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Neural Regeneration Research 2025年第7期20卷 2108-2115页

作者： yuhui Kou Zongxue Jin Yusong Yuan Bo Ma Wenyong Xie Na Han Department of Trauma and Orthopedics Peking University People’s HospitalBeijingChina National Center for Trauma Medicine Peking University People’s HospitalBeijingChina Key Laboratory of Trauma and Neural Regeneration(Peking University) Ministry of EducationBeijingChina Trauma Medicine Center Peking University People’s HospitalBeijingChina Department of Orthopedics China-Japan Friendship HospitalBeijingChina

FK506(Tacrolimus)is a systemic immunosuppressant approved by the *** and Drug ***506 has been shown to promote peripheral nerve regeneration,however,its precise mechanism of action and its pathways remain *** this study,we established a rat model of sciatic nerve injury and found that FK506 improved the morphology of the injured sciatic nerve,increased the numbers of motor and sensory neurons,reduced inflammatory responses,markedly improved the conduction function of the injured nerve,and promoted motor function *** findings suggest that FK506 promotes peripheral nerve structure recovery and functional regeneration by reducing the intensity of inflammation after neuronal injury and increasing the number of surviving neurons.

关键词： FK506 inflammation motor neurons nerve regeneration neuron peripheral nerve injury sensory neurons

Harnessing the Streptomyces-originating type I-E CRISPR/Cas system for efficient genome editing in Streptomyces

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Science China Life Sciences 2025年

作者： yuhui Xie Xiaoyan Liu Tingting Wu Yunzi Luo Frontiers Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering (Ministry of Education) School of Chemical Engineering and TechnologyTianjin University Department of Gastroenterology State Key Laboratory of BiotherapyWest China HospitalSichuan University Georgia Tech Shenzhen Institute Tianjin University Haihe Laboratory of Sustainable Chemical Transformations

Since their discovery,CRISPR/Cas systems have significantly expanded the genetic toolbox,aiding in the exploration and enhanced production of natural products across various *** these,class 2 CRISPR/Cas systems are simpler and more broadly used,but they frequently fail to function effectively in many Streptomyces *** this study,we present an engineered class 1 type I CRISPR/Cas system derived from Streptomyces avermitilis,which enables efficient gene editing in phylogenetically distant Streptomyces *** a plasmid interference assay,we identified the effective protospacer adjacent motif as 5′-AAN-3′.Utilizing this system,we achieved targeted chromosomal deletions ranging from 8 bp to 100 kb,with efficiencies exceeding 92%.We further utilized this system to insert DNA fragments into different Streptomyces genomes,facilitating the heterologous expression of exogenous genes and the activation of endogenous natural product biosynthetic gene ***,we established a type I CRISPR/Cas-based gene-editing methodology that significantly advances the exploration of Streptomyces,known for their rich natural product *** is the first report of a gene editing tool developed based on the endogenous class 1 type I CRISPR/Cas system in Streptomyces *** work enriches the Streptomyces gene manipulation toolbox and advances the discovery of valuable natural products within these organisms.

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Designing Electronic Structures of Multiscale Helical Converters for Tailored Ultrabroad Electromagnetic Absorption

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Nano-Micro Letters 2025年第1期17卷 439-455页

作者： Zhaobo Feng Chongbo Liu Xin Li Guangsheng Luo Naixin Zhai Ruizhe Hu Jing Lin Jinbin Peng yuhui Peng Renchao Che Key Laboratory of Jiangxi Province for Persistent Pollutants Control and Resources Recycle School of Environmental and Chemical EngineeringNanchang Hangkong UniversityNanchang 330063People’s Republic of China School of Physics and Materials Nanchang UniversityNanchang 330031People’s Republic of China Key Laboratory of Nondestructive Testing Ministry of EducationNanchang Hangkong UniversityNanchang 330063People’s Republic of China Laboratory of Advanced Materials Shanghai Key Lab of Molecular Catalysis and Innovative MaterialsAcademy for Engineering and TechnologyFudan UniversityShanghai 200438People’s Republic of China

Atomic-scale doping strategies and structure design play pivotal roles in tailoring the electronic structure and physicochemical property of electromagnetic wave absorption(EMWA)***,the relationship between configuration and electromagnetic(EM)loss mechanism has remained ***,drawing inspiration from the DNA transcription process,we report the successful synthesis of novel in situ Mn/N co-doped helical carbon nanotubes with ultrabroad EMWA *** calculation and EM simulation confirm that the orbital coupling and spin polarization of the Mn–N4–C configuration,along with cross polarization generated by the helical structure,endow the helical converters with enhanced EM *** a result,HMC-8 demonstrates outstanding EMWA performance,achieving a minimum reflection loss of−63.13 dB at an ultralow thickness of 1.29 *** precise tuning of the graphite domain size,HMC-7 achieves an effective absorption bandwidth(EAB)of 6.08 GHz at 2.02 mm ***,constructing macroscale gradient metamaterials enables an ultrabroadband EAB of 12.16 GHz at a thickness of only 5.00 mm,with the maximum radar cross section reduction value reaching 36.4 dB *** innovative approach not only advances the understanding of metal–nonmetal co-doping but also realizes broadband EMWA,thus contributing to the development of EMWA mechanisms and applications.

关键词： Metal-nonmetal co-doping 3d-2p orbital coupling Spin polarization Helical structure Broadband EM wave absorption

Criteria on ergodicity and strong ergodicity of single death processes

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Frontiers of Mathematics in China 2018年第5期13卷 1215-1243页

作者： yuhui ZHANG School of Mathematical Sciences Beijing Normal University Laboratory of Mathematicsand Complex Systems Ministry of Education Beijing 100875 China

Based on an explicit representation of moments of hitting times for single death processes, the criteria on ergodicity and strong ergodicity are obtained. These results can be applied for an extended class of branching processes. Meanwhile, some sufficient and necessary conditions for recurrence and exponential ergodicity as well as extinction probability for the processes are presented.

关键词： Single death process ergodicity strong ergodicity recurrence moments of hitting times

Moments of first hitting times for bitth-death processes on trees

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Frontiers of Mathematics in China 2019年第4期14卷 833-854页

作者： yuhui ZHANG School of Mathematical Sciences Beijing Normal University Laboratory of Mathematics and Complex Systems Ministry of Education Beijing 100875 China

An explicit and recursive representation is presented for moments of the first hitting times of birth-death processes on trees. Based on that, the criteria on ergodicity, strong ergodicity, and l-ergodicity of the pro... 详细信息

关键词： Eirth-death process on trees ergodicity hitting time returning time

Allocating workload to minimize the power consumption of data centers

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Frontiers of Computer Science 2017年第1期11卷 105-118页

作者： Ruihong LIN yuhui DENG Department of Computer Science Jinan University Guangzhou 510632 China

Reducing the power consumption has become one of the most important challenges in designing modem data centers due to the explosive growth of data. The tradi- tional approaches employed to decrease the power consump- tion normally do not consider the power of IT devices and the power of cooling system simultaneously. In contrast to existing works, this paper proposes a power model which can minimize the overall power consumption of data centers by balancing the computing power and cooling power. Fur- thermore, an enhanced genetic algorithm （EGA） is designed to explore the solution space of the power model since the model is a liner programming problem. However, EGA is computing intensive and the performance gradually decreases with the growth of the problem size. Therefore, heuristic greedy sequence （HGS） is proposed to simplify the calcu- lation by leveraging the nature of greed. In contrast to EGA, HGS can determine the workload allocation of a specific data center layout with only one calculation. Experimental results demonstrate that both the EGA and HGS can significantly reduce the power consumption of data centers in contrast to the random algorithm. Additionally, HGS significantly out- performs EGA in terms of the continuity of workload alloca- tion and execution performance.

关键词： data center energy conservation workload allocation power model

Moments of integral-type downward functionals for single death processes

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Frontiers of Mathematics in China 2020年第4期15卷 749-768页

作者： Jing WANG yuhui ZHANG School of Mathematical Sciences Beijing Normal UniversityLaboratory of Mathematics and Complex SystemsMinistry of EducationBeijing 100875China School of Mathematics and Statistics Yili Normal UniversityYili 835000China

We get an explicit and recursive representation for high order moments of integral-type downward functionals for single death ***,main results are applied to more general integral-type downward functionals.

关键词： Single death process integral-type functional moment

Property analysis of logic Petri nets by marking reachability graphs

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Frontiers of Computer Science 2014年第4期8卷 684-692页

作者： Yuyue DU yuhui NING College of Information Science and Engineering Shandong University of Science and Technology Qingdao 266590 China

Logic Petri nets （LPNs） are suitable to describe and analyze batch processing functions and passing value indeterminacy in cooperative systems. To investigate the dynamic properties of LPNs directly, a new method for analyzing LPNs is proposed based on marking reachability graphs in this paper. Enabled conditions of transitions are obtained and a marking reachability graph is constructed. All reach- able markings can be obtained based on the graph; the fairness and reversibility of LPNs are analyzed. Moreover, the computing complexity of the enabled conditions and reachable markings can be reduced by this method. The advantages of the proposed method are illustrated by examples and analysis.

关键词： logic Petri nets enabled condition reachable marking graph fairness reversibility

The role of DLL1 in long-term vascular normalization and cancer immunotherapy

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Cancer Biology & Medicine 2021年第4期18卷 940-943页

作者： Qiaozhen Wu yuhui Huang Suzhou Ninth Hospital Affiliated to Soochow University Suzhou 215200China Hematology Center Cyrus Tang Medical InstituteThe Collaborative Innovation Center of HematologyState Key Laboratory of Radiation Medicine and ProtectionSoochow UniversitySuzhou 215123China

Cancer immunotherapy,especially immune checkpoint blockade therapy(ICB),has revolutionized cancer treatment,providing a potential curable modality for advanced cancer *** immunogenic cancer,such as melanoma and lung cancers with a history of smoking,approximately 30%patients with anti-programmed death 1(PD1)monotherapy survive more than 5 ***,despite being a major breakthrough in the treatment of cancer,the majority of cancer patients have not yet benefited from ICB monotherapy^(1).Thus,innovative strategies to improve ICB efficacy are still needed.

关键词： PD1 immunotherapy breakthrough

Synthesis and Characterization of Electrodeposited Nanocrystalline Nickel

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材料热处理学报 2004年第05B期25卷 1283-1286页

作者： DAIPin-qiang yuhui LIQiang CollegeofMaterialsScienceandEngineering FuZhouUniversityFuzhouChina

Nanocrystalline nickel was synthesize d by direct current electrodeposition from a modified Watts-type bath. X-ray diffraction and transmission electron microscope were used to characterize the microstructure of nickel deposits. The results show that nanocrytalline nickel with grain sizes in the range 20～50nm can be synthesized from saccharin-containing Watts-type baths with current density range 5～30A/dm2. There existed preferred orientation in the deposits and it changed progressively from a (200) fibre texture to a (111) (200) double fibre texture as saccharin concentration increased. The hardness of the deposits increased prominently as grain size decreased to nanometer range.

关键词：毫微结晶电解淀积显微结构镍合金