强震动台站集中分布在西海岸与阿拉斯加地区,较硬的场地占比较高;②日本强震动台站分布密度最高,较软的场地占比较高;③给出了中、美两套规范下的强震动台站场地分类;④从震中距方面考虑,美国为近场强震动记录最为集中和丰富的国家;⑤不同国家和地区相同周期段绝对加速度反应谱具有明显的区域性差异。

关键词：强震动记录开源数据库绝对加速度反应谱场地分类

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ESCRT-I Component VPS23A Sustains Salt Tolerance by Strengthening the SOS Module in Arabidopsis

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Molecular Plant 2020年第8期13卷 1134-1148页

作者： Lijuan Lou Feifei Yu Miaomiao Tian Guangchao Liu Yaorong wu yujiao wu Ran Xia Jose M.Pardo Yan Guo Qi Xie State Key Laboratory of Plant Genomics Institute of Genetics and Developmental BiologyThe Innovative Academy of Seed DesignChinese Academy of SciencesBeijing 100101 P.R.China University of Chinese Academy of Sciences Beijing 100049P.R.China State Key Laboratory of Plant Physiology and Biochemistry College of Biological SciencesChina Agricultural UniversityBeijing 100193P.R.China Instituto de Bioquimica Vegetal y Fotosintesis Consejo Superior de Investigaciones Cientificas and Universidad de SevillaSevilla 41092Spain

The Salt-Overly-Sensitive(SOS)signaling module,comprising the sodium-transport protein SOS1 and the regulatory proteins SOS2 and SOS3,is well known as the central salt excretion system,which helps protect plants against salt *** we report that VPS23A,a component of the ESCRT(endosomal sorting complex required for transport),plays an essential role in the function of the SOS module in conferring plant salt ***23A enhances the interaction of SOS2 and *** the presence of salt stress,VPS23A positively regulates the redistribution of SOS2 to the plasma membrane,which then activates the antiporter activity of SOS1 to reduce Na+accumulation in plant *** evidence demonstrated that plant salt tolerance achieved by the overexpression of SOS2 and SOS3 dependeds on *** together,our results revealed that VPS23A is a crucial regulator of the SOS module and affects the localization of SOS2 to the cell ***,the strong salt tolerance of Arabidopsis seedlings conferred by the engineered membrane-bound SOS2 revealed the significance of SOS2 sorting to the cell membrane in achieving its function,providing a potential strategy for crop salt tolerance engineering.

关键词： SOS pathway ESCRTs VPS23a salt cell membrane

Dynamic changes of phosphatidylinositol and phosphatidylinositol 4-phosphate levels modulate H^(+)-ATPase and Na^(+)/H^(+) antiporter activities to maintain ion homeostasis in Arabidopsis under salt stress

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Molecular Plant 2021年第12期14卷 2000-2014页

作者： Yongqing Yang Xiuli Han Liang Ma yujiao wu Xiao Liu Haiqi Fu Guoyong Liu Xiaoguang Lei Yan Guo State Key Laboratory of Plant Physiology and Biochemistry College of Biological SciencesChina Agricultural UniversityBeijing 100193China College of Life Sciences Shandong University of TechnologyZibo 255049China Beijing National Laboratory for Molecular Sciences Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of EducationDepartment of Chemical BiologyCollege of Chemistry and Molecular EngineeringSynthetic and Functional Biomolecules Centerand Peking-Tsinghua Center for Life SciencesPeking UniversityBeijing 100871China

Plant metabolites are dynamically modified and distributed in response to environmental ***-ever,it is poorly understood how metabolic change functions in plant stress *** ion ho-meostasis under salt stress requires coordinated activation of two types of central regulators:plasma membrane(PM)H^(+)-ATPase and Na^(+)/H^(+) *** this study,we used a bioassay-guided isolation approach to identify endogenous small molecules that affect PM H^(+)-ATPase and Na^(+)/H^(+) antiporter activities and identified phosphatidylinositol(PI),which inhibits PM H^(+)-ATPase activity under non-stress conditions in Arabidopsis by directly binding to the C terminus of the PM H^(+)-ATPase *** salt stress,the phosphatidylinositol 4-phosphate-to-phosphatidylinositol(PI4P-to-PI)ratio increased,and PI4P bound and activated the PM Na^(+)/H^(+) *** prefers binding to the inactive form of PM H^(+)-ATPase,while PI4P tends to bind to the active form of the Na^(+)/H^(+) *** with this,pis1 mutants,with reduced levels of PI,displayed increased PM H^(+)-ATPase activity and salt stress toler-ance,while the pi4kβ1 mutant,with reduced levels of PI4P,displayed reduced PM Na^(+)/H^(+) antiporter activity and salt stress ***,our results reveal that the dynamic change between PI and PI4P in response to salt stress in Arabidopsis is crucial for maintaining ion homeostasis to protect plants from un-favorable environmental conditions.

关键词： Arabidopsis thaliana endogenous small molecules H^(+)-ATPase Na^(+)/H^(+)antiporter salt stress

盘形滚刀对TBM破岩效率的影响参数分析及优化设计

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福建理工大学学报 2024年第1期22卷 8-15页

作者：周亚来詹金武邵顺安郑晋溪刘国武玉娇福建理工大学土木工程学院福建福州350118 福建省建筑工程质量检测中心有限公司福建福州350118

为探究盘形滚刀形式对TBM破岩效率的影响,依托福州滨海快线工程项目,利用ABAQUS创建盘形滚刀破岩模型,通过优化单刃滚刀结构参数,分析多滚刀破岩方式对掘进效率的影响。结果表明:刃宽和贯入度对滚刀破岩的影响最大,随着刃宽和贯入度增加... 详细信息

为探究盘形滚刀形式对TBM破岩效率的影响,依托福州滨海快线工程项目,利用ABAQUS创建盘形滚刀破岩模型,通过优化单刃滚刀结构参数,分析多滚刀破岩方式对掘进效率的影响。结果表明:刃宽和贯入度对滚刀破岩的影响最大,随着刃宽和贯入度增加,滚刀受到的滚动力、垂直力和破岩体积逐渐增大,并在刃宽20 mm、贯入度10 mm时,达到最佳破岩效果;双滚刀下采用同步破岩的效率要明显高于顺次破岩,其最优刀间距为60 mm;随着四滚刀回转半径增加,滚刀受到的切向力、垂直力和合力均增大,侧向力呈现先增大后减小的趋势,在回转半径350 mm处达到最大。研究成果可为福州滨海快线项目TBM滚刀选型及施工方案优化设计提供依据。

关键词： ABAQUS数值模拟滚刀结构参数刀间距回转破岩

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常州市老年肺结核患者利福平耐药分析

预防医学 2024年第2期36卷 162-164,168页

作者：吴玉姣左小明秦科宇张志新张兴常州市第三人民医院药事科江苏常州213000 常州市第三人民医院江苏常州213000 常州市疾病预防控制中心江苏常州213000

目的了解江苏省常州市老年肺结核患者利福平耐药情况及其影响因素,为完善耐药结核病防控策略提供依据。方法选择2020—2022年在常州市结核病定点医院就诊的>60岁肺结核患者为研究对象,收集人口学信息、既往疾病与诊疗史、药敏试验等资... 详细信息

目的了解江苏省常州市老年肺结核患者利福平耐药情况及其影响因素,为完善耐药结核病防控策略提供依据。方法选择2020—2022年在常州市结核病定点医院就诊的>60岁肺结核患者为研究对象,收集人口学信息、既往疾病与诊疗史、药敏试验等资料,分析老年肺结核患者利福平耐药情况及其影响因素。结果共纳入249例老年肺结核患者,年龄为(69.75±4.36)岁。男性147例,女性102例,男女性别比为1.44∶1。初治患者183例,占73.49%;复治患者66例,占26.51%。利福平耐药21例,耐药率为8.43%。其中初治患者7例,耐药率为3.83%;复治患者14例,耐药率为21.21%。多因素logistic回归分析结果显示,老年肺结核复治患者利福平耐药风险较高(OR=10.551,95%CI:1.344~82.857)。结论常州市249例老年肺结核患者利福平耐药率为8.43%,治疗类型是利福平耐药的影响因素。

关键词：老年人肺结核利福平耐药影响因素

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草鱼敏感的负趋音筛选

水产学报 2024年第4期48卷 366-375页

作者：杨吉邬玉娇李晓兵尼玛旦增达瓦张占刘国勇许家炜柯森繁李卫东李冬晴石小涛三峡大学水利与环境学院三峡大学湖北省鱼类过坝技术国际科技合作基地中水北方勘测设计研究有限责任公司西藏自治区水利电力规划勘测设计研究院河海大学水利水电学院

声学屏障是一种阻拦鱼类进入危险区域进而保护鱼类资源的重要手段，为筛选鱼类敏感的负趋音作为声学屏障，本研究采用6种单频音(500～3 000 Hz)和1种宽频音(扬子鳄吼叫声)作为实验用音对草鱼幼鱼进行负趋音的筛选研究，通过在水槽两端... 详细信息

声学屏障是一种阻拦鱼类进入危险区域进而保护鱼类资源的重要手段，为筛选鱼类敏感的负趋音作为声学屏障，本研究采用6种单频音(500～3 000 Hz)和1种宽频音(扬子鳄吼叫声)作为实验用音对草鱼幼鱼进行负趋音的筛选研究，通过在水槽两端交替播音来对比草鱼幼鱼对不同声音的行为反应。结果显示，大多数实验鱼对声音有反应，扬子鳄吼叫声与其他声音组的差异显著。单频音实验组中播放500 Hz单频音时平均反应次数最大，为(1.7±0.6)次，而播放扬子鳄吼叫声时平均反应次数高达(5.0±0.9)次，显著高于其他实验音。在总平均速度中，宽频音组中草鱼的总平均速度显著高于其他组，表明草鱼对扬子鳄吼叫声敏感，产生逃窜行为。研究表明，草鱼对扬子鳄吼叫声具有负趋音性，扬子鳄吼叫声是一种对草鱼具有驱赶、威慑作用的声音。本研究可为过鱼设施中辅助诱驱鱼手段及水利结构中避免鱼类的夹带提供参考依据。

关键词：草鱼幼鱼扬子鳄负趋音性单频音宽频音

The Ca2+ sensor SCaBP3 Fine Tunes Arabidopsis Saline-alkali Tolerance by Modulating Plasma Membrane H+-ATPase Activity

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The Ca2+ sensor SCaBP3 Fine Tunes Arabidopsis Saline-alkali ...

Treatment with β-sitosterol ameliorates the effects of cerebral ischemia/reperfusion injury by suppressing cholesterol overload, endoplasmic reticulum stress, and apoptosis

2018全国植物生物学大会

作者： yujiao wu Yongqing Yang Yan Guo State Key Laboratory of Plant Physiology and Biochemistry College of Biological SciencesChina Agricultural University

Plasma membrane(PM) H-ATPases play an important role in the establishment of trans-plasma membrane pH gradient to support ion and metabolite *** Cterminal autoinhibitory domain is critical for the regulation of PM H-ATPase activity;however the underlying mechanism is not well ***,we report that the C terminus and the Centerloop region of the PM H-ATPase interact with each other,and that interaction of the SCaBP3 with the RI domain of the C terminus further enhances this interaction,this in turn promotes its autoinhibition to the PM H-ATPase ***,Arabidopsis SCaBP3 loss-of-function plants exhibit increased PM H-ATPase ***,SCaPB3 interacts with the SOS2 like protein kinase5(PKS5),a negative regulator of PM H-ATPase,and also enhances the interaction between PM H-ATPase AHA2 and *** plant and yeast systems,SCaBP3 augments PKS5 mediated inhibition of the PM *** together,our results suggest that the C-terminal autoinhibition of PM H-ATPase is at least partially established through directly interacting with the Centerloop region,and that SCaBP3/CBL7 plays a critical role in enahncing or stabilizing the repression of PM H-ATPase activity by simultaneously promoting the interaction between the C terminus and Centerloop and between the C terminus and PKS5.

关键词： plasma membrane H+-ATPase kinase Calcium binding protein

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Neural Regeneration Research 2024年第3期19卷 642-649页

作者： Xiuling Tang Tao Yan Saiying Wang Qingqing Liu Qi Yang Yongqiang Zhang yujiao Li Yumei wu Shuibing Liu Yulong Ma Le Yang Precision Pharmacy&Drug Development Center Department of PharmacyTangdu HospitalAir Force Medical UniversityXi’anShaanxi ProvinceChina Department of Clinical Pharmacy Jinling HospitalMedical School of Nanjing UniversityNanjingJiangsu ProvinceChina Department of Pharmacology School of PharmacyAir Force Medical UniversityXi’anShaanxi ProvinceChina Department of Anesthesiology The First Medical Center of Chinese PLA General HospitalBeijingChina Department of Anatomy Histology and Embryology and K.K.Leung Brain Research CentreAir Force Medical UniversityXi’anShaanxi ProvinceChina

β-Sitosterol is a type of phytosterol that occurs naturally in *** studies have shown that it has anti-oxidant,anti-hyperlipidemic,anti-inflammatory,immunomodulatory,and anti-tumor effects,but it is unknown whetherβ-sitosterol treatment reduces the effects of ischemic *** we found that,in a mouse model of ischemic stroke induced by middle cerebral artery occlusion,β-sitosterol reduced the volume of cerebral infarction and brain edema,reduced neuronal apoptosis in brain tissue,and alleviated neurological dysfunction;moreover,β-sitosterol increased the activity of oxygen-and glucose-deprived cerebral cortex neurons and reduced *** investigation showed that the neuroprotective effects ofβ-sitosterol may be related to inhibition of endoplasmic reticulum stress caused by intracellular cholesterol accumulation after ischemic *** addition,β-sitosterol showed high affinity for NPC1L1,a key transporter of cholesterol,and antagonized its *** conclusion,β-sitosterol may help treat ischemic stroke by inhibiting neuronal intracellular cholesterol overload/endoplasmic reticulum stress/apoptosis signaling pathways.

关键词： apoptosis blood-brain barrier β-sitosterol cerebral ischemia/reperfusion injury cholesterol overload cholesterol transport endoplasmic reticulum stress ischemic stroke molecular docking NPC1L1